Cited by 1,551Adipokines, Inflammation, and Metabolic DiseasesAdipose Tissue and MetabolismImmune cells in cancer

The cellular and signaling networks linking the immune system and metabolism in disease

Osborn, Olivia, Olefsky, Jerrold M·2012·Nature Medicine

Abstract

It is now recognized that obesity is driving the type 2 diabetes epidemic in Western countries. Obesity-associated chronic tissue inflammation is a key contributing factor to type 2 diabetes and cardiovascular disease, and a number of studies have clearly demonstrated that the immune system and metabolism are highly integrated. Recent advances in deciphering the various cellular and signaling networks that participate in linking the immune and metabolic systems together have contributed to understanding of the pathogenesis of metabolic diseases and may also inform new therapeutic strategies based on immunomodulation. Here we discuss how these various networks underlie the etiology of the inflammatory component of insulin resistance, with a particular focus on the central roles of macrophages in adipose tissue and liver.

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Crossref · 10.1038/nm.2627

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Authors
Osborn, O., & Olefsky, J. M.
Affiliations
University of California San Diego (US)
Corresponding author
Olefsky, Jerrold M
Venue
Nature Medicine
Published
2012-03
Volume
18
Issue
3
Pages
363-374
ISSN
  • 1078-8956 (ISSN-L)
  • 1546-170X
OpenAlex
W1966336914
Cited by
1,551
References
169
Citations by year
2026: 40 · 2025: 65 · 2024: 83 · 2023: 69 · 2022: 96 · 2021: 97 · 2020: 130 · 2019: 125 · 2018: 125 · 2017: 132 · 2016: 131 · 2015: 141 · 2014: 136 · 2013: 135 · 2012: 42
FWCI
18.11
Type
journal article
Language
en
Open access
closed
Locations
  • Nature Medicine (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
  • Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
  • Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
Keywords
immunometabolism, obesity, type 2 diabetes, insulin resistance, chronic inflammation, macrophages, adipose tissue, liver, immunomodulation, metabolic disorders, signaling networks
MeSH terms
Adipose Tissue, Cardiovascular Diseases, Diabetes Mellitus, Type 2, Humans, Immune System, Inflammation, Insulin Resistance, Macrophages, Metabolic Diseases, Obesity, Signal Transduction, Metabolic Networks and Pathways

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