Genome-Wide Association Identifies Nine Common Variants Associated With Fasting Proinsulin Levels and Provides New Insights Into the Pathophysiology of Type 2 Diabetes

Strawbridge, Rona J., Dupuis, Josée, Prokopenko, Inga, Barker, Adam, Ahlqvist, Emma, Rybin, Denis, Petrie, John R., Travers, Mary E., Bouatia-Naji, Nabila, Dimas, Antigone S., Nica, Alexandra, Wheeler, Eleanor, Chen, Han, Voight, Benjamin F., Taneera, Jalal, Kanoni, Stavroula, Peden, John F., Turrini, Fabiola, Gustafsson, Stefan, Zabena, Carina, Almgren, Peter, Barker, David J.P., Barnes, Daniel, Dennison, Elaine M., Eriksson, Johan G., Eriksson, Per, Eury, Elodie, Folkersen, Lasse, Fox, Caroline S., Frayling, Timothy M., Goel, Anuj, Gu, Harvest F., Horikoshi, Momoko, Isomaa, Bo, Jackson, Anne U., Jameson, Karen A., Kajantie, Eero, Kerr-Conte, Julie, Kuulasmaa, Teemu, Kuusisto, Johanna, Loos, Ruth J.F., Luan, Jian'an, Makrilakis, Konstantinos, Manning, Alisa K., Martínez-Larrad, María Teresa, Narisu, Narisu, Nastase Mannila, Maria, Öhrvik, John, Osmond, Clive, Pascoe, Laura, Payne, Felicity, Sayer, Avan A., Sennblad, Bengt, Silveira, Angela, Stančáková, Alena, Stirrups, Kathy, Swift, Amy J., Syvänen, Ann-Christine, Tuomi, Tiinamaija, van 't Hooft, Ferdinand M., Walker, Mark, Weedon, Michael N., Xie, Weijia, Zethelius, Björn, the DIAGRAM Consortium, the GIANT Consortium, the MuTHER Consortium, the CARDIoGRAM Consortium, the C4D Consortium, Ongen, Halit, Mälarstig, Anders, Hopewell, Jemma C., Saleheen, Danish, Chambers, John, Parish, Sarah, Danesh, John, Kooner, Jaspal, Östenson, Claes-Göran, Lind, Lars, Cooper, Cyrus C., Serrano-Ríos, Manuel, Ferrannini, Ele, Forsen, Tom J., Clarke, Robert, Franzosi, Maria Grazia, Seedorf, Udo, Watkins, Hugh, Froguel, Philippe, Johnson, Paul, Deloukas, Panos, Collins, Francis S., Laakso, Markku, Dermitzakis, Emmanouil T., Boehnke, Michael, McCarthy, Mark I., Wareham, Nicholas J., Groop, Leif, Pattou, François, Gloyn, Anna L., Dedoussis, George V., Lyssenko, Valeriya, Meigs, James B., Barroso, Inês, Watanabe, Richard M., Ingelsson, Erik, Langenberg, Claudia, Hamsten, Anders, Florez, Jose C.·2011·Diabetes

Cited by (359)

Items 201–300 of 359

  1. Heterogeneous Expression of Proinsulin Processing Enzymes in Beta Cells of Non-diabetic and Type 2 Diabetic Humans
    Gladys Teitelman · 2019 · Journal of Histochemistry & Cytochemistry
  2. ZnT8 Exerts Anti-apoptosis of Kidney Tubular Epithelial Cell in Diabetic Kidney Disease Through TNFAIP3-NF-κB Signal Pathways
    Yinmao Chi, Xiuli Zhang, Dan Liang, Yue Wang, Xiaoyi Cai, Jiqiu Dong, Lingzhi Li, Zhihong Chi · 2022 · Biological Trace Element Research
  3. Evaluation of the imputation performance of the program IMPUTE in an admixed sample from Mexico City using several model designs
    S. Krithika, Adán Valladares‐Salgado, Jesús Peralta‐Romero, Jorge Escobedo, J Kumate-Rodríguez, Miguel Cruz, Esteban Juan Parra · 2012 · BMC Medical Genomics
  4. Novel Common Variants Associated with Obesity and Type 2 Diabetes Detected Using a cFDR Method
    Qıang Zhang, Ke‐Hao Wu, Jingyang He, Yong Zeng, Jonathan Greenbaum, Xin Xia, Huimin Liu, Wan‐Qiang Lv, Lin Xu, Weidong Zhang et al. · 2017 · Scientific Reports
  5. Genetic risk score of common genetic variants for impaired fasting glucose and newly diagnosed type 2 diabetes influences oxidative stress
    Minjoo Kim, Minkyung Kim, Li‐Min Huang, Sun Ha Jee, Jong Ho Lee · 2018 · Scientific Reports
