Skeletal muscle inflammation and insulin resistance in obesity

Obesity is associated with macrophage accumulation in adipose tissue

Weisberg, S. P., McCann, D., Desai, M., Rosenbaum, M., Leibel, R. L., & Ferrante, A. W. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319246 · Cited by 10,041 · see citing works

Inflammation and metabolic disorders

Hotamisligil, G. S. (2006) · Nature · doi:10.1038/nature05485 · Cited by 9,199 · see citing works

Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance

Xu, H., Barnes, G. T., Yang, Q., Tan, G., Yang, D., Chou, C. J., Sole, J., Nichols, A., Ross, J. S., Tartaglia, L. A., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319451 · Cited by 6,760 · see citing works

Macrophage plasticity and polarization: in vivo veritas

Sica, A., & Mantovani, A. (2012) · Journal of Clinical Investigation · doi:10.1172/jci59643 · Cited by 6,335 · see citing works

A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis

Boström, P., Wu, J., Jedrychowski, M. P., Korde, A., Ye, L., Lo, J. C., Rasbach, K. A., Boström, E. A., Choi, J. H., Long, J. Z., et al. (2012) · Nature · doi:10.1038/nature10777 · Cited by 4,810 · see citing works

Obesity induces a phenotypic switch in adipose tissue macrophage polarization

Lumeng, C. N., Bodzin, J. L., & Saltiel, A. R. (2007) · Journal of Clinical Investigation · doi:10.1172/jci29881 · Cited by 4,664 · see citing works

Mutation of the mouse klotho gene leads to a syndrome resembling ageing

Kuro-o, M., Matsumura, Y., Aizawa, H., Kawaguchi, H., Suga, T., Utsugi, T., Ohyama, Y., Kurabayashi, M., Kaname, T., Kume, E., et al. (1997) · Nature · doi:10.1038/36285 · Cited by 3,837 · see citing works

Mechanisms of fatty acid-induced inhibition of glucose uptake.

Boden, G., Chen, X., Ruiz, J., White, J. V., & Rossetti, L. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117252 · Cited by 3,702 · see citing works

TLR4 links innate immunity and fatty acid-induced insulin resistance

Shi, H., Kokoeva, M. V., Inouye, K., Tzameli, I., Yin, H., & Flier, J. S. (2006) · Journal of Clinical Investigation · doi:10.1172/jci28898 · Cited by 3,690 · see citing works

A central role for JNK in obesity and insulin resistance

Hirosumi, J., Tuncman, G., Chang, L., Görgün, C. Z., Uysal, K. T., Maeda, K., Karin, M., & Hotamisligil, G. S. (2002) · Nature · doi:10.1038/nature01137 · Cited by 3,359 · see citing works

Obesity and Cardiovascular Disease: Pathophysiology, Evaluation, and Effect of Weight Loss: An Update of the 1997 American Heart Association Scientific Statement on Obesity and Heart Disease From the Obesity Committee of the Council on Nutrition, Physical Activity, and Metabolism

Poirier, P., Giles, T. D., Bray, G. A., Hong, Y., Stern, J. S., Pi-Sunyer, F. X., & Eckel, R. H. (2006) · Circulation · doi:10.1161/circulationaha.106.171016 · Cited by 3,165 · see citing works

Differential Significance of Plasma Visfatin Concentrations according to Adiposity in Children and Adolescents

Kim, H. J., Park, S. Y., Choi, Y. J., Han, S. J., Lee, K. W., & Kim, D. J. (2013) · Hormone Research in Paediatrics · doi:10.1159/000348848 · Cited by 3,061 · see citing works

Muscles, exercise and obesity: skeletal muscle as a secretory organ

Pedersen, B. K., & Febbraio, M. A. (2012) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2012.49 · Cited by 2,909 · see citing works

Macrophages, inflammation, and insulin resistance

Olefsky, J. M., & Glass, C. K. (2010) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021909-135846 · Cited by 2,733 · see citing works

The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance

Vandanmagsar, B., Youm, Y.-H., Ravussin, A., Galgani, J. E., Stadler, K., Mynatt, R. L., Ravussin, E., Stephens, J. M., & Dixit, V. D. (2011) · Nature Medicine · doi:10.1038/nm.2279 · Cited by 2,655 · see citing works

Inflammatory links between obesity and metabolic disease

Lumeng, C. N., & Saltiel, A. R. (2011) · Journal of Clinical Investigation · doi:10.1172/jci57132 · Cited by 2,319 · see citing works

Mechanisms for Insulin Resistance: Common Threads and Missing Links

Samuel, V. T., & Shulman, G. I. (2012) · Cell · doi:10.1016/j.cell.2012.02.017 · Cited by 2,294 · see citing works

Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes.

Guilherme, A., Virbasius, J. V., Puri, V., & Czech, M. P. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2391 · Cited by 2,292 · see citing works

Skeletal Muscle Insulin Resistance Is the Primary Defect in Type 2 Diabetes

DeFronzo, R. A., & Tripathy, D. (2009) · Diabetes Care · doi:10.2337/dc09-s302 · Cited by 2,102 · see citing works

Reversal of Obesity- and Diet-Induced Insulin Resistance with Salicylates or Targeted Disruption of <i>Ikkβ</i>

Yuan, M., Konstantopoulos, N., Lee, J., Hansen, L., Li, Z.-W., Karin, M., & Shoelson, S. E. (2001) · Science · doi:10.1126/science.1061620 · Cited by 1,884 · see citing works

IKK-β links inflammation to obesity-induced insulin resistance

Arkan, M. C., Hevener, A. L., Greten, F. R., Maeda, S., Li, Z.-W., Long, J. M., Wynshaw-Boris, A., Poli, G., Olefsky, J., & Karin, M. (2005) · Nature Medicine · doi:10.1038/nm1185 · Cited by 1,773 · see citing works

The cellular and signaling networks linking the immune system and metabolism in disease

Osborn, O., & Olefsky, J. M. (2012) · Nature Medicine · doi:10.1038/nm.2627 · Cited by 1,551 · see citing works

Lipid-Induced Insulin Resistance in Human Muscle Is Associated With Changes in Diacylglycerol, Protein Kinase C, and IκB-α

Itani, S. I., Ruderman, N. B., Schmieder, F., & Boden, G. (2002) · Diabetes · doi:10.2337/diabetes.51.7.2005 · Cited by 1,390 · see citing works

IKKβ/NF-κB Activation Causes Severe Muscle Wasting in Mice

Cai, D., Frantz, J. D., Tawa, N. E., Melendez, P. A., Oh, B.-C., Lidov, H. G. W., Hasselgren, P.-O., Frontera, W. R., Lee, J., Glass, D. J., et al. (2004) · Cell · doi:10.1016/j.cell.2004.09.027 · Cited by 1,367 · see citing works

Monocyte subsets differentially employ CCR2, CCR5, and CX3CR1 to accumulate within atherosclerotic plaques

Tacke, F., Alvarez, D., Kaplan, T. J., Jakubzick, C., Spanbroek, R., Llodra, J., Garin, A., Liu, J., Mack, M., van Rooijen, N., et al. (2007) · Journal of Clinical Investigation · doi:10.1172/jci28549 · Cited by 1,323 · see citing works

Macrophage-mediated inflammation in metabolic disease

Chawla, A., Nguyen, K. D., & Goh, Y. P. S. (2011) · Nature reviews. Immunology · doi:10.1038/nri3071 · Cited by 1,314 · see citing works

A Subpopulation of Macrophages Infiltrates Hypertrophic Adipose Tissue and Is Activated by Free Fatty Acids via Toll-like Receptors 2 and 4 and JNK-dependent Pathways

Nguyen, M. T. A., Favelyukis, S., Nguyen, A.-K., Reichart, D., Scott, P. A., Jenn, A., Liu-Bryan, R., Glass, C. K., Neels, J. G., & Olefsky, J. M. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m706762200 · Cited by 1,035 · see citing works

Neutrophils mediate insulin resistance in mice fed a high-fat diet through secreted elastase

Talukdar, S., Oh, D. Y., Bandyopadhyay, G. K., Li, D., Xu, J., McNelis, J., Lu, M. M., Li, P., Yan, Q., Zhu, Y., et al. (2012) · Nature Medicine · doi:10.1038/nm.2885 · Cited by 966 · see citing works

Inflammation and Lipid Signaling in the Etiology of Insulin Resistance

Glass, C. K., & Olefsky, J. M. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.04.001 · Cited by 942 · see citing works

SOCS-1 and SOCS-3 block insulin signaling by ubiquitin-mediated degradation of IRS1 and IRS2

Rui, L., Yuan, M., Frantz, D., Shoelson, S., & White, M. F. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.c200444200 · Cited by 904 · see citing works

Interleukin-6 Increases Insulin-Stimulated Glucose Disposal in Humans and Glucose Uptake and Fatty Acid Oxidation In Vitro via AMP-Activated Protein Kinase

Carey, A. L., Steinberg, G. R., Macaulay, S. L., Thomas, W. G., Holmes, A. G., Ramm, G., Prelovsek, O., Hohnen-Behrens, C., Watt, M. J., James, D. E., et al. (2006) · Diabetes · doi:10.2337/db05-1404 · Cited by 898 · see citing works

Lipoprotein lipase: from gene to obesity

Wang, H., & Eckel, R. H. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90920.2008 · Cited by 862 · see citing works

Interleukin-6 in acute exercise and training: what is the biological relevance?

