The role of glucagon-like peptide-1 receptor agonists (GLP1-RAs) in the management of the hypertensive patient with metabolic syndrome: a position paper from the Korean society of hypertension
Open accessAbstract
Obesity is the one of the most important components of metabolic syndrome. Because obesity related hypertension accounts for two thirds of essential hypertension, managing obesity and metabolic syndrome is a crucial task in the management of hypertension. However, the current non-pharmacological therapies have limitations for achieving or maintaining ideal body weight. Recently, glucagon-like peptide-1 receptor agonists (GLP1-RAs) have demonstrated excellent weight control effects, accompanied by corresponding reductions in blood pressure. GLP1-RAs have shown cardiovascular and renal protective effects in cardiovascular outcome trials both in primary and secondary prevention. In this document, the Korean Society of Hypertension intends to remark the current clinical results of GLP1-RAs and recommend the government and health-policy makers to define obesity as a disease and to establish forward-looking policies for GLP1-RA treatment for obesity treatment, including active reimbursement policies.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The effects of GLP-1 receptor agonists on blood pressure appear to be rather modest.
“For example, the effects of GLP-1 receptor agonists on blood pressure appear to be rather modest, as recently summarized (21), and are not in line with kidney outcomes observed with other agents that provide a similar reduction in blood pressure.”
From GLP-1 agonists in the treatment of chronic kidney disease in type 2 diabetes and obesity (2025) · cites this paper as [21]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
1 retracted
Hattori, Y., Jojima, T., Tomizawa, A., Satoh, H., Hattori, S., Kasai, K., & Hayashi, T. (2010) · Diabetologia · doi:10.1007/s00125-010-1831-8 · Cited by 183 · see citing works
RetractedLiraglutide and Cardiovascular Outcomes in Type 2 Diabetes
Marso, S. P., Daniels, G. H., Brown-Frandsen, K., Kristensen, P., Mann, J. F. E., Nauck, M. A., Nissen, S. E., Pocock, S., Poulter, N. R., Ravn, L. S., et al. (2016) · New England Journal of Medicine · doi:10.1056/nejmoa1603827 · Cited by 7,629 · cited 2× · see citing works
“…Outcomes study, and REWIND study, liraglutide, semaglu-tide, albiglutide, and dulaglutide showed a significant reduction in major adverse cardiac events (death from cardiovascular causes, nonfatal myocardial infarction, nonfatal stroke) compared to the placebo group, respectively [68, 69, 71, 72].”
ResultInfluentialAbarca-Gómez, L., Abdeen, Z. A., Hamid, Z. A., Abu-Rmeileh, N. M., Acosta-Cazares, B., Acuin, C., Adams, R. J., Aekplakorn, W., Afsana, K., Aguilar-Salinas, C. A., et al. (2017) · The Lancet · doi:10.1016/s0140-6736(17)32129-3 · Cited by 7,482 · see citing works
Semaglutide and Cardiovascular Outcomes in Patients with Type 2 Diabetes
Marso, S. P., Bain, S. C., Consoli, A., Eliaschewitz, F. G., Jódar, E., Leiter, L. A., Lingvay, I., Rosenstock, J., Seufert, J., Warren, M. L., et al. (2016) · New England Journal of Medicine · doi:10.1056/nejmoa1607141 · Cited by 6,900 · see citing works
Once-Weekly Semaglutide in Adults with Overweight or Obesity
Wilding, J. P. H., Batterham, R. L., Calanna, S., Davies, M., Van Gaal, L. F., Lingvay, I., McGowan, B. M., Rosenstock, J., Tran, M. T. D., Wadden, T. A., et al. (2021) · New England Journal of Medicine · doi:10.1056/nejmoa2032183 · Cited by 5,205 · see citing works
Obesity: global epidemiology and pathogenesis
Blüher, M. (2019) · Nature Reviews Endocrinology · doi:10.1038/s41574-019-0176-8 · Cited by 5,126 · see citing works
Cosentino, F., Grant, P. J., Aboyans, V., Bailey, C. J., Ceriello, A., Delgado, V., Federici, M., Filippatos, G., Grobbee, D. E., Hansen, T. B., et al. (2020) · European Heart Journal · doi:10.1093/eurheartj/ehz486 · Cited by 4,763 · see citing works
2013 AHA/ACC/TOS Guideline for the Management of Overweight and Obesity in Adults
Jensen, M. D., Ryan, D. H., Apovian, C. M., Ard, J. D., Comuzzie, A. G., Donato, K. A., Hu, F. B., Hubbard, V. S., Jakicic, J. M., Kushner, R. F., et al. (2014) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2013.11.004 · Cited by 4,058 · see citing works
Zhou, B., Carrillo-Larco, R. M., Danaei, G., Riley, L. M., Paciorek, C. J., Stevens, G. A., Gregg, E. W., Bennett, J. E., Solomon, B., Singleton, R. K., et al. (2021) · The Lancet · doi:10.1016/s0140-6736(21)01330-1 · Cited by 3,902 · see citing works
Self-citationDrucker, D. J., & Nauck, M. A. (2006) · The Lancet · doi:10.1016/s0140-6736(06)69705-5 · Cited by 3,896 · see citing works
Semaglutide and Cardiovascular Outcomes in Obesity without Diabetes
Lincoff, A. M., Brown-Frandsen, K., Colhoun, H. M., Deanfield, J., Emerson, S. S., Esbjerg, S., Hardt-Lindberg, S., Hovingh, G. K., Kahn, S. E., Kushner, R. F., et al. (2023) · New England Journal of Medicine · doi:10.1056/nejmoa2307563 · Cited by 3,236 · see citing works
Gerstein, H. C., Colhoun, H. M., Dagenais, G. R., Diaz, R., Lakshmanan, M., Pais, P., Probstfield, J., Riesmeyer, J. S., Riddle, M. C., Rydén, L., et al. (2019) · The Lancet · doi:10.1016/s0140-6736(19)31149-3 · Cited by 3,163 · see citing works
A Randomized, Controlled Trial of 3.0 mg of Liraglutide in Weight Management
Pi-Sunyer, X., Astrup, A., Fujioka, K., Greenway, F., Halpern, A., Krempf, M., Lau, D. C. W., le Roux, C. W., Violante Ortiz, R., Jensen, C. B., et al. (2015) · New England Journal of Medicine · doi:10.1056/nejmoa1411892 · Cited by 2,724 · see citing works
The gut-brain axis: interactions between enteric microbiota, central and enteric nervous systems.
