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Inflammatory Markers and Risk of Type 2 Diabetes
Open accessAbstract
OBJECTIVE: There has been growing evidence that inflammatory markers play a role in the development of type 2 diabetes. We aimed to systematically review prospective studies on the associations of elevated levels of interleukin-6 (IL-6) and C-reactive protein (CRP) with increased risk of type 2 diabetes by conducting a meta-analysis. RESEARCH DESIGN AND METHODS: A systematic search of the PubMed, EMBASE, ISI Web of Knowledge, and Cochrane Library databases up until 10 February 2012 was conducted to retrieve prospective studies matched to search terms. We used generalized least-squares trend estimation to assess dose-response relationships. The summary risk estimates were pooled using either fixed-effects or random-effects models to incorporate between-study variation. RESULTS: The meta-analysis, including 10 prospective studies, with a total of 19,709 participants and 4,480 cases, detected a significant dose-response association of IL-6 levels with type 2 diabetes risk (relative risk [RR] 1.31 [95% CI 1.17–1.46]). For CRP, the meta-analysis involving 22 cohorts, with a total of 40,735 participants and 5,753 cases, showed that elevated CRP levels were significantly associated with increased risk of type 2 diabetes (1.26 [1.16–1.37]), with the absence of publication bias. Sensitivity and subgroup analyses further supported the associations. CONCLUSIONS: This meta-analysis provides further evidence that elevated levels of IL-6 and CRP are significantly associated with increased risk of type 2 diabetes.
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“Prospective studies indicate that raised concentrations of IL-6 and CRP in the circulation are associated with increased risk of future T2DM 42.”
From Type 2 diabetes mellitus and psychological stress — a modifiable risk factor (2017) · cites this paper as [42]
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Measuring inconsistency in meta-analyses
Higgins, J. P. T., Thompson, S. G., Deeks, J. J., & Altman, D. G. (2003) · BMJ · doi:10.1136/bmj.327.7414.557 · Cited by 63,139
Meta-analysis of Observational Studies in Epidemiology<SUBTITLE>A Proposal for Reporting</SUBTITLE>
Stroup, D. F. (2000) · JAMA · doi:10.1001/jama.283.15.2008 · Cited by 20,623
Wild, S., Roglic, G., Green, A., Sicree, R., & King, H. (2004) · Diabetes Care · doi:10.2337/diacare.27.5.1047 · Cited by 15,297
Pearson, T. A., Mensah, G. A., Alexander, R. W., Anderson, J. L., Cannon, R. O., Criqui, M., Fadl, Y. Y., Fortmann, S. P., Hong, Y., Myers, G. L., et al. (2003) · Circulation · doi:10.1161/01.cir.0000052939.59093.45 · Cited by 6,401
C-Reactive Protein, Interleukin 6, and Risk of Developing Type 2 Diabetes Mellitus
Pradhan, A. D. (2001) · JAMA · doi:10.1001/jama.286.3.327 · Cited by 4,433
Type 2 diabetes as an inflammatory disease
Donath, M. Y., & Shoelson, S. E. (2011) · Nature Reviews Immunology · doi:10.1038/nri2925 · Cited by 3,737
PearsonT, A., MensahG, A., & AlexanderR, W. (2003) · Journal of Cardiopulmonary Rehabilitation · doi:10.1097/00008483-200305000-00016 · Cited by 2,937
Peters, J. L., Sutton, A. J., Jones, D. R., Abrams, K. R., & Rushton, L. (2008) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2007.11.010 · Cited by 2,053
Microvascular and Macrovascular Complications of Diabetes
Fowler, M. J. (2008) · Clinical Diabetes · doi:10.2337/diaclin.26.2.77 · Cited by 1,954
Medzhitov, R. M., & Janeway, C. A. (2000) · New England Journal of Medicine · doi:10.1056/nejm200008033430506 · Cited by 1,827
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Inflammation as a link between obesity, metabolic syndrome and type 2 diabetes