Fischer, C. P. (2026) · PubMed · doi:10.22029/eir.2006.1620 · Cited by 817 · see citing works

Ablation of CD11c-Positive Cells Normalizes Insulin Sensitivity in Obese Insulin Resistant Animals

Patsouris, D., Li, P.-P., Thapar, D., Chapman, J., Olefsky, J. M., & Neels, J. G. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.08.015 · Cited by 804 · see citing works

Irisin and FGF21 are cold-induced endocrine activators of brown fat function in humans

Lee, P., Linderman, J. D., Smith, S., Brychta, R. J., Wang, J., Idelson, C., Perron, R. M., Werner, C. D., Phan, G. Q., Kammula, U. S., et al. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2013.12.017 · Cited by 802 · see citing works

Exercise and IL‐6 infusion inhibit endotoxin‐induced TNF‐α production in humans

Starkie, R., Ostrowski, S. R., Jauffred, S., Febbraio, M., & Pedersen, B. K. (2003) · The FASEB Journal · doi:10.1096/fj.02-0670fje · Cited by 790 · see citing works

Irisin is expressed and produced by human muscle and adipose tissue in association with obesity and insulin resistance

Moreno-Navarrete, J. M., Ortega, F., Serrano, M., Guerra, E., Pardo, G., Tinahones, F., Ricart, W., & Fernández-Real, J. M. (2013) · The Journal of Clinical Endocrinology &amp; Metabolism · doi:10.1210/jc.2012-2749 · Cited by 788 · see citing works

Serine Phosphorylation of Insulin Receptor Substrate 1 by Inhibitor κB Kinase Complex

Gao, Z., Hwang, D. H., Bataille, F., Lefevre, M., York, D. A., Quon, M. J., & Ye, J. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m209459200 · Cited by 777 · see citing works

The role of skeletal muscle insulin resistance in the pathogenesis of the metabolic syndrome

Petersen, K. F., Dufour, S., Savage, D. B., Bilz, S., Solomon, G., Yonemitsu, S., Cline, G. W., Befroy, D., Zemany, L., Kahn, B. B., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0705408104 · Cited by 759 · see citing works

Tissue-specific overexpression of lipoprotein lipase causes tissue-specific insulin resistance

Kim, J. K., Fillmore, J. J., Chen, Y., Yu, C., Moore, I. K., Pypaert, M., Lutz, E. P., Kako, Y., Velez-Carrasco, W., Goldberg, I. J., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.121164498 · Cited by 753 · see citing works

Prevention of fat-induced insulin resistance by salicylate

Kim, J. K., Kim, Y.-J., Fillmore, J. J., Chen, Y., Moore, I., Lee, J., Yuan, M., Li, Z. W., Karin, M., Perret, P., et al. (2001) · Journal of Clinical Investigation · doi:10.1172/jci11559 · Cited by 737 · see citing works

Macrophages, Immunity, and Metabolic Disease

McNelis, J., & Olefsky, J. M. (2014) · Immunity · doi:10.1016/j.immuni.2014.05.010 · Cited by 728 · see citing works

The expression of TNF alpha by human muscle. Relationship to insulin resistance.

Saghizadeh, M., Ong, J. M., Garvey, W. T., Henry, R. R., & Kern, P. A. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118504 · Cited by 717 · see citing works

Thigh adipose tissue distribution is associated with insulin resistance in obesity and in type 2 diabetes mellitus

Goodpaster, B. H., Thaete, F. L., & Kelley, D. E. (2000) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/71.4.885 · Cited by 707 · see citing works

Lipid-induced insulin resistance mediated by the proinflammatory receptor TLR4 requires saturated fatty acid–induced ceramide biosynthesis in mice

Holland, W. L., Bikman, B. T., Wang, L.-P., Yuguang, G., Sargent, K. M., Bulchand, S., Knotts, T. A., Shui, G., Clegg, D. J., Wenk, M. R., et al. (2011) · Journal of Clinical Investigation · doi:10.1172/jci43378 · Cited by 705 · see citing works

Suppressor of Cytokine Signaling 1 (SOCS-1) and SOCS-3 Cause Insulin Resistance through Inhibition of Tyrosine Phosphorylation of Insulin Receptor Substrate Proteins by Discrete Mechanisms

Ueki, K., Kondo, T., & Kahn, C. R. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.12.5434-5446.2004 · Cited by 686 · see citing works

T-Cell Accumulation and Regulated on Activation, Normal T Cell Expressed and Secreted Upregulation in Adipose Tissue in Obesity

Wu, H., Ghosh, S., Perrard, X. D., Feng, L., García, G., Perrard, J. L., Sweeney, J. F., Peterson, L. E., Chan, L., Smith, C. W., et al. (2007) · Circulation · doi:10.1161/circulationaha.106.638379 · Cited by 682 · see citing works

Regulation of metabolism by the innate immune system

Lackey, D. E., & Olefsky, J. M. (2016) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2015.189 · Cited by 667 · see citing works

JNK Expression by Macrophages Promotes Obesity-Induced Insulin Resistance and Inflammation

Han, M. S., Jung, D. Y., Morel, C., Lakhani, S. A., Kim, J. K., Flavell, R. A., & Davis, R. J. (2012) · Science · doi:10.1126/science.1227568 · Cited by 635 · see citing works

Tumor Necrosis Factor-α Induces Skeletal Muscle Insulin Resistance in Healthy Human Subjects via Inhibition of Akt Substrate 160 Phosphorylation

Plomgaard, P., Bouzakri, K., Krogh-Madsen, R., Mittendorfer, B., Zierath, J. R., & Pedersen, B. K. (2005) · Diabetes · doi:10.2337/diabetes.54.10.2939 · Cited by 627 · see citing works

Local Proliferation of Macrophages Contributes to Obesity-Associated Adipose Tissue Inflammation

Amano, S. U., Cohen, J. L., Vangala, P., Tencerová, M., Nicoloro, S. M. C., Yawe, J. C., Shen, Y., Czech, M., & Aouadi, M. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2013.11.017 · Cited by 613 · see citing works

Inflammation Is Necessary for Long-Term but Not Short-Term High-Fat Diet–Induced Insulin Resistance

Lee, Y. S., Li, P., Huh, J. Y., Hwang, I. J., Lu, M., Kim, J. I., Ham, M., Talukdar, S., Chen, A., Lu, W. J., et al. (2011) · Diabetes · doi:10.2337/db11-0194 · Cited by 566 · see citing works

Differential Effects of Interleukin-6 and -10 on Skeletal Muscle and Liver Insulin Action In Vivo

Kim, H.-J., Higashimori, T., Park, S.-Y., Choi, H., Dong, J., Kim, Y.-J., Noh, H.-L., Cho, Y.-R., Cline, G., Kim, Y.-B., et al. (2004) · Diabetes · doi:10.2337/diabetes.53.4.1060 · Cited by 534 · see citing works

Interferon-γ, a Th1 Cytokine, Regulates Fat Inflammation

Rocha, V. Z., Folco, E. J. E., Sukhova, G. K., Shimizu, K., Gotsman, I., Vernon, A. H., & Libby, P. (2008) · Circulation Research · doi:10.1161/circresaha.108.177105 · Cited by 524 · see citing works

JNK1 in Hematopoietically Derived Cells Contributes to Diet-Induced Inflammation and Insulin Resistance without Affecting Obesity

Solinas, G., Vilcu, C., Neels, J. G., Bandyopadhyay, G. K., Luo, J.-L., Naugler, W., Grivennikov, S., Wynshaw-Boris, A., Scadeng, M., Olefsky, J. M., et al. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.09.011 · Cited by 513 · see citing works

PKC-θ knockout mice are protected from fat-induced insulin resistance

Kim, J. K., Fillmore, J. J., Sunshine, M. J., Albrecht, B., Higashimori, T., Kim, D.-W., Liu, Z.-X., Soos, T. J., Cline, G. W., O’Brien, W. R., et al. (2004) · Journal of Clinical Investigation · doi:10.1172/jci200422230 · Cited by 500 · see citing works

Astrocyte TLR4 activation induces a proinflammatory environment through the interplay between MyD88‐dependent NFκB signaling, MAPK, and Jak1/Stat1 pathways

Gorina, R., Font-Nieves, M., Márquez‐Kisinousky, L., Santalucı́a, T., & Planas, A. M. (2010) · Glia · doi:10.1002/glia.21094 · Cited by 470 · see citing works

Macrophage PPARγ is required for normal skeletal muscle and hepatic insulin sensitivity and full antidiabetic effects of thiazolidinediones

Hevener, A. L., Olefsky, J. M., Reichart, D., Nguyen, M. T. A., Bandyopadyhay, G., Leung, H.-Y., Watt, M. J., Benner, C., Febbraio, M. A., Nguyen, A.-K., et al. (2007) · Journal of Clinical Investigation · doi:10.1172/jci31561 · Cited by 459 · see citing works

An inhibitor of the protein kinases TBK1 and IKK-ɛ improves obesity-related metabolic dysfunctions in mice

Reilly, S. M., Chiang, S.-H., Decker, S. J., Chang, L. C., Uhm, M., Larsen, M. J., Rubin, J. R., Mowers, J. C., White, N. M. A., Hochberg, I., et al. (2013) · Nature Medicine · doi:10.1038/nm.3082 · Cited by 434 · see citing works

Diet and exercise reduce low-grade inflammation and macrophage infiltration in adipose tissue but not in skeletal muscle in severely obese subjects

Bruun, J. M., Helge, J. W., Richelsen, B., & Stallknecht, B. M. (2005) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00506.2005 · Cited by 431 · see citing works

Tumor Necrosis Factor α Produces Insulin Resistance in Skeletal Muscle by Activation of Inhibitor κB Kinase in a p38 MAPK-dependent Manner

de Álvaro, C., Teruel, T., Hernández, R., & Lorenzo, M. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m312021200 · Cited by 430 · see citing works

Role of diacylglycerol activation of PKCθ in lipid-induced muscle insulin resistance in humans

Szendroedi, J., Yoshimura, T., Phielix, E., Koliaki, C., Marcucci, M., Zhang, D., Jelenik, T., Müller, J., Herder, C., Nowotny, P., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1409229111 · Cited by 415 · see citing works

Interleukin-10 Prevents Diet-Induced Insulin Resistance by Attenuating Macrophage and Cytokine Response in Skeletal Muscle

Hong, E., Ko, H. J., Cho, Y.-R., Kim, H., Ma, Z., Yu, T. Y., Friedline, R. H., Kurt‐Jones, E. A., Finberg, R. W., Fischer, M. A., et al. (2009) · Diabetes · doi:10.2337/db08-1261 · Cited by 412 · see citing works

Skeletal Muscle Triglyceride

Kelley, D. E., & Goodpaster, B. H. (2001) · Diabetes Care · doi:10.2337/diacare.24.5.933 · Cited by 406 · see citing works

Myonectin (CTRP15), a novel myokine that links skeletal muscle to systemic lipid homeostasis

Seldin, M. M., Peterson, J. M., Byerly, M. S., Wei, Z., & Wong, G. W. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.336834 · Cited by 406 · see citing works

Pathogenesis of skeletal muscle insulin resistance in type 2 diabetes mellitus

Petersen, K. F., & Shulman, G. I. (2002) · The American Journal of Cardiology · doi:10.1016/s0002-9149(02)02554-7 · Cited by 390 · see citing works

Angiotensin II and inflammation: the effect of angiotensin-converting enzyme inhibition and angiotensin II receptor blockade

Dandona, P., Dhindsa, S., Ghanim, H., & Chaudhuri, A. (2006) · Journal of Human Hypertension · doi:10.1038/sj.jhh.1002101 · Cited by 384 · see citing works

Class II Major Histocompatibility Complex Plays an Essential Role in Obesity-Induced Adipose Inflammation

Deng, T., Lyon, C. J., Minze, L. J., Lin, J., Zou, J., Liu, J. Z., Ren, Y., Yin, Z., Hamilton, D. J., Reardon, P. R., et al. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.02.009 · Cited by 382 · see citing works

Elevated Toll-Like Receptor 4 Expression and Signaling in Muscle From Insulin-Resistant Subjects