(2015) · PubMed Central · Cited by 2,540 · see citing works
Lixisenatide in Patients with Type 2 Diabetes and Acute Coronary Syndrome
Pfeffer, M. A., Claggett, B., Diaz, R., Dickstein, K., Gerstein, H. C., Køber, L. V., Lawson, F. C., Ping, L., Wei, X., Lewis, E. F., et al. (2015) · New England Journal of Medicine · doi:10.1056/nejmoa1509225 · Cited by 2,409 · see citing works
The Metabolic Syndrome: Time for a Critical Appraisal
Kahn, R., Buse, J. B., Ferrannini, E., & Stern, M. P. (2005) · Diabetes Care · doi:10.2337/diacare.28.9.2289 · Cited by 2,377 · see citing works
Effects of once-weekly exenatide on cardiovascular outcomes in type 2 diabetes
Holman, R. R., Bethel, M. A., Mentz, R. J., Thompson, V. P., Lokhnygina, Y., Buse, J. B., Chan, J. C., Choi, J., Gustavson, S. M., Iqbal, N., et al. (2017) · New England Journal of Medicine · doi:10.1056/nejmoa1612917 · Cited by 2,162 · see citing works
Lean, M. E., Leslie, W. S., Barnes, A. C., Brosnahan, N., Thom, G., McCombie, L., Peters, C., Zhyzhneuskaya, S., Al-Mrabeh, A., Hollingsworth, K. G., et al. (2018) · The Lancet · doi:10.1016/s0140-6736(17)33102-1 · Cited by 2,095 · cited 1× · see citing works
“There are strong and consistent evidences that obesity management through intensive lifestyle modification can delay the progression from prediabetes to T2DM [56, 57].”
BackgroundMetabolic Syndrome as a Precursor of Cardiovascular Disease and Type 2 Diabetes Mellitus
Wilson, P. W. F., D’Agostino, R. B., Parise, H., SULLIVAN, L. M., & Meigs, J. B. (2005) · Circulation · doi:10.1161/circulationaha.105.539528 · Cited by 2,061 · see citing works
Oral Semaglutide and Cardiovascular Outcomes in Patients with Type 2 Diabetes
Husain, M., Birkenfeld, A. L., Donsmark, M., Dungan, K., Eliaschewitz, F. G., Franco, D. R., Jeppesen, O. K., Lingvay, I., Mosenzon, O., Pedersen, S. D., et al. (2019) · New England Journal of Medicine · doi:10.1056/nejmoa1901118 · Cited by 1,997 · see citing works
Garvey, W. T., Mechanick, J. I., Brett, E. M., Garber, A. J., Hurley, D. L., Jastreboff, A. M., Nadolsky, K., Pessah-Pollack, R., & Plodkowski, R. (2016) · Endocrine Practice · doi:10.4158/ep161365.gl · Cited by 1,914 · see citing works
Hernandez, A. F., Green, J. B., Janmohamed, S., D'Agostino, R. B., Granger, C. B., Jones, N. P., Leiter, L. A., Rosenberg, A. E., Sigmon, K. N., Somerville, M. C., et al. (2018) · The Lancet · doi:10.1016/s0140-6736(18)32261-x · Cited by 1,829 · see citing works
A Randomized Trial of a Low-Carbohydrate Diet for Obesity
Foster, G. D., Wyatt, H. R., Hill, J. O., McGuckin, B. G., Brill, C., Mohammed, B. S., Szapary, P. O., Rader, D. J., Edman, J. S., & Klein, S. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa022207 · Cited by 1,794 · see citing works
Semaglutide in Patients with Heart Failure with Preserved Ejection Fraction and Obesity
Kosiborod, M. N., Abildstrøm, S. Z., Borlaug, B. A., Butler, J., Rasmussen, S., Davies, M., Hovingh, G. K., Kitzman, D. W., Lindegaard, M. L., Møller, D. V., et al. (2023) · New England Journal of Medicine · doi:10.1056/nejmoa2306963 · Cited by 1,669 · cited 2× · see citing works
“These findings were similar to the PIONEER 6 study (Peptide Innovation for Early Diabetes Treatment) with oral semaglutide [74].”
BackgroundResultKristensen, S. L., Rørth, R., Jhund, P. S., Docherty, K. F., Sattar, N., Preiss, D., Køber, L., Petrie, M. C., & McMurray, J. J. V. (2019) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(19)30249-9 · Cited by 1,663 · cited 2× · see citing works
“In a meta-analysis, GLP1-RAs were shown to reduce the risk of renal composite outcomes (occurrence of sustained macroalbuminuria, doubling of serum creatinine, glomerular filtration rate decrease of 30% or 40%, need for renal replacement therapy, or death due to renal disease) by 17% [102].”
BackgroundMethodInfluentialNauck, M. A., Heimesaat, M. M., Orskov, C., Holst, J. J., Ebert, R., & Creutzfeldt, W. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116186 · Cited by 1,651 · see citing works
GLP-1 receptor agonists in the treatment of type 2 diabetes - state-of-the-art
Nauck, M. A., Quast, D. R., Wefers, J., & Meier, J. J. (2021) · Molecular Metabolism · doi:10.1016/j.molmet.2020.101102 · Cited by 1,647 · see citing works
Sattar, N., Lee, M. M. Y., Kristensen, S. L., Branch, K. R. H., Del Prato, S., Khurmi, N. S., Lam, C. S. P., Lopes, R. D., McMurray, J. J. V., Pratley, R. E., et al. (2021) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(21)00203-5 · Cited by 1,599 · cited 1× · see citing works
“Meta-analysis revealed promising trends regarding heart failure outcomes in terms of reduced rate of heart failure-related events [103].”
