Advancing Diabetic Retinopathy Diagnosis: Leveraging Optical Coherence Tomography Imaging with Convolutional Neural Networks
Open accessAbstract
Diabetic retinopathy (DR) is a vision-threatening complication of diabetes, necessitating early and accurate diagnosis.The combination of optical coherence tomography (OCT) imaging with convolutional neural networks (CNNs) has emerged as a promising approach for enhancing DR diagnosis.OCT provides detailed retinal morphology information, while CNNs analyze OCT images for automated detection and classification of DR.This paper reviews the current research on OCT imaging and CNNs for DR diagnosis, discussing their technical aspects and suitability.It explores CNN applications in detecting lesions, segmenting microaneurysms, and assessing disease severity, showing high sensitivity and accuracy.CNN models outperform traditional methods and rival expert ophthalmologists' results.However, challenges such as dataset availability and model interpretability remain.Future directions include multimodal imaging integration and realtime, point-of-care CNN systems for DR screening.The integration of OCT imaging with CNNs has transformative potential in DR diagnosis, facilitating early intervention, personalized treatments, and improved patient outcomes.
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In diabetic retinopathy diagnosis, CNN-based models have achieved performance on par with or even surpassing expert ophthalmologists.
“In DR diagnosis, CNN-based models have achieved performance on par with or even surpassing expert ophthalmologists [166, 167], overcoming the constraints of manual feature engineering.”
From Artificial intelligence-powered prediction of diabetic complications: from clinical data to molecular omics (2026) · cites this paper as [167]
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References 44 · Cited by 7
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- [1]Cheung N Mitchell P Wong TY Diabetic retinopathy Lancet 2010 376 9735 124 136 doi: 10.1016/S0140-6736(09)62124-3 20580421 · DOI · Paper page
- [2]Lee R Wong TY Sabanayagam C Epidemiology of diabetic retinopathy, diabetic macular edema and related vision loss Eye Vis (Lond) 2015 2 1 17 doi: 10.1186/s40662-015-0026-2 26605370 PMC4657234 · DOI
- [3]Virgili G Menchini F Murro V Peluso E Rosa F Casazza G Optical coherence tomography (OCT) for detection of macular oedema in patients with diabetic retinopathy Cochrane Database Syst Rev 2011 7 CD008081 doi: 10.1186/s40662-015-0026-2 21735421 · DOI
- [4]Yang D Ran AR Nguyen TX Deep learning in optical coherence tomography angiography: Current progress, challenges, and future directions Diagnostics (Basel) 2023 13 2 326 doi: 10.3390/diagnostics13020326 36673135 PMC9857993 · DOI
- [5]Sheng B Chen X Li T An overview of artificial intelligence in diabetic retinopathy and other ocular diseases Front Public Health 2022 10 971943 doi: 10.3389/fpubh.2022.971943 36388304 PMC9650481 · DOI
- [6]Reguant R Brunak S Saha S Understanding inherent image features in CNN-based assessment of diabetic retinopathy Sci Rep 2021 11 1 9704 doi: 10.1038/s41598-021-89225-0 33958686 PMC8102512 · DOI
- [7]Das D Biswas SK Bandyopadhyay S A critical review on diagnosis of diabetic retinopathy using machine learning and deep learning Multimed Tools Appl 2022 81 18 25613 25655 doi: 10.1007/s11042-022-12642-4 35342328 PMC8940593 · DOI
- [8]Tsiknakis N Theodoropoulos D Manikis G Deep learning for diabetic retinopathy detection and classification based on fundus images: A review Comput Biol Med 2021 135 104599 104599 doi: 10.1016/j.compbiomed.2021.104599 34247130 · DOI