Reyna, S. M., Ghosh, S., Tantiwong, P., Meka, C. S. R., Eagan, P. A., Jenkinson, C. P., Cersósimo, E., DeFronzo, R. A., Coletta, D. K., Sriwijitkamol, A., et al. (2008) · Diabetes · doi:10.2337/db08-0038 · Cited by 381 · see citing works

Angiotensin II Induces Vascular Cell Adhesion Molecule-1 Expression In Rat Vasculature

Tummala, P. E., Chen, X., Sundell, C. L., Laursen, J. B., Hammes, C. P., Alexander, R. W., Harrison, D. G., & Medford, R. M. (1999) · Circulation · doi:10.1161/01.cir.100.11.1223 · Cited by 376 · see citing works

Increased Macrophage Migration Into Adipose Tissue in Obese Mice

Oh, D. Y., Morinaga, H., Talukdar, S., Bae, E. J., & Olefsky, J. M. (2011) · Diabetes · doi:10.2337/db11-0860 · Cited by 365 · see citing works

Expression of CD68 and Macrophage Chemoattractant Protein-1 Genes in Human Adipose and Muscle Tissues

Di Gregorio, G. B., Yao-Borengasser, A., Rasouli, N., Varma, V., Lu, T., Miles, L. M., Ranganathan, G., Peterson, C. A., McGehee, R. E., & Kern, P. A. (2005) · Diabetes · doi:10.2337/diabetes.54.8.2305 · Cited by 362 · see citing works

Protein Kinase C θ Inhibits Insulin Signaling by Phosphorylating IRS1 at Ser1101

Li, Y., Soos, T. J., Li, X., Wu, J., DeGennaro, M., Sun, X., Littman, D. R., Birnbaum, M. J., & Polakiewicz, R. D. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.c400186200 · Cited by 358 · see citing works

The Protein Kinase IKKɛ Regulates Energy Balance in Obese Mice

Chiang, S.-H., Bazuine, M., Lumeng, C. N.-K., Geletka, L. M., Mowers, J. C., White, N. M. A., Ma, J.-T., Zhou, J., Qi, N., Westcott, D. J., et al. (2009) · Cell · doi:10.1016/j.cell.2009.06.046 · Cited by 344 · see citing works

Intensive Lifestyle Intervention or Metformin on Inflammation and Coagulation in Participants With Impaired Glucose Tolerance

The Diabetes Prevention Program Research Group (2005) · Diabetes · doi:10.2337/diabetes.54.5.1566 · Cited by 333 · see citing works

Increased secretion and expression of myostatin in skeletal muscle from extremely obese women

Hittel, D. S., Berggren, J. R., Shearer, J., Boyle, K., & Houmard, J. A. (2009) · Diabetes · doi:10.2337/db08-0943 · Cited by 324 · see citing works

LTB4 promotes insulin resistance in obese mice by acting on macrophages, hepatocytes and myocytes

Li, P., Oh, D. Y., Bandyopadhyay, G. K., Lagakos, W., Talukdar, S., Osborn, O., Johnson, A., Chung, H., Mayoral, R., Maris, M., et al. (2015) · Nature Medicine · doi:10.1038/nm.3800 · Cited by 318 · see citing works

Alterations in the Expression and Cellular Localization of Protein Kinase C Isozymes ε and θ Are Associated With Insulin Resistance in Skeletal Muscle of the High-Fat–Fed Rat

Schmitz-Peiffer, C., Browne, C. L., Oakes, N. D., Watkinson, A., Chisholm, D. J., Kraegen, E. W., & Biden, T. J. (1997) · Diabetes · doi:10.2337/diab.46.2.169 · Cited by 314 · see citing works

CCR5 Plays a Critical Role in Obesity-Induced Adipose Tissue Inflammation and Insulin Resistance by Regulating Both Macrophage Recruitment and M1/M2 Status

Kitade, H., Sawamoto, K., Nagashimada, M., Inoue, H., Yamamoto, Y., Sai, Y., Takamura, T., Yamamoto, H., Miyamoto, K., Ginsberg, H. N., et al. (2012) · Diabetes · doi:10.2337/db11-1506 · Cited by 292 · see citing works

Toll-like Receptor-2 Is Essential for the Development of Palmitate-induced Insulin Resistance in Myotubes

Senn, J. J. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m513304200 · Cited by 260 · see citing works

Skeletal muscle insulin resistance: role of inflammatory cytokines and reactive oxygen species

Wei, Y., Chen, K., Whaley‐Connell, A. T., Stump, C. S., Ibdah, J. A., & Sowers, J. R. (2007) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00561.2007 · Cited by 258 · see citing works

ACE2 Deficiency Worsens Epicardial Adipose Tissue Inflammation and Cardiac Dysfunction in Response to Diet-Induced Obesity

Patel, V. B., Mori, J., McLean, B. A., Basu, R., Das, S. K., Ramprasath, T., Parajuli, N., Penninger, J. M., Grant, M. B., Lopaschuk, G. D., et al. (2015) · Diabetes · doi:10.2337/db15-0399 · Cited by 257 · see citing works

Signaling Specificity of Interleukin-6 Action on Glucose and Lipid Metabolism in Skeletal Muscle

Al-Khalili, L., Bouzakri, K., Glund, S., Lönnqvist, F., Koistinen, H. A., & Krook, A. (2006) · Molecular Endocrinology · doi:10.1210/me.2005-0490 · Cited by 250 · see citing works

Implication of inflammatory signaling pathways in obesity-induced insulin resistance

Tanti, J., Ceppo, F., Jager, J., & Berthou, F. (2013) · Frontiers in Endocrinology · doi:10.3389/fendo.2012.00181 · Cited by 242 · see citing works

TNF-α impairs insulin signaling and insulin stimulation of glucose uptake in C2C12muscle cells

Aguila, L. F. D., Claffey, K. P., & Kirwan, J. P. (1999) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1999.276.5.e849 · Cited by 235 · see citing works

Functional Role of CD11c + Monocytes in Atherogenesis Associated With Hypercholesterolemia

Wu, H., Gower, R. M., Wang, H., Perrard, X. D., Ma, R., Bullard, D. C., Burns, A. R., Paul, A., Smith, C. W., Simon, S. I., et al. (2009) · Circulation · doi:10.1161/circulationaha.108.823740 · Cited by 232 · see citing works

Diet Induction of Monocyte Chemoattractant Protein‐1 and its Impact on Obesity

Chen, A., Mumick, S., Zhang, C., Lamb, J., Dai, H., Weingarth, D., Mudgett, J., Chen, H., MacNeil, D. J., Reitman, M. L., et al. (2005) · Obesity Research · doi:10.1038/oby.2005.159 · Cited by 231 · see citing works

Muscle inflammatory response and insulin resistance: synergistic interaction between macrophages and fatty acids leads to impaired insulin action

Varma, V., Yao-Borengasser, A., Rasouli, N., Nolen, G. T., Phanavanh, B., Starks, T., Gurley, C., Simpson, P., McGehee, R. E., Kern, P. A., et al. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90885.2008 · Cited by 229 · see citing works

Myokines in insulin resistance and type 2 diabetes

Eckardt, K., Görgens, S. W., Raschke, S., & Eckel, J. (2014) · Diabetologia · doi:10.1007/s00125-014-3224-x · Cited by 221 · see citing works

IL-6 selectively stimulates fat metabolism in human skeletal muscle

Wolsk, E., Mygind, H., Grøndahl, T. S., Pedersen, B. K., & van Hall, G. (2010) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00328.2010 · Cited by 221 · see citing works

Adipose tissue macrophages function as antigen-presenting cells and regulate adipose tissue CD4+ T cells in mice

Morris, D. L., Cho, K. W., DelProposto, J. L., Oatmen, K. E., Geletka, L. M., Martinez-Santibanez, G., Singer, K., & Lumeng, C. N. (2013) · Diabetes · doi:10.2337/db12-1404 · Cited by 217 · see citing works

The Renin Angiotensin Aldosterone System and Insulin Resistance in Humans

UNDERWOOD, P. C., & Adler, G. K. (2012) · Current Hypertension Reports · doi:10.1007/s11906-012-0323-2 · Cited by 214 · see citing works

Increased p85/55/50 Expression and Decreased Phosphotidylinositol 3-Kinase Activity in Insulin-Resistant Human Skeletal Muscle

Bandyopadhyay, G. K., Yu, J. G., Ofrecio, J., & Olefsky, J. M. (2005) · Diabetes · doi:10.2337/diabetes.54.8.2351 · Cited by 210 · see citing works

Activation of human peripheral monocytes by angiotensin II

Hahn, A. W. A., Jonas, U., Bühler, F. R., & Resink, T. J. (1994) · FEBS Letters · doi:10.1016/0014-5793(94)00531-1 · Cited by 208 · see citing works

Suppressor of Cytokine Signaling 3 Expression and Insulin Resistance in Skeletal Muscle of Obese and Type 2 Diabetic Patients

Rieusset, J., Bouzakri, K., Chevillotte, E., Ricard, N., Jacquet, D., Bastard, J.-P., Laville, M., & Vidal, H. (2004) · Diabetes · doi:10.2337/diabetes.53.9.2232 · Cited by 200 · see citing works

Pro‐Inflammatory macrophages increase in skeletal muscle of high fat‐Fed mice and correlate with metabolic risk markers in humans

Fink, L. N., Costford, S. R., Lee, Y. S., Jensen, T. E., Bilan, P. J., Oberbach, A., Blüher, M., Olefsky, J. M., Sams, A. G., & Klip, A. (2013) · Obesity · doi:10.1002/oby.20615 · Cited by 199 · see citing works

FGF21 as a Hepatokine, Adipokine, and Myokine in Metabolism and Diseases

Itoh, N. (2014) · Frontiers in Endocrinology · doi:10.3389/fendo.2014.00107 · Cited by 198 · see citing works

Angiotensin II-induced skeletal muscle insulin resistance mediated by NF-κB activation via NADPH oxidase

Wei, Y., Sowers, J. R., Clark, S. E., Li, W., Ferrario, C. M., & Stump, C. S. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00456.2007 · Cited by 197 · see citing works

Crosstalk between adipokines and myokines in fat browning

Rodrı́guez, A., Becerril, S., Ezquerro, S., Méndez-Giménez, L., & Frühbeck, G. (2016) · Acta Physiologica · doi:10.1111/apha.12686 · Cited by 192 · see citing works

Independent association of insulin resistance with larger amounts of intermuscular adipose tissue and a greater acute insulin response to glucose in African American than in white nondiabetic women

Albu, J., Kovera, A. J., Allen, L., Wainwright, M., Berk, E. S., Raja-Khan, N. T., Janumala, I., Burkey, B. F., Heshka, S., & Gallagher, D. (2005) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/82.6.1210 · Cited by 181 · see citing works

Intermuscular and perimuscular fat expansion in obesity correlates with skeletal muscle T cell and macrophage infiltration and insulin resistance

Khan, I. M., Perrard, X.-Y., Brunner, G., Lui, H., Sparks, L. M., Smith, S. R., Wang, X., Shi, Z.-Z., Lewis, D. E., Wu, H., et al. (2015) · International Journal of Obesity · doi:10.1038/ijo.2015.104 · Cited by 179 · see citing works

Are hypertriglyceridemia and low HDL causal factors in the development of insulin resistance?

