The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Performing the Exact Test of Hardy-Weinberg Proportion for Multiple Alleles
Abstract
The Hardy-Weinberg law plays an important role in the field of population genetics and often serves as a basis for genetic inference. Because of its importance, much attention has been devoted to tests of Hardy-Weinberg proportions (HWP) over the decades. It has long been recognized that large-sample goodness-of-fit tests can sometimes lead to spurious results when the sample size and/or some genotypic frequencies are small. Although a complete enumeration algorithm for the exact test has been proposed, it is not of practical use for loci with more than a few alleles due to the amount of computation required. We propose two algorithms to estimate the significance level for a test of HWP. The algorithms are easily applicable to loci with multiple alleles. Both are remarkably simple and computationally fast. Relative efficiency and merits of the two algorithms are compared. Guidelines regarding their usage are given. Numerical examples are given to illustrate the practicality of the algorithms.
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Equation of State Calculations by Fast Computing Machines
Metropolis, N., Rosenbluth, A. W., Rosenbluth, M. N., Teller, A. H., & Teller, E. (1953) · The Journal of Chemical Physics · doi:10.1063/1.1699114 · Cited by 37,192
Cited by
Second-generation PLINK: rising to the challenge of larger and richer datasets
Chang, C. C., Chow, C. C., Tellier, L. C., Vattikuti, S., Purcell, S. M., & Lee, J. J. (2015) · Gigascience · doi:10.1186/s13742-015-0047-8 · Cited by 12,709
Estimating African American Admixture Proportions by Use of Population-Specific Alleles
Parra, E. J., Marcini, A., Akey, J., Martinson, J., Batzer, M. A., Cooper, R., Forrester, T., Allison, D. B., Deka, R., Ferrell, R. E., et al. (1998) · The American Journal of Human Genetics · doi:10.1086/302148 · Cited by 771
“The fit of the genotype frequencies to the Hardy-Weinberg proportions was tested by Guo and Thomson's exact test (Guo and Thomson 1992) with the program ARLEQUIN 1.0 (Schneider et al. 1997), and the heterogeneity in the allele frequencies of the parental populations was analyzed by means of the…”
MethodInfluentialSchaeffer, L., Gohlke, H., Müller, M., Heid, I. M., Palmer, L. J., Kompauer, I., Demmelmair, H., Illig, T., Koletzko, B., & Heinrich, J. (2006) · Human Molecular Genetics · doi:10.1093/hmg/ddl117 · Cited by 561
Fine‐scaled geographical population structuring in a highly mobile marine species: the Atlantic cod
Knutsen, H., Jorde, P. E., André, C., & Stenseth, N. C. (2003) · Molecular Ecology · doi:10.1046/j.1365-294x.2003.01750.x · Cited by 370
Linkage disequilibrium in growing and stable populations.
Slatkin, M. (1994) · Genetics · doi:10.1093/genetics/137.1.331 · Cited by 352
Metadata
- Authors
- Guo, S. W., & Thompson, E. A.
- Venue
- Biometrics
- Publisher
- JSTOR
- Published
- 1992-06
- Volume
- 48
- Issue
- 2
- Pages
- 361
- ISSN
- 0006-341X (ISSN-L)
- OpenAlex
- W2046062863
- Cited by
- 4,880
- References
- 1
- FWCI
- 15.21
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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