  6. Loss of Znt8 function in diabetes mellitus: risk or benefit?
    Carla P. Barragán-Álvarez, Eduardo Padilla‐Camberos, Néstor Fabián Díaz, Agustín Cota-Coronado, Claudia Hernández-Jiménez, Carlos Bravo‐Reyna, Nestor Emmanuel Diaz-Martinez · 2021 · Molecular and Cellular Biochemistry
  7. Nutrigenetics: Bridging Two Worlds to Understand Type 2 Diabetes
    Janas M. Harrington, Catherine M. Phillips · 2014 · Current Diabetes Reports
  8. The Association of Genetic Markers for Type 2 Diabetes with Prediabetic Status - Cross-Sectional Data of a Diabetes Prevention Trial
    Birgit‐Christiane Zyriax, Ramona Salazar, Wolfgang Hoeppner, Eik Vettorazzi, Christian Herder, Eberhard E. T. Windler · 2013 · PLoS ONE
  9. Heterogeneous impact of type 2 diabetes mellitus-related genetic variants on gestational glycemic traits: review and future research needs
    Shasha Liu, Yunqiang Liu, Shunyao Liao · 2019 · Molecular Genetics and Genomics
  10. Association of Levels of Fasting Glucose and Insulin With Rare Variants at the Chromosome 11p11.2- MADD Locus
    Belinda K. Cornes, Jennifer A. Brody, Naghmeh Nikpoor, Alanna C. Morrison, Huan Chu Pham Dang, Byung Soo Ahn, Shuai Wang, Marco Dauriz, Joshua I. Barzilay, Josée Dupuis et al. · 2014 · Circulation Cardiovascular Genetics
  11. Expression and Secretion of Human Proinsulin-B10 from Mouse Salivary Glands: Implications for the Treatment of Type I Diabetes Mellitus
    Anne M. Rowzee, Paola Pérez Riveros, Changyu Zheng, Sarah Krygowski, Bruce J. Baum, Niamh X. Cawley · 2013 · PLoS ONE
  12. Joint effect of CENTD2 and KCNQ1 polymorphisms on the risk of type 2 diabetes mellitus among Chinese Han population
    Yun Qian, Meihua Dong, Feng Lu, Huizhang Li, Guangfu Jin, Zhibin Hu, Chong Shen, Hongbing Shen · 2015 · Molecular and Cellular Endocrinology
  13. Sexually dimorphic roles for the type 2 diabetes-associated C2cd4b gene in murine glucose homeostasis
    Seyedeh Neda Mousavy-Gharavy, Bryn M. Owen, Steven J. Millership, PAULINE L. CHABOSSEAU, Grazia Pizza, Aida Martínez-Sánchez, Emirhan Taşöz, Eleni Georgiadou, Ming Hu, Nicholas H. F. Fine et al. · 2021 · Diabetologia
  14. Beyond the Protein-Coding Sequence: Noncoding RNAs in the Pathogenesis of Type 2 Diabetes
    Johanna Kay DiStefano · 2015 · The Review of Diabetic Studies
  15. Type 2 Diabetes Prevention: Implications of Hemoglobin A1c Genetics
    Aaron Leong, James B. Meigs · 2015 · The Review of Diabetic Studies
  16. Plekhs1 and Prdx3 are candidate genes responsible for mild hyperglycemia associated with obesity in a new animal model of F344-fa-nidd6 rat
    Jun Kotoh, Daiki SASAKI, Kozo Matsumoto, Akihiko Maeda · 2016 · Journal of Veterinary Medical Science
  17. Genome-wide association study of plasma triglycerides, phospholipids and relation to cardio-metabolic risk factors
    Ayşe Demirkan, René Pool, Joris Deelen, Marian Beekman, Jun Liu, Amy C. Harms, Anika A. M. Vaarhorst, Fiona A. Hagenbeek, Gonneke A. H. M. Willemsen, Aswin Verhoeven et al. · 2019 · bioRxiv (Cold Spring Harbor Laboratory)
  18. Genetic Predisposition to Coronary Artery Disease in Type 2 Diabetes Mellitus
    Natalie R. van Zuydam, Claes Ladenvall, Benjamin F. Voight, Rona J. Strawbridge, Juan J. Fernandez-Tajes, Nigel William Rayner, Neil R. Robertson, Anubha Mahajan, Efthymia Vlachopoulou, Anuj Goel et al. · 2020 · Circulation Genomic and Precision Medicine