Li, N., Fu, J., Koonen, D. P. Y., Kuivenhoven, J. A., Snieder, H., & Hofker, M. H. (2014) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2013.12.013 · Cited by 176 · see citing works

Palmitate induces tumor necrosis factor-α expression in C2C12 skeletal muscle cells by a mechanism involving protein kinase C and nuclear factor-κB activation

Jové, M., Planavila, A., Sánchez, R. M., Merlos, M., Laguna, J. C., & Vázquez-Carrera, M. (2006) · Endocrinology · doi:10.1210/en.2005-0440 · Cited by 172 · see citing works

cJun NH2-terminal kinase 1 (JNK1): Roles in metabolic regulation of insulin resistance

Sabio, G., & Davis, R. J. (2010) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2010.04.004 · Cited by 170 · see citing works

Overexpression of Il6 leads to hyperinsulinaemia, liver inflammation and reduced body weight in mice

Franckhauser, S., Elias, I., Sopasakis, V. R., Ferré, T., Nagaev, I., Andersson, C. X., Agudo, J., Ruberte, J., Bosch, F., & Smith, U. (2008) · Diabetologia · doi:10.1007/s00125-008-0998-8 · Cited by 166 · see citing works

Renin‐Angiotensin System: An Old Player with Novel Functions in Skeletal Muscle

Cabello‐Verrugio, C., Morales, M. G., Rivera, J. C. A., Cabrera, D., & Simón, F. (2015) · Medicinal Research Reviews · doi:10.1002/med.21343 · Cited by 164 · see citing works

Inflammation and nitric oxide production in skeletal muscle of type 2 diabetic patients

Sh, T., Sanctis, J. B. D., Briceño, L., Hernandez, N., & Finol, H. (2004) · Journal of Endocrinology · doi:10.1677/joe.0.1810419 · Cited by 163 · see citing works

Protein Kinase C Function in Muscle, Liver, and β-Cells and Its Therapeutic Implications for Type 2 Diabetes

Schmitz‐Peiffer, C., & Biden, T. J. (2008) · Diabetes · doi:10.2337/db07-1769 · Cited by 160 · see citing works

Insulin resistance induced by tumor necrosis factor-α in myocytes and brown adipocytes12

Lorenzo, M., Fernández‐Veledo, S., Vila‐Bedmar, R., García‐Guerra, L., de Álvaro, C., & Nieto-Vázquez, I. (2007) · Journal of Animal Science · doi:10.2527/jas.2007-0462 · Cited by 156 · see citing works

Characterization of the metabolic effects of irisin on skeletal muscle <i>in vitro</i>

Vaughan, R. A., Gannon, N. P., Barberena, M. A., Garcia‐Smith, R., Bisoffi, M., Mermier, C. M., Conn, C. A., & Trujillo, K. A. (2014) · Diabetes Obesity and Metabolism · doi:10.1111/dom.12268 · Cited by 150 · see citing works

ICAM-1 expression in adipose tissue: effects of diet-induced obesity in mice

Brake, D. K., Smith, E. O., Mersmann, H. J., Smith, C. W., & Robker, R. L. (2006) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00008.2006 · Cited by 150 · see citing works

Deletion of Skeletal Muscle SOCS3 Prevents Insulin Resistance in Obesity

Jørgensen, S. B., O’Neill, H. M., Sylow, L., Honeyman, J. E., Hewitt, K. A., Palanivel, R., Fullerton, M. D., Öberg, L., Balendran, A., Galić, S., et al. (2012) · Diabetes · doi:10.2337/db12-0443 · Cited by 148 · see citing works

Role of Muscle c-Jun NH2-Terminal Kinase 1 in Obesity-Induced Insulin Resistance

Sabio, G., Kennedy, N. J., Cavanagh, J., Jung, D. Y., Ko, H. J., Ong, H., Barrett, T., Kim, J. K., & Davis, R. J. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.01162-09 · Cited by 144 · see citing works

Overproduction of Angiotensinogen from Adipose Tissue Induces Adipose Inflammation, Glucose Intolerance, and Insulin Resistance

Kalupahana, N. S., Massiéra, F., Quignard‐Boulangé, A., Ailhaud, G. P., Voy, B. H., Wasserman, D. H., & Moustaïd‐Moussa, N. (2011) · Obesity · doi:10.1038/oby.2011.299 · Cited by 140 · see citing works

CD11c Expression in Adipose Tissue and Blood and Its Role in Diet-Induced Obesity

Wu, H., Perrard, X. D., Wang, Q., Perrard, J. L., Polsani, V. R., Jones, P. H., Smith, C. W., & Ballantyne, C. M. (2009) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.109.198044 · Cited by 138 · see citing works

Constitutive STAT3 Phosphorylation Contributes to Skeletal Muscle Insulin Resistance in Type 2 Diabetes

Mashili, F. L., Chibalin, A., Krook, A., & Zierath, J. R. (2012) · Diabetes · doi:10.2337/db12-0337 · Cited by 125 · see citing works

Insulin Resistance is Associated with MCP1-Mediated Macrophage Accumulation in Skeletal Muscle in Mice and Humans

Patsouris, D., Cao, J.-J., Vial, G., Bravard, A., Lefai, E., Durand, A., Durand, C., Chauvin, M.-A., Laugerette, F., Debard, C., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0110653 · Cited by 122 · see citing works

Inhibition or deletion of the lipopolysaccharide receptor Toll-like receptor-4 confers partial protection against lipid-induced insulin resistance in rodent skeletal muscle

Radin, M. S., Sinha, S., Bhatt, B. A., Dedousis, N. L., & O'Doherty, R. M. (2007) · Diabetologia · doi:10.1007/s00125-007-0861-3 · Cited by 122 · see citing works

Overexpressing Human Lipoprotein Lipase in Mouse Skeletal Muscle Is Associated With Insulin Resistance

Ferreira, L. D., Pulawa, L. K., Jensen, D. R., & Eckel, R. H. (2001) · Diabetes · doi:10.2337/diabetes.50.5.1064 · Cited by 121 · see citing works

Toll-like Receptors 2 and 4 Activate STAT1 Serine Phosphorylation by Distinct Mechanisms in Macrophages

Rhee, S. H., Jones, B. W., Toshchakov, V. Y., Vogel, S. N., & Fenton, M. J. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m208633200 · Cited by 115 · see citing works

Skeletal Muscle–Specific Deletion of Lipoprotein Lipase Enhances Insulin Signaling in Skeletal Muscle but Causes Insulin Resistance in Liver and Other Tissues

Wang, H., Knaub, L. A., Jensen, D. R., Jung, D. Y., Hong, E., Ko, H. J., Coates, A. M., Goldberg, I. J., de la Houssaye, B. A., Janssen, R. C., et al. (2008) · Diabetes · doi:10.2337/db07-1839 · Cited by 115 · see citing works

Elevated NF-κB Activation Is Conserved in Human Myocytes Cultured From Obese Type 2 Diabetic Patients and Attenuated by AMP-Activated Protein Kinase

Green, C., Pedersen, M., Pedersen, B. K., & Scheele, C. C. (2011) · Diabetes · doi:10.2337/db11-0263 · Cited by 109 · see citing works

Expression of anti-inflammatory macrophage genes within skeletal muscle correlates with insulin sensitivity in human obesity and type 2 diabetes

Fink, L. N., Oberbach, A., Costford, S. R., Chan, K. L., Sams, A. G., Blüher, M., & Klip, A. (2013) · Diabetologia · doi:10.1007/s00125-013-2897-x · Cited by 107 · see citing works

Molecular Mechanisms of Skeletal Muscle Insulin Resistance in Type 2 Diabetes

Bouzakri, K., Koistinen, H., & Zierath, J. (2005) · Current Diabetes Reviews · doi:10.2174/1573399054022785 · Cited by 106 · see citing works

Large adipocytes function as antigen-presenting cells to activate CD4+ T cells via upregulating MHCII in obesity

Xiao, L., Yang, X., Lin, Y., Li, S., Jiang, J., Qian, S., Tang, Q., He, R., & Li, X. (2015) · International Journal of Obesity · doi:10.1038/ijo.2015.145 · Cited by 106 · see citing works

siRNA-Mediated Reduction of Inhibitor of Nuclear Factor-κB Kinase Prevents Tumor Necrosis Factor-α–Induced Insulin Resistance in Human Skeletal Muscle

Austin, R. L., Rune, A., Bouzakri, K., Zierath, J. R., & Krook, A. (2008) · Diabetes · doi:10.2337/db07-0763 · Cited by 105 · see citing works

Palmitoleic acid prevents palmitic acid-induced macrophage activation and consequent p38 MAPK-mediated skeletal muscle insulin resistance

Talbot, N. A., Wheeler-Jones, C. P. D., & Cleasby, M. E. (2014) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2014.06.010 · Cited by 104 · see citing works

Conditional disruption of IκB kinase 2 fails to prevent obesity-induced insulin resistance

Röhl, M., Pasparakis, M., Baudler, S., Baumgartl, J., Gautam, D., Huth, M., Lorenzi, R. D., Krone, W., Rajewsky, K., & Brüning, J. C. (2004) · Journal of Clinical Investigation · doi:10.1172/jci18712 · Cited by 103 · see citing works

Increased protein kinase C theta in skeletal muscle of diabetic patients

Itani, S. I., Pories, W. J., MacDonald, K. G., & Dohm, G. L. (2001) · Metabolism · doi:10.1053/meta.2001.22512 · Cited by 101 · see citing works

Liver‐specific suppressor of cytokine signaling‐3 deletion in mice enhances hepatic insulin sensitivity and lipogenesis resulting in fatty liver and obesity 1

Sachithanandan, N., Fam, B., Fynch, S., Dzamko, N., Watt, M., Wormald, S., Honeyman, J., Galic, S., Proietto, J., Andrikopoulos, S., et al. (2010) · Hepatology · doi:10.1002/hep.23861 · Cited by 100 · see citing works

The contribution of skeletal muscle tumor necrosis factor-α to insulin resistance and hypertension in fructose-fed rats

Togashi, N., Ura, N., Higashiura, K., Murakami, H., & Shimamoto, K. (2000) · Journal of Hypertension · doi:10.1097/00004872-200018110-00011 · Cited by 100 · see citing works

MicroRNA-106b induces mitochondrial dysfunction and insulin resistance in C2C12 myotubes by targeting mitofusin-2

Zhang, Y., Yang, L., Yuan-fu, G., Fan, Z., Cai, X., Liu, M., Guo, X., Gao, C., & Xia, Z. (2013) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2013.08.004 · Cited by 94 · see citing works

