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In-vitro evaluation of drug release and antioxidant activity of aloe loaded chitosan nanoparticles.

Kesharwani, Shivangi, Gupta, Durgesh Kumari, Gupta, Mahesh Kumar·2019·Journal of Drug Delivery and Therapeutics
DOI 10.22270/jddt.v9i4.2979
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Abstract

Antioxidants play significant responsibility during the treatment of cancer and it’s adverse effects, because in the treatment of cancer by using chemotherapy, free radicals are generated and these free radicals accumulated in the body and cause damage, side effect (such as neurodegenerated disease, atherosclerosis, depression, leukemia, skin disease, diabetes etc.) and even death due to the biological consequence. So, antioxidant inhibits the generation of new and destroys previously present free radicals. A recent study was aimed for novel approach of herbal nanoparticles to get improved efficacy of the drug with fewer side effects. In-vitro Evaluation of Drug Release and Antioxidant Activity of Aloe Loaded Chitosan Nanoparticles were includes in this research. Aloe has good antioxidant property, but in the form of nanoparticles formed with the help of chitosan polymer, it’s enhancing their stability, in-vitro release property. Chitosan is one of the best polymer for nanomedicine formulation because of their low toxicity and high compatibility. Six formulations of aloe loaded chitosan nanopaticles were prepared and evaluated as antioxidant study, in-vitro release and stability studies. Results have shown that the F6 was most stable, good release and high antioxidant property. So, it found that F6 was good formulation among all batches and these nanoparticles can be used as antioxidant agent during the treatment of cancer along with chemotherapeutic drugs for improve their effectiveness and reduce adverse effects. Keywords: Cancer, Chemotherapy, Herbal, Chitosan nanoparticles, Antioxidant.

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Crossref · 10.22270/jddt.v9i4.2979

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Image 1
CC-BY-NC · From the PDF
Image 2
CC-BY-NC · From the PDF
Fig 1 Preparation of plant extract loaded chitosan nanoparticles
Fig 1 Preparation of plant extract loaded chitosan nanoparticlesCC-BY-NC · From the PDF
Fig 2 Entrapment efficiency (%) of herbal extract (aloe) loaded chitosan nanoparticles
Fig 2 Entrapment efficiency (%) of herbal extract (aloe) loaded chitosan nanoparticlesCC-BY-NC · From the PDF
Fig 3 In-vitro release study of different formulation
Fig 3 In-vitro release study of different formulationCC-BY-NC · From the PDF
Figure 4 SEM image of aloe extract (0%) chitosan nanoparticles
Figure 4 SEM image of aloe extract (0%) chitosan nanoparticlesCC-BY-NC · From the PDF
Image 7
CC-BY-NC · From the PDF
Figure 6 SEM image of aloe extract (6%) chitosan nanoparticles
Figure 6 SEM image of aloe extract (6%) chitosan nanoparticlesCC-BY-NC · From the PDF
Figure 7 SEM image of aloe extract (9%) chitosan nanoparticles
Figure 7 SEM image of aloe extract (9%) chitosan nanoparticlesCC-BY-NC · From the PDF
Image 10
CC-BY-NC · From the PDF
Figure 9 SEM image of aloe extract (15%) chitosan nanoparticles
Figure 9 SEM image of aloe extract (15%) chitosan nanoparticlesCC-BY-NC · From the PDF
Figure 10 SEM image of aloe extract (18%) chitosan nanoparticles
Figure 10 SEM image of aloe extract (18%) chitosan nanoparticlesCC-BY-NC · From the PDF
Figure 11 TEM image of herbal extract (aloe) loaded chitosan nanoparticle (F6)
Figure 11 TEM image of herbal extract (aloe) loaded chitosan nanoparticle (F6)CC-BY-NC · From the PDF
Figure 12 DPPH scavenging assay of different formulation
Figure 12 DPPH scavenging assay of different formulationCC-BY-NC · From the PDF
Figure 13 Ferric reducing antioxidant power assay of different formulation
Figure 13 Ferric reducing antioxidant power assay of different formulationCC-BY-NC · From the PDF

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Research works printed but not linked: 26

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Cited by

Metadata

Authors
Kesharwani, S., Gupta, D. K., & Gupta, M. K.
Venue
Journal of Drug Delivery and Therapeutics
Publisher
Society of Pharmaceutical Tecnocrats
Published
2019-07-15
Volume
9
Issue
4
Pages
43-52
ISSN
2250-1177
DOI
10.22270/jddt.v9i4.2979
Cited by
3
References
0
Licence
creativecommons.org/licenses/by-nc/4.0 (unspecified)

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