The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Biocompatibility and Toxicity of Graphene Quantum Dots for Potential Application in Photodynamic Therapy
Open accessAbstract
AIM: Achieving reliably high production of reactive oxygen species (ROS) in photodynamic therapy (PDT) remains challenging. Graphene quantum dots (GQDs) hold great promise for PDT. However, the photochemical processes leading to GQD-derived ROS generation have not yet been fully elucidated. MATERIALS & METHODS: Physicochemical characteristics of GQDs were comprehensively investigated, including electron paramagnetic resonance analysis of singlet oxygen production. Dark toxicity was assessed in vitro and in vivo. RESULTS: GQDs demonstrated excellent photoluminescent features, corrosion resistance, high water solubility, high photo/pH-stability, in vitro and in vivo biocompatibility and very efficient singlet oxygen/ROS generation. CONCLUSION: The enhanced ROS generation, combined with good biocompatibility and minimal toxicity in vitro and in vivo support the potential of GQDs for future PDT application.
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Cites
Cancer nanotechnology: opportunities and challenges
Ferrari, M. (2005) · Nature Reviews Cancer · doi:10.1038/nrc1566 · Cited by 4,558
Renal clearance of quantum dots
Soo Choi, H., Liu, W., Misra, P., Tanaka, E., Zimmer, J. P., Itty Ipe, B., Bawendi, M. G., & Frangioni, J. V. (2007) · Nature Biotechnology · doi:10.1038/nbt1340 · Cited by 4,476
Glowing Graphene Quantum Dots and Carbon Dots: Properties, Syntheses, and Biological Applications
Zheng, X. T., Ananthanarayanan, A., Luo, K. Q., & Chen, P. (2015) · Small · doi:10.1002/smll.201402648 · Cited by 2,190
Cited by
Nanomaterials for Nanotheranostics: Tuning Their Properties According to Disease Needs
Wong, X. Y., Sena-Torralba, A., Álvarez-Diduk, R., Muthoosamy, K., & Merkoçi, A. (2020) · ACS Nano · doi:10.1021/acsnano.9b08133 · Cited by 363
Recent advances in photo‐responsive carbon dots for tumor therapy
Zhang, H., Liu, Y., & Qu, S. (2024) · Responsive Materials · doi:10.1002/rpm.20240012 · Cited by 121
Metadata
- Authors
- Tabish, T. A., Scotton, C. J., J Ferguson, D. C., Lin, L., der Veen, A. V., Lowry, S., Ali, M., Jabeen, F., Ali, M., Winyard, P. G., & Zhang, S.
- Venue
- Nanomedicine
- Publisher
- Informa UK Limited
- Published
- 2018-08
- Volume
- 13
- Issue
- 15
- Pages
- 1923-1937
- ISSN
- 1743-5889 (ISSN-L)
- 1748-6963
- OpenAlex
- W2887909456
- Cited by
- 224
- References
- 3
- FWCI
- 7.32
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Tabish, T. A., Scotton, C. J., J Ferguson, D. C., Lin, L., der Veen, A. V., Lowry, S., Ali, M., Jabeen, F., Ali, M., Winyard, P. G., & Zhang, S. (2018). Biocompatibility and Toxicity of Graphene Quantum Dots for Potential Application in Photodynamic Therapy. Nanomedicine. https://doi.org/10.2217/nnm-2018-0018
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