BackgroundObesity-Induced Hypertension: Interaction of Neurohumoral and Renal Mechanisms
Hall, J. E., do Carmo, J. M., da Silva, A. A., Wang, Z., & Hall, M. E. (2015) · Circulation Research · doi:10.1161/circresaha.116.305697 · Cited by 1,360 · see citing works
Effect of weight loss with lifestyle intervention on risk of diabetes
Hamman, R. F., Wing, R. R., Edelstein, S. L., Lachin, J. M., Bray, G. A., Delahanty, L., Hoskin, M., Kriska, A. M., Mayer-Davis, E. J., Pi-Sunyer, X., et al. (2006) · Diabetes Care · doi:10.2337/dc06-0560 · Cited by 1,344 · see citing works
GLP-1 receptor agonists for individualized treatment of type 2 diabetes mellitus
Meier, J. J. (2012) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2012.140 · Cited by 1,311 · cited 3× · see citing works
“Several strategies have been used to extend the biological effect of GLP1-RAs [41].”
BackgroundMethodInfluentialThe mechanism of pancreatic secretion
Bayliss, W. M., & Starling, E. H. (1902) · The Journal of Physiology · doi:10.1113/jphysiol.1902.sp000920 · Cited by 1,274 · see citing works
Davies, M. J., Bergenstal, R., Bode, B., Kushner, R. F., Lewin, A., Skjøth, T. V., Andreasen, A. H., Jensen, C. B., DeFronzo, R. A., & for the NN8022-1922 Study Group (2015) · JAMA · doi:10.1001/jama.2015.9676 · Cited by 1,198 · see citing works
Ban, K., Noyan-Ashraf, M. H., Hoefer, J., Bolz, S.-S., Drucker, D. J., & Husain, M. (2008) · Circulation · doi:10.1161/circulationaha.107.739938 · Cited by 1,057 · cited 1× · see citing works
“One of the primary actions of GLP1-RAs is to enhance insulin secretion from the pancreatic β-cells in a glucose-dependent manner [43, 44].”
BackgroundDavies, M. J., Aroda, V. R., Collins, B. S., Gabbay, R. A., Green, J., Maruthur, N. M., Rosas, S. E., Del Prato, S., Mathieu, C., Mingrone, G., et al. (2022) · Diabetologia · doi:10.1007/s00125-022-05787-2 · Cited by 1,048 · see citing works
The Public Health Impact of Obesity
Visscher, T. L. S., & Seidell, J. C. (2001) · Annual Review of Public Health · doi:10.1146/annurev.publhealth.22.1.355 · Cited by 1,013 · see citing works
The arcuate nucleus mediates GLP-1 receptor agonist liraglutide-dependent weight loss
Secher, A., Jelsing, J., Baquero, A. F., Hecksher-Sørensen, J., Cowley, M. A., Dalbøge, L. S., Hansen, G., Grove, K. L., Pyke, C., Raun, K., et al. (2014) · Journal of Clinical Investigation · doi:10.1172/jci75276 · Cited by 961 · see citing works
Deacon, C. F., Nauck, M. A., Toft-Nielsen, M.-B., Pridal, L., Willms, B., & Holst, J. J. (1995) · Diabetes · doi:10.2337/diabetes.44.9.1126 · Cited by 878 · see citing works
le Roux, C. W., Astrup, A., Fujioka, K., Greenway, F., Lau, D. C. W., Van Gaal, L., Ortiz, R. V., Wilding, J. P. H., Skjøth, T. V., Manning, L. S., et al. (2017) · The Lancet · doi:10.1016/s0140-6736(17)30069-7 · Cited by 850 · see citing works
Semaglutide lowers body weight in rodents via distributed neural pathways.
Gabery, S., Salinas, C. G., Paulsen, S. J., Ahnfelt-Rønne, J., Alanentalo, T., Baquero, A. F., Buckley, S. T., Farkas, E., Fekete, C., Frederiksen, K. S., et al. (2020) · JCI Insight · doi:10.1172/jci.insight.133429 · Cited by 717 · see citing works
Blundell, J., Finlayson, G., Axelsen, M., Flint, A., Gibbons, C., Kvist, T., & Hjerpsted, J. B. (2017) · Diabetes, Obesity and Metabolism · doi:10.1111/dom.12932 · Cited by 693 · see citing works
2018 Korean Society for the Study of Obesity Guideline for the Management of Obesity in Korea
Seo, M. H., Lee, W., Kim, S. S., Kang, J., Kang, J., Kim, K. K., Kim, B.-Y., Kim, Y., Kim, W., Kim, E. M., et al. (2019) · Journal of Obesity & Metabolic Syndrome · doi:10.7570/jomes.2019.28.1.40 · Cited by 680 · see citing works
Self-citationBjerre Knudsen, L., Madsen, L. W., Andersen, S., Almholt, K., de Boer, A. S., Drucker, D. J., Gotfredsen, C., Egerod, F. L., Hegelund, A. C., Jacobsen, H., et al. (2010) · Endocrinology · doi:10.1210/en.2009-1272 · Cited by 672 · see citing works
Exon duplication and divergence in the human preproglucagon gene
Bell, G. I., Sanchez-Pescador, R., Laybourn, P. J., & Najarian, R. C. (1983) · Nature · doi:10.1038/304368a0 · Cited by 593 · see citing works
Glucagon-like peptide 1 receptor agonists: cardiovascular benefits and mechanisms of action
Ussher, J. R., & Drucker, D. J. (2023) · Nature Reviews Cardiology · doi:10.1038/s41569-023-00849-3 · Cited by 577 · see citing works
Filippatos, T. D., Panagiotopoulou, T. V., & Elisaf, M. S. (2014) · The Review of Diabetic Studies · Cited by 560 · see citing works
Transcellular Stomach Absorption of a Derivatized Glucagon-Like Peptide-1 Receptor Agonist
