Chronic GLP-1 Receptor Activation by Exendin-4 Induces Expansion of Pancreatic Duct Glands in Rats and Accelerates Formation of Dysplastic Lesions and Chronic Pancreatitis in the KrasG12D Mouse Model

Cited by (256)

Items 101–200 of 256

  1. Antihyperglycaemic therapies and cancer risk
    Stefan Z Lutz, Harald Staiger, Andreas Fritsche, Hans‐Ulrich Häring · 2014 · Diabetes and Vascular Disease Research
  2. Synergy Between Gαz Deficiency and GLP-1 Analog Treatment in Preserving Functional β-Cell Mass in Experimental Diabetes
    Allison L. Brill, Jaclyn A. Wisinski, Mark T. Cadena, Mary F. Thompson, Rachel J. Fenske, Harpreet K. Brar, Michael D. Schaid, Renee L. Pasker, Michelle E. Kimple · 2016 · Molecular Endocrinology
  3. A Review of the Long-Term Efficacy, Tolerability, and Safety of Exenatide Once Weekly for Type 2 Diabetes
    Stefano Genovese, Edoardo Mannucci, Antonio Ceriello · 2017 · Advances in Therapy
  4. Vascular Complications of Diabetes Mellitus
    Yien Chiong, Carmella Evans‐Molina · 2014 · Springer eBooks
  5. The double trouble of metabolic diseases: the diabetes–cancer link
    Slavica Tudzarova, Mahasin A. Osman · 2015 · Molecular Biology of the Cell
  6. Immunohistochemical assessment of glucagon‐like peptide 1 receptor ( GLP‐1R ) expression in the pancreas of patients with type 2 diabetes
    Rikke Kaae Kirk, Charles Pyke, Matthias G. von Herrath, Jane Preuss Hasselby, Lars Pedersen, Pia G. Mortensen, Lotte Bjerre Knudsen, Ken T. Coppieters · 2017 · Diabetes Obesity and Metabolism
  7. Islet inflammation and ductal proliferation may be linked to increased pancreatitis risk in type 2 diabetes
    Belinda Schludi, Abu Saleh Md Moin, Chiara Montemurro, Tatyana Gurlo, Aleksey V. Matveyenko, David Kirakossian, David W. Dawson, Sarah Dry, Peter C. Butler, Alexandra E. Butler · 2017 · JCI Insight
  8. Effects of the glucagon-like peptide-1 receptor agonist liraglutide in juvenile transgenic pigs modeling a pre-diabetic condition
    Elisabeth Streckel, Christina Braun-Reichhart, Nadja Herbach, Maik Dahlhoff, Barbara Keßler, Andreas Blutke, Andrea Bähr, Nicole Übel, Matthias Eddicks, Mathias Ritzmann et al. · 2015 · Journal of Translational Medicine
  9. Hope and fear for new classes of type 2 diabetes drugs: is there preclinical evidence that incretin-based therapies alter pancreatic morphology?
