Global, regional, and national burden of diabetes from 1990 to 2021, with projections of prevalence to 2050: a systematic analysis for the Global Burden of Disease Study 2021
Open accessAbstract
BACKGROUND: Diabetes is one of the leading causes of death and disability worldwide, and affects people regardless of country, age group, or sex. Using the most recent evidentiary and analytical framework from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD), we produced location-specific, age-specific, and sex-specific estimates of diabetes prevalence and burden from 1990 to 2021, the proportion of type 1 and type 2 diabetes in 2021, the proportion of the type 2 diabetes burden attributable to selected risk factors, and projections of diabetes prevalence through 2050. METHODS: Estimates of diabetes prevalence and burden were computed in 204 countries and territories, across 25 age groups, for males and females separately and combined; these estimates comprised lost years of healthy life, measured in disability-adjusted life-years (DALYs; defined as the sum of years of life lost [YLLs] and years lived with disability [YLDs]). We used the Cause of Death Ensemble model (CODEm) approach to estimate deaths due to diabetes, incorporating 25 666 location-years of data from vital registration and verbal autopsy reports in separate total (including both type 1 and type 2 diabetes) and type-specific models. Other forms of diabetes, including gestational and monogenic diabetes, were not explicitly modelled. Total and type 1 diabetes prevalence was estimated by use of a Bayesian meta-regression modelling tool, DisMod-MR 2.1, to analyse 1527 location-years of data from the scientific literature, survey microdata, and insurance claims; type 2 diabetes estimates were computed by subtracting type 1 diabetes from total estimates. Mortality and prevalence estimates, along with standard life expectancy and disability weights, were used to calculate YLLs, YLDs, and DALYs. When appropriate, we extrapolated estimates to a hypothetical population with a standardised age structure to allow comparison in populations with different age structures. We used the comparative risk assessment framework to estimate the risk-attributable type 2 diabetes burden for 16 risk factors falling under risk categories including environmental and occupational factors, tobacco use, high alcohol use, high body-mass index (BMI), dietary factors, and low physical activity. Using a regression framework, we forecast type 1 and type 2 diabetes prevalence through 2050 with Socio-demographic Index (SDI) and high BMI as predictors, respectively. FINDINGS: In 2021, there were 529 million (95% uncertainty interval [UI] 500-564) people living with diabetes worldwide, and the global age-standardised total diabetes prevalence was 6·1% (5·8-6·5). At the super-region level, the highest age-standardised rates were observed in north Africa and the Middle East (9·3% [8·7-9·9]) and, at the regional level, in Oceania (12·3% [11·5-13·0]). Nationally, Qatar had the world's highest age-specific prevalence of diabetes, at 76·1% (73·1-79·5) in individuals aged 75-79 years. Total diabetes prevalence-especially among older adults-primarily reflects type 2 diabetes, which in 2021 accounted for 96·0% (95·1-96·8) of diabetes cases and 95·4% (94·9-95·9) of diabetes DALYs worldwide. In 2021, 52·2% (25·5-71·8) of global type 2 diabetes DALYs were attributable to high BMI. The contribution of high BMI to type 2 diabetes DALYs rose by 24·3% (18·5-30·4) worldwide between 1990 and 2021. By 2050, more than 1·31 billion (1·22-1·39) people are projected to have diabetes, with expected age-standardised total diabetes prevalence rates greater than 10% in two super-regions: 16·8% (16·1-17·6) in north Africa and the Middle East and 11·3% (10·8-11·9) in Latin America and Caribbean. By 2050, 89 (43·6%) of 204 countries and territories will have an age-standardised rate greater than 10%. INTERPRETATION: Diabetes remains a substantial public health issue. Type 2 diabetes, which makes up the bulk of diabetes cases, is largely preventable and, in some cases, potentially reversible if identified and managed early in the disease course. However, all evidence indicates that diabetes prevalence is increasing worldwide, primarily due to a rise in obesity caused by multiple factors. Preventing and controlling type 2 diabetes remains an ongoing challenge. It is essential to better understand disparities in risk factor profiles and diabetes burden across populations, to inform strategies to successfully control diabetes risk factors within the context of multiple and complex drivers. FUNDING: Bill & Melinda Gates Foundation.
AI snapshot
Written from the paper’s full text.
