The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Dendrimer Pharmacokinetics: The Effect of Size, Structure and Surface Characteristics on ADME Properties
Abstract
Dendrimers show increasing promise as drug-delivery vectors and can be generated with a wide range of scaffold structures, sizes and surface functionalities. To this point, the majority of studies of dendrimer-based drug-delivery systems have detailed pharmacodynamic outcomes, or have followed the pharmacokinetics of a solubilized or conjugated drug. By contrast, detailed commentary on the in vivo fate of the dendrimer carrier is less evident, even though the pharmacokinetics of the carrier will likely dictate both pharmacodynamic and toxicokinetic outcomes. In the current article, the influence of size, structure and surface functionality on the absorption, distribution, metabolism and elimination (ADME) properties of dendrimers have been examined and the implications of these findings for delivery system design are discussed.
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Citations
Cites
Effect of pegylation on pharmaceuticals
Harris, J. M., & Chess, R. B. (2003) · Nature Reviews Drug Discovery · doi:10.1038/nrd1033 · Cited by 3,431
Kaminskas, L. M., Kelly, B. D., McLeod, V. M., Sberna, G., Owen, D. J., Boyd, B. J., & Porter, C. J. H. (2011) · Journal of Controlled Release · doi:10.1016/j.jconrel.2011.02.005 · Cited by 137
Self-citationKaminskas, L. M., Kelly, B. D., McLeod, V. M., Sberna, G., Boyd, B. J., Owen, D. J., & Porter, C. J. H. (2011) · Molecular Pharmaceutics · doi:10.1021/mp1001872 · Cited by 64
Cited by
Pharmaceutical nanotechnology for oral delivery of anticancer drugs
Mei, L., Zhang, Z., Zhao, L., Huang, L., Yang, X.-L., Tang, J., & Feng, S.-S. (2013) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2012.11.005 · Cited by 373
Zhong, Q., Bielski, E. R., Rodrigues, L. S., Brown, M. R., Reineke, J. J., & da Rocha, S. R. P. (2016) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.6b00126 · Cited by 88
Metadata
- Authors
- Kaminskas, L. M., Boyd, B. J., & Porter, C. J.
- Venue
- Nanomedicine
- Publisher
- Informa UK Limited
- Published
- 2011-08
- Volume
- 6
- Issue
- 6
- Pages
- 1063-1084
- ISSN
- 1743-5889 (ISSN-L)
- 1748-6963
- OpenAlex
- W2156440914
- Cited by
- 204
- References
- 3
- FWCI
- 10.64
- Type
- journal article
- Language
- en
- Open access
- closed
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- Kaminskas, L. M., Boyd, B. J., & Porter, C. J. (2011). Dendrimer Pharmacokinetics: The Effect of Size, Structure and Surface Characteristics on ADME Properties. Nanomedicine. https://doi.org/10.2217/nnm.11.67
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