    Benjamin J. Lamont, Sofianos Andrikopoulos · 2014 · Journal of Endocrinology
  10. Beneficial long‐term antidiabetic actions of N ‐ and C ‐terminally modified analogues of apelin‐13 in diet‐induced obese diabetic mice
    Vadivel Parthsarathy, Christopher Hogg, Peter R. Flatt, Finbarr P.M. O'Harte · 2017 · Diabetes Obesity and Metabolism
  11. Treatment of type 2 diabetes, lifestyle, GLP1 agonists and DPP4 inhibitors
    Tomkin, Gerald H · 2014 · World Journal of Diabetes
  12. Challenges of Managing Type 3c Diabetes in the Context of Pancreatic Resection, Cancer and Trauma
    Colton D. Wayne, Chahrazed Benbetka, Gail Ellen Besner, Siddharth Narayanan · 2024 · Journal of Clinical Medicine
  13. Risk of Esophageal and Gastric Cancer in Patients with Type 2 Diabetes Receiving Glucagon-like Peptide-1 Receptor Agonists (GLP-1 RAs): A National Analysis
    Mark Ayoub, Rafi Aibani, Tiana M. Dodd, Muhammed Murtada Ceesay, Muhammad Mujtaba Bhinder, Carol Faris, Nisar A. Amin, Ebubekir S. Daglilar · 2024 · Cancers
  14. Tumour Risk with Once-Weekly Glucagon-Like Peptide-1 Receptor Agonists in Type 2 Diabetes Mellitus Patients: A Systematic Review
    Xia Nan Guo, Qing Yang, Jianjun Dong, Lin Liao, Weiwei Zhang, Fupeng Liu · 2016 · Clinical Drug Investigation
  15. Incretin-based pharmacotherapy and risk of adverse pancreatic events in the ethnic Chinese with diabetes mellitus: A population-based study in Taiwan
    Chao‐Ming Tseng, Wei‐Chih Liao, Chi‐Yang Chang, Ching‐Tai Lee, Cheng‐Hao Tseng, Yao‐Chun Hsu, Jaw‐Town Lin · 2016 · Pancreatology
  16. Basal insulin analogs: From pathophysiology to therapy. What we see, know, and try to comprehend?
    Louis Monnier, C Colette, David R. Owens · 2013 · Diabetes & Metabolism
  17. Expression of Glucagon-Like Peptide 1 Receptor and its Effects on Biologic Behavior in Pancreatic Neuroendocrine Tumors
    Ana Inés Cases, Takao Ohtsuka, Minoru Fujino, Noboru Ideno, Shingo Kozono, Ming Zhao, Kenoki Ohuchida, Shinichi Aishima, Masatoshi Nomura, Yoshinao Oda et al. · 2013 · Pancreas
  18. Dogfish glucagon analogues counter hyperglycaemia and enhance both insulin secretion and action in diet‐induced obese diabetic mice
    Finbarr P.M. O'Harte, MT Ng, Angela M. Lynch, John Michael Conlon, Peter R. Flatt · 2016 · Diabetes Obesity and Metabolism
  19. Role of SGLT2 Inhibitors, DPP-4 Inhibitors, and Metformin in Pancreatic Cancer Prevention
    Tooba Laeeq, Maheen Ahmed, Hina Sattar, Muhammad Hamayl Zeeshan, Meher Binte Ali · 2024 · Cancers
  20. Anti-diabetic therapies and the risk of acute pancreatitis: a nationwide retrospective cohort study from Taiwan
    Hsien‐Yen Chang, Chi-Feng Hsieh, Sonal Singh, Wenze Tang, Yi-Ting Chiang, Weng-Foung Huang · 2015 · Pharmacoepidemiology and Drug Safety
  21. A pooled analysis of exenatide use and risk of acute pancreatitis
    David D. Dore, Mohamed Hussein, Clorinda Hoffman, Elise M. Pelletier, Daniel B. Smith, John D. Seeger · 2013 · Current Medical Research and Opinion
  22. Chronic Continuous Exenatide Infusion Does Not Cause Pancreatic Inflammation and Ductal Hyperplasia in Non-Human Primates
    Teresa Vanessa Fiorentino, Michael A. Owston, GREGORY A. ABRAHAMIAN, Stefano La Rosa, Alessandro Marando, Carla Perego, E.S. Di Cairano, Giovanna Finzi, Carlo Capella, Fausto Sessa et al. · 2014 · American Journal Of Pathology
