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An Exact Test for Hardy-Weinberg and Multiple Alleles
Abstract
Algorithms for generating the exact distribution of a finite sample drawn from a population in Hardy-Weinberg equilibrium are given for multiple alleles. The finite sampling distribution is derived analogously to Fisher's 2 X 2 exact distribution and is equivalent to Levene's conditional finite sampling distribution for Hardy-Weinberg populations. The algorithms presented are fast computationally and allow for quick alternatives to standard methods requiring corrections and approximations. Computation time is on the order of a few seconds for three-allele examples and up to 2 minutes for four-allele examples on an IBM 3081 machine.
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Cited by
Conservation and the Genomics of Populations
Allendorf, F. W., Funk, W. C., Aitken, S. N., Byrne, M., Luikart, G., & Antunes, A. (2022) · doi:10.1093/oso/9780198856566.001.0001 · Cited by 207
The city-fox phenomenon: genetic consequences of a recent colonization of urban habitat
Wandeler, P., Funk, S. M., Largiadèr, C. R., Gloor, S., & Breitenmoser, U. (2003) · Molecular Ecology · doi:10.1046/j.1365-294x.2003.01768.x · Cited by 189
Optimal testing strategies for large, sparse multinomial models
Maiste, P. J., & Weir, B. S. (2004) · Computational Statistics & Data Analysis · doi:10.1016/j.csda.2003.08.002 · Cited by 8
Metadata
- Authors
- Louis, E. J., & Dempster, E. R.
- Venue
- Biometrics
- Publisher
- JSTOR
- Published
- 1987-12
- Volume
- 43
- Issue
- 4
- Pages
- 805
- ISSN
- 0006-341X (ISSN-L)
- OpenAlex
- W1975600922
- Cited by
- 329
- References
- 0
- FWCI
- 0.44
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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