Esser, N., Legrand-Poels, S., Piette, J., Scheen, A. J., & Paquot, N. (2014) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2014.04.006 · Cited by 1,981
Sleep duration and risk of type 2 diabetes: a meta-analysis of prospective studies
Shan, Z., Ma, H., Xie, M., Yan, P., Guo, Y., Bao, W., Rong, Y., Jackson, C. L., Hu, F. B., & Liu, L. (2015) · Diabetes Care · doi:10.2337/dc14-2073 · Cited by 902
Self-citationVascular Inflammation and Oxidative Stress: Major Triggers for Cardiovascular Disease
Steven, S., Frenis, K., Oelze, M. W., Kalinovic, S., Kuntić, M., Jiménez, M. T. B., Vujačić-Mirski, K., Helmstädter, J., Kröller‐Schön, S., Münzel, T. F., et al. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/7092151 · Cited by 750
Risk factors for type 2 diabetes mellitus: An exposure-wide umbrella review of meta-analyses
Bellou, V., Belbasis, L., Tzoulaki, I., & Evangelou, E. (2018) · PLOS ONE · doi:10.1371/journal.pone.0194127 · Cited by 713
The link between depression and diabetes: the search for shared mechanisms
Moulton, C. D., Pickup, J. C., & Ismail, K. (2015) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(15)00134-5 · Cited by 670
Schwingshackl, L., & HOFFMANN, G. E. (2014) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2014.03.003 · Cited by 612
Ha, D. H., Kim, H.-K., Lee, J., Kwon, H. H., Park, G., Yang, S. H., Jung, J. Y., Choi, H., Lee, J. H., Sung, S., et al. (2020) · Cells · doi:10.3390/cells9051157 · Cited by 551
The association between Diabetes mellitus and Depression.
Bădescu, S., Tataru, C. I., Kobylinska, L., Margarint, E. L. G., Zahiu, D., Am, Z., & Zăgrean, A. (2016) · PubMed Central · Cited by 514
A journey into a Mediterranean diet and type 2 diabetes: a systematic review with meta-analyses
Esposito, K., Maiorino, M. I., Bellastella, G., Chiodini, P., Panagiotakos, D., & Giugliano, D. (2015) · BMJ Open · doi:10.1136/bmjopen-2015-008222 · Cited by 501
Effect of periodontal disease on diabetes: systematic review of epidemiologic observational evidence
Borgnakke, W. S., Ylöstalo, P., Taylor, G. W., & Genco, R. J. (2013) · Journal of Periodontology · doi:10.1902/jop.2013.1340013 · Cited by 499
Type 2 diabetes mellitus and psychological stress — a modifiable risk factor
Hackett, R. A., & Steptoe, A. (2017) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2017.64 · Cited by 480
Liu, C., Feng, X., Li, Q., Wang, Y., Li, Q., & Hua, M. (2016) · Cytokine · doi:10.1016/j.cyto.2016.06.028 · Cited by 470
Halim, M., & Halim, A. (2019) · Diabetes & Metabolic Syndrome Clinical Research & Reviews · doi:10.1016/j.dsx.2019.01.040 · Cited by 422
de Mello, V. D., Paananen, J., Lindström, J., Lankinen, M. A., Shi, L. S., Kuusisto, J., Pihlajamäki, J., Auriola, S. O. K., Lehtonen, M., Rolandsson, O., et al. (2017) · Scientific Reports · doi:10.1038/srep46337 · Cited by 395
Tonucci, L. B., dos Santos, K. M. O., de Oliveira, L. L., Ribeiro, S. M. R., & Martino, H. S. D. (2015) · Clinical Nutrition · doi:10.1016/j.clnu.2015.11.011 · Cited by 402
Beyond the stomach: An updated view ofHelicobacter pyloripathogenesis, diagnosis, and treatment
Testerman, T. L. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i36.12781 · Cited by 337
Helicobacter pyloriand extragastric diseases: A review
Gravina, A. G., Zagari, R. M., Musis, C. D., Romano, L., Loguercio, C., & Romano, M. (2018) · World Journal of Gastroenterology · doi:10.3748/wjg.v24.i29.3204 · Cited by 332
Social support, social integration, and inflammatory cytokines: a meta-analysis
Uchino, B. N., Trettevik, R., Kent de Grey, R. G., Cronan, S., Hogan, J., & Baucom, B. R. W. (2018) · Health Psychology · doi:10.1037/hea0000594 · Cited by 320