  23. Dipeptidyl Peptidase-4 Inhibitor Use Is Not Associated With Acute Pancreatitis in High-Risk Type 2 Diabetic Patients
    Chia‐Hsuin Chang, Jou‐Wei Lin, Shu‐Ting Chen, Mei‐Shu Lai, Lee‐Ming Chuang, Yi‐Cheng Chang · 2016 · Medicine
  24. An Assessment of Semaglutide Safety Based on Real World Data: From Popularity to Spontaneous Reporting in EudraVigilance Database
    Anca Butucă, Carmen Maximiliana Dobrea, Anca Maria Arseniu, Adina Frum, Adriana Aurelia Chiş, Luca Liviu Rus, Stéliana Ghibu, Anca Maria Juncan, Andrei Cătălin Muntean, Antonina Evelina Lazăr et al. · 2024 · Biomedicines
  25. Benefit-Risk Assessment of GLP-1 Receptor Agonists: Implications for Dermatologists and Plastic Surgeons
    Stephano Cedirian, Monia Donati, Luca Rapparini, Francesca Pampaloni, M. La Plaça, Rossella Sgarzani, Luca Negosanti, Emanuel Raschi, Michela Valeria Rita Starace · 2025 · Dermatology and Therapy
  26. Adverse Effects Associated With Newer Diabetes Therapies
    Oluwaranti Akiyode, Adebola A. Adesoye · 2015 · Journal of Pharmacy Practice
  27. Lower risks of new-onset acute pancreatitis and pancreatic cancer in sodium glucose cotransporter 2 (SGLT2) inhibitors compared to dipeptidyl peptidase-4 (DPP4) inhibitors: A propensity score-matched study with competing risk analysis
    Oscar Hou In Chou, Jiandong Zhou, Jonathan V Mui, Danish Iltaf Satti, Cheuk To Chung, Teddy Tai Loy Lee, Sharen Lee, Edward Christopher Dee, Kenrick Ng, Bernard M.Y. Cheung et al. · 2022 · Diabetes Epidemiology and Management
  28. Something old, something new and something very old: drugs for treating type 2 diabetes
    Diana Kaiser, Elke Oetjen · 2014 · British Journal of Pharmacology
  29. Are incretin mimetics and enhancers linked to pancreatitis and malignant transformations in pancreas?
    Jocelyn de Heer, Burkhard Göke · 2014 · Expert Opinion on Drug Safety
  30. Incretin Therapies Do Not Expand β-Cell Mass or Alter Pancreatic Histology in Young Male Mice
    Aaron R. Cox, Carol J. Lam, Matthew M. Rankin, Jacqueline S. Rios, Julia Chavez, Claire W. Bonnyman, Kourtney B. King, Roger A. Wells, Deepti Anthony, Justin X. Tu et al. · 2017 · Endocrinology
  31. Acting on Hormone Receptors with Minimal Side Effect on Cell Proliferation: A Timely Challenge Illustrated with GLP-1R and GPER
    Véronique Gigoux, Daniel Fourmy · 2013 · Frontiers in Endocrinology
  32. Incretins and risk of neoplasia
    Thorvardur Ragnar Halfdanarson, Rahul Pannala · 2013 · BMJ
  33. Glucagon-Like Peptide 1–Based Therapies and Risk of Pancreatic Cancer in Patients With Diabetes and Obesity
    Arunkumar Krishnan, Yousaf Bashir Hadi, William R. Hutson, Shyam J Thakkar, Shailendra Pratap Singh · 2022 · Pancreas
  34. Histological changes in endocrine and exocrine pancreatic tissue from patients exposed to incretin‐based therapies
    Sandra Ueberberg, Hendrik Jütte, Waldemar H. Uhl, Wolfgang Ekkehard Schmidt, Michael Albrecht Nauck, Eduard Montanya, Andrea Tannapfel, Juris Jendrik Meier · 2016 · Diabetes Obesity and Metabolism
  35. Islet cell dysfunction in patients with chronic pancreatitis
    Ayan Roy, Jayaprakash Sahoo, Sadishkumar Kamalanathan, Dukhabandhu Naik, Pazhanivel Mohan, Biju Pottakkat · 2020 · World Journal of Diabetes
