Aripiprazole for Irritability Associated with Autistic Disorder in Children and Adolescents Aged 6–17 Years
Open accessAbstract
Aripiprazole was recently US FDA-approved to treat irritability in children and adolescents with autistic disorder aged 6-17 years. There are currently only two psychotropics approved by the FDA to treat irritability in the autistic population. This drug profile will discuss available studies of aripiprazole in individuals with pervasive developmental disorders, two of which led to its recent FDA approval. We will discuss the efficacy, as well as the safety and tolerability of the drug documented in these studies. In addition, the chemistry, pharmacokinetics, metabolism and mechanism of action of aripiprazole will be reviewed.
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Only two drugs have been approved by the U.S. FDA for use in the ASD population: risperidone and aripiprazole, both approved for treatment of irritability in children and adolescents with ASD.
“Currently, only two drugs have been approved by the United States (U.S.) Food and Drug Administration (FDA) for use in the ASD population: risperidone [23] and aripiprazole [24]. Both drugs are approved for the treatment of irritability in children and adolescents with ASD.”
From Pharmacological treatment in autism: a proposal for guidelines on common co-occurring psychiatric symptoms (2025) · cites this paper as [24]
As the two drugs that have received FDA approval for use in ASD, risperidone and aripiprazole are both for the indication of 'irritability'.
“as the two drugs that have received FDA approval for use in ASD, risperidone, and aripiprazole, are both for the indication of “irritability” [23, 24]”
From Pharmacological treatment in autism: a proposal for guidelines on common co-occurring psychiatric symptoms (2025) · cites this paper as [24]
Risperidone and aripiprazole are both FDA-approved for irritability in children and adolescents with ASD.
“risperidone and aripiprazole, which are both FDA-approved for irritability in children and adolescents with ASD [23, 24].”
From Pharmacological treatment in autism: a proposal for guidelines on common co-occurring psychiatric symptoms (2025) · cites this paper as [24]
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- Authors
- Blankenship, K., Erickson, C. A., Stigler, K. A., Posey, D. J., & McDougle, C. J.
- Affiliations
- Riley Hospital for Children (US)
- Corresponding author
- McDougle, Christopher J
- Venue
- Pediatric Health
- Publisher
- Informa UK Limited
- Published
- 2010-08
- Volume
- 4
- Issue
- 4
- Pages
- 375-381
- ISSN
- 1745-5111 (ISSN-L)
- 1745-512X
- PMC
- PMC3043611
- OpenAlex
- W1972769106
- Cited by
- 75
- References
- 24
- Citations by year
- 2026: 8 · 2025: 11 · 2024: 6 · 2023: 9 · 2022: 6 · 2021: 2 · 2020: 5 · 2019: 2 · 2018: 2 · 2017: 1 · 2016: 6 · 2015: 3 · 2014: 4 · 2013: 2 · 2012: 6
- FWCI
- 1.94
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Pediatric Health (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- IUScholarWorks (Indiana University) (submittedVersion)
- Funders
- Division of Disability and Rehabilitative Services, Indiana Family and Social Services Administration
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
- Keywords
- aripiprazole, irritability, autistic disorder, pervasive developmental disorders, children and adolescents, FDA approval, efficacy, safety and tolerability, pharmacokinetics, drug metabolism, mechanism of action, atypical antipsychotics
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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