  19. Association of LRP5, TCF7L2, and GCG variants and type 2 diabetes mellitus as well as fasting plasma glucose and lipid metabolism indexes
    Jinjin Wang, Guoli Yan, Jianfeng Zhang, Kaiping Gao, Ming Zhang, Linlin Li, Yan Wang, Qian Wang, Yujia Zhai, Haifei You et al. · 2015 · Human Immunology
  20. The Role of Genetic Polymorphism in the Formation of Arterial Hypertension, Type 2 Diabetes and their Comorbidity
    Anna Shalimova, G. D. Fadieienko, Olena Vadymivna Kolesnikova, Ganna Isayeva, Vira Vladislavovna Zlatkina, Valeriya Danilovna Nemtsova, Kostyantyn Prosolenko, Valentyna Psarova, N. Kyrychenko, Maryna Mykolayivna Kochuieva · 2019 · Current Pharmaceutical Design
  21. Genetic aetiology of glycaemic traits: approaches and insights
    Eleanor Wheeler, Gaëlle Marenne, Inês Barroso · 2017 · Human Molecular Genetics
  22. Phenome-wide Mendelian randomization study evaluating the association of circulating vitamin D with complex diseases
    Jinjian Xu, Xiaobin Zhang, Wen-tao Tong, Teng Ying, Ke-qi Liu · 2023 · Frontiers in Nutrition
  23. Bridging the Gap Between Genetic Associations and Molecular Mechanisms for Type 2 Diabetes
    Hui Jin Ng, Anna L. Gloyn · 2013 · Current Diabetes Reports
  24. From genotype to human β cell phenotype and beyond
    Piero Marchetti, Farooq Syed, Mara Suleiman, Marco Bugliani, Lorella Marselli · 2012 · Islets
  25. Peptide-modified nanochannel system for carboxypeptidase B activity detection
    Xiaotong Zhang, Ling Zhang, Jinghong Li · 2019 · Analytica Chimica Acta
  26. Impaired Glucose-Stimulated Proinsulin Secretion Is an Early Marker of β-Cell Impairment Before Prediabetes Stage
    Ying Yang, Min Wang, Jingzhi Tong, Zuoliang Dong, Min Deng, Xiaojun Ren, Hui Li, Jing Yang, Zhaowei Meng, Jinhong Sun et al. · 2019 · The Journal of Clinical Endocrinology & Metabolism
  27. Chromatin 3D interaction analysis of the STARD10 locus unveils FCHSD2 as a regulator of insulin secretion
    Ming Hu, Inês Cebola, Gaëlle Carrat, Shuying Sue Jiang, Sameena Nawaz, Amna Khamis, Mickaël Canouil, Philippe Froguel, Anke Schulte, Michele Solimena et al. · 2021 · Cell Reports
  28. Genetic Architecture of Type 2 Diabetes
    Rashmi B. Prasad, Leif Groop · 2016 · Wiley eBooks
  29. Genetic Correlation and Bidirectional Causal Association Between Type 2 Diabetes and Pulmonary Function
    Jiahao Zhu, Huanling Zhao, Dingwan Chen, Lap Ah Tse, Sanjay Kinra, Yingjun Li · 2021 · Frontiers in Endocrinology
  30. C2CD4B Evokes Oxidative Stress and Vascular Dysfunction via a PI3K/Akt/PKCα–Signaling Pathway
    Paola Di Pietro, Angela Carmelita Abate, Valeria Prete, Antonio Damato, Eleonora Venturini, Maria Rosaria Rusciano, Carmine Izzo, Valeria Visco, Michele Ciccarelli, Carmine Vecchione et al. · 2024 · Antioxidants
  31. Additive genetic effect of GCKR, G6PC2, and SLC30A8 variants on fasting glucose levels and risk of type 2 diabetes
    Guanjie Chen, Daniel Shriner, Jianhua Zhang, Jie Zhou, Poorni R. Adikaram, Ayo Priscille Doumatey, Amy R. Bentley, Adebowale Adeyemo, Charles N. Rotimi · 2022 · PLoS ONE
  32. Complete loss of SLC30A8 in humans improves glucose metabolism and beta cell function
