Deficiency of Cbl-b Gene Enhances Infiltration and Activation of Macrophages in Adipose Tissue and Causes Peripheral Insulin Resistance in Mice

Hirasaka, Katsuya; Kohno, Shohei; Goto, Jumpei; Furochi, Harumi; Mawatari, Kazuaki; Harada, Nagakatsu; Hosaka, Toshio; Nakaya, Yutaka; Ishidoh, Kazumi; Obata, Toshiyuki; Ebina, Yousuke; Gu, Hua; Takeda, Shin'ichi; Kishi, Kyoichi; Nikawa, Takeshi

doi:10.2337/db06-1768

Deficiency of Cbl-b Gene Enhances Infiltration and Activation of Macrophages in Adipose Tissue and Causes Peripheral Insulin Resistance in Mice

OBJECTIVE—c-Cbl plays an important role in whole-body fuel homeostasis by regulating insulin action. In the present study, we examined the role of Cbl-b, another member of the Cbl family, in insulin action. RESEARCH DESIGN AND METHODS—C57BL/6 (Cbl-b+/+) or Cbl-b-deficient (Cbl-b−/−) mice were sub…