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Testing the Statistical Certainty of a Response to Increasing Doses of a Drug
Abstract
Experiments in which the treatments are composed of a series of doses of a compound and a zero dose control are often used in animal toxicity studies. A test procedure is proposed to assess trends in the response variable. The notion of a no-statistical-significance-of-trend (NOSTASOT) dose is introduced, and questions of multiplicity of statistical tests in this context are addressed.
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Cited by
Do multiple outcome measures require p-value adjustment?
Feise, R. J. (2002) · BMC Medical Research Methodology · doi:10.1186/1471-2288-2-8 · Cited by 1,299
Alendronate for the Prevention and Treatment of Glucocorticoid-Induced Osteoporosis
Saag, K. G., Emkey, R., Schnitzer, T. J., Brown, J. P., Hawkins, F., Goemaere, S., Thamsborg, G., Liberman, U. A., Delmas, P. D., Malice, M.-P., et al. (1998) · New England Journal of Medicine · doi:10.1056/nejm199807303390502 · Cited by 1,258
Bretz, F., Hothorn, T., & Westfall, P. (2016) · doi:10.1201/9781420010909 · Cited by 1,233
In Vitro Antiretroviral Properties of S/GSK1349572, a Next-Generation HIV Integrase Inhibitor
Kobayashi, M., Yoshinaga, T., Seki, T., Wakasa-Morimoto, C., Brown, K. W., Ferris, R., Foster, S. A., Hazen, R. J., Miki, S., Suyama-Kagitani, A., et al. (2011) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01209-10 · Cited by 382
Test No. 426: Developmental Neurotoxicity Study
OECD (2007) · OECD Guidelines for the Testing of Chemicals, Section 4 · doi:10.1787/9789264067394-en · Cited by 107
Metadata
- Authors
- Tukey, J. W., Ciminera, J. L., & Heyse, J. F.
- Venue
- Biometrics
- Publisher
- JSTOR
- Published
- 1985-03
- Volume
- 41
- Issue
- 1
- Pages
- 295
- ISSN
- 0006-341X (ISSN-L)
- OpenAlex
- W2084368735
- Cited by
- 486
- References
- 0
- FWCI
- 6.99
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Testing the Statistical Certainty of a Response to Increasing Doses of a Drug. https://app.cochat.ai/papers/10.2307/2530666
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- Tukey, J. W., Ciminera, J. L., & Heyse, J. F. (1985). Testing the Statistical Certainty of a Response to Increasing Doses of a Drug. Biometrics. https://doi.org/10.2307/2530666
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
