The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Gold Nanoparticle Imaging and Radiotherapy of Brain Tumors in Mice
Open accessAbstract
AIM: To test intravenously injected gold nanoparticles for x-ray imaging and radiotherapy enhancement of large, imminently lethal, intracerebral malignant gliomas. MATERIALS & METHODS: Gold nanoparticles approximately 11 nm in size were injected intravenously and brains imaged using microcomputed tomography. A total of 15 h after an intravenous dose of 4 g Au/kg was administered, brains were irradiated with 30 Gy 100 kVp x-rays. RESULTS: Gold uptake gave a 19:1 tumor to normal brain ratio with 1.5% w/w gold in tumor, calculated to increase local radiation dose by approximately 300%. Mice receiving gold and radiation (30 Gy) demonstrated 50% long term (>1 year) tumor-free survival, whereas all mice receiving radiation only died. CONCLUSION: Intravenously injected gold nanoparticles cross the blood-tumor barrier, but are largely blocked by the normal blood-brain barrier, enabling high-resolution computed tomography tumor imaging. Gold radiation enhancement significantly improved long-term survival compared with radiotherapy alone. This approach holds promise to improve therapy of human brain tumors and other cancers.
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In vivo tumor targeting and spectroscopic detection with surface-enhanced Raman nanoparticle tags
Qian, X., Peng, X.-H., Ansari, D. O., Yin-Goen, Q., Chen, G. Z., Shin, D. M., Yang, L., Young, A. N., Wang, M. D., & Nie, S. (2008) · Nature Biotechnology · doi:10.1038/nbt1377 · Cited by 2,201
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Recent biomedical applications of gold nanoparticles: A review
Elahi, N., Kamali, M., & Baghersad, M. H. (2018) · Talanta · doi:10.1016/j.talanta.2018.02.088 · Cited by 1,174
Gold nanoparticles for applications in cancer radiotherapy: Mechanisms and recent advancements
Her, S., Jaffray, D. A., & Allen, C. (2017) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2015.12.012 · Cited by 865
Wang, H., Mu, X., He, H., & Zhang, X.-D. (2018) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2017.11.003 · Cited by 572
Nanoparticles for Radiation Therapy Enhancement: the Key Parameters
Retif, P., Pinel, S., Toussaint, M., Frochot, C., Chouikrat, R., Bastogne, T., & Barberi-Heyob, M. (2015) · Theranostics · doi:10.7150/thno.11642 · Cited by 385
Gold Nanoparticles as Radiosensitizers in Cancer Radiotherapy
Chen, Y., Yang, J., Fu, S., & Wu, J. (2020) · International Journal of Nanomedicine · doi:10.2147/ijn.s272902 · Cited by 319
Metadata
- Authors
- Hainfeld, J. F., Smilowitz, H. M., O‘Connor, M. J., Dilmanian, F. A., & Slatkin, D. N.
- Venue
- Nanomedicine
- Publisher
- Informa UK Limited
- Published
- 2013-09-30
- Volume
- 8
- Issue
- 10
- Pages
- 1601-1609
- ISSN
- 1743-5889 (ISSN-L)
- 1748-6963
- OpenAlex
- W2163011235
- Cited by
- 430
- References
- 1
- FWCI
- 17.31
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Hainfeld, J. F., Smilowitz, H. M., O‘Connor, M. J., Dilmanian, F. A., & Slatkin, D. N. (2013). Gold Nanoparticle Imaging and Radiotherapy of Brain Tumors in Mice. Nanomedicine. https://doi.org/10.2217/nnm.12.165
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