Buckley, S. T., Bækdal, T. A., Vegge, A., Maarbjerg, S. J., Pyke, C., Ahnfelt-Rønne, J., Madsen, K. G., Schéele, S. G., Alanentalo, T., Kirk, R. K., et al. (2018) · Science Translational Medicine · doi:10.1126/scitranslmed.aar7047 · Cited by 553 · see citing works
Landsberg, L., Aronne, L. J., Beilin, L. J., Burke, V., Igel, L. I., Lloyd‐Jones, D., & Sowers, J. (2013) · The Journal of Clinical Hypertension · doi:10.1111/jch.12049 · Cited by 528 · see citing works
Kim, M., Platt, M. J., Shibasaki, T., Quaggin, S. E., Backx, P. H., Seino, S., Simpson, J. A., & Drucker, D. J. (2013) · Nature Medicine · doi:10.1038/nm.3128 · Cited by 514 · see citing works
Rakipovski, G., Rolin, B., Nøhr, J., Klewe, I., Frederiksen, K. S., Augustin, R., Hecksher-Sørensen, J., Ingvorsen, C., Polex-Wolf, J., & Knudsen, L. B. (2018) · JACC: Basic to Translational Science · doi:10.1016/j.jacbts.2018.09.004 · Cited by 509 · see citing works
Pancreatic safety of incretin-based drugs–FDA and EMA assessment
Egan, A. G., Blind, E., Dunder, K., de Graeff, P. A., Hummer, B. T., Bourcier, T., & Rosebraugh, C. (2014) · New England Journal of Medicine · doi:10.1056/nejmp1314078 · Cited by 498 · see citing works
Glucagon-Like Peptide 1 Induces Natriuresis in Healthy Subjects and in Insulin-Resistant Obese Men
Gutzwiller, J.-P., Tschopp, S., Bock, A., Zehnder, C. E., Huber, A. R., Kreyenbuehl, M., Gutmann, H., Drewe, J., Henzen, C., Goeke, B., et al. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-031403 · Cited by 442 · see citing works
Ge, L., Sadeghirad, B., Ball, G. D. C., da Costa, B. R., Hitchcock, C. L., Svendrovski, A., Kiflen, R., Quadri, K., Kwon, H. Y., Karamouzian, M., et al. (2020) · BMJ · doi:10.1136/bmj.m696 · Cited by 426 · see citing works
GLP-1 and the kidney: from physiology to pharmacology and outcomes in diabetes
Muskiet, M. H. A., Tonneijck, L., Smits, M. M., van Baar, M. J. B., Kramer, M. H. H., Hoorn, E. J., Joles, J. A., & van Raalte, D. H. (2017) · Nature Reviews Nephrology · doi:10.1038/nrneph.2017.123 · Cited by 407 · see citing works
Direct medical costs of obesity in the United States and the most populous states
Cawley, J., Biener, A., Meyerhoefer, C., Ding, Y., Zvenyach, T., Smolarz, B. G., & Ramasamy, A. (2021) · Journal of Managed Care & Specialty Pharmacy · doi:10.18553/jmcp.2021.20410 · Cited by 400 · see citing works
Shariq, O. A., & McKenzie, T. J. (2020) · Gland Surgery · doi:10.21037/gs.2019.12.03 · Cited by 396 · see citing works
Bellicha, A., van Baak, M. A., Battista, F., Beaulieu, K., Blundell, J. E., Busetto, L., Carraça, E. V., Dicker, D., Encantado, J., Ermolao, A., et al. (2021) · Obesity Reviews · doi:10.1111/obr.13256 · Cited by 375 · see citing works
Bettge, K., Kahle, M., Abd El Aziz, M. S., Meier, J. J., & Nauck, M. A. (2017) · Diabetes, Obesity and Metabolism · doi:10.1111/dom.12824 · Cited by 374 · see citing works
Diabetes Fact Sheet in Korea 2021
Bae, J. H., Han, K., Ko, S., Yang, Y., Choi, J. H., Choi, K. M., Kwon, H., & Won, K. C. (2022) · Diabetes & Metabolism Journal · doi:10.4093/dmj.2022.0106 · Cited by 361 · see citing works
Self-citationHe, L., Wang, J., Ping, F., Yang, N., Huang, J., Li, Y., Xu, L., Li, W., & Zhang, H. (2022) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2022.0338 · Cited by 356 · see citing works
2020 Korean Society for the Study of Obesity Guidelines for the Management of Obesity in Korea
Kim, B.-Y., Kang, S. M., Kang, J., Kang, S. Y., Kim, K. K., Kim, K.-B., Kim, B., Kim, S. J., Kim, Y., Kim, J. H., et al. (2021) · Journal of Obesity & Metabolic Syndrome · doi:10.7570/jomes21022 · Cited by 344 · see citing works
Self-citationExecutive summary: Guidelines (2013) for the management of overweight and obesity in adults
Members, E. P., Jensen, M. D., Ryan, D. H., Donato, K. A., Apovian, C. M., Ard, J. D., Comuzzie, A. G., Hu, F. B., Hubbard, V. S., Jakicic, J. M., et al. (2014) · Obesity · doi:10.1002/oby.20821 · Cited by 337 · see citing works
Sun, F., Wu, S., Guo, S., Yu, K., Yang, Z., Li, L., Zhang, Y., Quan, X., Ji, L., & Zhan, S. (2015) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2015.07.015 · Cited by 304 · see citing works
Eberly, L. A., Yang, L., Essien, U. R., Eneanya, N. D., Julien, H. M., Luo, J., Nathan, A. S., Khatana, S. A. M., Dayoub, E. J., Fanaroff, A. C., et al. (2021) · JAMA Health Forum · doi:10.1001/jamahealthforum.2021.4182 · Cited by 288 · see citing works
Further purification of a polypeptide demonstrating enterogastrone activity
Brown, J. C., Mutt, V., & Pederson, R. A. (1970) · The Journal of Physiology · doi:10.1113/jphysiol.1970.sp009155 · Cited by 276 · see citing works
Recent updates on GLP-1 agonists: Current advancements & challenges
Sharma, D., Verma, S., Vaidya, S. P., Kalia, K., & Tiwari, V. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.08.088 · Cited by 272 · see citing works
