Galantamine: A Review Update
Open accessAbstract
Galantamine, like nor-belladine, is a benzazepine. Galanthus and other plants of the Amaryllidaceae are the most common sources of it. Galantamine is used to combat the muscle effects of gallamine triethiodide and tubocurarine by acting as a cholinesterase inhibitor. The review reveals the protective effects of galantamine on the functions and integrity of the liver, brain and memory impairment. Various independent studies have shown anti-Alzheimer, antioxidant, antidiabetic and neuroprotective effect of galantamine. The current review highlights current knowledge and the health-promoting effects of a drug known as galantamine. This review summarizes the current state in the pharmacology of galantamine, focusing on its effects on tolerance, dosage, drug interactions and pharmacological studies in animal models. Keywords: Galantamine, Pharmacology, Acetylcholinesterase inhibitor, Neuroprotective, Protective effect.
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Galantamine is a first-line medication for mild-to-severe AD with good efficacy and tolerability in improving behavioral symptoms, activities of daily living, and cognitive performance.
“It is a first-line medication for mild-to-severe AD that has a good efficacy and tolerability in improving behavioral symptoms, activities of daily living, and cognitive performance [110,112,113].”
From Recent Advances in Therapeutics for the Treatment of Alzheimer’s Disease (2024) · cites this paper as [112]
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Cites
β-Amyloid1–42 Binds to α7 Nicotinic Acetylcholine Receptor with High Affinity
Wang, H.-Y., Lee, D. H. S., D’Andrea, M. R., Peterson, P. A., Shank, R. P., & Reitz, A. B. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.8.5626 · Cited by 818 · see citing works
APP mouse models for Alzheimer’s disease preclinical studies.
Sasaguri, H., Nilsson, P., Hashimoto, S., Nagata, K., Saito, T., De Strooper, B., Hardy, J., Vassar, R., Winblad, B., & Saido, T. C. (2017) · The EMBO Journal · doi:10.15252/embj.201797397 · Cited by 793 · see citing works
The Evolution of Preclinical Alzheimer’s Disease: Implications for Prevention Trials
Sperling, R., Mormino, E., & Johnson, K. (2014) · Neuron · doi:10.1016/j.neuron.2014.10.038 · Cited by 725 · see citing works
A 24-week, randomized, double-blind study of donepezil in moderate to severe Alzheimer’s disease
Feldman, H., Gauthier, S. G., Hecker, J., Vellas, B. J., Subbiah, P., Whalen, E., & the Donepezil MSAD Study Investigators Group* (2001) · Neurology · doi:10.1212/wnl.57.4.613 · Cited by 600 · see citing works
Hansen, R. A., Webb, A. P., Moore, C. G., Gartlehner, G., Jonas, D. E., & Morgan, L. C. (2020) · PubMed Central · doi:10.17615/ae8c-2p76 · Cited by 523 · see citing works
To: A 24-week, randomized, double-blind study of donepezil in moderate to severe Alzheimer’s disease
(2001) · Neurology · doi:10.1212/wnl.57.11.2153-a · Cited by 490 · see citing works
Pavlov, V. A., Parrish, W. R., Rosas‐Ballina, M., Ochani, M., Gallowitsch‐Puerta, M., Ochani, K., Chavan, S. S., Al‐Abed, Y., & Tracey, K. J. (2008) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2008.06.011 · Cited by 437 · see citing works
Scott, L. J., & Goa, K. L. (2000) · Drugs · doi:10.2165/00003495-200060050-00008 · Cited by 383 · see citing works
Structure of acetylcholinesterase complexed with (−)‐galanthamine at 2.3 Å resolution
Greenblatt, H. M., Kryger, G., Lewis, T., Silman, I., & Sussman, J. L. (1999) · FEBS Letters · doi:10.1016/s0014-5793(99)01637-3 · Cited by 312 · see citing works
