Estrogen enhances wound healing in the penis of rats
Open accessAbstract
Estrogen receptor (ER) alpha and beta and aromatase are expressed in various cell-types and compartments of the penis, including the epidermis of glans penis. Here, we hypothesize that estrogen helps maintain the viability and integrity of glans penis and test the hypothesis by treating lesioned glans penis with either 17beta-estradiol or vehicle only. Estrogen was found to facilitate wound healing and increase vascular endothelial growth factor (VEGF) immunoreactivity compared to control, as revealed by scanning electron microscopy, histology, and immunohistochemistry. We conclude that estrogen plays a role in maintaining glans penis integrity, in part, by facilitating penile healing, possibly via up-regulating VEGF levels.
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Estradiol is of utmost importance in the process of wound healing.
“Recent studies have increasingly shown that estradiol is of utmost importance in the process of wound healing [49–51].”
From The pathophysiology of endometriosis and adenomyosis, tissue injury and repair (2009) · cites this paper as [51]
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- Authors
- CN, M., R, H., CL, M., S, J., G, H., & G, H.
- Affiliations
- Appalachian State University (US)
- Venue
- Biomedical Research
- Publisher
- Biomedical Research Press
- Published
- 2008
- Volume
- 29
- Issue
- 5
- Pages
- 267-270
- ISSN
- 0388-6107 (ISSN-L)
- 1880-313X
- OpenAlex
- W2009354629
- Cited by
- 21
- References
- 22
- Citations by year
- 2024: 1 · 2023: 1 · 2020: 2 · 2019: 1 · 2016: 2 · 2015: 2 · 2014: 2
- FWCI
- 3.56
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Biomedical Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Appalachian State University
- Topics
- Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
- Health Sciences › Medicine › Surgery › Genital Health and Disease
- Health Sciences › Medicine › Urology › Urological Disorders and Treatments
- Keywords
- estrogen, wound healing, glans penis, estrogen receptor alpha, estrogen receptor beta, aromatase, estradiol, vascular endothelial growth factor, tissue integrity
- MeSH terms
- Animals, Castration, Estradiol, Estrogens, Humans, Male, Penis, Wound Healing, Rats, Sprague-Dawley, Vascular Endothelial Growth Factor A, Rats
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