    Lindsey B. Lamarche, Christopher Koch, Shareef Khalid, Maleeha Zaman Khan, Richard Zessis, Matthew E. Clement, Daniel P. Denning, Allison B. Goldfine, Igor Splawski, Ali Abbasi et al. · 2025 · Diabetologia
  33. rqt: an R package for gene-level meta-analysis
    Ilya Y. Zhbannikov, Konstantin G. Arbeev, Anatoliy I. Yashin · 2017 · Bioinformatics
  34. The next generation cohort: a description of a cohort at high risk for childhood onset type 2 diabetes
    Farrah Jabar, Silvia Colatruglio, Elizabeth A. C. Sellers, Kristine Kroeker, Brandy Alexandra Wicklow · 2018 · Journal of Developmental Origins of Health and Disease
  35. Pancreatic beta cell ER export in health and diabetes
    Cesar Barrabi, Kezhong Zhang, Ming Rong Liu, Xuequn Chen · 2023 · Frontiers in Endocrinology
  36. Evaluation of mild cognitive impairment genetic susceptibility risks in a Chinese population
    Yelei Zhang, Xiaoyue Li, Yu Xin Hu, Hongwei Yuan, Xiaodong Wu, Yating Yang, Tongtong Zhao, Ke Hu, Zhiqiang Wang, Guoqiang Wang et al. · 2022 · BMC Psychiatry
  37. Novel insights from genetic and epigenetic studies in understanding the complex uraemic phenotype
    Anna Witasp, Tomas J. Ekström, Bengt Lindholm, Peter Stenvinkel, Martin Schalling, Louise Nordfors · 2013 · Nephrology Dialysis Transplantation
  38. SLC30A8 rs13266634 polymorphism is related to a favorable cardiometabolic lipid profile in HIV/hepatitis C virus-coinfected patients
    Daniel Pineda Tenor, Dariela Micheloud, Juan Berenguer, María Ángeles Jiménez‐Sousa, Amanda Fernández‐Rodríguez, Pilar García‐Broncano, María G. Guzmán, Cristina Díez, José María Bellón, Ana Carrero et al. · 2014 · AIDS
  39. Identifying the association between single nucleotide polymorphisms in KCNQ1, ARAP1, and KCNJ11 and type 2 diabetes mellitus in a Chinese population
    Yiping Li, Keyu Shen, Chuanyin Li, Ying Yang, Man Yang, Wenyu Tao, Siqi He, Li Shi, Yufeng Yao · 2020 · International Journal of Medical Sciences
  40. Type 2 diabetes genes – Present status and data from Norwegian studies
    Jens Kristoffer Hertel, Stefan Johansson, Kristian Midthjell, Ottar Kjell Nygard, Pål R. Njølstad, Anders Molven · 2013 · Norsk Epidemiologi
  41. Common variants in PCSK1 influence blood pressure and body mass index
    Q Gu, Mojgan Yazdanpanah, Mandy van Hoek, Albert Hofman D, Xin Gao, Felix W.M. de Rooij, Eric J.G. Sijbrands · 2014 · Journal of Human Hypertension
  42. Dyslipidemia in Diabetes
    Savitha Subramanian, Alan Chait · 2018 · Elsevier eBooks
  43. Diabetes mellitus, glycemic traits, and cerebrovascular disease: a Mendelian randomization study
    Marios K. Georgakis, Eric L. Harshfield, Rainer Malik, Nora Franceschini, Claudia Langenberg, Nicholas J. Wareham, Hugh Stephen Markus, Martin Dichgans · 2019 · medRxiv
  44. Targeted sequencing of genome wide significant loci associated with bone mineral density (BMD) reveals significant novel and rare variants: the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) targeted sequencing study
    Yi‐Hsiang Hsu, Li Guo, Ching‐Ti Liu, Jennifer A. Brody, David Karasik, Wen‐Chi Chou, Serkalem Demissie, Kannabiran Nandakumar, Yanhua Zhou, Chia‐Ho Cheng et al. · 2016 · Human Molecular Genetics
  45. Diabetes and Renin-Angiotensin-Aldosterone System: Pathophysiology and Genetics
    A.H.M. Nurun Nabi, Akio Ebihara · 2021 · IntechOpen eBooks