Lilienfeld, S. (2002) · CNS Drug Reviews · doi:10.1111/j.1527-3458.2002.tb00221.x · Cited by 309 · see citing works
Effects of a flexible galantamine dose in Alzheimer's disease: a randomised, controlled trial
Rockwood, K. J. (2001) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.71.5.589 · Cited by 277 · see citing works
88. A new reaction of hydrazones
Barton, D. H. R., O'Brien, R. E., & Sternhell, S. (1962) · Journal of the Chemical Society (Resumed) · doi:10.1039/jr9620000470 · Cited by 219 · see citing works
Galantamine for Alzheimer's disease
Loy, C. T., & Schneider, L. S. S. (2004) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd001747.pub2 · Cited by 178 · see citing works
Central nicotinic receptors, neurotrophic factors and neuroprotection
Belluardo, N., Mudò, G., Blum, M., & Fuxé, K. (2000) · Behavioural Brain Research · doi:10.1016/s0166-4328(00)00197-2 · Cited by 176 · see citing works
153. Phenol oxidation and biosynthesis. Part V. The synthesis of galanthamine
Barton, D. H. R., & KIRBY, G. W. (1962) · Journal of the Chemical Society (Resumed) · doi:10.1039/jr9620000806 · Cited by 140 · see citing works
The intramolecular Heck reaction
Gibson, S. E., & Middleton, R. J. (1996) · Contemporary Organic Synthesis · doi:10.1039/co9960300447 · Cited by 138 · see citing works
Galantamine hydrobromide: An agent for Alzheimer’s disease
Zarotsky, V., Sramek, J. J., & Cutler, N. R. (2003) · American Journal of Health-System Pharmacy · doi:10.1093/ajhp/60.5.446 · Cited by 136 · see citing works
Nicotinic α7 receptors protect against glutamate neurotoxicity and neuronal ischemic damage
Shimohama, S., Greenwald, D. L., Shafron, D. H., et al. (1998) · Brain Research · doi:10.1016/s0006-8993(97)00194-7 · Cited by 135 · see citing works
Clinical Pharmacokinetics of Galantamine
Farlow, M. R. (2003) · Clinical Pharmacokinetics · doi:10.2165/00003088-200342150-00005 · Cited by 134 · see citing works
Abiola, M., Favier, M., Christodoulou‐Vafeiadou, E., Pichard, A., Martelly, I., & Guillet-Deniau, I. (2009) · PLoS ONE · doi:10.1371/journal.pone.0008509 · Cited by 124 · see citing works
Galantamine modulates nicotinic receptor and blocks Aβ-enhanced glutamate toxicity
Kihara, T., Sawada, H., Nakamizo, T., Kanki, R., Yamashita, H., Maelicke, A., & Shimohama, S. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.10.132 · Cited by 124 · see citing works
Differential diagnosis of Alzheimer's disease
Geldmacher, D. S., & Whitehouse, P. J. (1997) · Neurology · doi:10.1212/wnl.48.5_suppl_6.2s · Cited by 122 · see citing works
Satapathy, S. K., Ochani, M., Dancho, M. E., Hudson, L., Rosas‐Ballina, M., Valdés‐Ferrer, S. I., Olofsson, P. S., Harris, Y., Roth, J., Chavan, S. S., et al. (2011) · Molecular Medicine · doi:10.2119/molmed.2011.00083 · Cited by 119 · see citing works
Storch, A., Schrattenholz, A. S., Cooper, J. C., Ghani, E. M. A., Gutbrod, O., Weber, K. H., Reinhardt, S., Lobron, C., Hermsen, B., Šoškić, V., et al. (1995) · European Journal of Pharmacology Molecular Pharmacology · doi:10.1016/0922-4106(95)00080-1 · Cited by 117 · see citing works
Galantamine for Alzheimer's disease
Prvulovic, D., Hampel, H. J., & Pantel, J. (2010) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1517/17425251003592137 · Cited by 110 · see citing works
d-cycloserine attenuates scopolamine-induced learning and memory deficits in rats
Fishkin, R. J., İnce, E., Carlezon, W. A., & Dunn, R. W. (1993) · Behavioral and Neural Biology · doi:10.1016/0163-1047(93)90886-m · Cited by 108 · see citing works