The role of the renin-angiotensin system in the development of insulin resistance in skeletal muscle

Henriksen, E. J., & Prasannarong, M. (2012) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2012.04.011 · Cited by 90 · see citing works

Foamy Monocytes Form Early and Contribute to Nascent Atherosclerosis in Mice With Hypercholesterolemia

Lu, X., Perrard, X. D., Perrard, J. L., Yang, D., Xiao, X., Teng, B.-B., Simon, S. I., Ballantyne, C. M., & Wu, H. (2015) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.115.305609 · Cited by 89 · see citing works

Angiotensin II-induced effects on adipose and skeletal muscle tissue blood flow and lipolysis in normal-weight and obese subjects

Goossens, G. H., Blaak, E. E., Saris, W. H. M., & van Baak, M. A. (2004) · The Journal of Clinical Endocrinology &amp; Metabolism · doi:10.1210/jc.2003-032053 · Cited by 84 · see citing works

Macrophage deletion of SOCS1 increases sensitivity to LPS and palmitic acid and results in systemic inflammation and hepatic insulin resistance

Sachithanandan, N., Graham, K. L., Galic, S., Honeyman, J. E., Fynch, S. L., Hewitt, K. A., Steinberg, G. R., & Kay, T. W. (2011) · Diabetes · doi:10.2337/db11-0259 · Cited by 81 · see citing works

Angiotensin 1-7 as Means to Prevent the Metabolic Syndrome

Marcus, Y., Shefer, G., Sasson, K., Kohen, F., Limor, R., Pappo, O., Nevo, N., Biton, I. E., Bach, M. Y., Berkutzki, T., et al. (2012) · Diabetes · doi:10.2337/db12-0792 · Cited by 75 · see citing works

Weight Gain Reveals Dramatic Increases in Skeletal Muscle Extracellular Matrix Remodeling

Tam, C. S., Covington, J. D., Bajpeyi, S., Tchoukalova, Y. D., Burk, D. H., Johannsen, D. L., Zingaretti, C. M., Cinti, S., & Ravussin, É. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-4381 · Cited by 73 · see citing works

Essential Role of CD11a in CD8 + T-Cell Accumulation and Activation in Adipose Tissue

Jiang, E., Perrard, X. D., Yang, D., Khan, I. M., Perrard, J. L., Smith, C. W., Ballantyne, C. M., & Wu, H. (2013) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.113.302077 · Cited by 69 · see citing works

Angiotensin II: a hormone that affects lipid metabolism in adipose tissue

Goossens, G. H., Blaak, E. E., Arner, P., Saris, W. H. M., & van Baak, M. A. (2006) · International Journal of Obesity · doi:10.1038/sj.ijo.0803388 · Cited by 68 · see citing works

Altered Myokine Secretion Is an Intrinsic Property of Skeletal Muscle in Type 2 Diabetes

Ciaraldi, T. P., Ryan, A. J., Mudaliar, S. R., & Henry, R. R. (2016) · PLOS ONE · doi:10.1371/journal.pone.0158209 · Cited by 65 · see citing works

IL-15 concentrations in skeletal muscle and subcutaneous adipose tissue in lean and obese humans: Local effects of IL-15 on adipose tissue lipolysis

Pierce, J. R., Maples, J. M., & Hickner, R. C. (2015) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00575.2014 · Cited by 60 · see citing works

Angiotensin-converting enzyme inhibition reverses diet-induced obesity, insulin resistance and inflammation in C57BL/6J mice

Premaratna, S. D., Manickam, E., Begg, D. P., Rayment, D. J., Hafandi, A., Jois, M., Cameron‐Smith, D., & Weisinger, R. S. (2011) · International Journal of Obesity · doi:10.1038/ijo.2011.95 · Cited by 59 · see citing works

Effect of protein, unsaturated fat, and carbohydrate intakes on plasma apolipoprotein B and VLDL and LDL containing apolipoprotein C-III: results from the OmniHeart Trial

Furtado, J. D., Campos, H., Appel, L. J., Miller, E. R., Laranjo, N., Carey, V. J., & Sacks, F. M. (2008) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/87.6.1623 · Cited by 59 · see citing works

Palmitate-Activated Macrophages Confer Insulin Resistance to Muscle Cells by a Mechanism Involving Protein Kinase C θ and ε

Kewalramani, G., Fink, L. N., Asadi, F., & Klip, A. (2011) · PLoS ONE · doi:10.1371/journal.pone.0026947 · Cited by 57 · see citing works

Obesity and cardiovascular disease: role of adipose tissue, inflammation, and the renin-angiotensin-aldosterone system

Lastra, G., & Sowers, J. R. (2013) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci-2013-0025 · Cited by 54 · see citing works

Postprandial Interleukin-6 Release from Skeletal Muscle in Men with Impaired Glucose Tolerance Can Be Reduced by Weight Loss

Corpeleijn, E., Saris, W. H. M., Jansen, E. H. J. M., Roekaerts, P. M. H. J., Feskens, E. J. M., & Blaak, E. E. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-0668 · Cited by 46 · see citing works

Low Macrophage Accumulation in Skeletal Muscle of Obese Type 2 Diabetics and Elderly Subjects

Tam, C. S., Sparks, L. M., Johannsen, D. L., Covington, J. D., Church, T. S., & Ravussin, É. (2012) · Obesity · doi:10.1038/oby.2012.24 · Cited by 45 · see citing works

Associations of calf inter- and intra-muscular adipose tissue with cardiometabolic health and physical function in community-dwelling older adults.

Scott, D. S., Trbojević, T., Skinner, E. P., Clark, R. A., Levinger, P., Haines, T. P., Sanders, K. M., & Ebeling, P. R. (2015) · Europe PMC (PubMed Central) · Cited by 45 · see citing works

Short-term high-fat diet increases macrophage markers in skeletal muscle accompanied by impaired insulin signalling in healthy male subjects

Boon, M. R., Bakker, L. E. H., Haks, M. C., Quinten, E., Schaart, G., van Beek, L., Wang, Y., van Schinkel, L. D., van Harmelen, V., Meinders, A. E., et al. (2014) · Clinical Science · doi:10.1042/cs20140179 · Cited by 45 · see citing works

Effects of changes in regional body composition on physical function in older adults: A pilot randomized controlled trial

Santanasto, A. J., Newman, A. B., Strotmeyer, E. S., Boudreau, R. M., Goodpaster, B. H., & Glynn, N. W. (2015) · The journal of nutrition health & aging · doi:10.1007/s12603-015-0523-y · Cited by 44 · see citing works

PLIN2 inhibits insulin-induced glucose uptake in myoblasts through the activation of the NLRP3 inflammasome

CHO, K.-A., & KANG, P. B. (2015) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2015.2276 · Cited by 43 · see citing works

Alteration of JNK-1 Signaling in Skeletal Muscle Fails to Affect Glucose Homeostasis and Obesity-Associated Insulin Resistance in Mice

Pál, M., Wunderlich, C. M., Spohn, G., Brönneke, H. S., Schmidt‐Supprian, M., & Wunderlich, F. T. (2013) · PLoS ONE · doi:10.1371/journal.pone.0054247 · Cited by 42 · see citing works

Energy‐Restricted High‐Fat Diets Only Partially Improve Markers of Systemic and Adipose Tissue Inflammation

Kalupahana, N. S., Voy, B. H., Saxton, A. M., & Moustaïd‐Moussa, N. (2010) · Obesity · doi:10.1038/oby.2010.196 · Cited by 42 · see citing works

High Sugar Intake and Development of Skeletal Muscle Insulin Resistance and Inflammation in Mice: A Protective Role for PPAR-δAgonism

Benetti, E., Mastrocola, R., Rogazzo, M., Chiazza, F., Aragno, M., Fantozzi, R., Collino, M., & Minetto, M. A. (2013) · Mediators of Inflammation · doi:10.1155/2013/509502 · Cited by 42 · see citing works

Chronic Angiotensin-(1–7) Improves Insulin Sensitivity in High-Fat Fed Mice Independent of Blood Pressure

Williams, I. M., Otero, Y. F., Bracy, D. P., Wasserman, D. H., Biaggioni, I., & Arnold, A. C. (2016) · Hypertension · doi:10.1161/hypertensionaha.115.06935 · Cited by 42 · see citing works

Role of PKCδ in Insulin Sensitivity and Skeletal Muscle Metabolism

Li, M., Vienberg, S. G., Bézy, O., O'Neill, B. T., & Kahn, C. R. (2015) · Diabetes · doi:10.2337/db14-1891 · Cited by 40 · see citing works

Critical role of the transient activation of p38 MAPK in the etiology of skeletal muscle insulin resistance induced by low-level in vitro oxidant stress

Diamond-Stanic, M. K., Marchionne, E. M., Teachey, M. K., Durazo, D. E., Kim, J. S., & Henriksen, E. J. (2011) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2011.01.049 · Cited by 37 · see citing works

Muscle-specific inflammation induced by MCP-1 overexpression does not affect whole-body insulin sensitivity in mice

Evers-van Gogh, I. J. A., Oteng, A.-B., Alex, S., Hamers, N., Catoire, M., Stienstra, R., Kalkhoven, E., & Kersten, S. (2016) · Diabetologia · doi:10.1007/s00125-015-3822-2 · Cited by 33 · see citing works

Constitutive expression of suppressor of cytokine signalling-3 in skeletal muscle leads to reduced mobility and overweight in mice

Lebrun, P., Cognard, E., Paul, R., Gontard, P., Filloux, C., Jehl-Piétri, C., Grimaldi, P. A., Samson, M., Pénicaud, L., Ruberte, J., et al. (2009) · Diabetologia · doi:10.1007/s00125-009-1474-9 · Cited by 30 · see citing works

The effect of exercise on expression of myokine and angiogenesis mRNA in skeletal muscle of high fat diet induced obese rat

Shin, K. O., Bae, J. Y., Woo, J., Jang, K. S., Kim, K. S., Park, J. S., Kim, I. K., & Kang, S. (2015) · Physical Activity and Nutrition · doi:10.5717/jenb.2015.15061006 · Cited by 29 · see citing works

Knockout of STAT3 in skeletal muscle does not prevent high-fat diet-induced insulin resistance

White, A. T., LaBarge, S. A., McCurdy, C. E., & Schenk, S. (2015) · Molecular Metabolism · doi:10.1016/j.molmet.2015.05.001 · Cited by 29 · see citing works

ApoE and the role of very low density lipoproteins in adipose tissue inflammation

Wang, J., Perrard, X. D., Perrard, J. L., Mukherjee, A., Rosales, C., Chen, Y., Smith, C. W., Pownall, H. J., Ballantyne, C. M., & Wu, H. (2012) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2012.06.003 · Cited by 29 · see citing works