  36. Glucagonlike Peptide 1–Based Drugs and Pancreatitis: Clarity at Last, but What About Pancreatic Cancer?
    Belinda Gier, Peter C. Butler · 2013 · JAMA Internal Medicine
  37. GLP-1 mimetic drugs and the risk of exocrine pancreatic disease: Cell and animal studies
    John A. Williams · 2015 · Pancreatology
  38. Long-Term Liraglutide Administration Induces Pancreas Neogenesis in Adult T2DM Mice
    Hongjun Deng, Fengying Yang, Xiaoyi Ma, Ying Wang, Qi Chen, Yuan Li · 2020 · Cell Transplantation
  39. Incretin mimetics and acute pancreatitis: enemy or innocent bystander?
    Richard E. Pratley, Zeb Ijaz Saeed, Anna Casu · 2024 · Current Opinion in Gastroenterology
  40. Pancreatitis and Pancreatic Cancer Risk Among Patients With Type 2 Diabetes Receiving Dipeptidyl Peptidase 4 Inhibitors: An Updated Meta-Analysis of Randomized Controlled Trials
    Adili Tuersun, Guanxin Hou, Gang Cheng · 2024 · Clinical Therapeutics
  41. Fighting Type-2 Diabetes: Present and Future Perspectives
    Cai‐Guo Yu, Ying Fu, Yuan Fang, Ning Zhang, Rongxin Sun, Dong Zhao, Yingmei Feng, Baoyu Zhang · 2017 · Current Medicinal Chemistry
  42. Glucagon-like Peptide-1 Receptor Agonists
    Ja Young Jeon, Hae Jin Kim · 2021 · Stroke revisited
  43. Incretins and the intensivist: what are they and what does an intensivist need to know about them?
    Mark Philip Plummer, Marianne J. Chapman, Michael Horowitz, Adam M. Deane · 2014 · Critical Care
  44. Risk of all–cause death and pancreatic events following GLP-1 RA initiation in people with obesity or type 2 diabetes: observations from a federated research network
    Enrico Tartaglia, Tommaso Bucci, Michele Rossi, Andrea Galeazzo Rigutini, Amir Askarinejad, Uazman Alam, Katarzyna Nabrdalik, Giuseppe Boriani, Gregory Y.H. Lip · 2025 · Cardiovascular Diabetology
  45. Exploring the potential impact of GLP-1 receptor agonists in cancer therapy
    Baseer Aslam, Muhammad Daim Bin Zafar, Mah I Kan Changez, Muhammad ABDULLAH, Muhammad Safwan, Bisma QAMAR, Abdullah SHINWARI, Sanjana RAI · 2023 · Minerva Endocrinology
  46. Glucagon-like peptide 1 receptor agonists and cancer risk: the good, the bad and the unknown
    Edoardo Mannucci, Ilaria Dicembrini · 2026 · Nature Reviews Clinical Oncology
  47. The glucagon‐like peptide‐1‐based therapeutics exenatide and saxagliptin did not cause detrimental effects on the pancreas in mice, rats, dogs and monkeys
    Denis Roy, Kristina D. Chadwick, Krystyna Tatarkiewicz, Carl LaCerte, Ann‐Marie Bergholm, Thomas Brodie, Raja S. Mangipudy, David G. Parkes, Michael J. Graziano, Tim Reilly · 2014 · Diabetes Obesity and Metabolism
  48. Pancreatic Safety of Tirzepatide and Its Effects on Islet Cell Function: A Systematic Review and Meta‐Analysis
    Abul B. M. Kamrul-Hasan, Sunetra Mondal, Deep Dutta, Lakshmi Nagendra, Mohammed Ruhul Kabir, Joseph M Pappachan · 2024 · Obesity Science & Practice