Expert panel report: Guidelines (2013) for the management of overweight and obesity in adults
(2014) · Obesity · doi:10.1002/oby.20660 · Cited by 257 · see citing works
Gier, B., Matveyenko, A. V., Kirakossian, D., Dawson, D., Dry, S. M., & Butler, P. C. (2012) · Diabetes · doi:10.2337/db11-1109 · Cited by 255 · see citing works
3. Prevention or Delay of Diabetes and Associated Comorbidities: Standards of Care in Diabetes—2023
ElSayed, N. A., Aleppo, G., Aroda, V. R., Bannuru, R. R., Brown, F. M., Bruemmer, D., Collins, B. S., Gaglia, J. L., Hilliard, M. E., Isaacs, D. M., et al. (2022) · Diabetes Care · doi:10.2337/dc23-s003 · Cited by 210 · see citing works
Gaspari, T. A., Liu, H., Welungoda, I., Hu, Y., Widdop, R. E., Knudsen, L. B., Simpson, R. W., & Dear, A. E. (2011) · Diabetes and Vascular Disease Research · doi:10.1177/1479164111404257 · Cited by 203 · see citing works
Glucagon-like peptide-1 relaxes rat conduit arteries via an endothelium-independent mechanism
Nyström, T., Gonon, A. T., Sjöholm, Å., & Pernow, J. (2005) · Regulatory Peptides · doi:10.1016/j.regpep.2004.08.024 · Cited by 188 · see citing works
Christensen, P., Meinert Larsen, T., Westerterp‐Plantenga, M., Macdonald, I., Martinez, J. A., Handjiev, S., Poppitt, S., Hansen, S., Ritz, C., Astrup, A., et al. (2018) · Diabetes, Obesity and Metabolism · doi:10.1111/dom.13466 · Cited by 188 · see citing works
Eguchi, Y., Kitajima, Y., Hyogo, H., Takahashi, H., Kojima, M., Ono, M., Araki, N., Tanaka, K., Yamaguchi, M., Matsuda, Y., et al. (2015) · Hepatology Research · doi:10.1111/hepr.12351 · Cited by 182 · see citing works
Ishibashi, Y., Matsui, T., Takeuchi, M., & Yamagishi, S. (2009) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2009.12.075 · Cited by 173 · see citing works
Kim, H., Lee, E. M., Ahn, S. Y., Kim, K., Kim, H. C., Kim, J. H., Lee, H., Lee, J. H., Park, J., Cho, E. J., et al. (2023) · Clinical Hypertension · doi:10.1186/s40885-023-00234-9 · Cited by 167 · see citing works
Self-citationKadouh, H., Chedid, V., Halawi, H., Burton, D. D., Clark, M. M., Khemani, D., Vella, A., Acosta, A., & Camilleri, M. (2020) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgz140 · Cited by 166 · see citing works
Schutte, A. E., Jafar, T. H., Poulter, N. R., Damasceno, A., Khan, N. A., Nilsson, P. M., Alsaid, J., Neupane, D., Kario, K., Beheiry, H., et al. (2022) · Cardiovascular Research · doi:10.1093/cvr/cvac130 · Cited by 164 · see citing works
Kim, K. K., Haam, J.-H., Kim, B. T., Kim, E. M., Park, J. H., Rhee, S. Y., Jeon, E. J., Kang, E., Nam, G. E., Koo, H. Y., et al. (2023) · Journal of Obesity & Metabolic Syndrome · doi:10.7570/jomes23016 · Cited by 163 · see citing works
Self-citationGlucagon-like peptide-1, glucose homeostasis and diabetes
Holst, J. J., Deacon, C. F., Vilsbøll, T., Krarup, T., & Madsbad, S. (2008) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2008.01.003 · Cited by 160 · see citing works
Ferdinand, K. C., White, W. B., Calhoun, D. A., Lonn, E., Sager, P. T., Brunelle, R. L., Jiang, H. H., Threlkeld, R. J., Robertson, K. E., & Geiger, M. J. (2014) · Hypertension · doi:10.1161/hypertensionaha.114.03062 · Cited by 146 · see citing works
Iurilli, M. L., Zhou, B., Bennett, J. E., Carrillo-Larco, R. M., Sophiea, M. K., Rodriguez‐Martinez, A., Bixby, H., Solomon, B. D., Taddei, C., Danaei, G., et al. (2021) · eLife · doi:10.7554/elife.60060 · Cited by 144 · see citing works
Chowdhury, M. Z. I., Rahman, M. M., Akter, T., Akhter, T., Ahmed, A., Shovon, M. A., Farhana, Z., Chowdhury, N. A., & Turin, T. C. (2020) · Clinical Hypertension · doi:10.1186/s40885-020-00143-1 · Cited by 143 · see citing works
Glucagon-Like Peptide 1 Receptor Activation Attenuates Platelet Aggregation and Thrombosis
Cameron-Vendrig, A., Adili, R., Siraj, M. A., Xu, X., Wang, Y., Lei, X., Afroze, T., Shikatani, E. A., El-Mounayri, O., Noyan, H., et al. (2016) · Diabetes · doi:10.2337/db15-1141 · Cited by 141 · see citing works
The effect of dulaglutide on stroke: an exploratory analysis of the REWIND trial
Gerstein, H. C., Hart, R., Colhoun, H. M., Diaz, R., Lakshmanan, M., Botros, F. T., Probstfield, J., Riddle, M. C., Rydén, L., Atisso, C. M., et al. (2020) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(19)30423-1 · Cited by 137 · see citing works
Safety and tolerability of once‐weekly GLP‐1 receptor agonists in type 2 diabetes
Trujillo, J. M. (2020) · Journal of Clinical Pharmacy and Therapeutics · doi:10.1111/jcpt.13225 · Cited by 131 · see citing works
Luna-Marco, C., de Marañon, A. M., Hermo-Argibay, A., Rodriguez-Hernandez, Y., Hermenejildo, J., Fernández-Reyes, M., Apostolova, N., Vila, J. M., Solá, E., Morillas, C., et al. (2023) · Redox Biology · doi:10.1016/j.redox.2023.102849 · Cited by 130 · see citing works