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Kistner, T. M., Pedersen, B. K., & Lieberman, D. E. (2022) · Nature Metabolism · doi:10.1038/s42255-022-00538-4 · Cited by 295
Oxidative stress, inflammation, endothelial dysfunction and incidence of type 2 diabetes
Odegaard, A. O., Jacobs, D. R., Sanchez, O. A., Goff, D. C., Reiner, A. P., & Gross, M. D. (2016) · Cardiovascular Diabetology · doi:10.1186/s12933-016-0369-6 · Cited by 286
West, C. E., Renz, H. E., Jenmalm, M. C., Kozyrskyj, A. L., Allen, K. J., Vuillermin, P., Prescott, S. L., Mackay, C. R., Salminen, S., Wong, G., et al. (2015) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2014.11.012 · Cited by 288
Arterial Stiffness Preceding Diabetes
Zheng, M., Zhang, X., Chen, S., Song, Y., Zhao, Q., Gao, X., & Wu, S. (2020) · Circulation Research · doi:10.1161/circresaha.120.317950 · Cited by 259
The impact of smoking on the development of diabetes and its complications
Śliwińska‐Mossoń, M., & Milnerowicz, H. (2017) · Diabetes and Vascular Disease Research · doi:10.1177/1479164117701876 · Cited by 269
Inflammageing and metaflammation: The yin and yang of type 2 diabetes
Prattichizzo, F., Nigris, V. D., Spiga, R., Mancuso, E., Sala, L. L., Antonicelli, R., Testa, R., Procopio, A. D., Olivieri, F., & Ceriello, A. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2017.10.003 · Cited by 255
Anti-inflammatory effects of Rhodiola rosea L.: A review
Pu, W.-L., Zhang, M.-Y., Bai, R.-Y., Sun, L.-K., Li, W.-H., Yu, Y.-L., Zhang, Y., Song, L., Wang, Z.-X., Peng, Y.-F., et al. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2019.109552 · Cited by 227
Self-citationEpidemiology of selenium and type 2 diabetes: Can we make sense of it?
Rayman, M. P., & Stranges, S. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.04.003 · Cited by 220
Novel biomarkers for prediabetes, diabetes, and associated complications
Dorcely, B., Katz, K., Jagannathan, R., Chiang, S. S., Oluwadare, B., Goldberg, I. J., & Bergman, M. (2017) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s100074 · Cited by 236
Sedentary Time and Markers of Chronic Low-Grade Inflammation in a High Risk Population
Henson, J. J., Yates, T. E., Edwardson, C. L., Khunti, K. K., Talbot, D. C. S., Gray, L. J., Leigh, T. M., Carter, P., & Davies, M. J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0078350 · Cited by 219
Natural Phyto-Bioactive Compounds for the Treatment of Type 2 Diabetes: Inflammation as a Target
Gothai, S., Ganesan, P., Park, S., Fakurazi, S., Choi, D., & Arulselvan, P. (2016) · Nutrients · doi:10.3390/nu8080461 · Cited by 226
Prins, B. P., Abbasi, A., Wong, A., Vaez, A., Nolte, I., Franceschini, N., Stuart, P. E., Guterriez Achury, J., Mistry, V., Bradfield, J. P., et al. (2016) · PLOS Medicine · doi:10.1371/journal.pmed.1001976 · Cited by 199
Role of C-Reactive Protein in Diabetic Inflammation
Stanimirović, J., Radovanović, J., Banjac, K., Obradovic, M. M., Essack, M., Zafirovic, S. S., Gluvic, Z. M., Gojobori, T., & Isenović, E. R. (2022) · Mediators of Inflammation · doi:10.1155/2022/3706508 · Cited by 221
Hart, M. J., Torres, S. J., McNaughton, S. A., & Milte, C. M. (2021) · Nutrition Journal · doi:10.1186/s12937-021-00674-9 · Cited by 201
Wang, Q., Holmes, M. V., Smith, G. D., & Ala‐Korpela, M. (2017) · Diabetes Care · doi:10.2337/dc17-1642 · Cited by 182
Preconception and early pregnancy air pollution exposures and risk of gestational diabetes mellitus
Robledo, C. A., Mendola, P., Yeung, E. H., Männistö, T. I., Sundaram, R., Liu, D., Ying, Q., Sherman, S. J., & Grantz, K. L. (2015) · Environmental Research · doi:10.1016/j.envres.2014.12.020 · Cited by 181
