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Isolation and structural elucidation of the causative toxin of the diarrhetic shellfish poisoning.

Open access
MURATA, Michio, SHIMATANI, Masaharu, SUGITANI, Hiroshi, OSHIMA, Yasukatsu, YASUMOTO, Takeshi·1982·NIPPON SUISAN GAKKAISHI

Abstract

The major toxin involved in the diarrhetic shellfish poisoning was isolated from the hepatopancreas of the mussel Mytilus edulis and was named dinophysistoxin-1. It was obtained as a colorless solid: mp. 134°C, [d]20D 28°, LD99 160μg/kg (ip to mouse). Comparison of the toxin by various spectrometries with okadaic acid isolated from the marine dinoflagellate Prorocentrum lima established that dinophysistoxin-1 is 35S-methyl okadaic acid C45H70O13. Gas chromatographic analysis evidenced the presence of dinophysistoxin-l in the dinoflagellate Dinophysis fortii, confirming that this organism is the progenitor of the toxin.

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Metadata

Authors
MURATA, M., SHIMATANI, M., SUGITANI, H., OSHIMA, Y., & YASUMOTO, T.
Venue
NIPPON SUISAN GAKKAISHI
Published
1982
Volume
48
Issue
4
Pages
549-552
ISSN
  • 0021-5392 (ISSN-L)
  • 1349-998X
OpenAlex
W2314795980
Cited by
286
References
0
FWCI
4.54
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Isolation and structural elucidation of the causative toxin of the diarrhetic shellfish poisoning. https://app.cochat.ai/papers/10.2331/suisan.48.549
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MURATA, M., SHIMATANI, M., SUGITANI, H., OSHIMA, Y., & YASUMOTO, T. (1982). Isolation and structural elucidation of the causative toxin of the diarrhetic shellfish poisoning. NIPPON SUISAN GAKKAISHI. https://doi.org/10.2331/suisan.48.549

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Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.