Leptin deficiency-induced obesity affects the density of mast cells in abdominal fat depots and lymph nodes in mice

Altintas, M. M., Nayer, B., Walford, E. C., Johnson, K. B., Gaidosh, G., Reiser, J., Cruz-Munoz, N. F. D. L., Ortega, L. M., & Nayer, A. (2012) · Lipids in Health and Disease · doi:10.1186/1476-511x-11-21 · Cited by 29 · see citing works

JNK deficiency enhances fatty acid utilization and diverts glucose from oxidation to glycogen storage in cultured myotubes

Vijayvargia, R., Mann, K., Weiss, H. R., Pownall, H. J., & Ruan, H. (2010) · Obesity · doi:10.1038/oby.2009.501 · Cited by 25 · see citing works

Contribution of the serine kinase c-Jun N-terminal kinase (JNK) to oxidant-induced insulin resistance in isolated rat skeletal muscle

Santos, F. R., Diamond-Stanic, M. K., Prasannarong, M., & Henriksen, E. J. (2012) · Archives of Physiology and Biochemistry · doi:10.3109/13813455.2012.713366 · Cited by 17 · see citing works

Inflammation versus Host Defense in Obesity

Wu, H., & Ballantyne, C. M. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.10.013 · Cited by 14 · see citing works

Intermuscular adipose tissue is associated with monocyte chemoattractant protein-1, independent of visceral adipose tissue

Haam, J.-H., Kim, Y., Koo, H. S., Haam, J., Seo, N., Kim, H. Y., Park, K., Park, K., & Kim, M. J. (2015) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2015.12.003 · Cited by 14 · see citing works

Treatment with IFN‐γ prevents insulin‐dependent PKB, p70S6k phosphorylation and protein synthesis in mouse C2C12 myogenic cells

Grzelkowska‐Kowalczyk, K., & Wieteska‐Skrzeczyńska, W. (2009) · Cell Biology International · doi:10.1042/cbi20090135 · Cited by 12 · see citing works

Pathophysiology of type 2 diabetes mellitus

Galicia-Garcia, U., Benito-Vicente, A., Jebari, S., Larrea-Sebal, A., Siddiqi, H., Uribe, K. B., Ostolaza, H., & Martín, C. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21176275 · Cited by 3,360 · see citing works

Inflammatory mechanisms linking obesity and metabolic disease

Saltiel, A. R., & Olefsky, J. M. (2017) · Journal of Clinical Investigation · doi:10.1172/jci92035 · Cited by 2,212 · see citing works

Metabolic Inflammation and Insulin Resistance in Obesity

Wu, H., & Ballantyne, C. M. (2020) · Circulation Research · doi:10.1161/circresaha.119.315896 · Cited by 1,059 · see citing works

The Liver as an Endocrine Organ—Linking NAFLD and Insulin Resistance

Watt, M. J., Miotto, P. M., De Nardo, W., & Montgomery, M. K. (2019) · Endocrine Reviews · doi:10.1210/er.2019-00034 · Cited by 615 · see citing works

Short-chain fatty acids as potential regulators of skeletal muscle metabolism and function

Frampton, J. E., Murphy, K. G., Frost, G. S., & Chambers, E. S. (2020) · Nature Metabolism · doi:10.1038/s42255-020-0188-7 · Cited by 532 · see citing works

Natural products for the treatment of type 2 diabetes mellitus: Pharmacology and mechanisms

Xu, L., Li, Y., Dai, Y., & Peng, J. (2018) · Pharmacological Research · doi:10.1016/j.phrs.2018.01.015 · Cited by 452 · see citing works

Effects of Exercise to Improve Cardiovascular Health

Pinckard, K. M., Baskin, K. K., & Stanford, K. I. (2019) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2019.00069 · Cited by 477 · see citing works

Obesity and heart failure with preserved ejection fraction: new insights and pathophysiological targets

Borlaug, B. A., Jensen, M. D., Kitzman, D. W., Lam, C. S. P., Obokata, M., & Rider, O. J. (2023) · Cardiovascular Research · doi:10.1093/cvr/cvac120 · Cited by 450 · see citing works

An Integrated View of Immunometabolism

Lee, Y. S., Wollam, J., & Olefsky, J. M. (2018) · Cell · doi:10.1016/j.cell.2017.12.025 · Cited by 440 · see citing works

Cellular and molecular pathobiology of heart failure with preserved ejection fraction

Mishra, S., & Kass, D. A. (2021) · Nature Reviews Cardiology · doi:10.1038/s41569-020-00480-6 · Cited by 423 · see citing works

Sarcopenic obesity, insulin resistance, and their implications in cardiovascular and metabolic consequences

Hong, S.-H., & Choi, K. M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21020494 · Cited by 390 · see citing works

Metabolic Syndrome Pathophysiology and Predisposing Factors

Bovolini, A., Garcia, J., Andrade, M. A., & Duarte, J. A. (2020) · International Journal of Sports Medicine · doi:10.1055/a-1263-0898 · Cited by 414 · see citing works

Obesity cardiomyopathy: evidence, mechanisms, and therapeutic implications

Ren, J. T., Wu, N. N., Wang, S., Sowers, J. R., & Zhang, Y. (2021) · Physiological Reviews · doi:10.1152/physrev.00030.2020 · Cited by 377 · see citing works

Macrophage polarization and meta-inflammation

Li, C., Xu, M. M., Wang, K., Adler, A. J., Vella, A. T., & Zhou, B. (2017) · Translational research · doi:10.1016/j.trsl.2017.10.004 · Cited by 369 · see citing works

The many actions of insulin in skeletal muscle, the paramount tissue determining glycemia

Sylow, L., Tokarz, V. L., Richter, E. A., & Klip, A. (2021) · Cell Metabolism · doi:10.1016/j.cmet.2021.03.020 · Cited by 366 · see citing works

Inflamm-ageing: the role of inflammation in age-dependent cardiovascular disease

Liberale, L., Montecucco, F., Tardif, J., Libby, P., & Camici, G. G. (2020) · European Heart Journal · doi:10.1093/eurheartj/ehz961 · Cited by 347 · see citing works

Type 2 Diabetes Mellitus: New Pathogenetic Mechanisms, Treatment and the Most Important Complications

Młynarska, E., Czarnik, W., Kurys, N., Jędraszak, W., Majchrowicz, G., Prusinowski, F., Stabrawa, M., Rysz, J., & Franczyk, B. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26031094 · Cited by 419 · see citing works

Peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1) family in physiological and pathophysiological process and diseases

Lu, Q., Zhu, Y., Deng, C., Liang, Z., Chen, J., Chen, Y., Wang, X., Liu, Y., Tian, Y., & Yang, Y. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01756-w · Cited by 360 · see citing works

Chronic tissue inflammation and metabolic diseasePreprint

Lee, Y. S., & Olefsky, J. M. (2021) · Genes & Development · doi:10.1101/gad.346312.120 · Cited by 342 · see citing works

The role of macrophages in osteoarthritis and cartilage repair

Wu, C., Harasymowicz, N. S., Klimak, M., Collins, K. H., & Guilak, F. (2020) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2019.12.007 · Cited by 328 · see citing works

Macrophages, Chronic Inflammation, and Insulin Resistance

He, L., Meng, Y., He, S., Tan, X., Zhang, Y., Zhang, X., Wang, L., & Zheng, W. (2022) · Cells · doi:10.3390/cells11193001 · Cited by 278 · see citing works

Macrophage function in adipose tissue homeostasis and metabolic inflammation

Chavakis, T., Alexaki, V. I., & Ferrante, A. W. (2023) · Nature Immunology · doi:10.1038/s41590-023-01479-0 · Cited by 264 · see citing works

Insulin resistance and insulin sensitizing agents

Mastrototaro, L., & Roden, M. (2021) · Metabolism · doi:10.1016/j.metabol.2021.154892 · Cited by 259 · see citing works

Multifactorial Mechanism of Sarcopenia and Sarcopenic Obesity. Role of Physical Exercise, Microbiota and Myokines

Bilski, J., Pierzchalski, P., Szczepanik, M., Bonior, J., & Zoladz, J. A. (2022) · Cells · doi:10.3390/cells11010160 · Cited by 251 · see citing works

Deciphering the “obesity paradox” in the elderly: A systematic review and meta‐analysis of sarcopenic obesity

Liu, C., Wong, P. Y., Chung, Y. L., Chow, S. K., Cheung, W. H., Law, S. W., Chan, J. C. N., & Wong, R. M. Y. (2023) · Obesity Reviews · doi:10.1111/obr.13534 · Cited by 247 · see citing works

Mechanisms of muscle insulin resistance and the cross‐talk with liver and adipose tissue

Rosa, S. C. D. S., Nayak, N., Caymo, A. M., & Gordon, J. W. (2020) · Physiological Reports · doi:10.14814/phy2.14607 · Cited by 251 · see citing works

Inflammaging as a common ground for the development and maintenance of sarcopenia, obesity, cardiomyopathy and dysbiosis

Livshits, G., & Kalinkovich, A. (2019) · Ageing Research Reviews · doi:10.1016/j.arr.2019.100980 · Cited by 239 · see citing works

Pathophysiology and mechanisms of primary sarcopenia (Review)

Nishikawa, H., Fukunishi, S., Asai, A., Yokohama, K., Nishiguchi, S., & Higuchi, K. (2021) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2021.4989 · Cited by 235 · see citing works

Obesity and weight gain in persons with HIV

Bailin, S. S., Gabriel, C. L., Wanjalla, C. N., & Koethe, J. R. (2020) · Current HIV/AIDS Reports · doi:10.1007/s11904-020-00483-5 · Cited by 213 · see citing works

Aging, obesity, sarcopenia and the effect of diet and exercise intervention

Colleluori, G., & Villareal, D. T. (2021) · Experimental Gerontology · doi:10.1016/j.exger.2021.111561 · Cited by 207 · see citing works

Reference Values for Skeletal Muscle Mass – Current Concepts and Methodological Considerations

Walowski, C. O., Braun, W., Maisch, M. J., Jensen, B., Peine, S., Norman, K., Müller, M. J., & Bosy-Westphal, A. (2020) · Nutrients · doi:10.3390/nu12030755 · Cited by 200 · see citing works

Saturated Fatty Acids in Obesity-Associated Inflammation

Zhou, H., Urso, C. J., & Jadeja, V. (2020) · Journal of Inflammation Research · doi:10.2147/jir.s229691 · Cited by 198 · see citing works

Flavonoids and type 2 diabetes: Evidence of efficacy in clinical and animal studies and delivery strategies to enhance their therapeutic efficacy

Hussain, T., Tan, B., Murtaza, G., Liu, G., Rahu, N., Kalhoro, M. S., Kalhoro, D. H., Adebowale, T. O., Mazhar, M. U., Rehman, Z. U., et al. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.104629 · Cited by 194 · see citing works

Low muscle mass and strength in pediatrics patients: Why should we care?