- [9]Ong J Zarnegar A Corradetti G Singh SR Chhablani J Advances in optical coherence tomography imaging technology and techniques for choroidal and retinal disorders J Clin Med 2022 11 17 5139 doi: 10.3390/jcm11175139 36079077 PMC9457394 · DOI
- [11]Le PH Patel BC Optical Coherence Tomography Angiography 2022 StatPearls Publishing 33085382
- [12]Bhende M Shetty S Parthasarathy MK Ramya S Optical coherence tomography: A guide to interpretation of common macular diseases Indian J Ophthalmol 2018 66 1 20 35 doi: 10.4103/ijo.IJO_902_17 29283118 PMC5778576 · DOI
- [13]Mahmoudinezhad G Mohammadzadeh V Amini N Local macular thickness relationships between 2 OCT devices Ophthalmol Glaucoma 2021 4 2 209 215 doi: 10.1016/j.ogla.2020.08.012 32866692 PMC7914265 · DOI
- [14]Mukherjee S De Silva T Grisso P Retinal layer segmentation in optical coherence tomography (OCT) using a 3D deep-convolutional regression network for patients with age-related macular degeneration Biomed Opt Express 2022 13 6 3195 3210 doi: 10.1364/BOE.450193 35781941 PMC9208604 · DOI
- [15]Kim EK Park HYL Park CK Relationship between retinal inner nuclear layer thickness and severity of visual field loss in glaucoma Sci Rep 2017 7 1 5543 doi: 10.1038/s41598-017-05282-4 28717139 PMC5514146 · DOI
- [16]Cifuentes-Canorea P Ruiz-Medrano J Gutierrez-Bonet R Analysis of inner and outer retinal layers using spectral domain optical coherence tomography automated segmentation software in ocular hypertensive and glaucoma patients PLoS One 2018 13 4 e0196112 doi: 10.1371/journal.pone.0196112 29672563 PMC5908140 · DOI
- [17]Kodjikian L Parravano M Clemens A Fluid as a critical biomarker in neovascular age-related macular degeneration management: literature review and consensus recommendations EYE 2021 35 8 2119 2135 doi: 10.1038/s41433-021-01487-0 33795837 PMC8302650 · DOI
- [18]Chang YC Huang YT Hsu AY Optical coherence tomography biomarkers in predicting treatment outcomes of diabetic macular edema after ranibizumab injections Medicina (Kaunas) 2023 59 3 629 doi: 10.3390/medicina59030629 36984630 PMC10053215 · DOI
- [19]Chua J Sim R Tan B Optical coherence tomography angiography in diabetes and diabetic retinopathy J Clin Med 2020 9 6 1723 doi: 10.3390/jcm9061723 32503234 PMC7357089 · DOI
- [20]Sarvamangala DR Kulkarni RV Convolutional neural networks in medical image understanding: a survey Evol Intell 2022 15 1 1 22 doi: 10.1007/s12065-020-00540-3 33425040 PMC7778711 · DOI
- [23]De Cesarei A Cavicchi S Cristadoro G Lippi M Do humans and deep convolutional neural networks use visual information similarly for the categorization of natural scenes? Cogn Sci 2021 45 6 e13009 doi: 10.1111/cogs.13009 34170027 PMC8365760 · DOI
- [24]Liang G Ganesh H Steffe D Liu L Jacobs N Zhang J Development of CNN models for the enteral feeding tube positioning assessment on a small scale data set BMC Med Imaging 2022 22 1 52 doi: 10.1186/s12880-022-00766-w 35317725 PMC8939093 · DOI
- [25]Vaz JM Balaji S Convolutional neural networks (CNNs): concepts and applications in pharmacogenomics Mol Divers 2021 25 3 1569 1584 doi: 10.1007/s11030-021-10225-3 34031788 PMC8342355 · DOI
- [26]Ryu G Lee K Park D Kim I Park SH Sagong M A deep learning algorithm for classifying diabetic retinopathy using optical coherence tomography angiography Transl Vis Sci Technol 2022 11 2 39 doi: 10.1167/tvst.11.2.39 PMC8899862 35703566 · DOI
- [27]Elgafi M Sharafeldeen A Elnakib A Detection of diabetic retinopathy using extracted 3D features from OCT images Sensors (Basel) 2022 22 20 7833 doi: 10.3390/s22207833 36298186 PMC9610651 · DOI