  46. Deep Resequencing of 9 Candidate Genes Identifies a Role for ARAP1 and IGF2BP2 in Modulating Insulin Secretion Adjusted for Insulin Resistance in Obese Southern Europeans
    Diego Bailetti, Federica Sentinelli, Sabrina Prudente, Flavia Agata Cimini, Ilaria Barchetta, Maria Totaro, Alessia Di Costanzo, Arcangelo Barbonetti, Frida Leonetti, Maria Gisella Cavallo et al. · 2022 · International Journal of Molecular Sciences
  47. Disproportionately Elevated Proinsulin Levels as an Early Indicator ofβ-Cell Dysfunction in Nondiabetic Offspring of Chinese Diabetic Patients
    Ming Li, Dan Feng, Kui Zhang, Shan Gao, Juming Lu · 2016 · International Journal of Endocrinology
  48. Hyperproinsulinemia in obesity and in type 2 diabetes and its relation to cardiovascular disease
    Michael Einar Røder · 2017 · Expert Review of Endocrinology & Metabolism
  49. Fast and Accurate Genome-Wide Association Test of Multiple Quantitative Traits
    Baolin Wu, James S. Pankow · 2018 · Computational and Mathematical Methods in Medicine
  50. Understanding the Genetic Landscape of Gestational Diabetes: Insights into the Causes and Consequences of Elevated Glucose Levels in Pregnancy
    Caroline Brito Nunes, Maria Carolina Borges, Rachel M. Freathy, Debbie A. Lawlor, Elisabeth Qvigstad, David M. Evans, Gunn-Helen Moen · 2024 · Metabolites
  51. Understanding signatures of positive natural selection in human zinc transporter genes
    Ana Roca‐Umbert, Rocio Caro-Consuegra, Diego Londoño-Correa, Gabriel Felipe Rodriguez-Lozano, Rubén Vicente, Elena Bosch · 2022 · Scientific Reports
  52. Decoding the genetic relationship between Alzheimer’s disease and type 2 diabetes: potential risk variants and future direction for North Africa
    Wided Boukhalfa, Haifa Jmel, Nadia Kheriji, Ismail Gouiza, Hamza Dallali, Mariem Hechmi, Rym Kéfi · 2023 · Frontiers in Aging Neuroscience
  53. Genome-Wide Association Studies of Type 2 Diabetes
    ROBERT M. SLADEK, Inga Prokopenko · 2016 · Springer eBooks
  54. The Association between Dietary Insulin Index and Load with Gastric Cancer in Afghanistan
    Freshta Amiry, Ahmad Mujtaba Barekzai, Azadeh Aminianfar, Ahmad Esmaillzadeh · 2021 · Nutrition and Cancer
  55. Genetic Background of Metabolically Healthy and Unhealthy Obesity Phenotypes in Hungarian Adult Sample Population
    Péter Pikó, Erand Llanaj, Károly Nagy, Róza Ádány · 2023 · International Journal of Molecular Sciences
  56. The non-synonymous polymorphism at position 114 of the WRN protein affects cholesterol efflux in vitro and correlates with cholesterol levels in vivo
    Julien Bérubé, Chantal Garand, Guillaume Lettre, Michel Lebel · 2013 · Experimental Gerontology
  57. Genetic underpinnings of left superior temporal gyrus thickness in patients with schizophrenia
    Rick P.F. Wolthusen, Johanna Haß, Esther Walton, Jessica A. Turner, Veit Roessner, Scott R. Sponheim, Beng‐Choon Ho, Daphne J. Holt, Randy L. Gollub, Vince D. Calhoun et al. · 2015 · The World Journal of Biological Psychiatry
  58. Gene-Diet Interactions in Type 2 Diabetes
    Marilyn C. Cornelis · 2014 · Current Nutrition Reports
  59. A comparison study on multivariate methods for joint-SNVs association analysis
    Jin-Xiong L.V., Hanchen Huang, Runsheng Chen, Lei Xu · 2016 · IEEE International Conference on Bioinformatics and Biomedicine (BIBM)