Orsso, C. E., Tibães, J. R. B., Oliveira, C. L. P., Rubin, D. A., Field, C. J., Heymsfield, S. B., Prado, C. M. M., & Haqq, A. M. (2019) · Clinical Nutrition · doi:10.1016/j.clnu.2019.04.012 · Cited by 187 · see citing works

Metaflammation in obesity and its therapeutic targeting

Schleh, M. W., Caslin, H. L., Garcia, J. N., Mashayekhi, M., Srivastava, G., Bradley, A. B., & Hasty, A. H. (2023) · Science Translational Medicine · doi:10.1126/scitranslmed.adf9382 · Cited by 191 · see citing works

Coordinated Modulation of Energy Metabolism and Inflammation by Branched-Chain Amino Acids and Fatty Acids

Ye, Z., Wang, S., Zhang, C., & Zhao, Y. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.00617 · Cited by 173 · see citing works

Endothelial Dysfunction and Chronic Inflammation: The Cornerstones of Vascular Alterations in Age-Related Diseases

Pacinella, G., Ciaccio, A. M., & Tuttolomondo, A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232415722 · Cited by 171 · see citing works

Adipose tissue macrophage-derived exosomal miR-29a regulates obesity-associated insulin resistance

Liu, T., Sun, Y., Cheng, P., & Shao, H. (2019) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2019.05.113 · Cited by 154 · see citing works

Nutritional regulation of microbiota-derived metabolites: Implications for immunity and inflammation

Arifuzzaman, M., Collins, N., Guo, C., & Artis, D. (2024) · Immunity · doi:10.1016/j.immuni.2023.12.009 · Cited by 155 · see citing works

T Cells in Adipose Tissue: Critical Players in Immunometabolism

Wang, Q., & Wu, H. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02509 · Cited by 146 · see citing works

Fat infiltration in skeletal muscle: Influential triggers and regulatory mechanism

Wang, L., Valencak, T. G., & Shan, T. (2024) · iScience · doi:10.1016/j.isci.2024.109221 · Cited by 149 · see citing works

Mechanisms of Macrophage Polarization in Insulin Signaling and Sensitivity

Orliaguet, L., Dalmas, É., Drareni, K., Venteclef, N., & Alzaïd, F. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.00062 · Cited by 143 · see citing works

Sirtuins and Insulin Resistance

Zhou, S., Tang, X., & Chen, H. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00748 · Cited by 143 · see citing works

Mechanisms and therapeutic opportunities in metabolic aberrations of diabetic wounds: a narrative review

Xiong, Y., Knoedler, S. A., Alfertshofer, M. G., Kim, B., Jiang, D., Liu, G., Rinkevich, Y., & Mi, B. (2025) · Cell Death and Disease · doi:10.1038/s41419-025-07583-3 · Cited by 140 · see citing works

Inflammation initiates a vicious cycle between obesity and nonalcoholic fatty liver disease

Luo, Y., & Lin, H. (2020) · Immunity Inflammation and Disease · doi:10.1002/iid3.391 · Cited by 127 · see citing works

Endoplasmic reticulum stress and development of insulin resistance in adipose, skeletal, liver, and foetoplacental tissue in diabesity

Villalobos-Labra, R., Subiabre, M., Toledo, F., Pardo, F., & Sobrevía, L. (2018) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2018.11.001 · Cited by 124 · see citing works

Type 2 Diabetes: How Much of an Autoimmune Disease?

de Candia, P., Prattichizzo, F., Garavelli, S., Rosa, V. D., Galgani, M., Rella, F. D., Spagnuolo, M. I., Colamatteo, A., Fusco, C., Micillo, T., et al. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00451 · Cited by 118 · see citing works

Inflammatory Mechanisms of Diabetes and Its Vascular Complications

Nedosugova, L. V., Markina, Y. V., Бочкарева, Л. А., Кузина, И. А., Petunina, N. A., Yudina, I. Y., & Kirichenko, T. V. (2022) · Biomedicines · doi:10.3390/biomedicines10051168 · Cited by 133 · see citing works

Obesity and breast cancer: A case of inflamed adipose tissue

Kolb, R., & Zhang, W. (2020) · Cancers · doi:10.3390/cancers12061686 · Cited by 119 · see citing works

Insulin Resistance across the Spectrum of Nonalcoholic Fatty Liver Disease

Armandi, A., Rosso, C., Caviglia, G. P., & Bugianesi, E. (2021) · Metabolites · doi:10.3390/metabo11030155 · Cited by 115 · see citing works

Naringenin improves insulin sensitivity in gestational diabetes mellitus mice through AMPK

Li, S., Zhang, Y., Sun, Y., Zhang, G., Bai, J., Guo, J., Su, X., Du, H., Cao, X., Yang, J., et al. (2019) · Nutrition and Diabetes · doi:10.1038/s41387-019-0095-8 · Cited by 114 · see citing works

FGF19 protects skeletal muscle against obesity‐induced muscle atrophy, metabolic derangement and abnormal irisin levels via the AMPK/SIRT‐1/PGC‐α pathway

Guo, A., Li, K., Tian, H., Fan, Z., Chen, Q., Yang, Y., Yu, J., Wu, Y., & Xiao, Q. (2021) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.16448 · Cited by 112 · see citing works

Molecular aspects of diabetes mellitus: Resistin, microRNA, and exosome

Borujeni, M. J. S., Esfandiary, E., Taheripak, G., Codoñer‐Franch, P., Alonso‐Iglesias, E., & Mirzaei, H. (2017) · Journal of Cellular Biochemistry · doi:10.1002/jcb.26271 · Cited by 106 · see citing works

Anti-Inflammatory Strategies Targeting Metaflammation in Type 2 Diabetes

Kuryłowicz, A., & Koźniewski, K. (2020) · Molecules · doi:10.3390/molecules25092224 · Cited by 101 · see citing works

GLP-1RA Liraglutide and Semaglutide Improves Obesity-Induced Muscle Atrophy via SIRT1 Pathway

Xiang, J., Qin, L., Zhong, J., Xia, N., & Liang, Y. (2023) · Diabetes, Metabolic Syndrome and Obesity · doi:10.2147/dmso.s425642 · Cited by 100 · see citing works

Update on the Impact of Omega 3 Fatty Acids on Inflammation, Insulin Resistance and Sarcopenia: A Review

Stella, A. B., Cappellari, G. G., Barazzoni, R., & Zanetti, M. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19010218 · Cited by 100 · see citing works

Frailty in patients on dialysis

Chan, G. C., Kalantar‐Zadeh, K., Ng, J. K., Tian, N., Burns, A. P., Chow, K. M., Szeto, C., & Li, P. K. (2024) · Kidney International · doi:10.1016/j.kint.2024.02.026 · Cited by 96 · see citing works

Excess Accumulation of Lipid Impairs Insulin Sensitivity in Skeletal Muscle

Park, S. S., & Seo, Y. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21061949 · Cited by 101 · see citing works

Meteorin-like/Metrnl, a novel secreted protein implicated in inflammation, immunology, and metabolism: A comprehensive review of preclinical and clinical studies

Li, Z., Gao, Z., Sun, T., Zhang, S., Yang, S., Zheng, M., & Shen, H. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1098570 · Cited by 97 · see citing works

The ambiguous role of obesity in oncology by promoting cancer but boosting antitumor immunotherapy

Assumpção, J. A. F., Pasquarelli-do-Nascimento, G., Viegas, M. S., Bonamino, M., & Magalhães, K. G. (2022) · Journal of Biomedical Science · doi:10.1186/s12929-022-00796-0 · Cited by 94 · see citing works

Searching for the link between inflammaging and sarcopenia

Wang, T. (2022) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101611 · Cited by 88 · see citing works

Adipose tissue macrophages and their role in obesity-associated insulin resistance: an overview of the complex dynamics at play

Guria, S., Hoory, A., Das, S., Chattopadhyay, D., & Mukherjee, S. (2023) · Bioscience Reports · doi:10.1042/bsr20220200 · Cited by 89 · see citing works

Signaling pathways and intervention for therapy of type 2 diabetes mellitus

Cao, R. Y., Tian, H., Zhang, Y., Liu, G., Xu, H., Rao, G., Tian, Y., & Fu, X. (2023) · MedComm · doi:10.1002/mco2.283 · Cited by 87 · see citing works

Resveratrol alleviates obesity-induced skeletal muscle inflammation via decreasing M1 macrophage polarization and increasing the regulatory T cell population

Shabani, M., Sadeghi, A., Hosseini, H., Teimouri, M., Khorzoughi, R. B., Pasalar, P., & Meshkani, R. (2020) · Scientific Reports · doi:10.1038/s41598-020-60185-1 · Cited by 87 · see citing works

The Role of Hypothalamic Inflammation in Diet-Induced Obesity and Its Association with Cognitive and Mood Disorders

Dionysopoulou, S., Charmandari, E., Bargiota, Α., Vlahos, N., Mastorakos, G. P., & Valsamakis, G. (2021) · Nutrients · doi:10.3390/nu13020498 · Cited by 88 · see citing works

Sarcopenic obesity: Myokines as potential diagnostic biomarkers and therapeutic targets?

Guo, A., Li, K., & Xiao, Q. (2020) · Experimental Gerontology · doi:10.1016/j.exger.2020.111022 · Cited by 83 · see citing works

NLRP3 inflammasome and IL-1β pathway in type 2 diabetes and atherosclerosis: Friend or foe?

