Effect of pegylation on pharmaceuticals

Principles of nanoparticle design for overcoming biological barriers to drug delivery

Blanco, E., Shen, H., & Ferrari, M. (2015) · Nature Biotechnology · doi:10.1038/nbt.3330 · Cited by 7,002 · see citing works

Drug Delivery Systems: Entering the Mainstream

Allen, T. M., & Cullis, P. R. (2004) · Science · doi:10.1126/science.1095833 · Cited by 4,552 · see citing works

Nanoparticle therapeutics: an emerging treatment modality for cancer

Davis, M. E., Chen, Z., & Shin, D. M. (2008) · Nature Reviews Drug Discovery · doi:10.1038/nrd2614 · Cited by 4,233 · see citing works

Exploiting the enhanced permeability and retention effect for tumor targeting

Iyer, A. K., Khaled, G., Fang, J., & Maeda, H. (2006) · Drug Discovery Today · doi:10.1016/j.drudis.2006.07.005 · Cited by 1,846 · see citing works

Recent Strategies to Develop Innovative Photosensitizers for Enhanced Photodynamic Therapy

Pham, T. C., Nguyen, V.-N., Choi, Y., Lee, S., & Yoon, J. (2021) · Chemical Reviews · doi:10.1021/acs.chemrev.1c00381 · Cited by 1,813 · see citing works

Polymers for Drug Delivery Systems

Liechty, W. B., Kryscio, D. R., Slaughter, B. V., & Peppas, N. A. (2010) · Annual Review of Chemical and Biomolecular Engineering · doi:10.1146/annurev-chembioeng-073009-100847 · Cited by 1,608 · see citing works

EPR: Evidence and fallacy

Nichols, J. W., & Bae, Y. H. (2014) · Journal of Controlled Release · doi:10.1016/j.jconrel.2014.03.057 · Cited by 834 · see citing works

PEGylation of therapeutic proteins

Jevševar, S., Kunstelj, M., & Porekar, V. G. (2010) · Biotechnology Journal · doi:10.1002/biot.200900218 · Cited by 681 · see citing works

Potential of solid lipid nanoparticles in brain targeting.

Kaur, I. P., Bhandari, R., Bhandari, S., & Kakkar, V. (2008) · Journal of Controlled Release · doi:10.1016/j.jconrel.2007.12.018 · Cited by 615 · see citing works

Atrp in the design of functional materials for biomedical applications

Siegwart, D. J., Oh, J. K., & Matyjaszewski, K. (2012) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2011.08.001 · Cited by 613 · see citing works

Anti‐ <scp>PEG</scp> immunity: emergence, characteristics, and unaddressed questions

Yang, Q., & Lai, S. K. (2015) · WIREs Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.1339 · Cited by 593 · see citing works

Delivery of Therapeutic Proteins

Pisal, D. S., Kosloski, M. P., & Balu-Iyer, S. V. (2010) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.22054 · Cited by 532 · see citing works

Biodegradable polymer nanoparticles that rapidly penetrate the human mucus barrier

Tang, B. C., Dawson, M., Lai, S. K., Wang, Y.-Y., Suk, J. S., Yang, M., Zeitlin, P., Boyle, M. P., Fu, J., & Hanes, J. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0905998106 · Cited by 453 · see citing works

Pre-existing Anti–Adeno-Associated Virus Antibodies as a Challenge in AAV Gene Therapy

Louis Jeune, V., Joergensen, J. A., Hajjar, R. J., & Weber, T. (2013) · Human Gene Therapy Methods · doi:10.1089/hgtb.2012.243 · Cited by 358 · see citing works

Control of hyperuricemia in subjects with refractory gout, and induction of antibody against poly(ethylene glycol) (PEG), in a phase I trial of subcutaneous PEGylated urate oxidase

Ganson, N. J., Kelly, S. J., Scarlett, E., Sundy, J. S., & Hershfield, M. S. (2005) · Arthritis Research &amp; Therapy · doi:10.1186/ar1861 · Cited by 350 · see citing works

Breaking Down the Barriers to Precision Cancer Nanomedicine

von Roemeling, C., Jiang, W., Chan, C. K., Weissman, I. L., & Kim, B. Y. S. (2017) · Trends in Biotechnology · doi:10.1016/j.tibtech.2016.07.006 · Cited by 330 · see citing works