  60. An Enrichment Analysis for Cardiometabolic Traits Suggests Non-Random Assignment of Genes to microRNAs
    Rima Mustafa, Mohsen Ghanbari, Marina Evangelou, Abbas Dehghan · 2018 · International Journal of Molecular Sciences
  61. A Common Haplotype Lowers PU.1 Expression in Myeloid Cells and Delays Onset of Alzheimer's Disease
    Huang, Kuan-lin, Marcora, Edoardo, Pimenova, Anna A, Di Narzo, Antonio F, Kapoor, Manav, Jin, Sheng Chih, Harari, Oscar, Bertelsen, Sarah, Fairfax, Benjamin P, Czajkowski, Jake et al. · 2017
  62. Genetics and Diabetes
    Yoriko Heianza, Lu Qi · 2017 · Elsevier eBooks
  63. A framework for pathway knowledge driven prioritization in genome‐wide association studies
    Shrayashi Biswas, Soumen Pal, Partha Pratim Majumder, Samsiddhi Bhattacharjee · 2020 · Genetic Epidemiology
  64. Integration of genetic colocalizations with physiological and pharmacological perturbations identifies cardiometabolic disease genes
    Michael J. Gloudemans, Brunilda Balliu, Daniel C. Nachun, Matthew G. Durrant, Erik Ingelsson, Martin Wabitsch, Thomas Quertermous, Stephen B. Montgomery, Joshua W. Knowles, Ivan Carcamo‐Orive · 2022 · Metabolism
  65. Role of EPO and TCF7L2 Gene Polymorphism Contribution to the Occurrence of Diabetic Retinopathy
    Chao Liu, Ga-Li Bai, Ping Liu, Lin Wang · 2022 · Disease Markers
  66. Genetically predicted brain cortical structure mediates the causality between insulin resistance and cognitive impairment
    Chaojuan Huang, Yuyang Zhang, Mingxu Li, Qiu-ju Gong, Siqi Yu, Zhiwei Li, Mengmeng Ren, Xia Zhou, Xiaoqun Zhu, Zhongwu Sun · 2025 · Frontiers in Endocrinology
  67. Joint Effect of Unlinked Genotypes: Application to Type 2 Diabetes in the EPIC‐Potsdam Case‐Cohort Study
    Sven Knüppel, Karina Meidtner, Maria Arregui, Hermann−Georg Holzhütter, Heiner Boeing · 2015 · Annals of Human Genetics
  68. Physiology Helps GWAS Take a Step Closer to Mechanism
    Timothy M. Frayling, Andrew Tym Hattersley · 2014 · Diabetes
  69. Regulated Proteolysis of Signaling Molecules: The Proprotein Convertases
    Bruno Ramos‐Molina, Iris Lindberg, Juan R. Peinado · 2015 · Elsevier eBooks
  70. Association of PCSK1 and PPARG1 Allelic Variants with Obesity and Metabolic Syndrome in Mexican Adults
    Jorge A. Velazquez-Roman, Uriel Alberto Angulo Zamudio, Nidia Maribel León-Sicairos, Héctor M. Flores-Villaseñor, Miriam Jaqueline Benitez-Baez, Ana Espinoza-Salomón, Alejandra Karam-León, Hugo Villamil‐Ramírez, Samuel Canizales‐Quinteros, Luis R. Macías Kauffer et al. · 2023 · Genes
  71. A double knockout for zinc transporter 8 and somatostatin in mice reveals their distinct roles in regulation of insulin secretion and obesity
    Zhongyue Yang, Catherine P. Kirschke, Yimeng Cai, Liping Huang · 2024 · Genes & Nutrition
  72. No association between the type 2 diabetes mellitus susceptibility gene, SLC30A8 and schizophrenia in a Chinese population
    Xuan Zhang, Songlei Guan, Z.Q. Wang, Yang You, Shilong Sun, Li Hui, Lining Miao, Yaqin Yu, Thomas R. Kosten, Xiangyang Zhang · 2012 · Human Psychopharmacology Clinical and Experimental
  73. Distribution of Six Polymorphisms in Two Communities with a Historical High Incidence of Diabetes and Obesity in Yucatan, Mexico
