Epidermal nerve innervation in impaired glucose tolerance and diabetes-associated neuropathy
Abstract
The authors describe skin biopsy findings in patients with peripheral neuropathy associated with diabetes and impaired glucose tolerance (IGT). Six patients with IGT, eight with early diabetes-associated neuropathy, and five controls were recruited. Most subjects underwent nerve conduction studies (NCS) and quantitative sensory tests (QST). Skin biopsy was abnormal in all neuropathy subjects and correlated poorly with NCS. Neuropathy associated with IGT primarily affects small fibers and is similar to early diabetes-associated neuropathy.
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Evidence is accumulating on increased prevalence of idiopathic polyneuropathy among prediabetic individuals, with IGT being more strongly related to painful than non-painful neuropathy.
“Finally, evidence is accumulating on increased prevalence of idiopathic polyneuropathy (eg, idiopathic sensory/painful neuropathy,73–78 and sensory/small fibre only neuropathy)73,75,78 among prediabetic individuals with IGT being more strongly related to painful than non-painful neuropathy.73,75,78”
From Prediabetes: a high-risk state for diabetes development (2012) · cites this paper as [77]
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Microvascular Dysfunction in the Context of Diabetic Neuropathy
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Prediabetes/early diabetes‐associated neuropathy predominantly involves sensory small fibres
Divišová, Š., Vlčková, E., Hnojčíková, M., Škorňa, M., Němec, M., Dubový, P., Dušek, L., Jarkovský, J., Bělobrádková, J., & Bednařík, J. (2012) · Journal of the Peripheral Nervous System · doi:10.1111/j.1529-8027.2012.00420.x · Cited by 65 · see citing works
Prediabetic Neuropathy: Does It Exist?
Παπάνας, Ν., & Ziegler, D. (2012) · Current Diabetes Reports · doi:10.1007/s11892-012-0278-3 · Cited by 66 · see citing works
Polyneuropathy with impaired glucose tolerance: Implications for diagnosis and therapy
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Diabetic Peripheral Neuropathy: Diagnosis and Treatment
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- Authors
- Smith, A. G., Ramachandran, P., Tripp, S., & Singleton, J. R.
- Affiliations
- University of Utah (US)
- Venue
- Neurology
- Published
- 2001-11-13
- Volume
- 57
- Issue
- 9
- Pages
- 1701-1704
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W2164336720
- Cited by
- 235
- References
- 8
- Citations by year
- 2025: 2 · 2024: 4 · 2023: 4 · 2022: 5 · 2021: 3 · 2020: 7 · 2019: 6 · 2018: 6 · 2017: 10 · 2016: 10 · 2015: 7 · 2014: 23 · 2013: 12 · 2012: 20
- FWCI
- 5.78
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
- Health Sciences › Medicine › Neurology › Peripheral Neuropathies and Disorders
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Hereditary Neurological Disorders
- Keywords
- impaired glucose tolerance, peripheral neuropathy, small fiber neuropathy, skin biopsy, nerve conduction studies, quantitative sensory testing, diabetic polyneuropathy
- MeSH terms
- Biopsy, Diabetic Neuropathies, Epidermis, Glucose Tolerance Test, Humans, Neural Conduction, Peroneal Nerve, Sural Nerve, Thiolester Hydrolases, Ubiquitin Thiolesterase
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