Polymeric carriers: preclinical safety and the regulatory implications for design and development of polymer therapeutics

Gaspar, R., & Duncan, R. (2009) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2009.06.003 · Cited by 304 · see citing works

Diffusion of Macromolecules in the Brain: Implications for Drug Delivery

Wolak, D. J., & Thorne, R. G. (2013) · Molecular Pharmaceutics · doi:10.1021/mp300495e · Cited by 299 · see citing works

Manufacturing challenges and rational formulation development for AAV viral vectors

Srivastava, A., Mallela, K. M. G., Deorkar, N., & Brophy, G. (2021) · Journal of Pharmaceutical Sciences · doi:10.1016/j.xphs.2021.03.024 · Cited by 269 · see citing works

The Ever-Expanding Myokinome: Discovery Challenges and Therapeutic Implications

Whitham, M., & Febbraio, M. A. (2016) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2016.153 · Cited by 279 · see citing works

Irinotecan—Still an Important Player in Cancer Chemotherapy: A Comprehensive Overview

Kciuk, M., Marciniak, B., & Kontek, R. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21144919 · Cited by 266 · see citing works

Gemcitabine versus Modified Gemcitabine: A Review of Several Promising Chemical Modifications

Moysan, E., Bastiat, G., & Benoit, J.-P. (2013) · Molecular Pharmaceutics · doi:10.1021/mp300370t · Cited by 225 · see citing works

Main-chain poly(phosphoester)s: History, syntheses, degradation, bio-and flame-retardant applications

Bauer, K. N., Tee, H. T., Velencoso, M. M., & Wurm, F. R. (2017) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2017.05.004 · Cited by 189 · see citing works

Alternative binding proteins: Anticalins – harnessing the structural plasticity of the lipocalin ligand pocket to engineer novel binding activities

Skerra, A. (2008) · The FEBS Journal · doi:10.1111/j.1742-4658.2008.06439.x · Cited by 176 · see citing works

High molecular weight polyethylene glycol cellular distribution and PEG-associated cytoplasmic vacuolation is molecular weight dependent and does not require conjugation to proteins

Rudmann, D. G., Alston, J. T., Hanson, J. C., & Heidel, S. (2013) · Toxicologic Pathology · doi:10.1177/0192623312474726 · Cited by 170 · see citing works

Understanding the Role and Impact of Poly (Ethylene Glycol) (PEG) on Nanoparticle Formulation: Implications for COVID-19 Vaccines

Padín-González, E., Lancaster, P., Bottini, M., Gasco, P., Tran, L., Fadeel, B., Wilkins, T., & Monopoli, M. P. (2022) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2022.882363 · Cited by 166 · see citing works

Oral Apomorphine Delivery from Solid Lipid Nanoparticles with Different Monostearate Emulsifiers: Pharmacokinetic and Behavioral Evaluations

Tsai, M.-J., Huang, Y.-B., Wu, P.-C., Fu, Y.-S., Kao, Y.-R., Fang, J.-Y., & Tsai, Y.-H. (2011) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.22285 · Cited by 137 · see citing works

Protein nanocages that penetrate airway mucus and tumor tissue

Huang, X., Chisholm, J., Zhuang, J., Xiao, Y., Duncan, G., Chen, X., Suk, J. S., & Hanes, J. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1705407114 · Cited by 131 · see citing works

Stability of responsive polymer–protein bioconjugates

Shakya, A. K., Sami, H., Srivastava, A., & Kumar, A. (2010) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2010.01.003 · Cited by 110 · see citing works

An ultrasound-responsive nano delivery system of tissue-type plasminogen activator for thrombolytic therapy

Uesugi, Y., Kawata, H., Jo, J.-I., Saito, Y., & Tabata, Y. (2010) · Journal of Controlled Release · doi:10.1016/j.jconrel.2010.07.127 · Cited by 103 · see citing works

Celastrol-loaded PEG- <i>b</i> -PPS nanocarriers as an anti-inflammatory treatment for atherosclerosis

Allen, S. D., Liu, Y.-G., Kim, T., Bobbala, S., Yi, S., Zhang, X., Choi, J., & Scott, E. A. (2019) · Biomaterials Science · doi:10.1039/c8bm01224e · Cited by 95 · see citing works

