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Cited by 381Diabetes Management and ResearchDiabetes Treatment and ManagementDiabetes and associated disorders

Youth-Onset Type 2 Diabetes Consensus Report: Current Status, Challenges, and Priorities

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Nadeau, Kristen J., Anderson, Barbara J., Berg, Erika G., Chiang, Jane L., Chou, Hubert, Copeland, Kenneth C., Hannon, Tamara S., Huang, Terry T.-K. +5 more·2016·Diabetes Care
DOI 10.2337/dc16-1066PMC PMC5314694
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Abstract

Type 2 diabetes is a significant and increasing burden in adolescents and young adults. Clear strategies for research, prevention, and treatment of the disease in these vulnerable patients are needed. Evidence suggests that type 2 diabetes in children is different not only from type 1 but also from type 2 diabetes in adults. Understanding the unique pathophysiology of type 2 diabetes in youth, as well as the risk of complications and the psychosocial impact, will enable industry, academia, funding agencies, advocacy groups, and regulators to collectively evaluate both current and future research, treatment, and prevention approaches. This Consensus Report characterizes type 2 diabetes in children, evaluates the fundamental differences between childhood and adult disease, describes the current therapeutic options, and discusses challenges to and approaches for developing new treatments.

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Authors
Nadeau, K. J., Anderson, B. J., Berg, E. G., Chiang, J. L., Chou, H., Copeland, K. C., Hannon, T. S., Huang, T. T.-K., Lynch, J. L., Powell, J., Sellers, E., Tamborlane, W. V., & Zeitler, P.
Affiliations
  • Children's Hospital Colorado (US)
  • Baylor College of Medicine (US)
  • American Diabetes Association (US)
  • Daiichi Sankyo (United States) (US)
  • University of Oklahoma (US)
  • Indiana University School of Medicine (US)
  • City University of New York (US)
  • The University of Texas at San Antonio Health Science Center (US)
  • Indian Health Service (US)
  • Health Sciences Centre (CA)
  • Yale University (US)
Corresponding author
Zeitler, Philip
ORCID
Venue
Diabetes Care
Publisher
American Diabetes Association
Published
2016-08-11
Volume
39
Issue
9
Pages
1635-1642
ISSN
  • 0149-5992 (ISSN-L)
  • 1935-5548
DOI
10.2337/dc16-1066
PMC
PMC5314694
OpenAlex
W2499174776
Cited by
381
References
66
Citations by year
2026: 12 · 2025: 28 · 2024: 38 · 2023: 50 · 2022: 64 · 2021: 53 · 2020: 41 · 2019: 28 · 2018: 35 · 2017: 28 · 2016: 3
FWCI
31.50
Type
journal article
Language
en
Open access
Licence
diabetesjournals.org/site/license (vor, 12 d)
Locations
  • Diabetes Care (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • American Diabetes Association
  • Bristol-Myers Squibb
  • Eli Lilly and Company
  • AstraZeneca
  • Sanofi
  • Pediatric Endocrine Society
  • Novo Nordisk
  • International Society for Pediatric and Adolescent Diabetes
  • National Institutes of Health (UL1TR001863)
  • Agency for Healthcare Research and Quality
  • National Institute of Diabetes and Digestive and Kidney Diseases (P30DK045735)
  • National Center for Advancing Translational Sciences
  • Daiichi Sankyo Europe
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
Keywords
youth-onset type 2 diabetes, pediatric type 2 diabetes, adolescents, young adults, diabetes pathophysiology, diabetes complications, psychosocial impact, diabetes prevention, diabetes treatment, treatment options, research priorities
MeSH terms
Adolescent, Child, Delivery of Health Care, Diabetes Mellitus, Type 2, Diet Therapy, Ethnicity, Exercise Therapy, Humans, Hypoglycemic Agents, Minority Groups, Risk, Socioeconomic Factors, United States, Age of Onset, Disease Management, Consensus, Risk Reduction Behavior, Diabetes Complications, Allostasis, Young Adult

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