Renal effects of glucagon-like peptide in rats
Moreno, C., Mistry, M., & Roman, R. J. (2002) · European Journal of Pharmacology · doi:10.1016/s0014-2999(01)01542-4 · Cited by 121 · see citing works
GLP1R Attenuates Sympathetic Response to High Glucose via Carotid Body Inhibition
Pauza, A. G., Thakkar, P., Tasic, T., Felippe, I., Bishop, P., Greenwood, M. P., Rysevaite-Kyguoliene, K., Ast, J., Broichhagen, J., Hodson, D. J., et al. (2022) · Circulation Research · doi:10.1161/circresaha.121.319874 · Cited by 106 · see citing works
Jojima, T., Uchida, K., Akimoto, K., Tomotsune, T., Yanagi, K., Iijima, T., Suzuki, K., Kasai, K., & Aso, Y. (2017) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2017.04.001 · Cited by 105 · see citing works
Fonseca, V. A., DeVries, J. H., Henry, R. R., Donsmark, M., Thomsen, H. F., & Plutzky, J. (2014) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2014.01.009 · Cited by 98 · see citing works
GLP-1 Agonists and Blood Pressure: A Review of the Evidence
Goud, A., Zhong, J., Peters, M. C., Brook, R. D., & Rajagopalan, S. (2016) · Current Hypertension Reports · doi:10.1007/s11906-015-0621-6 · Cited by 94 · see citing works
Asmar, A., Simonsen, L., Asmar, M., Madsbad, S., Holst, J. J., Frandsen, E., Moro, C., Jonassen, T. E. N., & Bülow, J. (2015) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00429.2014 · Cited by 93 · see citing works
Strain, W. D., Frenkel, O., James, M. A., Leiter, L. A., Rasmussen, S., Rothwell, P. M., Sejersten Ripa, M., Truelsen, T. C., & Husain, M. (2022) · Stroke · doi:10.1161/strokeaha.121.037775 · Cited by 93 · see citing works
GLP-1 Inhibits High-Glucose-Induced Oxidative Injury of Vascular Endothelial Cells
Li, Q., Lin, Y., Wang, S., Zhang, L., & Guo, L. (2017) · Scientific Reports · doi:10.1038/s41598-017-06712-z · Cited by 86 · see citing works
Caruso, I., Cignarelli, A., Sorice, G. P., Natalicchio, A., Perrini, S., Laviola, L., & Giorgino, F. (2022) · Metabolites · doi:10.3390/metabo12020183 · Cited by 86 · see citing works
Kim, N., Wang, J., Burudpakdee, C., Song, Y., Ramasamy, A., Xie, Y., Sun, R., Kumar, N., Wu, E. Q., & Sullivan, S. D. (2022) · Journal of Managed Care & Specialty Pharmacy · doi:10.18553/jmcp.2022.28.7.740 · Cited by 81 · see citing works
GLP1 and cancer: friend or foe?
Vangoitsenhoven, R., Mathieu, C., & der Schueren, B. V. (2012) · Endocrine Related Cancer · doi:10.1530/erc-12-0111 · Cited by 75 · see citing works
Anholm, C., Kumarathurai, P., Pedersen, L. R., Samkani, A., Walzem, R. L., Nielsen, O. W., Kristiansen, O. P., Fenger, M., Madsbad, S., Sajadieh, A., et al. (2019) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2019.07.007 · Cited by 75 · see citing works
Jannah, N., Hild, J., Gallagher, C., & Dietz, W. (2018) · Obesity · doi:10.1002/oby.22307 · Cited by 72 · see citing works
Ribeiro-Silva, J. C., Tavares, C. A. M., & Girardi, A. C. C. (2023) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2023.102355 · Cited by 71 · see citing works
† (2021) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(21)00240-0 · Cited by 70 · see citing works
20-Year Trends in Metabolic Syndrome Among Korean Adults From 2001 to 2020
Park, D., Shin, M., Després, J., Eckel, R. H., Tuomilehto, J. O., & Lim, S. K. (2023) · JACC Asia · doi:10.1016/j.jacasi.2023.02.007 · Cited by 62 · see citing works
Kim, H. C., Lee, H., Lee, H., Lee, G. B., Kim, E., Song, M., Moon, J., & Seo, Y. (2023) · Clinical Hypertension · doi:10.1186/s40885-023-00243-8 · Cited by 57 · see citing works
Self-citationNomoto, H., Miyoshi, H., Furumoto, T., Oba, K., Tsutsui, H., Miyoshi, A., Kondo, T., Tsuchida, K., Atsumi, T., Manda, N., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0135854 · Cited by 52 · see citing works
Saumoy, M., Gandhi, D., Buller, S., Patel, S., Schneider, Y., Coté, G. A., Kochman, M. L., Thiruvengadam, N. R., & Sharaiha, R. Z. (2023) · Gut · doi:10.1136/gutjnl-2023-330437 · Cited by 52 · see citing works
Yeh, T., Tsai, M.-C., Tsai, W.-H., Tu, Y., & Chien, K. (2023) · PLoS ONE · doi:10.1371/journal.pone.0278685 · Cited by 51 · see citing works
The Role of Glucagon-Like Peptide-1 in Energy Homeostasis
Salehi, M., & Purnell, J. Q. (2019) · Metabolic Syndrome and Related Disorders · doi:10.1089/met.2018.0088 · Cited by 49 · see citing works
Katsurada, K., Nakata, M., Saito, T., Zhang, B., Maejima, Y., Nandi, S. S., Sharma, N. M., Patel, K. P., Kario, K., & Yada, T. (2019) · Scientific Reports · doi:10.1038/s41598-019-49364-x · Cited by 46 · see citing works
Hu, M., Cai, X., Yang, W., Zhang, S., Nie, L., & Ji, L. (2020) · Journal of the American Heart Association · doi:10.1161/jaha.119.015323 · Cited by 46 · see citing works
