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High Serum Uric Acid as a Novel Risk Factor for Type 2 Diabetes
Abstract
OBJECTIVE—To investigate the association between serum uric acid level and risk of type 2 diabetes. RESEARCH DESIGN AND METHODS—The population for analysis consisted of 4,536 subjects free from diabetes at baseline. During a mean of 10.1 years of follow-up, 462 subjects developed diabetes. RESULTS—The age- and sex-adjusted hazard ratios (HRs) (95% CIs) for diabetes were 1.30 (0.96–1.76) for the second, 1.63 (1.21–2.19) for the third, and 2.83 (2.13–3.76) for the fourth quartile of serum uric acid, in comparison with the first quartile. After adjustment for BMI, waist circumference, systolic and diastolic blood pressure, and HDL cholesterol, the HRs decreased to 1.08 (0.78–1.49), 1.12 (0.81–1.53), and 1.68 (1.22–2.30), respectively. CONCLUSIONS—The results of this population-based study suggest that serum uric acid is a strong and independent risk factor for diabetes.
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Cited by
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Tappy, L., & Lê, K.-A. (2010) · Physiological Reviews · doi:10.1152/physrev.00019.2009 · Cited by 1,256
Uric Acid Induces Hepatic Steatosis by Generation of Mitochondrial Oxidative Stress
Lanaspa, M. A., Sanchez-Lozada, L. G., Choi, Y.-J., Cicerchi, C., Kanbay, M., Roncal-Jimenez, C. A., Ishimoto, T., Li, N., Marek, G., Duranay, M., et al. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.399899 · Cited by 710
Wearable salivary uric acid mouthguard biosensor with integrated wireless electronics
Kim, J., Imani, S., de Araujo, W. R., Warchall, J., Valdés-Ramírez, G., Paixão, T. R. L. C., Mercier, P. P., & Wang, J. (2015) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2015.07.039 · Cited by 678
Association Between Serum Uric Acid and Development of Type 2 Diabetes
Kodama, S., Saito, K., Yachi, Y., Asumi, M., Sugawara, A., Totsuka, K., Saito, A., & Sone, H. (2009) · Diabetes Care · doi:10.2337/dc09-0288 · Cited by 549
The Role of Oxidative Stress in the Pathophysiology of Gestational Diabetes Mellitus
Lappas, M., Hiden, U., Desoye, G., Froehlich, J., Mouzon, S. H.-D., & Jawerbaum, A. (2011) · Antioxidants & Redox Signaling · doi:10.1089/ars.2010.3765 · Cited by 442
Metadata
- Authors
- Dehghan, A., van Hoek, M., Sijbrands, E. J. G., Hofman, A., & Witteman, J. C. M.
- Venue
- Diabetes Care
- Publisher
- American Diabetes Association
- Published
- 2008-02-01
- Volume
- 31
- Issue
- 2
- Pages
- 361-362
- ISSN
- 0149-5992 (ISSN-L)
- 1935-5548
- OpenAlex
- W2171699178
- Cited by
- 652
- References
- 0
- FWCI
- 25.44
- Type
- journal article
- Language
- en
- Open access
- closed
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- Dehghan, A., van Hoek, M., Sijbrands, E. J. G., Hofman, A., & Witteman, J. C. M. (2008). High Serum Uric Acid as a Novel Risk Factor for Type 2 Diabetes. Diabetes Care. https://doi.org/10.2337/dc07-1276
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