Chen, M., Lan, W.-H., Hsu, J.-W., Huang, K., Su, T., Li, C., Lin, W.-C., Tsai, C.-F., Tsai, S., Lee, Y.-C., et al. (2016) · Diabetes Care · doi:10.2337/dc15-1807 · Cited by 175
Bril, F., Lomonaco, R., Orsak, B., Ortiz‐Lopez, C., Webb, A., Tio, F. O., Hecht, J., & Cusi, K. J. (2013) · Hepatology · doi:10.1002/hep.26988 · Cited by 173
Zuo, H., Ueland, P. M., Ulvik, A., Eussen, S. J. P. M., Vollset, S. E., Nygard, O. K., Midttun, Ø., Theofylaktopoulou, D., Meyer, K., & Tell, G. S. (2016) · American Journal of Epidemiology · doi:10.1093/aje/kwv242 · Cited by 169
Daiber, A., & Chłopicki, S. (2020) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2020.02.026 · Cited by 171
Dietary Glycemic Index and Load and the Risk of Type 2 Diabetes: Assessment of Causal Relations
Livesey, G., Taylor, R., Livesey, H. F., Buyken, A. E., Jenkins, D. J. A., Augustin, L. S. A., Sievenpiper, J. L., Barclay, A. W., Liu, S., Wolever, T. M. S., et al. (2019) · Nutrients · doi:10.3390/nu11061436 · Cited by 163
Gut microbiota and probiotics: Focus on diabetes mellitus
Tonucci, L. B., dos Santos, K. M. O., Ferreira, C. L. D. L. F., Ribeiro, S. M. R., de Oliveira, L. L., & Martino, H. S. D. (2015) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2014.934438 · Cited by 168
IL ‐6 in diabetes and cardiovascular complications
Qu, D. C., Liu, J., Lau, C. W., & Huang, Y. (2014) · British Journal of Pharmacology · doi:10.1111/bph.12713 · Cited by 166
Self-citationRanderia, S. N., Thomson, G. J. A., Nell, T. A., Roberts, T. J., & Pretorius, E. (2019) · Cardiovascular Diabetology · doi:10.1186/s12933-019-0870-9 · Cited by 157
Maiorino, M. I., Bellastella, G., Giugliano, D., & Esposito, K. (2018) · Journal of Endocrinological Investigation · doi:10.1007/s40618-018-0872-6 · Cited by 144
Whole grain consumption and human health: an umbrella review of observational studies
Tieri, M., Ghelfi, F., Vitale, M., Vetrani, C., Marventano, S., Lafranconi, A., Godos, J., Titta, L., Gambera, A., Alonzo, E., et al. (2020) · International Journal of Food Sciences and Nutrition · doi:10.1080/09637486.2020.1715354 · Cited by 142
Su, B., Liu, H., Li, J., Sunli, Y., Liu, B., Liu, D., Zhang, P., & Meng, X. (2014) · Journal of Diabetes · doi:10.1111/1753-0407.12232 · Cited by 136
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Prattichizzo, F., De Nigris, V., La Sala, L., Procopio, A. D., Olivieri, F., & Ceriello, A. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/1810327 · Cited by 129
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Yu, X., Pu, H., & Voss, M. (2024) · British Journal of Nutrition · doi:10.1017/s0007114524001405 · Cited by 134
Al-Hamodi, Z. H., Al‐Habori, M., Al‐Meeri, A., & Saif-Ali, R. (2014) · Diabetology & Metabolic Syndrome · doi:10.1186/1758-5996-6-99 · Cited by 139
Demmer, R. T., Trinquart, L., Zuk, A. M., Fu, B. C., Blomkvist, J., Michalowicz, B. S., Ravaud, P., & Desvarieux, M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0077441 · Cited by 138
Mediterranean diet for type 2 diabetes: cardiometabolic benefits
Esposito, K., Maiorino, M. I., Bellastella, G., Panagiotakos, D. B., & Giugliano, D. (2016) · Endocrine · doi:10.1007/s12020-016-1018-2 · Cited by 144
Corte, K. W. D., Perrar, I., Penczynski, K. J., Schwingshackl, L., Herder, C., & Buyken, A. E. (2018) · Nutrients · doi:10.3390/nu10050606 · Cited by 138
Meta-analysis investigating the role of interleukin-6 mediated inflammation in type 2 diabetes
Bowker, N., Shah, R. L., Sharp, S. J., Luan, J., Stewart, I. D., Wheeler, E., Ferreira, M. A. R., Baras, A., Wareham, N. J., Langenberg, C., et al. (2020) · EBioMedicine · doi:10.1016/j.ebiom.2020.103062 · Cited by 133