    Miriam Givisay Domínguez-Cruz, Marı́a de Lourdes Muñoz, Armando Totomoch-Serra, María Guadalupe García‐Escalante, Nina Valadéz-González, Doris del Carmen Pinto-Escalante, Álvaro Díaz-Badillo · 2016 · Journal of Advances in Medicine and Medical Research
  74. Physiologic Interpretation of GWAS Signals for Type 2 Diabetes
    Richard M. Watanabe · 2018 · Methods in molecular biology
  75. Białka z rodziny Vps13 – od funkcji molekularnej do patogenezy chorób neurodegeneracyjnych
    Joanna Kamińska, Damian Kołakowski · 2018 · Postępy Biochemii
  76. Implications of publicly available genomic data resources in searching for therapeutic targets of obesity and type 2 diabetes
    Sungwon Jung · 2018 · Experimental & Molecular Medicine
  77. Association of proinsulin and hepatic steatosis in a random, population-based sample
    Sonja Wengert, Suemeyra Oeztuerk, Mark Martin Haenle, Wolfgang Köenig, Armin Imhof, Bernhard Otto Boehm, Manfred G. Wilhelm, Ren Mao, Richard Andrew Mason, Wolfgang Kratzer et al. · 2012 · European Journal of Endocrinology
  78. Genetic risk of prediabetes and diabetes development in chronic myeloid leukemia patients treated with nilotinib
    Bruno Martino, Corrado Mammì, Claudia Labate, Silvia Rodi, Domenica Ielo, Manuela Priolo, Maurizio Postorino, Giovanni Luigi Tripepi, Francesca Ronco, Carmelo Laganà et al. · 2017 · Experimental Hematology
  79. Mapping of Susceptibility Genes for Obesity, Type 2 Diabetes, and the Metabolic Syndrome in Human Populations
    Rector Arya, Sobha Puppala, Vidya S. Farook, Geetha Chittoor, Christopher P. Jenkinson, John Blangero, Daniel Esten Hale, Ravindranath Duggirala, Laura A. Almasy · 2015 · Springer eBooks
  80. Genetics of Diabetes and Diabetic Complications
    Rashmi B. Prasad, Emma Ahlqvist, Leif Groop · 2018 · Endocrinology
  81. Shared genetic contribution to type 1 and type 2 diabetes risk
    Anthony Aylward, Joshua Chiou, Mei-Lin Okino, Nikita Kadakia, Kyle J. Gaulton · 2018 · bioRxiv (Cold Spring Harbor Laboratory)
  82. Mendelian Randomization Analysis Dissects the Relationship between NAFLD, T2D, and Obesity and Provides Implications to Precision Medicine
    Liu, Zhipeng, Zhang, Yang, Graham, Sarah, Pique-Regi, Roger, Dong, Xiaocheng Charlie, Chen, Y. Eugene, Willer, Cristen, Liu, Wanqing · 2019
  83. Association of GIPR gene variant on the risk of type 2 diabetes mellitus: A case-control study
    Shahrzad Manavi Nameghi · 2023 · Endocrine and Metabolic Science
  84. A splice site variant in MADD affects hormone expression in pancreatic β cells and pituitary gonadotropes
    Kristiina Pulli, Jonna Saarimäki‐Vire, Pekka Ahonen, Xiaonan Liu, Hazem Ibrahim, Vikash Chandra, Alice Santambrogio, Yafei Wang, Kirsi Vaaralahti, Anna-Pauliina Iivonen et al. · 2024 · JCI Insight
  85. TBC1D30 regulates proinsulin and insulin secretion and is the target of a genomic association signal for proinsulin
    Victoria A. Parsons, Swarooparani Vadlamudi, Kayleigh M. Voos, Abigail E. Rohy, Anne H. Moxley, Maren E. Cannon, Jonathan D. Rosen, Christine A. Mills, Laura E. Herring, K. Alaine Broadaway et al. · 2025 · Diabetologia
  86. Investigation of Novel Therapeutic Targets for Rheumatoid Arthritis Through Human Plasma Proteome
    Hong Wang, Chengyi Huang, Kangkang Huang, Tingkui Wu, Hao Liu · 2025 · Biomedicines
