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Cited by 292

The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.

CCR5 Plays a Critical Role in Obesity-Induced Adipose Tissue Inflammation and Insulin Resistance by Regulating Both Macrophage Recruitment and M1/M2 Status

Open access
Kitade, Hironori, Sawamoto, Kazuki, Nagashimada, Mayumi, Inoue, Hiroshi, Yamamoto, Yasuhiko, Sai, Yoshimichi, Takamura, Toshinari, Yamamoto, Hiroshi, Miyamoto, Ken-ichi, Ginsberg, Henry N., Mukaida, Naofumi, Kaneko, Shuichi, Ota, Tsuguhito·2012·Diabetes
DOI 10.2337/db11-1506
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Abstract

C-C motif chemokine receptor (CCR)2 and its ligand, monocyte chemoattractant protein (MCP)-1, are pivotal for adipose tissue macrophage (ATM) recruitment and the development of insulin resistance. However, other chemokine systems also may play a role in these processes. In this study, we investigated the role of CCR5 in obesity-induced adipose tissue inflammation and insulin resistance. We analyzed expression levels of CCR5 and its ligands in white adipose tissue (WAT) of genetically (ob/ob) and high-fat (HF) diet–induced obese (DIO) mice. Furthermore, we examined the metabolic phenotype of Ccr5−/− mice. CCR5 and its ligands were markedly upregulated in WAT of DIO and ob/ob mice. Fluorescence-activated cell sorter analysis also revealed that DIO mice had a robust increase in CCR5+ cells within ATMs compared with chow-fed mice. Furthermore, Ccr5−/− mice were protected from insulin resistance, glucose intolerance, and hepatic steatosis induced by HF feeding. The effects of loss of CCR5 were related to both reduction of total ATM content and an M2-dominant shift in ATM polarization. It is noteworthy that transplantation of Ccr5−/− bone marrow was sufficient to protect against impaired glucose tolerance. CCR5 plays a critical role in ATM recruitment and polarization and subsequent development of insulin resistance.

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Metadata

Authors
Kitade, H., Sawamoto, K., Nagashimada, M., Inoue, H., Yamamoto, Y., Sai, Y., Takamura, T., Yamamoto, H., Miyamoto, K.-I., Ginsberg, H. N., Mukaida, N., Kaneko, S., & Ota, T.
Venue
Diabetes
Publisher
American Diabetes Association
Published
2012-06-15
Volume
61
Issue
7
Pages
1680-1690
ISSN
  • 0012-1797 (ISSN-L)
  • 1939-327X
DOI
10.2337/db11-1506
OpenAlex
W2120805022
Cited by
292
References
20
FWCI
14.65
Type
journal article
Language
en
Open access
hybrid

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CoChat. (2026). Citation check: CCR5 Plays a Critical Role in Obesity-Induced Adipose Tissue Inflammation and Insulin Resistance by Regulating Both Macrophage Recruitment and M1/M2 Status. https://app.cochat.ai/papers/10.2337/db11-1506
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Kitade, H., Sawamoto, K., Nagashimada, M., Inoue, H., Yamamoto, Y., Sai, Y., Takamura, T., Yamamoto, H., Miyamoto, K.-I., Ginsberg, H. N., Mukaida, N., Kaneko, S., & Ota, T. (2012). CCR5 Plays a Critical Role in Obesity-Induced Adipose Tissue Inflammation and Insulin Resistance by Regulating Both Macrophage Recruitment and M1/M2 Status. Diabetes. https://doi.org/10.2337/db11-1506

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.