Cost-effectiveness analysis of 4 GLP-1RAs in the treatment of obesity in a US setting
Hu, Y., Zheng, S.-L., Ye, X.-L., Shi, J.-N., Zheng, X.-W., Pan, H.-S., Zhang, Y.-W., Yang, X.-L., & Huang, P. (2022) · Annals of Translational Medicine · doi:10.21037/atm-22-200 · Cited by 45 · see citing works
Cost-Effectiveness of Pharmacotherapy for the Treatment of Obesity in Adolescents
Lim, F., Bellows, B. K., Tan, S. X., Aziz, Z., Woo Baidal, J. A., Kelly, A. S., & Hur, C. (2023) · JAMA Network Open · doi:10.1001/jamanetworkopen.2023.29178 · Cited by 42 · see citing works
Banerjee, M., Pal, R., Mukhopadhyay, S., & Nair, K. (2023) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgad076 · Cited by 41 · see citing works
Metabolomics profiling in hypertension and blood pressure regulation: a review
Onuh, J. O., & Aliani, M. (2020) · Clinical Hypertension · doi:10.1186/s40885-020-00157-9 · Cited by 40 · see citing works
Adding Liraglutide to Oral Antidiabetic Drug Monotherapy: Efficacy and Weight Benefits
Nauck, M. A., & Marre, M. (2009) · Postgraduate Medicine · doi:10.3810/pgm.2009.05.1997 · Cited by 38 · see citing works
Roessler, J., Leistner, D. M., Landmesser, U., & Haghikia, A. (2022) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2022.08.018 · Cited by 37 · see citing works
Cost-effectiveness analysis of five anti-obesity medications from a US payer's perspective
Gómez-Lumbreras, A., Tan, M. S., Zapata, L. V., Ilham, S., Earl, J. C., & Malone, D. C. (2023) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2023.03.012 · Cited by 37 · see citing works
Lee, G. B., Kim, Y., Park, S., Kim, H. C., & Oh, K. (2022) · Epidemiology and Health · doi:10.4178/epih.e2022041 · Cited by 36 · see citing works
Self-citationKim, Y., Nho, S. J., Woo, G.-J., Kim, H.-J., Park, S., Kim, Y., Park, O., & Oh, K. (2021) · Epidemiology and Health · doi:10.4178/epih.e2021028 · Cited by 35 · see citing works
Self-citationGlucagon-Like Peptide 1 Receptor Agonists: A Medication for Obesity Management
Taha, M. B., Yahya, T., Satish, P., Laird, R., Agatston, A. S., Cainzos-Achirica, M., Patel, K. V., & Nasir, K. (2022) · Current Atherosclerosis Reports · doi:10.1007/s11883-022-01041-7 · Cited by 31 · see citing works
Fan, S., Xiong, Q., Wang, L., Zhang, L., & Shi, Y. (2020) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2020.111005 · Cited by 30 · see citing works
Pradhan, R., Patorno, E., Tesfaye, H., Schneeweiß, S., Yin, H., Franklin, J. M., Pawar, A. M., Santella, C., Yu, O. H. Y., Renoux, C., et al. (2022) · American Journal of Epidemiology · doi:10.1093/aje/kwac021 · Cited by 30 · see citing works
Woronow, D. I., Chamberlain, C. E., Niak, A., Avigan, M., Houstoun, M., & Kortepeter, C. M. (2022) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2022.3810 · Cited by 30 · see citing works
Current opinion on dietary advice in order to preserve fat-free mass during a low-calorie diet
Rondanelli, M., Faliva, M. A., Gasparri, C., Peroni, G., Spadaccini, D., Maugeri, R., Nichetti, M., Infantino, V., & Perna, S. (2020) · Nutrition · doi:10.1016/j.nut.2019.110667 · Cited by 29 · see citing works
Increased prevalence of metabolic syndrome among hypertensive population
Lee, S., Cha, M., Kang, D., Oh, K.-C., Shin, D., & Lee, H. (2011) · International Journal of Cardiology · doi:10.1016/j.ijcard.2011.11.095 · Cited by 28 · see citing works
Self-citationCurrent Long-Term Pharmacotherapies for the Management of Obesity
Kim, B.-Y., Kang, S. M., Kang, J., Kim, K. K., Kim, B., Kim, S. J., Kim, Y., Kim, J. H., Kim, J. H., Nam, G. E., et al. (2020) · Journal of Obesity & Metabolic Syndrome · doi:10.7570/jomes20010 · Cited by 27 · see citing works
Self-citationResistant hypertension: consensus document from the Korean society of hypertension
Park, S., Shin, J., Ihm, S., Kim, K., Kim, H., Kim, H. C., Lee, E. M., Lee, J. H., Ahn, S. Y., Cho, E. J., et al. (2023) · Clinical Hypertension · doi:10.1186/s40885-023-00255-4 · Cited by 26 · see citing works
Self-citationObesity-related hypertension and chronic kidney disease: from evaluation to management
Jung, M., & Ihm, S. (2023) · Kidney Research and Clinical Practice · doi:10.23876/j.krcp.23.072 · Cited by 24 · see citing works
Self-citationWang, W., Wei, R., Huang, Z., Luo, J., Pan, Q., & Guo, L. (2023) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.3680 · Cited by 22 · see citing works
Suboptimal control status of young hypertensive population
Shin, D., Choi, J., & Lee, H. (2023) · Clinical Hypertension · doi:10.1186/s40885-023-00237-6 · Cited by 22 · see citing works
Self-citationChoi, J. H., Cho, Y. J., Kim, H., Ko, S., Chon, S., Kang, J., Kim, K. K., Kim, H. J., Kim, H. J., Song, K., et al. (2022) · Clinical Hypertension · doi:10.1186/s40885-022-00207-4 · Cited by 21 · see citing works