TL;DR
In 2021, an estimated 529 million people worldwide were living with diabetes, with a global age-standardised prevalence of 6·1%, and type 2 diabetes accounted for 96·0% of cases and 95·4% of diabetes DALYs. Projections indicate more than 1·31 billion people will have diabetes by 2050, with no countries or territories expected to see prevalence decrease.
Key findings
In 2021, there were 529 million (95% UI 500–564) people with diabetes globally, and the global age-standardised total diabetes prevalence was 6·1% (5·8–6·5); type 2 diabetes made up 96·0% (95·1–96·8) of cases and 95·4% (94·9–95·9) of DALYs.
- The highest age-standardised rates were in north Africa and the Middle East (9·3% [8·7–9·9]) and, regionally, Oceania (12·3% [11·5–13·0]); Qatar had the highest age-specific prevalence at 76·1% (73·1–79·5) in people aged 75–79 years.
- High BMI was the leading risk factor, accounting for 52·2% (25·5–71·8) of global type 2 diabetes DALYs in 2021, and its contribution rose by 24·3% (18·5–30·4) between 1990 and 2021.
- By 2050, more than 1·31 billion (1·22–1·39) people are projected to have diabetes, with global age-standardised total prevalence expected to reach 9·8% (9·4–10·2); 89 (43·6%) of 204 countries and territories are projected to exceed 10%, and no countries are expected to see a decrease.
Methods
The study produced estimates for 204 countries and territories across 25 age groups for males and females separately and combined, covering prevalence, mortality, YLLs, YLDs, and DALYs from 1990 to 2021, plus type-specific proportions, risk-attributable burden, and forecasts to 2050.
- Mortality was modelled with CODEm using 25 666 location-years of vital registration and verbal autopsy data; non-fatal estimates used DisMod-MR 2.1 with 1527 location-years from 172 countries, and type 2 diabetes was computed by subtracting type 1 diabetes from total diabetes.
- Risk-attributable type 2 diabetes burden was estimated for 16 risk factors using comparative risk assessment; forecasting used regression models with Socio-demographic Index for type 1 diabetes and high BMI for type 2 diabetes.
Limitations
Stated by the paper: self-reported diabetes not validated by blood glucose tests was excluded; estimates and forecasts do not reflect COVID-19 impacts in 2020–2021; ICD coding variation and reallocation of unspecified diabetes deaths relied on data from high-income and high-middle-income locations; single glucose tests may overestimate prevalence; blood collection method was missing for about half of data sources; gestational and monogenic diabetes were not modelled; all individuals younger than 15 years were assumed to have type 1 diabetes; and risk factor analyses were limited to modifiable risk–outcome pairs, with no cohort effects except tobacco.
- Evident from the text: type 2 diabetes estimates were derived by subtracting type 1 diabetes from total diabetes because available data labelled as type 2 were not considered accurate, so type 2 estimates depend on the type 1 model; forecasts use only SDI for type 1 and high BMI for type 2 as predictors, not all known risk factors.
Model-written summary. Check it against the paper before relying on it.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
20 of 41 cited sources checked · 9 supported · 0 flagged · accuracy not yet measured
- Study design and conductcitation
ICD coding practices documenting the underlying cause of death can vary.
“Other limitations of our study include, first, that ICD coding practices documenting the underlying cause of death can vary.”
Quote in the paperNot a substantial claim2 of 3 sources checked- cites [84] Jougla, 1992, Death certificate coding practices related to diabetes in European countries—the ‘EURODIAB Subarea C’ Study, Int J Epidemiol source
- cites [85] McEwen, 2006, Diabetes reporting as a cause of death: results from the Translating Research Into Action for Diabetes (TRIAD) study, Diabetes Care source
- cites [86] Rampatige, 2014, Systematic review of statistics on causes of deaths in hospitals: strengthening the evidence for policy-makers, Bull World Health Organ source
- Interpretationreasoning
Differences between estimates produced by GBD and IDF or NCD-RisC are likely to be due to differences in methods, case inclusion criteria, and data sources used.
“Differences between estimates produced by GBD and IDF or NCD-RisC are likely to be due to differences in methods, case inclusion criteria, and data sources used.”
