Cited by 235Pain Mechanisms and TreatmentsPeripheral Neuropathies and DisordersHereditary Neurological Disorders

Epidermal nerve innervation in impaired glucose tolerance and diabetes-associated neuropathy

Smith, A. Gordon, Ramachandran, Pam, Tripp, Sheryl, Singleton, J. Robinson·2001·Neurology

Abstract

The authors describe skin biopsy findings in patients with peripheral neuropathy associated with diabetes and impaired glucose tolerance (IGT). Six patients with IGT, eight with early diabetes-associated neuropathy, and five controls were recruited. Most subjects underwent nerve conduction studies (NCS) and quantitative sensory tests (QST). Skin biopsy was abnormal in all neuropathy subjects and correlated poorly with NCS. Neuropathy associated with IGT primarily affects small fibers and is similar to early diabetes-associated neuropathy.

Integrity signals

Registry

Crossref · 10.1212/wnl.57.9.1701

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8 of 8 references verified0 citation errors · 0 not checkable

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  • Evidence is accumulating on increased prevalence of idiopathic polyneuropathy among prediabetic individuals, with IGT being more strongly related to painful than non-painful neuropathy.

    “Finally, evidence is accumulating on increased prevalence of idiopathic polyneuropathy (eg, idiopathic sensory/painful neuropathy,73–78 and sensory/small fibre only neuropathy)73,75,78 among prediabetic individuals with IGT being more strongly related to painful than non-painful neuropathy.73,75,78”

    From Prediabetes: a high-risk state for diabetes development (2012) · cites this paper as [77]

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Authors
Smith, A. G., Ramachandran, P., Tripp, S., & Singleton, J. R.
Affiliations
University of Utah (US)
Venue
Neurology
Published
2001-11-13
Volume
57
Issue
9
Pages
1701-1704
ISSN
  • 0028-3878 (ISSN-L)
  • 1526-632X
OpenAlex
W2164336720
Cited by
235
References
8
Citations by year
2025: 2 · 2024: 4 · 2023: 4 · 2022: 5 · 2021: 3 · 2020: 7 · 2019: 6 · 2018: 6 · 2017: 10 · 2016: 10 · 2015: 7 · 2014: 23 · 2013: 12 · 2012: 20
FWCI
5.78
Type
journal article
Language
en
Open access
closed
Locations
  • Neurology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
  • Health Sciences › Medicine › Neurology › Peripheral Neuropathies and Disorders
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Hereditary Neurological Disorders
Keywords
impaired glucose tolerance, peripheral neuropathy, small fiber neuropathy, skin biopsy, nerve conduction studies, quantitative sensory testing, diabetic polyneuropathy
MeSH terms
Biopsy, Diabetic Neuropathies, Epidermis, Glucose Tolerance Test, Humans, Neural Conduction, Peroneal Nerve, Sural Nerve, Thiolester Hydrolases, Ubiquitin Thiolesterase

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