- [28]Gulshan V Peng L Coram M Development and validation of a deep learning algorithm for detection of diabetic retinopathy in retinal fundus photographs JAMA 2016 316 22 2402 2410 doi: 10.1001/jama.2016.17216 27898976 · DOI · Paper page
- [29]Lang GE Tadayoni R Tang W Bradykinin 1 receptor antagonist BI1026706 does not reduce central retinal thickness in center-involved diabetic macular edema Transl Vis Sci Technol 2020 9 4 25 doi: 10.1167/tvst.9.4.25 PMC7396196 32818112 · DOI
- [30]Yasashvini Raja Sarobin MV Panjanathan R Jasmine G Anbarasi J Diabetic retinopathy classification using CNN and hybrid deep convolutional neural networks Symmetry (Basel) 2022 14 9 1932 doi: 10.3390/sym14091932 · DOI
- [31]Shaban M Ogur Z Mahmoud A A convolutional neural network for the screening and staging of diabetic retinopathy PLoS One 2020 15 6 e0233514 doi: 10.1371/journal.pone.0233514 32569310 PMC7307769 · DOI
- [32]Kugunavar S Prabhakar CJ Convolutional neural networks for the diagnosis and prognosis of the coronavirus disease pandemic Vis Comput Ind Biomed Art 2021 4 1 12 doi: 10.1186/s42492-021-00078-w 33950399 PMC8097673 · DOI
- [34]Chen Y Clayton EW Novak LL Anders S Malin B Human-centered design to address biases in artificial intelligence J Med Internet Res 2023 25 e43251 doi: 10.2196/43251 36961506 PMC10132017 · DOI
- [35]Lam C Yi D Guo M Lindsey T Automated detection of diabetic retinopathy using deep learning AMIA Summits Transl Sci Proc 2018 2017 147 155 29888061 PMC5961805
- [36]Bhimavarapu U Battineni G Deep learning for the detection and classification of diabetic retinopathy with an improved activation function Healthcare (Basel) 2022 11 1 97 doi: 10.3390/healthcare11010097 36611557 PMC9819317 · DOI
- [37]Bajwa A Nosheen N Talpur KI Akram S A prospective study on Diabetic Retinopathy detection based on a modified convolutional neural network using fundus images at Sindh Institute of Ophthalmology & Visual Sciences Diagnostics (Basel) 2023 13 3 393 doi: 10.3390/diagnostics13030393 36766498 PMC9914220 · DOI
- [38]Nadeem MW Goh HG Hussain M Liew SY Andonovic I Khan MA Deep learning for diabetic retinopathy analysis: A review, research challenges, and future directions Sensors (Basel) 2022 22 18 6780 doi: 10.3390/s22186780 36146130 PMC9505428 · DOI
- [39]Tempany CMC Jayender J Kapur T Multimodal imaging for improved diagnosis and treatment of cancers: Multimodal Imaging: IGT for Cancers Cancer 2015 121 6 817 827 doi: 10.1002/cncr.29012 25204551 PMC4352132 · DOI
- Authors
- Yavuzer, K., Çıtırık, M., & Yavuzer, B.
- Affiliations
- Sağlık Bilimleri Üniversitesi (TR)
- Venue
- romanian journal of ophthalmology
- Publisher
- Societatea Romana de Oftalmologie
- Published
- 2023-12-15
- Volume
- 67
- Issue
- 4
- Pages
- 326-336
- ISSN
- 2457-4325 (ISSN-L)
- 2501-2533
- PMC
- PMC10793365
- OpenAlex
- W4390826298
- Cited by
- 7
- References
- 44
- Citations by year
- 2026: 2 · 2025: 5
- FWCI
- 1.16
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Romanian Journal of Ophthalmology (publishedVersion)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Retinal Imaging and Analysis
- Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
- Physical Sciences › Computer Science › Computer Vision and Pattern Recognition › Advanced Neural Network Applications
- Keywords
- diabetic retinopathy, optical coherence tomography, convolutional neural networks, automated disease detection, disease severity assessment, retinal lesion detection, multimodal imaging, point-of-care screening, data availability, model interpretability
- MeSH terms
- Fovea Centralis, Humans, Retina, Retinal Ganglion Cells, Retinitis Pigmentosa, Tomography, Optical Coherence
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