  49. Significance of expression of glucagon-like peptide 1 receptor in pancreatic cancer
    Ana Inés Cases, Takao Ohtsuka, Hideyo Kimura, BIAO ZHENG, Koji Shindo, Yoshinao Oda, Kazuhiro Mizumoto, Masafumi Nakamura, Masao Tanaka · 2015 · Oncology Reports
  50. A synopsis of factors regulating beta cell development and beta cell mass
    Krishna L. Prasadan, Chiyo Shiota, Xiangwei Xiao, David Matthew Ricks, Joseph C. Fusco, George K. Gittes · 2016 · Cellular and Molecular Life Sciences
  51. GLP-1 Receptor Agonist Effects on Normal and Neoplastic Pancreata
    Michael Goggins · 2012 · Diabetes
  52. Incretin-mimetics associated pancreatitis: evidence from the spontaneous adverse drug reactions reporting in Italy
    Marcello Delfino, Domenico Motola, Angela Benini, Gian Pietro Franzè, Marcella Barotto, Anna Campi, Vincenzo Maria Monda · 2013 · Expert Opinion on Drug Safety
  53. Gene expression signature: a powerful approach for drug discovery in diabetes
    Smithamol Sithara, Tamsyn M. Crowley, Ken R. Walder, Kathryn Aston‐Mourney · 2016 · Journal of Endocrinology
  54. Incretin-based drugs and risk of acute pancreatitis: A nested-case control study within a healthcare database
    Davide Soranna, Cristina Bosetti, Manuela Casula, Elena Tragni, Alberico Luigi Catapano, Carlo La Vecchia, Luca Giuseppe Merlino, Giovanni Corrao · 2015 · Diabetes Research and Clinical Practice
  55. An Investigative Study of Pancreatic Exocrine Biomarkers, Histology, and Histomorphometry in Male Zucker Diabetic Fatty (ZDF) Rats Given Dulaglutide by Subcutaneous Injection Twice Weekly for 13 Weeks
    Amy L. Usborne, Richard A. Byrd, James Meehan, Jamie L. Blackbourne, John Sullivan, Florence Poitout‐Belissent, Annick Préfontaine, Jennifer A. Martin, John L. Vahle · 2015 · Toxicologic Pathology
  56. Comment on: Butler et al. Marked Expansion of Exocrine and Endocrine Pancreas With Incretin Therapy in Humans With Increased Exocrine Pancreas Dysplasia and the Potential for Glucagon-Producing Neuroendocrine Tumors. Diabetes 2013;62:2595–2604
    Robert J. Heine, Haoda Fu, David M. Kendall, David E. Moller · 2013 · Diabetes
  57. Reponse to Comments on: Butler et al. Marked Expansion of Exocrine and Endocrine Pancreas With Incretin Therapy in Humans With Increased Exocrine Pancreas Dysplasia and the Potential for Glucagon-Producing Neuroendocrine Tumors. Diabetes 2013;62:2595–2604
    Alexandra E. Butler, Martha Campbell‐Thompson, Tatyana Gurlo, David W. Dawson, Mark A. Atkinson, Peter C. Butler · 2013 · Diabetes
  58. Incretin-based drugs decrease the incidence of prostate cancer in type 2 diabetics: A pooling-up analysis
    Yuxiang Lin, Guangyong Xu, Liangyu Li, Jingyi Xiang, Lingyun Zhai · 2024 · Medicine