Association between air pollution and type 2 diabetes: an updated review of the literature
Li, Y., Xu, L., Shan, Z., Teng, W., & Han, C. (2019) · Therapeutic Advances in Endocrinology and Metabolism · doi:10.1177/2042018819897046 · Cited by 136
Self-citationDeng, F. E., Shivappa, N., Tang, Y., Mann, J. R., & Hébert, J. R. (2016) · European Journal of Nutrition · doi:10.1007/s00394-016-1158-4 · Cited by 128
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Alzoubi, A., Abunaser, R., Khassawneh, A., Alfaqih, M. A., Khasawneh, A. G., & Abdo, N. M. (2018) · Korean Journal of Family Medicine · doi:10.4082/kjfm.2018.39.3.137 · Cited by 130
Hackett, R. A., Kivimäki, M., Kumari, M., & Steptoe, A. (2016) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2015-2853 · Cited by 121
Homayouni, F., Haidari, F., Hedayati, M., Zakerkish, M., & Angali, K. A. (2018) · Phytotherapy Research · doi:10.1002/ptr.6046 · Cited by 126
IgG glycan patterns are associated with type 2 diabetes in independent European populations
Lemmers, R. F. H., Vilaj, M. Ć., Urda, D., Agakov, F. V., Šimurina, M., Klarić, L., Rudan, I., Campbell, H. J., Hayward, C., Wilson, J., et al. (2017) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2017.06.020 · Cited by 121
Association of Diurnal Patterns in Salivary Cortisol With Type 2 Diabetes in the Whitehall II Study
Hackett, R. A., Steptoe, A., & Kumari, M. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2014-2459 · Cited by 118
Parrinello, C. M., Lutsey, P. L., Ballantyne, C. M., Folsom, A. R., Pankow, J. S., & Selvin, E. (2015) · American Heart Journal · doi:10.1016/j.ahj.2015.04.017 · Cited by 123
Racial discrimination and health: a prospective study of ethnic minorities in the United Kingdom
Hackett, R. A., Ronaldson, A., Bhui, K. S., Steptoe, A., & Jackson, S. E. (2020) · BMC Public Health · doi:10.1186/s12889-020-09792-1 · Cited by 139
Loneliness and type 2 diabetes incidence: findings from the English Longitudinal Study of Ageing
Hackett, R. A., Hudson, J. L., & Chilcot, J. (2020) · Diabetologia · doi:10.1007/s00125-020-05258-6 · Cited by 108
Phosat, C., Phienluphon, P. P., Chumpathat, N., Prangthip, P., Chantratita, N., Soonthornworasiri, N., Puduang, S., & Kwanbunjan, K. (2017) · BMC Endocrine Disorders · doi:10.1186/s12902-017-0189-z · Cited by 107
Rehling, T., Bjørkman, A.-S. D., Andersen, M. B., Ekholm, O., & Mølsted, S. (2019) · Journal of Diabetes Research · doi:10.1155/2019/6324348 · Cited by 104
Extra-Gastric Manifestations of Helicobacter pylori Infection
Gravina, A. G., Priadko, K., Ciamarra, P., Granata, L., Facchiano, A., Miranda, A., Dallio, M., Federico, A., & Romano, M. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9123887 · Cited by 102
Hyperglycaemia, oxidative stress and inflammatory markers
Butkowski, E., & Jelinek, H. F. (2016) · Redox Report · doi:10.1080/13510002.2016.1215643 · Cited by 103
Debono, M., Harrison, R. F., Chadarevian, R., Gueroult, C., Abitbol, J.-L., & Newell-Price, J. (2017) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2017-00823 · Cited by 100
Periodontitis and incident type 2 diabetes: a prospective cohort study
Winning, L., Patterson, C., Neville, C. E., Kee, F., & Linden, G. J. (2016) · Journal Of Clinical Periodontology · doi:10.1111/jcpe.12691 · Cited by 99
Shan, Z., Bao, W., Zhang, Y., Rong, Y., Wang, X., Jin, Y., Song, Y., Yao, P., Sun, C., Hu, F. B., et al. (2013) · Diabetes · doi:10.2337/db13-0606 · Cited by 99
Self-citationMediterranean diet and type 2 diabetes
Esposito, K., & Giugliano, D. (2014) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.2516 · Cited by 96