Marrero, M. B., Lucas, R., Salet, C., Hauser, T. A., Mazurov, A. A., Lippiello, P. M., & Bencherif, M. (2009) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.109.154633 · Cited by 105 · see citing works
In vitro neuroprotective properties of the novel cholinergic channel activator (ChCA), ABT-418
Donnelly‐Roberts, D. L., Xue, I. C., Arnerić, S. P., & Sullivan, J. P. (1996) · Brain Research · doi:10.1016/0006-8993(96)00063-7 · Cited by 103 · see citing works
Thomsen, T., Kaden, B., Fischer, J. P., Bickel, U., Barz, H., Gusztony, G., Cervós‐Navarro, J., & Kewitz, H. (1991) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm.1991.29.8.487 · Cited by 92 · see citing works
Thomsen, T., Zendeh, B., Fischer, J. P., & Kewitz, H. (1991) · Biochemical Pharmacology · doi:10.1016/0006-2952(91)90022-w · Cited by 87 · see citing works
Chemical and biological aspects of Amaryllidaceae alkaloids
Armengol, J. B., Berkov, S. H., Torras‐Claveria, L., Pigni, N. B., de Andrade, J. P., Martínez, V., Codina, C., & Meya, F. V. (2011) · Dipòsit Digital de la Universitat de Barcelona (Universitat de Barcelona) · Cited by 83 · see citing works
Cholinesterase inhibition by galanthamine and lycoramine
Irwin, R. L., & Smith, H. J. (1960) · Biochemical Pharmacology · doi:10.1016/0006-2952(60)90030-7 · Cited by 78 · see citing works
Profiling donepezil template into multipotent hybrids with antioxidant properties
Mezeiová, E., Špilovská, K., Nepovimová, E., Górecki, L., Soukup, O., Doležal, R., Maliňák, D., Janočková, J., Jun, D., Kuča, K., et al. (2018) · Journal of Enzyme Inhibition and Medicinal Chemistry · doi:10.1080/14756366.2018.1443326 · Cited by 74 · see citing works
Donepezil–Ferulic Acid Hybrids as Anti-Alzheimer Drugs
Benchekroun, M., Ismaïli, L., Pudlo, M., et al. (2015) · Future Medicinal Chemistry · doi:10.4155/fmc.14.148 · Cited by 70 · see citing works
Nicotine rescues PC12 cells from death induced by nerve growth factor deprivation
Yamashita, H., & Nakamura, S. (1996) · Neuroscience Letters · doi:10.1016/0304-3940(96)12829-9 · Cited by 70 · see citing works
Sweeney, J. E., Puttfarcken, P. S., & Coyle, J. T. (1989) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(89)90364-x · Cited by 67 · see citing works
Galantamine protects against oxidative stress induced by amyloid‐beta peptide in cortical neurons
Melo, J. B., Sousa, C., Garção, P., Oliveira, C. R., & Agostinho, P. M. (2009) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2009.06612.x · Cited by 63 · see citing works
Stereoselectivity of cholinesterase inhibition by galanthamine and tolerance in humans
Thomsen, T., Bickel, U., Fischer, J. P., & Kewitz, H. (1990) · European Journal of Clinical Pharmacology · doi:10.1007/bf00316106 · Cited by 62 · see citing works
Indicators of neuroprotection with galantamine
Geerts, H. (2004) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2004.11.002 · Cited by 61 · see citing works
Mechanism of Action of Galantamine on N-Methyl-d-Aspartate Receptors in Rat Cortical Neurons
Moriguchi, S., Marszalec, W., Zhao, X., Yeh, J. Z., & Narahashi, T. (2004) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.104.067603 · Cited by 57 · see citing works
Schröder, B., Reinhardt-Maelicke, S., Schrattenholz, A. S., McLane, K. E., Kretschmer, A., Conti-Tronconi, B. M., & Maelicke, A. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)34075-9 · Cited by 56 · see citing works
Antidiabetic Effect of Galantamine: Novel Effect for a Known Centrally Acting Drug