  59. Incretin Therapy and Pancreatic Pathologies: Background Pathology Versus Drug-Induced Pathology in Rats
    Josephine Mary Egan, Chee W. Chia · 2014 · Diabetes
  60. The role of glucagon-like peptide-1 receptor agonists (GLP1-RAs) in the management of the hypertensive patient with metabolic syndrome: a position paper from the Korean society of hypertension
    Lee, Hae Young, Ko, Seung-Hyun, Park, Sungjoon, Kim, Kyuho, Kim, Song-Yi, Cho, In-Jeong, Cho, Eun Joo, Kim, Hyeon Chang, Park, Jae-Hyeong, Ryu, Sung Kee et al. · 2024 · Clinical Hypertension
  61. Incretin signaling at the crossroads of metabolism, inflammation, and tumorigenesis: implications for obesity patients
    Katarzyna Wawrzak-Pienkowska, Tomasz Pienkowski, Aleksandra Golonko, Anna Krupa, Marcin Warpechowski, Adam Filip Płoński, Patrycja Mojsak, Jarosław Daniluk, A Dâbrowski, Krzysztof Kurek · 2025 · European Journal of Pharmacology
  62. Dose-dependent pancreatitis risk associated with GLP-1 agonists
    Joyce Hanyue Gu, Mark Samarneh · 2025 · Journal of Diabetes & Metabolic Disorders
  63. Risk Factors for Pancreatic Ductal Adenocarcinoma Specifically Stimulate Pancreatic Duct Glands in Mice
    Alexej Bobrowski, Marie Spitzner, Stefanie Bethge, Fabian Müller‐Graf, Brigitte Vollmar, Dietmar Zechner · 2013 · American Journal Of Pathology
  64. Use of glucagon-like peptide-1 receptor agonists in people with history of acute pancreatitis: TriNetX analysis
    Mahmoud Nassar, Hazem Maarouf Abosheaishaa, Anoop Misra, Paresh Dandona, Husam Ghanim, Ajay Chaudhuri · 2025 · Diabetes & Metabolism
  65. Exendin-4 impairs the autophagic flux to induce apoptosis in pancreatic acinar AR42J cells by down-regulating LAMP-2
    Zhiqiang Li, Shaihong Zhu, Lihua Huang, Mingming Shang, Can Yu, Hongwei Zhu, Duo Han, Hui Huang, Xiao Yu, Xia Li · 2018 · Biochemical and Biophysical Research Communications
  66. Effects of the GLP-1 Receptor Agonist Dulaglutide on the Structure of the Exocrine Pancreas of Cynomolgus Monkeys
    John L. Vahle, Richard A. Byrd, Jamie L. Blackbourne, Jennifer A. Martin, Steven D. Sorden, Thomas E. Ryan, Thomas P. Pienkowski, Thomas J. Rosol, Paul W. Snyder, Günter Klöppel · 2015 · Toxicologic Pathology
  67. Extended Exenatide Administration Enhances Lipid Metabolism and Exacerbates Pancreatic Injury in Mice on a High Fat, High Carbohydrate Diet
    Rodney L. Rouse, Leshuai W. Zhang, Katherine I Shea, Hongfei Zhou, Lin Xu, Sharron R. Stewart, Barry A. Rosenzweig, Jun Zhang · 2014 · PLoS ONE
  68. Approach to the Patient With Pancreatogenic Diabetes
    Katie Larson Ode, Yumi Imai, Andrew W. Norris · 2025 · The Journal of Clinical Endocrinology & Metabolism
  69. A systematic review of the safety of incretin-based therapies in type 2 diabetes
    Marc Evans, Stephen Charles Bain, Jiten P Vora · 2016 · Expert Review of Endocrinology & Metabolism