Exploring the relationship between anti-PEG IgM behaviors and PEGylated nanoparticles and its significance for accelerated blood clearance

Shiraishi, K., Kawano, K., Maitani, Y., Aoshi, T., Ishii, K. J., Sanada, Y., Mochizuki, S., Sakurai, K., & Yokoyama, M. (2016) · Journal of Controlled Release · doi:10.1016/j.jconrel.2016.05.010 · Cited by 87 · see citing works

Treatment of type 2 diabetes with the designer cytokine IC7Fc

Findeisen, M., Allen, T. L., Henstridge, D. C., Kammoun, H., Brandon, A. E., Baggio, L. L., Watt, K. I., Pal, M., Cron, L., Estevez, E., et al. (2019) · Nature · doi:10.1038/s41586-019-1601-9 · Cited by 86 · see citing works

Utility of PEGylated recombinant adeno-associated viruses for gene transfer

Le, H. T., Yu, Q.-C., Wilson, J. M., & Croyle, M. A. (2005) · Journal of Controlled Release · doi:10.1016/j.jconrel.2005.07.019 · Cited by 82 · see citing works

Side chain variations radically alter the diffusion of poly (2-alkyl-2-oxazoline) functionalised nanoparticles through a mucosal barrier

Mansfield, E. D. H., de la Rosa, V. R., Kowalczyk, R. M., Grillo, I., Hoogenboom, R., Sillence, K., Hole, P., Williams, A. C., & Khutoryanskiy, V. V. (2016) · Biomaterials Science · doi:10.1039/c6bm00375c · Cited by 75 · see citing works

Conjugation of hyaluronan to proteins

Mero, A., Pasqualin, M., Campisi, M., Renier, D., & Pasut, G. (2013) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2012.11.090 · Cited by 69 · see citing works

Site-specific PEGylated adeno-associated viruses with increased serum stability and reduced immunogenicity

Yao, T., Zhou, X., Zhang, C., Yu, X., Tian, Z., Zhang, L., & Zhou, D. (2017) · Molecules · doi:10.3390/molecules22071155 · Cited by 68 · see citing works

Mannose-Based Molecular Patterns on Stealth Microspheres for Receptor-Specific Targeting of Human Antigen-Presenting Cells

Wattendorf, U., Coullerez, G., Vörös, J., Textor, M., & Merkle, H. P. (2008) · Langmuir · doi:10.1021/la801085d · Cited by 58 · see citing works

Neutral Lipopolyplexes for In Vivo Delivery of Conventional and Replicative RNA Vaccine

Perche, F., Clemençon, R., Schulze, K., Ebensen, T., Guzmán, C. A., & Pichon, C. (2019) · Molecular Therapy - Nucleic Acids · doi:10.1016/j.omtn.2019.07.014 · Cited by 55 · see citing works

Application of High-Z Nanoparticles to Enhance Current Radiotherapy Treatment

Jackson, N., Cecchi, D., Beckham, W., & Chithrani, D. B. (2024) · Molecules · doi:10.3390/molecules29112438 · Cited by 52 · see citing works

Targeting oncogenic KRAS with molecular brush-conjugated antisense oligonucleotides

Wang, D., Wang, Q., Wang, Y., Chen, P., Lu, X., Jia, F., Sun, Y., Sun, T., Zhang, L., Che, F., et al. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2113180119 · Cited by 43 · see citing works

GLP-1R Signaling and Functional Molecules in Incretin Therapy

Wan, W., Qin, Q., Xie, L., Zhang, H., Wu, F., Stevens, R. C., & Liu, Y. (2023) · Molecules · doi:10.3390/molecules28020751 · Cited by 44 · see citing works

Characterization of a PEGylated protein therapeutic by ion exchange chromatography with on-line detection by native ESI MS and MS/MS

Muneeruddin, K., Bobst, C. E., Frenkel, R., Houde, D., Turyan, I., Sosic, Z., & Kaltashov, I. A. (2017) · The Analyst · doi:10.1039/c6an02041k · Cited by 38 · see citing works

Tannic acid-based sustained-release system for protein drugs

Utatsu, K., Motoyama, K., Nakamura, T., Onodera, R., & Higashi, T. (2023) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2023.123229 · Cited by 31 · see citing works