Cited by 820Adipokines, Inflammation, and Metabolic DiseasesDiabetes, Cardiovascular Risks, and LipoproteinsInflammatory Biomarkers in Disease Prognosis

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Inflammatory Markers and Risk of Type 2 Diabetes

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Wang, Xia, Bao, Wei, Liu, Jun, OuYang, Ying-Ying, Wang, Di, Rong, Shuang, Xiao, Xiao, Shan, Zhi-Lei, Zhang, Yan, Yao, Ping, Liu, Lie-Gang·2013·Diabetes Care

DOI 10.2337/dc12-0702PMC PMC3526249

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Abstract

OBJECTIVE: There has been growing evidence that inflammatory markers play a role in the development of type 2 diabetes. We aimed to systematically review prospective studies on the associations of elevated levels of interleukin-6 (IL-6) and C-reactive protein (CRP) with increased risk of type 2 diabetes by conducting a meta-analysis. RESEARCH DESIGN AND METHODS: A systematic search of the PubMed, EMBASE, ISI Web of Knowledge, and Cochrane Library databases up until 10 February 2012 was conducted to retrieve prospective studies matched to search terms. We used generalized least-squares trend estimation to assess dose-response relationships. The summary risk estimates were pooled using either fixed-effects or random-effects models to incorporate between-study variation. RESULTS: The meta-analysis, including 10 prospective studies, with a total of 19,709 participants and 4,480 cases, detected a significant dose-response association of IL-6 levels with type 2 diabetes risk (relative risk [RR] 1.31 [95% CI 1.17–1.46]). For CRP, the meta-analysis involving 22 cohorts, with a total of 40,735 participants and 5,753 cases, showed that elevated CRP levels were significantly associated with increased risk of type 2 diabetes (1.26 [1.16–1.37]), with the absence of publication bias. Sensitivity and subgroup analyses further supported the associations. CONCLUSIONS: This meta-analysis provides further evidence that elevated levels of IL-6 and CRP are significantly associated with increased risk of type 2 diabetes.

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Authors: Wang, X., Bao, W., Liu, J., OuYang, Y.-Y., Wang, D., Rong, S., Xiao, X., Shan, Z.-L., Zhang, Y., Yao, P., & Liu, L.-G.
Affiliations: Shandong University (CN)
Huazhong University of Science and Technology (CN)
Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
ORCID: Wang, Xia
Bao, Wei
Liu, Jun
Wang, Di
Rong, Shuang
Xiao, Xiao
Zhang, Yan
Yao, Ping
Venue: Diabetes Care
Publisher: American Diabetes Association
Published: 2012-12-11
Volume: 36
Issue: 1
Pages: 166-175
ISSN: 0149-5992 (ISSN-L)
1935-5548
DOI: 10.2337/dc12-0702
PMC: PMC3526249
OpenAlex: W2136759091
Cited by: 820
References: 43
Citations by year: 2026: 28 · 2025: 63 · 2024: 79 · 2023: 68 · 2022: 68 · 2021: 72 · 2020: 100 · 2019: 78 · 2018: 61 · 2017: 66 · 2016: 48 · 2015: 45 · 2014: 32 · 2013: 11 · 2012: 1
FWCI: 3.55
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc-nd
creativecommons.org/licenses/by-nc-nd/3.0/ (vor, 3186 d)
Locations: Diabetes Care (publishedVersion, cc-by-nc-nd)
PubMed Central (publishedVersion, cc-by-nc-nd)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Health Sciences › Medicine › Oncology › Inflammatory Biomarkers in Disease Prognosis
Keywords: type 2 diabetes, interleukin-6, C-reactive protein, inflammatory markers, diabetes risk, dose-response relationship, inflammation
MeSH terms: C-Reactive Protein, Diabetes Mellitus, Type 2, Humans, Risk Factors, Biomarkers, Interleukin-6

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Inflammatory Markers and Risk of Type 2 Diabetes

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