  70. Does the use of incretin‐based medications increase the risk of cancer in patients with type‐2 diabetes mellitus?
    Igor Karp, Atul Sivaswamy, Christopher M. Booth · 2019 · Pharmacoepidemiology and Drug Safety
  71. Unraveling the safety profile of GLP-1 receptor agonists: Mechanistic insights with a focus on semaglutide
    Xinyi He, Zimo Zhao, Yan Sun, Xi Jiang · 2025 · European Journal of Medicinal Chemistry
  72. Glucagon-Like Peptide-1 Receptor Expression in Normal and Neoplastic Human Pancreatic Tissues
    Marco Dal Molin, Haeryoung Kim, Amanda L. Blackford, Rajni B Sharma, Michael Goggins · 2015 · Pancreas
  73. The potential adverse effects of hypodermic glucagon‐like peptide ‐1 receptor agonist on patients with type 2 diabetes: A population‐based study
    Zhiyuan Cheng, Shuang Wang, Fu‐Rong Li, Cheng Jin, Chunbao Mo, Jing Zheng, Xia Li, Fengchao Liang, Jin-Kui Yang, Dongfeng Gu · 2024 · Journal of Diabetes
  74. Smoke or Fire? Acute Pancreatitis and the Liraglutide Trials
    Edwin AM Gale · 2015 · Diabetes Care
  75. The Effects of Dipeptidyl-Peptidase-IV Inhibitor, Vildagliptin, on the Exocrine Pancreas in Spontaneously Diabetic Goto-Kakizaki Rats
    Hiroki Mizukami, Wataru Inaba, Kazunori Takahashi, Kosuke Kamata, Kentaro Tsuboi, Soroku Yagihashi · 2013 · Pancreas
  76. Current Issues in Glp-1 Receptor Agonist Therapy for Type 2 Diabetes
    Zachary T. Bloomgarden, Lawrence Blonde, Alan J. Garber, Carol Wysham · 2012 · Endocrine Practice
  77. The Relationship Between Dipeptidyl Peptidase-4 Inhibitor Usage and Asymptomatic Amylase Lipase Increment in Type 2 Diabetes Mellitus Patients
    Zeynel Abidin Sayıner, Gamze İnan Demiroğlu, Ersin Akarsu, Mustafa Araz · 2018 · Turkish Journal of Pharmaceutical Sciences
  78. Pancreatitis Incidence in the Exenatide BID, Exenatide QW, and Exenatide QW Suspension Development Programs: Pooled Analysis of 35 Clinical Trials
    Marion L. Vetter, Kristina M. Johnsson, Elise Hardy, Hui Wang, Nayyar Iqbal · 2019 · Diabetes Therapy
  79. Acute Pancreatitis Induced by Linagliptin: A Rare but Dangerous Side Effect
    Artem Sharko, Shirly Samuel, Nikita Jain · 2021 · Cureus
  80. In the setting of β-cell stress, the pancreatic duct gland transcriptome shows characteristics of an activated regenerative response
    Alexandra E. Butler, David Kirakossian, Tatyana Gurlo, Fuying Gao, Giovanni Coppola, Peter C. Butler · 2018 · American Journal of Physiology-Gastrointestinal and Liver Physiology
  81. Glucagon from the phylogenetically ancient paddlefish provides a template for the design of a long-acting peptide with effective anti-diabetic and anti-obesity activities
    Galyna V. Graham, John Michael Conlon, Yasser H.A. Abdel‐Wahab, Peter R. Flatt · 2020 · European Journal of Pharmacology
  82. Glucose-Lowering Drugs to Reduce Cardiovascular Risk in Type 2 Diabetes
    Silvio E Inzucchi, Aldo J. Peixoto, Jeffrey M Testani · 2021 · New England Journal of Medicine
  83. A glimpse into the pipeline of anti-obesity medication development: combining multiple receptor pathways
    Christine Park, Yushin Kim, Sawye Raygani, Eduardo L. Grunvald · 2025 · Frontiers in Endocrinology
  84. Τhiazolidine-4-One Derivatives with Variable Modes of Inhibitory Action Against DPP4, a Drug Target with Multiple Activities and Established Role in Diabetes Mellitus Type II
    Dionysia Amanatidou, Phaedra T. Eleftheriou, Anthi Petrou, Athina A. Geronikaki, Theodore S. Lialiaris · 2025 · Pharmaceuticals
