Cited by 3,017Nanoparticle-Based Drug DeliveryNanoparticles: synthesis and applicationsNanotechnology research and applications

Biomolecular coronas provide the biological identity of nanosized materials

Open access
Monopoli, Marco P., Åberg, Christoffer, Salvati, Anna, Dawson, Kenneth A.·2012·Nature Nanotechnology

Abstract

The search for understanding the interactions of nanosized materials with living organisms is leading to the rapid development of key applications, including improved drug delivery by targeting nanoparticles, and resolution of the potential threat of nanotechnological devices to organisms and the environment. Unless they are specifically designed to avoid it, nanoparticles in contact with biological fluids are rapidly covered by a selected group of biomolecules to form a corona that interacts with biological systems. Here we review the basic concept of the nanoparticle corona and its structure and composition, and highlight how the properties of the corona may be linked to its biological impacts. We conclude with a critical assessment of the key problems that need to be resolved in the near future.

Integrity signals

Registry

Crossref · 10.1038/nnano.2012.207

Cites

2 of 2 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Monopoli, M. P., Åberg, C., Salvati, A., & Dawson, K. A.
Affiliations
University College Dublin (IE)
Corresponding author
Dawson, Kenneth A.
Venue
Nature Nanotechnology
Published
2012-12
Volume
7
Issue
12
Pages
779-786
ISSN
  • 1748-3387 (ISSN-L)
  • 1748-3395
OpenAlex
W2110634891
Cited by
3,017
References
2
Citations by year
2026: 413 · 2025: 175 · 2024: 142 · 2023: 164 · 2022: 233 · 2021: 228 · 2020: 221 · 2019: 214 · 2018: 227 · 2017: 219 · 2016: 209 · 2015: 234 · 2014: 219 · 2013: 117
FWCI
9.47
Type
journal article
Language
en
Open access
Licence
Locations
  • Nature Nanotechnology (publishedVersion)
  • PubMed (publishedVersion)
  • Research Repository UCD (University College Dublin) (submittedVersion, cc-by-nc-nd)
  • Arrow@dit (Dublin Institute of Technology) (submittedVersion, cc-by-nc-nd)
Funders
  • European Commission (266737)
  • Science Foundation Ireland
Topics
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
  • Physical Sciences › Materials Science › Materials Chemistry › Nanoparticles: synthesis and applications
  • Physical Sciences › Engineering › Biomedical Engineering › Nanotechnology research and applications
Keywords
nanoparticle corona, biomolecular adsorption, nanoparticle-biomolecule interactions, nanoparticle biocompatibility, targeted drug delivery, nanoparticle toxicity, environmental risk of nanomaterials, nanoparticle surface modification
MeSH terms
Animals, Biocompatible Materials, Body Fluids, Humans, Kinetics, Particle Size, Proteins, Drug Delivery Systems, Nanotechnology, Nanoparticles

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review