  87. Developmental origins of genotype-phenotype correlations in chronic diseases of old age.
    Shana Erin McCormack, Qianghua Xia, Struan F.A. Grant · 2012 · Europe PMC (PubMed Central)
  88. The N221D variant in PCSK1 is highly prevalent in childhood obesity and can influence the metabolic profile
    Blanca Guijo, Jesús Argente, Gabriel Ángel Martos‐Moreno · 2023 · Journal of Pediatric Endocrinology and Metabolism
  89. Causal relationships between type 2 diabetes, glycemic traits and keratoconus
    Xueying Zhu, Dan Cheng, Kaiming Ruan, Meixiao Shen, Yufeng Ye · 2023 · Frontiers in Medicine
  90. Assessing the effect of modifiable risk factors on hepatocellular carcinoma: evidence from a bidirectional Mendelian randomization analysis
    Lijuan Wei, Enci Ding, Dongyan Lu, Zhongying Rui, Jie Shen, Guoju Fan · 2025 · Discover Oncology
  91. Genome-Wide Association Identifies Nine Common Variants Associated With Fasting Proinsulin Levels and Provides New Insights Into the Pathophysiology of Type 2 Diabetes
    Elke Oetjen · 2012 · Yearbook of Endocrinology
  92. Genetics of Type 2 Diabetes
    José C. Florez, Miriam S. Udler, Robert L. Hanson · 2021 · Europe PMC (PubMed Central)
  93. Identification of a novel proinsulin-associated SNP and demonstration that proinsulin is unlikely to be a causal factor in subclinical vascular remodelling using Mendelian randomisation
    Rona J. Strawbridge, Angela Maria Vidigal Silveira, Marcel den Hoed, Stefan Gustafsson, Jian’an Luan, Denis V. Rybin, Josée Dupuis, Ruifang Li‐Gao, Maryam Kavousi, Abbas Dehghan et al. · 2017 · Atherosclerosis
  94. Type 2 Diabetes
    M. O. Goodarzi · 2014 · Elsevier eBooks
  95. Genetic Risk Factors for Type 2 Diabetes and Related Traits
    Jens Kristoffer Hertel · 2012 · NORA - Norwegian Open Research Archives
  96. Reduced expression of TCF7L2 in adipocyte impairs glucose tolerance associated with decreased insulin secretion, incretins levels and lipid metabolism dysregulation in male mice
    Marie‐Sophie Nguyen‐Tu, Aida Martínez-Sánchez, Isabelle Leclerc, Guy A. Rutter, Gabriela da Silva Xavier · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
  97. Functional mechanisms for type 2 diabetes-associated genetic variants
    Xiao-Wei Zhu, Fei‐Yan Deng, Long‐Fei Wu, Zaixiang Tang, Shu‐Feng Lei · 2015 · Journal of Diabetes and its Complications
  98. SLC30A8: A Complex Road from Association to Function
    Jason A. Flannick, William L. Lowe · 2016 · Springer eBooks
  99. Loss of Human Beta Cell Identity in a Reconstructed Omental Stromal Cell Environment
    Blandine Secco, Kevin Saitoski, Karima Drareni, Antoine Soprani, Sèverine Pechberty, Latif Rachdi, Nicolas Venteclef, Raphaël Scharfmann · 2022 · Cells
  100. Characterizing Common and Rare Variations in Nontraditional Glycemic Biomarkers Using Multivariate Approaches on Multiancestry ARIC Study
    Debashree Ray, Stephanie J. Loomis, Sowmya Venkataraghavan, Jiachen Zhang, Adrienne Tin, Bing Yu, Nilanjan Chatterjee, Elizabeth Selvin, Priya Duggal · 2024 · Diabetes