  85. Pancreatic safety of GLP-1-based therapeutic agents: further insights from rodent studies?
    Jens Juul Holst · 2013 · Diabetologia
  86. GLP-1 Agonist Use in a Patient With an Explainable Cause of Pancreatitis
    Sean M. Brady, Michael P. Kane, Robert S. Busch · 2015 · AACE Clinical Case Reports
  87. Glucagon‐like peptide‐1 receptor agonist exenatide has no acute effect on MRI ‐measured exocrine pancreatic function in patients with type 2 diabetes: a randomized trial
    Mark M. Smits, Lennart Tonneijck, Marcel H.A. Muskiet, Mark H.H. Kramer, Michaëla Diamant, Indra C. Pieters-van den Bos, Daniël H. van Raalte, Djuna L. Cahen · 2015 · Diabetes Obesity and Metabolism
  88. Cancer biology in diabetes update: Focusing on antidiabetic drugs
    Emi Kawakita, Keizo Kanasaki · 2024 · Journal of Diabetes Investigation
  89. Recent Updates on Glucagon-Like Peptide 1 Receptor Agonist
    Hae Jin Kim · 2021 · Journal of Korean Diabetes
  90. Uncovering the mechanisms of beta-cell neogenesis and maturation toward development of a regenerative therapy for diabetes
    Takeshi Miyatsuka · 2015 · Diabetology International
  91. GLP- 1R status using validated monoclonal antibody in 689 cases of neuroendocrine neoplasm and its correlation with somatostatin receptor scintigraphy, insulin production, and histological grades
    Hirofumi Watanabe, Fumiyoshi Fujishima, Yuto Yamazaki, Masayuki Imamura, Susumu Hijioka, Kazuo Hara, Takamichi Kuwahara, Yasushi Yatabe, Kazuhiro Sakamoto, Hisashi Shiga et al. · 2025 · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin
  92. Incretin-based therapies and pancreatitis risk: myth or reality
    Joseph M Pappachan · 2014 · Endocrine
  93. Exenatide Induces Impairment of Autophagy Flux to Damage Rat Pancreas
    Zhiqiang Li, Lihua Huang, Xiao Yu, Can Yu, Hongwei Zhu, Xia Li, Duo Han, Hui Huang · 2016 · Pancreas
  94. Exploring the GLP-1–GLP-1R axis in porcine pancreas and gastrointestinal tract in vivo by ex vivo autoradiography
    Elin Manell, Emmi Puuvuori, Anna Christina Svensson, Irina Velikyan, Gry Hulsart‐Billström, Patricia Hedenqvist, Jens Juul Holst, Marianne Jensen‐Waern, Olof Eriksson · 2021 · BMJ Open Diabetes Research & Care
  95. Can we exonerate GLP-1 receptor agonists from blame for adverse pancreatic events?
    Conor F. Murphy, Carel Wynand le Roux · 2018 · Annals of Translational Medicine
  96. Glucagon-like peptide-1 receptor agonists for treatment of diabetes and obesity: advantage of oral delivery
    Roger R. C. New, Michal Bogus, G. N. Travers, U. Hahn, Agne Vaiceliunaite, Michael W. M. Burnet, J. H. Wang, H. Wen · 2024 · Frontiers in Drug Delivery
  97. Disproportionality analysis of GLP-1 receptor agonists combined with metformin based on the FAERS database
    Boyi Liu, Ruizhe Huang, Wenchao Zhang, J H Tian, Yao Xian, Danna Chen · 2025 · Scientific Reports
  98. Acute pancreatitis and euglycemic non-diabetic ketoacidosis caused by an intentional semaglutide overdose
    Anthony Acosta, Ashley Fanco, H P Rohan, Zane Z. Elfessi · 2025 · JEM Reports
  99. Proglucagon-Derived Peptides Do Not Significantly Affect Acute Exocrine Pancreas in Rats
    Elina Akalestou, Ioannis A. Christakis, Antonia Solomou, JAMES S. MINNION, Guy A. Rutter, Stephen Robert Bloom · 2016 · Pancreas
  100. Exocrine and Endocrine Inflammation Increases Cellular Replication in the Pancreatic Duct Compartment in Type 1 Diabetes
    Shweta Kulkarni, Amanda L. Posgai, Irina Kusmartseva, Clive Henry Wasserfall, Mark A. Atkinson, Alexandra E. Butler · 2022 · Journal of the Endocrine Society