Chen, X., Zhang, D., Li, Y., Wang, W., Bei, W., & Guo, J. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2021.105885 · Cited by 84 · see citing works

Sarcopenia, frailty and type 2 diabetes mellitus (Review)

Nishikawa, H., Fukunishi, S., Asai, A., Yokohama, K., Ohama, H., Nishiguchi, S., & Higuchi, K. (2021) · Molecular Medicine Reports · doi:10.3892/mmr.2021.12494 · Cited by 78 · see citing works

Role and Treatment of Insulin Resistance in Patients with Chronic Kidney Disease: A Review

Nakashima, A., Kato, K., Ohkido, I., & Yokoo, T. (2021) · Nutrients · doi:10.3390/nu13124349 · Cited by 78 · see citing works

Impact of Adipose Tissue and Lipids on Skeletal Muscle in Sarcopenia

Jang, S. Y., & Choi, K. M. (2025) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.70000 · Cited by 81 · see citing works

The Impact of Obesity on Microglial Function: Immune, Metabolic and Endocrine Perspectives

Alexaki, V. I. (2021) · Cells · doi:10.3390/cells10071584 · Cited by 83 · see citing works

High-Intensity Interval Training Improves Markers of Oxidative Metabolism in Skeletal Muscle of Individuals With Obesity and Insulin Resistance

Matos, M. A. D., Vieira, D. V., Pinhal, K. C., Lopes, J. F., Dias-Peixoto, M. F., Pauli, J. R., Castro Magalhães, F. D., Little, J. P., Rocha-Vieira, E., & Amorim, F. T. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.01451 · Cited by 75 · see citing works

Cellular and Molecular Mechanisms Associating Obesity to Bone Loss

Forte, Y. S., Renovato‐Martins, M., & Barja‐Fidalgo, C. (2023) · Cells · doi:10.3390/cells12040521 · Cited by 74 · see citing works

Obesity-induced inflammation: The impact of the hematopoietic stem cell niche

Bowers, E., & Singer, K. (2021) · JCI Insight · doi:10.1172/jci.insight.145295 · Cited by 67 · see citing works

Molecular pathways behind acquired obesity: Adipose tissue and skeletal muscle multiomics in monozygotic twin pairs discordant for BMI

van der Kolk, B. W., Saari, S., Lovrić, A., Arif, M., Alvarez, M., Ko, A., Miao, Z., Sahebekhtiari, N., Muniandy, M., Heinonen, S., et al. (2021) · Cell Reports Medicine · doi:10.1016/j.xcrm.2021.100226 · Cited by 70 · see citing works

Current and Future Nutritional Strategies to Modulate Inflammatory Dynamics in Metabolic Disorders

van den Brink, W., van Bilsen, J. H. M., Salic, K., Hoevenaars, F. P. M., Verschuren, L., Kleemann, R., Bouwman, J., Ronnett, G. V., van Ommen, B., & Wopereis, S. (2019) · Frontiers in Nutrition · doi:10.3389/fnut.2019.00129 · Cited by 70 · see citing works

Muscle in Endocrinology: From Skeletal Muscle Hormone Regulation to Myokine Secretion and Its Implications in Endocrine–Metabolic Diseases

Iglesias, P. (2025) · Journal of Clinical Medicine · doi:10.3390/jcm14134490 · Cited by 76 · see citing works

TGR5 agonist ameliorates insulin resistance in skeletal muscles and improves glucose homeostasis in diabetic mice

Huang, S., Ma, S.-Y., Ning, M., Yang, W., Ye, Y., Zhang, L., Shen, J., & Leng, Y. (2019) · Metabolism · doi:10.1016/j.metabol.2019.07.003 · Cited by 63 · see citing works

Gut microbiota and its metabolites: Bridge of dietary nutrients and obesity-related diseases

Zhou, M., Johnston, L. J., Wu, C., & Ma, X. (2021) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2021.1986466 · Cited by 63 · see citing works

Higher Risk of Sarcopenia in Older Adults with Type 2 Diabetes: NHANES 1999–2018

Dai, S., Shu, D., Meng, F., Chen, Y., Wang, J., Liu, X., Xiao, X., Guo, W., & Chen, F. (2023) · Obesity Facts · doi:10.1159/000530241 · Cited by 63 · see citing works

The Impact of Immune Cells on the Skeletal Muscle Microenvironment During Cancer Cachexia

VanderVeen, B. N., Murphy, E. A., & Carson, J. A. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.01037 · Cited by 52 · see citing works

Skeletal muscle and MASLD: Mechanistic and clinical insights

Marjot, T., Armstrong, M. J., & Stine, J. G. (2025) · Hepatology Communications · doi:10.1097/hc9.0000000000000711 · Cited by 73 · see citing works

Asprosin, a novel pleiotropic adipokine implicated in fasting and obesity-related cardio-metabolic disease: Comprehensive review of preclinical and clinical evidence

Shabir, K., Brown, J. E. P., Afzal, I., Gharanei, S., Weickert, M. O., Barber, T. M., Kyrou, I., & Randeva, H. S. (2021) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2021.05.002 · Cited by 61 · see citing works

Identification of key genes and pathways associated with feed efficiency of native chickens based on transcriptome data via bioinformatics analysis

Yang, L., He, T., Xiong, F., Chen, X., Fan, X., Jin, S., & Geng, Z. (2020) · BMC Genomics · doi:10.1186/s12864-020-6713-y · Cited by 61 · see citing works

Glucagon-like peptide-1 receptor agonists and muscle mass effects

Ceasovschih, A., Asaftei, A., Lupo, M. G., Kotlyarov, S., Bartušková, H., Balta, A., Sorodoc, V., Sorodoc, L., & Banach, M. (2025) · Pharmacological Research · doi:10.1016/j.phrs.2025.107927 · Cited by 64 · see citing works

Obesity-Related Heart Failure with Preserved Ejection Fraction

Harada, T., & Obokata, M. (2020) · Heart Failure Clinics · doi:10.1016/j.hfc.2020.02.004 · Cited by 60 · see citing works

Inflammation and Metabolic Complications in HIV

Bourgi, K., Wanjalla, C. N., & Koethe, J. R. (2018) · Current HIV/AIDS Reports · doi:10.1007/s11904-018-0411-2 · Cited by 57 · see citing works

Attenuation of Free Fatty Acid (FFA)-Induced Skeletal Muscle Cell Insulin Resistance by Resveratrol is Linked to Activation of AMPK and Inhibition of mTOR and p70 S6K

Hartogh, D. J. D., Vlavcheski, F., Giacca, A., & Tsiani, E. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21144900 · Cited by 57 · see citing works

NLRP3 Inflammasome: Potential Role in Obesity Related Low-Grade Inflammation and Insulin Resistance in Skeletal Muscle

Jorquera, G., Russell‐Guzmán, J., Monsalves‐Álvarez, M., Cruz, G., Valladares-Ide, D., Basualto-Alarcón, C., Barrientos, G. C., Estrada, M., & Llanos, P. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22063254 · Cited by 56 · see citing works

T Cells in Adipose Tissue in Aging

Antony, A. K., Lian, Z., & Wu, H. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02945 · Cited by 58 · see citing works

Aerobic Exercise Ameliorates Myocardial Inflammation, Fibrosis and Apoptosis in High-Fat-Diet Rats by Inhibiting P2X7 Purinergic Receptors

Chen, X., Li, H., Wang, K., Liang, X., Wang, W., Hu, X., Huang, Z., & Wang, Y. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.01286 · Cited by 56 · see citing works

Inhibition of autophagy in theca cells induces CYP17A1 and PAI-1 expression via ROS/p38 and JNK signalling during the development of polycystic ovary syndrome

Kobayashi, M., Yoshino, O., Nakashima, A., Ito, M., Nishio, K., Ono, Y., Kusabiraki, T., Kunitomi, C., Takahashi, N., Harada, M., et al. (2020) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2020.110792 · Cited by 54 · see citing works

Insulin/IGF Axis and the Receptor for Advanced Glycation End Products: Role in Meta-inflammation and Potential in Cancer Therapy

Vella, V., Lappano, R., Bonavita, E., Maggiolini, M., Clarke, R. B., Belfiore, A., & Francesco, E. M. D. (2023) · Endocrine Reviews · doi:10.1210/endrev/bnad005 · Cited by 55 · see citing works

Metabolic responsiveness to training depends on insulin sensitivity and protein content of exosomes in insulin-resistant males

Apostolopoulou, M., Mastrototaro, L., Hartwig, S., Pesta, D. H., Straßburger, K., Filippo, E. D., Jeleník, T., Karusheva, Y., Gancheva, S., Markgraf, D. F., et al. (2021) · Science Advances · doi:10.1126/sciadv.abi9551 · Cited by 53 · see citing works

A high-fat, high-fructose diet induced hepatic steatosis, renal lesions, dyslipidemia, and hyperuricemia in non-obese rats

Yustisia, I., Tandiari, D., Cangara, M. H., Hamid, F., & Daud, N. A. (2022) · Heliyon · doi:10.1016/j.heliyon.2022.e10896 · Cited by 53 · see citing works

NAD+ metabolism-based immunoregulation and therapeutic potential

Fang, J., Chen, W., Hou, P., Liu, Z., Zuo, M., Liu, S., Feng, C., Han, Y., Li, P., Shi, Y., et al. (2023) · Cell & Bioscience · doi:10.1186/s13578-023-01031-5 · Cited by 54 · see citing works

Dendrobium Officinale Polysaccharide Attenuates Insulin Resistance and Abnormal Lipid Metabolism in Obese Mice

Qu, J., Tan, S., Xie, X., Wu, W., Zhu, H., Li, H., Liao, X., Wang, J., Zhou, Z.-A., Huang, S. M., et al. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.659626 · Cited by 53 · see citing works

HDAC11, an emerging therapeutic target for metabolic disorders

Chen, H., Xie, C., Chen, Q., & Zhuang, S. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.989305 · Cited by 52 · see citing works

Markers of adipose tissue inflammation are transiently elevated during intermittent fasting in women who are overweight or obese

Liu, B., Hutchison, A. T., Thompson, C. H., Lange, K. M., & Heilbronn, L. K. (2019) · Obesity Research & Clinical Practice · doi:10.1016/j.orcp.2019.07.001 · Cited by 52 · see citing works

Immunometabolism and metainflammation in obesity

Romantsova, T. I., & Sych, Y. P. (2019) · Obesity and metabolism · doi:10.14341/omet12218 · Cited by 52 · see citing works

Muscle inflammatory response and insulin resistance: synergistic interaction between macrophages and fatty acids leads to impaired insulin action

Varma, V., Yao-Borengasser, A., Rasouli, N., Nolen, G. T., Phanavanh, B., Starks, T., Gurley, C., Simpson, P., McGehee, R. E., Kern, P. A., et al. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90885.2008 · Cited by 229 · see citing works

Impaired protein metabolism: interlinks between obesity, insulin resistance and inflammation

Guillet, C., Masgrau, A., Walrand, S., & Boirie, Y. (2012) · Obesity Reviews · doi:10.1111/j.1467-789x.2012.01037.x · Cited by 118 · see citing works

Physiopathologie de l’insulinorésistance dans le muscle squelettique et implication des fonctions mitochondriales

Barquissau, V., & Morio, B. (2011) · Nutrition Clinique et Métabolisme · doi:10.1016/j.nupar.2011.07.003 · Cited by 4 · see citing works

Skeletal Muscle Insulin Resistance and Absence of Inflammation Characterize Insulin-Resistant Grade I Obese Women

Amouzou, C., Breuker, C., Fabre, O., Bourret, A., Lambert, K., Birot, O., Fédou, C., Dupuy, A., Cristol, J., Sutra, T., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0154119 · Cited by 37 · see citing works

Altered Interleukin-10 Signaling in Skeletal Muscle Regulates Obesity-Mediated Inflammation and Insulin Resistance

Dağdeviren, S., Jung, D. Y., Lee, E., Friedline, R. H., Noh, H. L., Kim, J. H., Patel, P. R., Tsitsilianos, N., Tsitsilianos, A. V., Tran, D. A., et al. (2016) · Molecular and Cellular Biology · doi:10.1128/mcb.00181-16 · Cited by 65 · see citing works