Ali, M. A., El-Abhar, H. S., Kamel, M. A. E.-N., & Attia, A. S. (2015) · PLoS ONE · doi:10.1371/journal.pone.0134648 · Cited by 56 · see citing works
Effects of Donepezil, Galantamine and Rivastigmine in 938 Italian Patients with Alzheimerʼs Disease
Santoro, A., Siviero, P., Minicuci, N., Bellavista, E., Mishto, M., Olivieri, F., Marchegiani, F., Chiamenti, A. M., Benussi, L., Ghidoni, R., et al. (2010) · CNS Drugs · doi:10.2165/11310960-000000000-00000 · Cited by 56 · see citing works
Kowal, N. M., Ahring, P. K., Liao, V. W. Y., Indurti, D. C., Harvey, B. S., O'Connor, S. M., Chebib, M., Ólafsdóttir, E. S., & Balle, T. (2018) · British Journal of Pharmacology · doi:10.1111/bph.14329 · Cited by 51 · see citing works
Prolonged QT Interval, Syncope, and Delirium with Galantamine
Fisher, A. A., & Davis, M. W. (2008) · Annals of Pharmacotherapy · doi:10.1345/aph.1k514 · Cited by 49 · see citing works
Stimulation of nicotinic acetylcholine receptors protects motor neurons
Nakamizo, T., Kawamata, J., Yamashita, H., Kanki, R., Kihara, T., Sawada, H., Akaike, A., & Shimohama, S. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.03.115 · Cited by 47 · see citing works
Antioxidant Properties of Galantamine Hydrobromide
Traykova, M., Traykov, T. T., Hadjimitova, V. A., et al. (2003) · Zeitschrift für Naturforschung C · doi:10.1515/znc-2003-5-613 · Cited by 47 · see citing works
Pentacyclo[5.4.0.02,6.03,10.05,9]undecylamines. Synthesis and pharmacology
Dw, O., Dekker, T., & SNYCKERS, F. O. (1991) · European Journal of Medicinal Chemistry · doi:10.1016/0223-5234(91)90097-7 · Cited by 43 · see citing works
A general approach to the galanthamine ring system
Parsons, P. J., Charles, M. D., Harvey, D. M., et al. (2001) · Tetrahedron Letters · doi:10.1016/s0040-4039(01)00111-3 · Cited by 39 · see citing works
Vagus nerve stimulation as a strategy to prevent and manage metabolic syndrome
Das, U. N. (2010) · Medical Hypotheses · doi:10.1016/j.mehy.2010.11.013 · Cited by 35 · see citing works
Current status and new developments with galantamine in the treatment of Alzheimer’s disease
Tariot, P. N. (2001) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.2.12.2027 · Cited by 35 · see citing works
Halpin, C. M., Reilly, C., & Walsh, J. J. (2010) · Journal of Chemical Education · doi:10.1021/ed100388x · Cited by 34 · see citing works
A Naturalistic Study of Galantamine for Alzheimer???s Disease
Brodaty, H., Woodward, M., Boundy, K. L., Barnes, N., & Allen, G. (2006) · CNS Drugs · doi:10.2165/00023210-200620110-00006 · Cited by 28 · see citing works
Dunbar, F., Zhu, Y., & Brashear, H. R. (2006) · Clinical Therapeutics · doi:10.1016/j.clinthera.2006.03.002 · Cited by 19 · see citing works
Marco-Contelles, J. L., Rodríguez, C., & Garcı́a, A. G. (2005) · Expert Opinion on Therapeutic Patents · doi:10.1517/13543776.15.5.575 · Cited by 19 · see citing works
Inden, M., Takata, K., Yanagisawa, D., Ashihara, E., Tooyama, I., Shimohama, S., & Kitamura, Y. (2016) · Neurochemistry International · doi:10.1016/j.neuint.2016.02.008 · Cited by 18 · see citing works
Geronikolou, S. A., Albanopoulos, K., Chrousos, G. P., & Cokkinos, D. V. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-56246-9_20 · Cited by 16 · see citing works
Efficacy and Safety of Incretin Therapy in Type 2 Diabetes: Systematic Review and Meta-analysis
Amori, R. E., Lau, J., & Pittas, A. G. (2007) · JAMA · doi:10.1001/jama.298.2.194 · Cited by 12 · see citing works
Bullous pemphigoid precipitated by galantamine hydrobromide.
