No Difference in Small or Large Nerve Fiber Function Between Individuals With Normal Glucose Tolerance and Impaired Glucose Tolerance
Open accessAbstract
OBJECTIVE: To assess small and large nerve fiber function in people with normal glucose tolerance (NGT), impaired glucose tolerance (IGT), and type 2 diabetes (T2D). RESEARCH DESIGN AND METHODS: Participants were recruited consecutively from a population-based cohort: NGT (n = 39), IGT (n = 29), and T2D (n = 51). Electrophysiological measures included nerve conduction studies and thermal thresholds. Intraepidermal nerve fiber density (IENFD) in skin biopsies was calculated. RESULTS: There was no difference between IGT and NGT in sural nerve conduction, IENFD, and thermal thresholds. IENFD was significantly lower in T2D (median = 2.8 fibers/mm [interquartile range 1.1-4.7 fibers/mm]) than NGT individuals (4.5 fibers/mm [3.4-6.1 fibers/mm]; P < 0.05). T2D participants had poorer nerve conduction and higher heat thresholds than NGT and IGT. CONCLUSIONS: Large and small nerve function in people with IGT did not differ from those with NGT. Our finding does not support the existence of neuropathy in a prediabetic stage.
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There is controversy regarding the effect of glucose dysmetabolism on small nerve fibers and symptom severity in FMS.
“There is controversy regarding the effect of glucose dysmetabolism on small nerve fibers34,42 and symptom severity16,48,56 in FMS.”
From Pain and small fiber pathology in men with fibromyalgia syndrome (2024) · cites this paper as [34]
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The spectrum of neuropathy in diabetes and impaired glucose tolerance
Sumner, C. J., Sheth, S., Griffin, J. W., Cornblath, D. R., & Polydefkis, M. (2003) · Neurology · doi:10.1212/wnl.60.1.108 · Cited by 708 · cited 1× · see citing works
“In addition, it has been reported that there is a loss of IENFD in individuals with IGT (14, 15) suggestive of small nerve fiber dysfunction being present in a pre-diabetic stage.”
BackgroundIncreased Prevalence of Impaired Glucose Tolerance in Patients With Painful Sensory Neuropathy
Singleton, J. R., Smith, A. G., & Bromberg, M. B. (2001) · Diabetes Care · doi:10.2337/diacare.24.8.1448 · Cited by 364 · cited 3× · see citing works
“When addressing the question of whether ‘IGT neuropathy’ truly exists, objective measures of nerve dysfunction are frequently crude and focused on large nerve fibers, while small nerve fiber dysfunction is often overlooked (1, 4, 6)”
BackgroundEpidermal nerve innervation in impaired glucose tolerance and diabetes-associated neuropathy
Smith, A. G., Ramachandran, P., Tripp, S., & Singleton, J. R. (2001) · Neurology · doi:10.1212/wnl.57.9.1701 · Cited by 235 · see citing works
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Research works printed but not linked: 11
- [2]Papanas N Vinik AI Ziegler D Neuropathy in prediabetes: does the clock start ticking early? Nat Rev Endocrinol 2011; 7: 682– 690 21750507
- [3]Dyck PJ Dyck PJ Klein CJ Weigand SD Does impaired glucose metabolism cause polyneuropathy? Review of previous studies and design of a prospective controlled population-based study. Muscle Nerve 2007; 36: 536– 541 17626290
- [4]Ziegler D Rathmann W Dickhaus T Meisinger C Mielck A KORA Study Group Prevalence of polyneuropathy in pre-diabetes and diabetes is associated with abdominal obesity and macroangiopathy: the MONICA/KORA Augsburg Surveys S2 and S3. Diabetes Care 2008; 31: 464– 469 18039804
- [5]Eriksson KF Nilsson H Lindgärde F Diabetes mellitus but not impaired glucose tolerance is associated with dysfunction in peripheral nerves. Diabet Med 1994; 11: 279– 285 8033527
- [6]Dyck PJ Clark VM Overland CJ Impaired glycemia and diabetic polyneuropathy: the OC IG Survey. Diabetes Care 2012; 35: 584– 591 22355020 PMC3322692
- [7]Pourhamidi K Dahlin LB Boman K Rolandsson O Heat shock protein 27 is associated with better nerve function and fewer signs of neuropathy. Diabetologia 2011; 54: 3143– 3149 21909836
- [8]Heldestad V Linder J Sellersjö L Nordh E Reproducibility and influence of test modality order on thermal perception and thermal pain thresholds in quantitative sensory testing. Clin Neurophysiol 2010; 121: 1878– 1885 20478739
- [10]Thomsen NO Englund E Thrainsdottir S Rosén I Dahlin LB Intraepidermal nerve fibre density at wrist level in diabetic and non-diabetic patients. Diabet Med 2009; 26: 1120– 1126 19929990
- [11]Lauria G, Hsieh ST, Johansson O, et al.; European Federation of Neurological Societies; Peripheral Nerve Society. European Federation of Neurological Societies/Peripheral Nerve Society Guideline on the use of skin biopsy in the diagnosis of small fiber neuropathy. Report of a joint task force of the European Federation of Neurological Societies and the Peripheral Nerve Society. Eur J Neurol 2010;17:903–912, e44–e49
- [12]Novella SP Inzucchi SE Goldstein JM The frequency of undiagnosed diabetes and impaired glucose tolerance in patients with idiopathic sensory neuropathy. Muscle Nerve 2001; 24: 1229– 1231 11494278
- [13]Umapathi T Tan WL Loke SC Soon PC Tavintharan S Chan YH Intraepidermal nerve fiber density as a marker of early diabetic neuropathy. Muscle Nerve 2007; 35: 591– 598 17221881
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Pain and small fiber pathology in men with fibromyalgia syndrome
Feulner, B., Gross, F., Evdokimov, D., Malik, R. A., Kampik, D., & Üçeyler, N. (2024) · PAIN Reports · doi:10.1097/pr9.0000000000001212 · Cited by 8 · see citing works
- Authors
- Pourhamidi, K., Dahlin, L. B., Englund, E., & Rolandsson, O.
- Affiliations
- Umeå University (SE)
- Lund University (SE)
- Corresponding author
- Pourhamidi, Kaveh
- Venue
- Diabetes Care
- Publisher
- American Diabetes Association
- Published
- 2013-03-14
- Volume
- 36
- Issue
- 4
- Pages
- 962-964
- ISSN
- 0149-5992 (ISSN-L)
- 1935-5548
- PMC
- PMC3609489
- OpenAlex
- W2170605183
- Cited by
- 21
- References
- 3
- Citations by year
- 2025: 1 · 2024: 2 · 2022: 1 · 2021: 2 · 2020: 3 · 2019: 4 · 2018: 1 · 2017: 1 · 2016: 2 · 2015: 3 · 2013: 1
- FWCI
- 0.86
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Diabetes Care (publishedVersion, cc-by-nc-nd)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- KTH Publication Database DiVA (KTH Royal Institute of Technology) (submittedVersion, other-oa)
- Lund University Publications (Lund University) (submittedVersion, other-oa)
- Topics
- Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
- Health Sciences › Medicine › Neurology › Peripheral Neuropathies and Disorders
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Peripheral Nerve Disorders
- Keywords
- impaired glucose tolerance, type 2 diabetes, small fiber neuropathy, intraepidermal nerve fiber density, nerve conduction, temperature thresholds, prediabetes, diabetic neuropathy
- MeSH terms
- Diabetes Mellitus, Type 2, Electrophysiology, Female, Glucose, Humans, Male, Middle Aged, Nerve Fibers, Sural Nerve, Glucose Intolerance
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