Cited by 13Chemical synthesis and alkaloidsMedicinal Plants and NeuroprotectionCholinesterase and Neurodegenerative Diseases

Galantamine: A Review Update

Open access
Kaur, Jaspreet, Melkani, Indu, Singh, Ajeet Pal, Singh, Amar Pal, Bala, Kiran·2022·Journal of Drug Delivery and Therapeutics

Abstract

Galantamine, like nor-belladine, is a benzazepine. Galanthus and other plants of the Amaryllidaceae are the most common sources of it. Galantamine is used to combat the muscle effects of gallamine triethiodide and tubocurarine by acting as a cholinesterase inhibitor. The review reveals the protective effects of galantamine on the functions and integrity of the liver, brain and memory impairment. Various independent studies have shown anti-Alzheimer, antioxidant, antidiabetic and neuroprotective effect of galantamine. The current review highlights current knowledge and the health-promoting effects of a drug known as galantamine. This review summarizes the current state in the pharmacology of galantamine, focusing on its effects on tolerance, dosage, drug interactions and pharmacological studies in animal models. Keywords: Galantamine, Pharmacology, Acetylcholinesterase inhibitor, Neuroprotective, Protective effect.

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Crossref · 10.22270/jddt.v12i4.5426

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  • Galantamine is a first-line medication for mild-to-severe AD with good efficacy and tolerability in improving behavioral symptoms, activities of daily living, and cognitive performance.

    “It is a first-line medication for mild-to-severe AD that has a good efficacy and tolerability in improving behavioral symptoms, activities of daily living, and cognitive performance [110,112,113].”

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  1. parallel-group 6-month study." Clinical therapeutics 28.3 (2006): 365-372

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Authors
Kaur, J., Melkani, I., Singh, A. P., Singh, A. P., & Bala, K.
Venue
Journal of Drug Delivery and Therapeutics
Published
2022-07-15
Volume
12
Issue
4
Pages
167-173
ISSN
2250-1177 (ISSN-L)
OpenAlex
W4286751082
Cited by
13
References
65
Citations by year
2026: 2 · 2025: 5 · 2024: 4 · 2023: 2
FWCI
1.05
Type
journal article
Language
en
Open access
Locations
Journal of Drug Delivery and Therapeutics (publishedVersion, cc-by-nc)
Topics
  • Physical Sciences › Chemistry › Organic Chemistry › Chemical synthesis and alkaloids
  • Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
  • Health Sciences › Medicine › Pharmacology › Cholinesterase and Neurodegenerative Diseases
Keywords
galantamine, acetylcholinesterase inhibitors, benzazepines, Amaryllidaceae, neuroprotection, Alzheimer's disease, antioxidant activity, antidiabetic effect, memory impairment, drug interactions, tolerance (pharmacology and immunology), dosage

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