Cited by 10Diabetes Treatment and ManagementPharmacology and Obesity TreatmentBlood Pressure and Hypertension Studies

The role of glucagon-like peptide-1 receptor agonists (GLP1-RAs) in the management of the hypertensive patient with metabolic syndrome: a position paper from the Korean society of hypertension

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Lee, Hae Young, Ko, Seung-Hyun, Park, Sungjoon, Kim, Kyuho, Kim, Song-Yi, Cho, In-Jeong, Cho, Eun Joo, Kim, Hyeon Chang +5 more·2024·Clinical Hypertension

Abstract

Obesity is the one of the most important components of metabolic syndrome. Because obesity related hypertension accounts for two thirds of essential hypertension, managing obesity and metabolic syndrome is a crucial task in the management of hypertension. However, the current non-pharmacological therapies have limitations for achieving or maintaining ideal body weight. Recently, glucagon-like peptide-1 receptor agonists (GLP1-RAs) have demonstrated excellent weight control effects, accompanied by corresponding reductions in blood pressure. GLP1-RAs have shown cardiovascular and renal protective effects in cardiovascular outcome trials both in primary and secondary prevention. In this document, the Korean Society of Hypertension intends to remark the current clinical results of GLP1-RAs and recommend the government and health-policy makers to define obesity as a disease and to establish forward-looking policies for GLP1-RA treatment for obesity treatment, including active reimbursement policies.

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Registry

Crossref · 10.1186/s40885-024-00279-4

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  • The effects of GLP-1 receptor agonists on blood pressure appear to be rather modest.

    “For example, the effects of GLP-1 receptor agonists on blood pressure appear to be rather modest, as recently summarized (21), and are not in line with kidney outcomes observed with other agents that provide a similar reduction in blood pressure.”

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Authors
Lee, H. Y., Ko, S.-H., Park, S., Kim, K., Kim, S.-Y., Cho, I.-J., Cho, E. J., Kim, H. C., Park, J.-H., Ryu, S. K., Moon, M. K., Ihm, S.-H., & the Korean Society of Hypertension
Affiliations
  • Seoul National University (KR)
  • Ewha Womans University (KR)
Corresponding author
Ihm, Sang-Hyun
Venue
Clinical Hypertension
Publisher
XMLink
Published
2024
Volume
30
Issue
1
Pages
24-24
ISSN
2056-5909 (ISSN-L)
OpenAlex
W4402115627
Cited by
10
References
136
Citations by year
2026: 8 · 2025: 2
FWCI
0.59
Type
journal article
Language
en
Open access
Locations
  • Clinical Hypertension (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
  • Health Sciences › Medicine › Pharmacology › Pharmacology and Obesity Treatment
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
Keywords
GLP-1 receptor agonists, metabolic syndrome, obesity, obesity-related hypertension, essential hypertension, weight management, blood pressure reduction, cardioprotection, renal protection, obesity as a disease, health policy, drug reimbursement

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