Diab, M. S., Coloe, J. R., & Bechtel, M. A. (2009) · PubMed · Cited by 10 · see citing works
Pilger, C., Westermann, B., Flörke, U., et al. (2000) · Synlett · doi:10.1055/s-2000-6735 · Cited by 10 · see citing works
Akilo, O. D., Kumar, P., Choonara, Y., Pradeep, P., du Toit, L. D., & Pillay, V. (2018) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.13484 · Cited by 10 · see citing works
A Review on Pharmacological Potential of Galantamine
Upadhyay, S. D., Ahmad, Y., & Kohli, S. (2020) · Pharmacognosy Communications · doi:10.5530/pc.2020.2.13 · Cited by 9 · see citing works
P4‐009: TRIAL OF OXALOACETATE IN ALZHEIMER'S DISEASE (TOAD): INTERIM FDG PET ANALYSIS
Vidoni, E. D., Clutton, J., Becker, A. M., et al. (2018) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2018.06.2411 · Cited by 4 · see citing works
Cardiac Autonomic Functions in Obese Children - Original Article
Taşçılar, M. E., Yokuşoğlu, M., Boyraz, M., et al. (2011) · Journal of Clinical Research in Pediatric Endocrinology · doi:10.4274/jcrpe.v3i2.13 · Cited by 3 · see citing works
Jojo, G. M., Kuppusamy, G., Selvaraj, K., & Baruah, U. K. (2019) · Journal of Diabetes & Metabolic Disorders · doi:10.1007/s40200-019-00405-2 · Cited by 2 · see citing works
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Recent Advances in Therapeutics for the Treatment of Alzheimer’s Disease
Thawabteh, A. M., Ghanem, A. W., AbuMadi, S., Thaher, D., Jaghama, W., Karaman, D., & Karaman, R. (2024) · Molecules · doi:10.3390/molecules29215131 · Cited by 56 · see citing works
“It is a first-line medication for mild-to-severe AD that has a good efficacy and tolerability in improving behavioral symptoms, activities of daily living, and cognitive performance [110,112,113].”
Background
- Authors
- Kaur, J., Melkani, I., Singh, A. P., Singh, A. P., & Bala, K.
- Venue
- Journal of Drug Delivery and Therapeutics
- Publisher
- Society of Pharmaceutical Tecnocrats
- Published
- 2022-07-15
- Volume
- 12
- Issue
- 4
- Pages
- 167-173
- ISSN
- 2250-1177 (ISSN-L)
- OpenAlex
- W4286751082
- Cited by
- 13
- References
- 65
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 4 · 2023: 2
- FWCI
- 1.05
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- Locations
- Journal of Drug Delivery and Therapeutics (publishedVersion, cc-by-nc)
- Topics
- Physical Sciences › Chemistry › Organic Chemistry › Chemical synthesis and alkaloids
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
- Health Sciences › Medicine › Pharmacology › Cholinesterase and Neurodegenerative Diseases
- Keywords
- galantamine, acetylcholinesterase inhibitors, benzazepines, Amaryllidaceae, neuroprotection, Alzheimer's disease, antioxidant activity, antidiabetic effect, memory impairment, drug interactions, tolerance (pharmacology and immunology), dosage
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