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A Markov Model for Analysing Cancer Markers and Disease States in Survival Studies
Abstract
In studies of serial cancer markers or disease states and their relation to survival, data on the marker or state are usually obtained at infrequent time points during follow-up. A Markov model is developed to assess the dependence of risk of death on marker level or disease state and inferences within this model are based directly on data collected in this haphazard way. An application relating changing levels of serum alpha-fetoprotein to death in hepatocellular carcinoma is discussed in detail.
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Cited by
Corpechot, C., Carrat, F., Bonnand, A.-M., Poupon, R. E., & Poupon, R. (2000) · Hepatology · doi:10.1053/jhep.2000.20240 · Cited by 316
Statistical analysis of the stages of HIV infection using a Markov model
Longini, I. M., Clark, W. S., Byers, R. H., Ward, J. W., Darrow, W. W., Lemp, G. F., & Hethcote, H. W. (1989) · Statistics in Medicine · doi:10.1002/sim.4780080708 · Cited by 304
Suresh, K., Psoter, K. J., Voong, K. R., Shankar, B., Forde, P. M., Ettinger, D. S., Marrone, K. A., Kelly, R. J., Hann, C. L., Levy, B., et al. (2019) · Journal of Thoracic Oncology · doi:10.1016/j.jtho.2018.11.016 · Cited by 186
The value of mHealth for managing chronic conditions
Agnihothri, S., Cui, L., Delasay, M., & Rajan, B. (2020) · Health Care Management Science · doi:10.1007/s10729-018-9458-2 · Cited by 96
Multi-state models for bleeding episodes and mortality in liver cirrhosis
Andersen, P. K., Esbjerg, S., & S�rensen, T. I. A. (2000) · Statistics in Medicine · doi:10.1002/(sici)1097-0258(20000229)19:4<587::aid-sim358>3.0.co;2-0 · Cited by 88
Metadata
- Authors
- Kay, R.
- Venue
- Biometrics
- Publisher
- JSTOR
- Published
- 1986-12
- Volume
- 42
- Issue
- 4
- Pages
- 855
- ISSN
- 0006-341X (ISSN-L)
- OpenAlex
- W1981298860
- Cited by
- 299
- References
- 0
- FWCI
- 0.94
- Type
- journal article
- Language
- en
- Open access
- closed
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- Kay, R. (1986). A Markov Model for Analysing Cancer Markers and Disease States in Survival Studies. Biometrics. https://doi.org/10.2307/2530699
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