Lindekilde, N., Rutters, F., Henriksen, J. E., Lasgaard, M., Schram, M. T., Rubin, K. H., Mika Kivimaki, B., Nefs, G., & Pouwer, F. (2021) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2021.108855 · Cited by 102
Chemoprevention of nonalcoholic fatty liver disease by dietary natural compounds
Pan, M., Lai, C., Tsai, M., & Ho, C. (2013) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201300522 · Cited by 95
Patients with psoriasis are insulin resistant
Gyldenløve, M., Storgaard, H., Holst, J. J., Vilsbøll, T., Knop, F. K., & Skov, L. (2015) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2015.01.004 · Cited by 101
Inflammatory Trajectory of Type 2 Diabetes: Novel Opportunities for Early and Late Treatment
Pellegrini, V., Grotta, R. L., Carreras, F., Giuliani, A., Sabbatinelli, J., Olivieri, F., Berra, C., Ceriello, A., & Prattichizzo, F. (2024) · Cells · doi:10.3390/cells13191662 · Cited by 101
Interventions for age-related diseases: Shifting the paradigm
Figueira, I., Fernandes, A. M. A., Mladenović, A., Lopez-Contreras, A. J., Henriques, C. M., Selman, C., Ferreiro, E. B., Gonos, E. S., Trejo, J. L., Misra, J., et al. (2016) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2016.09.009 · Cited by 92
Pretorius, E., Bester, J., Vermeulen, N., Alummoottil, S., Soma, P., Buys, A. V., & Kell, D. B. (2015) · Cardiovascular Diabetology · doi:10.1186/s12933-015-0192-5 · Cited by 89
Clinical reviews in allergy and immunology
Leung, D. Y. M., Ledford, D. K., Wechsler, M. E., Fulkerson, P. C., Bochner, B. S., Gauvreau, G. M., Gleich, G. J., Henkel, T., Kolbeck, R., Mathur, S. K., et al. (2012) · Cited by 87
Mokkala, K., Pellonperä, O., Röytiö, H., Pussinen, P. J., Rönnemaa, T., & Laitinen, K. (2017) · Metabolism · doi:10.1016/j.metabol.2016.12.015 · Cited by 86
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Guerra, J. V. D. S., Dias, M. M. G., Brilhante, A. J. V. C., Terra, M. F., García‐Arévalo, M., & Figueira, A. C. M. (2021) · Nutrients · doi:10.3390/nu13082830 · Cited by 92
Alrouji, M., Al-Kuraishy, H. M., Al-Gareeb, A. I., Alexiou, A. T., Papadakis, M., Jabir, M. S., Saad, H. M., & Batiha, G. E. (2023) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.17784 · Cited by 87
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van Dooren, F. E. P., Denollet, J., Verhey, F. R. J., Stehouwer, C. D. A., Sep, S. J. S., Henry, R. M. A., Kremers, S., Dagnelie, P. C., Schaper, N. C., Kallen, C., et al. (2016) · BMC Psychiatry · doi:10.1186/s12888-016-0722-z · Cited by 84
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Metadata
- Authors
- Wang, X., Bao, W., Liu, J., OuYang, Y.-Y., Wang, D., Rong, S., Xiao, X., Shan, Z.-L., Zhang, Y., Yao, P., & Liu, L.-G.
- Affiliations
- Shandong University (CN)
- Huazhong University of Science and Technology (CN)
- Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
- Venue
- Diabetes Care
- Publisher
- American Diabetes Association
- Published
- 2012-12-11
- Volume
- 36
- Issue
- 1
- Pages
- 166-175
- ISSN
- 0149-5992 (ISSN-L)
- 1935-5548
- PMC
- PMC3526249
- OpenAlex
- W2136759091
- Cited by
- 820
- References
- 43
- Citations by year
- 2026: 28 · 2025: 63 · 2024: 79 · 2023: 68 · 2022: 68 · 2021: 72 · 2020: 100 · 2019: 78 · 2018: 61 · 2017: 66 · 2016: 48 · 2015: 45 · 2014: 32 · 2013: 11 · 2012: 1
- FWCI
- 3.55
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Diabetes Care (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Oncology › Inflammatory Biomarkers in Disease Prognosis
- Keywords
- type 2 diabetes, interleukin-6, C-reactive protein, inflammatory markers, diabetes risk, dose-response relationship, inflammation
- MeSH terms
- C-Reactive Protein, Diabetes Mellitus, Type 2, Humans, Risk Factors, Biomarkers, Interleukin-6
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