Reducing rates of severe hypoglycemia in a population-based cohort of children and adolescents with type 1 diabetes over the decade 2000–2009
Open accessAbstract
OBJECTIVE: To examine rates of severe hypoglycemia (SH) in a large population-based cohort of children with type 1 diabetes and relationships to HbA1c. RESEARCH DESIGN AND METHODS: Data from 1,683 children (mean [SD] age at diagnosis 10.5 [4.2]; range 1–18 years) from 2000 to 2009 were analyzed from the Western Australian Children's Diabetes Database. Rates of SH were related to HbA1c using negative binomial regression. RESULTS: A total of 7,378 patient-years of data and 780 SH events were recorded. The rate of SH per 100 patient-years peaked at 17.3 in 2001 and then declined from 2004 to a nadir of 5.8 in 2006. HbA1c <7% was not associated with higher risk of SH (incidence rate ratio 1.2 [95% CI 0.9–1.6], P = 0.29) compared with HbA1c of 8–9%. CONCLUSIONS: In a sample of youth with type 1 diabetes, there has been a decrease in rates of SH and a weaker relationship with glycemic control than previously observed.
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The rate of severe hypoglycaemia needing help from another person is 16-20 per 100 person-years.
“Severe hypoglycaemic events requiring treatment assistance from another person occur at rates of 16–20 per 100 person-years;”
From Type 1 diabetes (2018) · cites this paper as [104]
The Abstract Results report a peak of 17.3 severe hypoglycemia events per 100 patient-years in 2001, within the claimed range, but a decline to 5.8 by 2006; they do not support 16–20 as a general rate. The Research Design and Methods section defines an event as one causing loss of consciousness or seizure, not one requiring assistance from another person. (LLM, conf=0.88)
Experimental — accuracy not yet measuredHypoglycaemic events leading to loss of consciousness or seizure occur at 2-8 per 100 person-years.
“hypoglycaemic events leading to loss of consciousness or seizure occur at a rate of 2–8 per 100 person-years.103–105”
From Type 1 diabetes (2018) · cites this paper as [104]
The Research Design and Methods section defines these events as hypoglycemia leading to loss of consciousness or seizure. The reported rate reached 5.8 per 100 patient-years, within the claimed range, but peaked at 17.3; the paper therefore does not support 2–8 as the range for its cohort of children with type 1 diabetes (Abstract, Results; page unavailable). (LLM, conf=0.88)
Experimental — accuracy not yet measuredRates of severe hypoglycaemic events have been decreasing over time.
“Notably, rates of severe hypoglycaemic events have been decreasing over time104”
From Type 1 diabetes (2018) · cites this paper as [104]
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References 9 · Cited by 81
- Authors
- O'Connell, S. M., Cooper, M. N., Bulsara, M. K., Davis, E. A., & Jones, T. W.
- Affiliations
- The Kids Research Institute Australia (AU)
- The University of Notre Dame Australia (AU)
- Corresponding author
- Jones, Timothy W.
- Venue
- Diabetes Care
- Publisher
- American Diabetes Association
- Published
- 2011-10-15
- Volume
- 34
- Issue
- 11
- Pages
- 2379-2380
- ISSN
- 0149-5992 (ISSN-L)
- 1935-5548
- PMC
- PMC3198282
- OpenAlex
- W1964078034
- Cited by
- 81
- References
- 9
- Citations by year
- 2025: 2 · 2024: 2 · 2023: 5 · 2022: 2 · 2021: 5 · 2020: 3 · 2019: 5 · 2018: 9 · 2017: 6 · 2016: 7 · 2015: 12 · 2014: 12 · 2013: 5 · 2012: 6
- FWCI
- 6.02
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Diabetes Care (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- UWA Profiles and Research Repository (UWA) (publishedVersion, other-oa)
- PubMed (publishedVersion)
- ResearchOnline@ND (The University of Notre Dame) (submittedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Education
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
- Keywords
- severe hypoglycemia, type 1 diabetes, children and adolescents, HbA1c, glycemic control
- MeSH terms
- Adolescent, Australia, Blood Glucose, Child, Child, Preschool, Diabetes Mellitus, Type 1, Female, Glycated Hemoglobin, Hospitals, Pediatric, Humans, Hypoglycemia, Hypoglycemic Agents, Infant, Insulin, Male, Population Surveillance, Risk, Models, Statistical, Cohort Studies, Incidence
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