Self-citationElSayed, N. A., Aleppo, G., Aroda, V. R., Bannuru, R. R., Brown, F. M., Bruemmer, D., Collins, B. S., Hilliard, M. E., Isaacs, D. M., Johnson, E. L., et al. (2023) · Diabetes Care · doi:10.2337/dc23-ad08a · Cited by 16 · see citing works
Molecular Processes Involved in the Shared Pathways between Cardiovascular Diseases and Diabetes
Tokarek, J., Budny, E., Saar, M., Stańczak, K., Wojtanowska, E., Młynarska, E., Rysz, J., & Franczyk, B. (2023) · Biomedicines · doi:10.3390/biomedicines11102611 · Cited by 12 · see citing works
Scalzo, R. L., Rafferty, D., Schauer, I. E., Huebschmann, A. G., Cree‐Green, M., Reusch, J. E. B., & Regensteiner, J. G. (2019) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2019.05.002 · Cited by 12 · see citing works
SELECTing Treatments for Cardiovascular Disease — Obesity in the Spotlight
Khera, A., & Powell‐Wiley, T. M. (2023) · New England Journal of Medicine · doi:10.1056/nejme2312646 · Cited by 12 · see citing works
Shim, S. Y., Jung, S. J., Kim, S. U., & Kim, H. C. (2023) · Clinical Hypertension · doi:10.1186/s40885-022-00227-0 · Cited by 10 · see citing works
Self-citationMerchenthaler (1999) · doi:10.1002/(sici)1096-9861(19990111)403:2
Flagged first, then by citations
Cited by
Sorted by citations
GLP-1 agonists in the treatment of chronic kidney disease in type 2 diabetes and obesity
Cooper, M. E., & van Raalte, D. H. (2025) · Journal of Clinical Investigation · doi:10.1172/jci194749 · Cited by 24 · see citing works
“For example, the effects of GLP-1 receptor agonists on blood pressure appear to be rather modest, as recently summarized (21), and are not in line with kidney outcomes observed with other agents that provide a similar reduction in blood pressure.”
Bank, N. C., Perle, S. J., Lauck, B. J., Rajesh, A. J., Jeffs, A. D., & Draeger, R. W. (2025) · Journal of Hand Surgery Global Online · doi:10.1016/j.jhsg.2025.100746 · Cited by 4 · see citing works
Uti, D. E., Egbung, J. E., Alum, E. U., Bawa, I., Agada, S. A., Ogbu, C. O., & Ugwu, O. P.-C. (2026) · Obesity Medicine · doi:10.1016/j.obmed.2026.100712 · Cited by 1 · see citing works
Long-Term Impact of New-Onset Diabetes Mellitus in Hypertensive Patients
Park, S., Kim, S., Shin, H. G., Park, K., Lee, S., Lee, H., Lee, J., Kim, K., Kang, S., Lee, J. H., et al. (2026) · Korean Circulation Journal · doi:10.4070/kcj.2026.0017 · Cited by 1 · see citing works
Self-citationMedenica, S., Prelević, V., Zanković, N., Maggio, V., & Rizzo, M. (2026) · Expert Opinion on Drug Safety · doi:10.1080/14740338.2026.2648248
Matsushita, T., Wada, Y., Saburi, M., Kobayashi, K., Tsukamoto, S., Kawanami, D., Suzuki, D., Tsuriya, D., Wakui, H., Kanasaki, K., et al. (2026) · Hypertension Research · doi:10.1038/s41440-026-02695-5
Singh, A. K., Yadav, D., & Singh, M. P. (2026) · Indian Journal of Pharmacology · doi:10.4103/ijp.ijp_1343_25
Tristan, C. D., Irnizarifka, I., Kynaya, E. M., Gani, M., Wijayanto, M. A., Asrial, A. A., & Pranata, R. (2026) · American Journal of Cardiovascular Drugs · doi:10.1007/s40256-026-00812-w
Hypertension as a Metabolic Disease: New-Onset Diabetes in the Korean Hypertension Cohort
Kim, H. (2026) · Korean Circulation Journal · doi:10.4070/kcj.2026.0358
Self-citationRavić, M. P., Srejovic, I. M., Andjic, M. M., Nikolić, M., Sretenovic, J. Z., Jeremic, N. S., Milosavljevic, I. M., Vuletić, M. L., Muric, N. N., Ravić, K. R., et al. (2026) · Medical Sciences · doi:10.3390/medsci14050590
- Authors
- Lee, H. Y., Ko, S.-H., Park, S., Kim, K., Kim, S.-Y., Cho, I.-J., Cho, E. J., Kim, H. C., Park, J.-H., Ryu, S. K., Moon, M. K., Ihm, S.-H., & the Korean Society of Hypertension
- Affiliations
- Seoul National University (KR)
- Ewha Womans University (KR)
- Corresponding author
- Ihm, Sang-Hyun
- ORCID
- Venue
- Clinical Hypertension
- Publisher
- XMLink
- Published
- 2024
- Volume
- 30
- Issue
- 1
- Pages
- 24-24
- ISSN
- 2056-5909 (ISSN-L)
- PMC
- PMC11366170
- OpenAlex
- W4402115627
- Cited by
- 10
- References
- 136
- Citations by year
- 2026: 8 · 2025: 2
- FWCI
- 0.59
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- Locations
- Clinical Hypertension (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Health Sciences › Medicine › Pharmacology › Pharmacology and Obesity Treatment
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Keywords
- GLP-1 receptor agonists, metabolic syndrome, obesity, obesity-related hypertension, essential hypertension, weight management, blood pressure reduction, cardioprotection, renal protection, obesity as a disease, health policy, drug reimbursement
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review