Quote in the paperNot a substantial claim1 of 2 sources checked- cites [4] 2021
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
- cites [11] Zhou, 2016, Worldwide trends in diabetes since 1980: a pooled analysis of 751 population-based studies with 4·4 million participants, Lancet source
The Discussion (page not provided) reports that this paper’s diabetes estimates differed from IDF estimates in some countries and regions. The Methods describe its data sources and diabetes definitions, but our copy does not say that differences between GBD and IDF or NCD-RisC estimates are likely caused by differences in methods, case inclusion criteria, and data sources. (LLM, conf=0.78)
Experimental — accuracy not yet measured
- Study design and conductcitation
Under the GBD's comparative risk assessment framework, we do not currently capture risk factors that have been reported in the literature for type 1 diabetes.
“Under the GBD's comparative risk assessment framework, we do not currently capture risk factors that have been reported in the literature for type 1 diabetes.93, 94”
Quote in the paperNot a substantial claim1 of 2 sources checked - Findingown data
At the super-region level, the highest age-standardised total diabetes prevalence rate in 2021 was in north Africa and the Middle East, at 9·3% (95% UI 8·7-9·9).
“At the super-region level, the highest age-standardised rates were observed in north Africa and the Middle East (9·3% [8·7–9·9])”
- Also stated in: § Total diabetes prevalence · plain
“north Africa and the Middle East had an age-standardised total diabetes prevalence rate of 9·3% (8·7–9·9)”
Quote in the paperNot a substantial claim - Also stated in: § Total diabetes prevalence · plain
- Findingown data
In 2021, type 2 diabetes accounted for 96·0% (95% UI 95·1-96·8) of diabetes cases worldwide.
“type 2 diabetes, which in 2021 accounted for 96·0% (95·1–96·8) of diabetes cases”
Quote in the paperNot a substantial claim- The authors state this as an assumption: All deaths due to diabetes in people younger than 15 years were from type 1 diabetes.
- The authors state this as an assumption: There was no remission (no cure) in the type 1 diabetes model.
- The authors state this as an assumption: All diabetes cases in people aged younger than 15 years were type 1 diabetes.
- The authors state this as an assumption: All patients aged younger than 15 years with diabetes had sought hospital care due to their insulin dependence.
- Findingown data
Nationally, Qatar had the world's highest age-specific prevalence of diabetes in 2021, at 76·1% (95% UI 73·1-79·5) in individuals aged 75-79 years.
“Nationally, Qatar had the world's highest age-specific prevalence of diabetes, at 76·1% (73·1–79·5) in individuals aged 75–79 years.”
Quote in the paperNot a substantial claim - Findingown data
In 2021, there were 529 million (95% UI 500-564) people living with diabetes worldwide.
“In 2021, there were 529 million (95% uncertainty interval [UI] 500–564) people living with diabetes worldwide”
- Also stated in: § Total diabetes prevalence · plain
“In 2021, there were 529 million (95% UI 500–564) people of all ages, worldwide, living with diabetes”
Quote in the paperSubstantial claim - Also stated in: § Total diabetes prevalence · plain
- Findingown data
In 2021, type 2 diabetes accounted for 95·4% (95% UI 94·9-95·9) of diabetes DALYs worldwide.
“and 95·4% (94·9–95·9) of diabetes DALYs worldwide.”
Quote in the paperNot a substantial claim- The authors state this as an assumption: All deaths due to diabetes in people younger than 15 years were from type 1 diabetes.
- The authors state this as an assumption: There was no remission (no cure) in the type 1 diabetes model.
- The authors state this as an assumption: All diabetes cases in people aged younger than 15 years were type 1 diabetes.
- The authors state this as an assumption: All patients aged younger than 15 years with diabetes had sought hospital care due to their insulin dependence.
- Findingown data
The global age-standardised total diabetes prevalence was 6·1% (95% UI 5·8-6·5) in 2021.
“the global age-standardised total diabetes prevalence was 6·1% (5·8–6·5)”
- Also stated in: § Total diabetes prevalence · plain
“yielding a global age-standardised prevalence of 6·1% (5·8–6·5; figure 1)”
Quote in the paperNot a substantial claim - Also stated in: § Total diabetes prevalence · plain
- Findingown data
The contribution of high BMI to type 2 diabetes DALYs rose by 24·3% (95% UI 18·5-30·4) worldwide between 1990 and 2021.
“The contribution of high BMI to type 2 diabetes DALYs rose by 24·3% (18·5–30·4) worldwide between 1990 and 2021.”
Quote in the paperNot a substantial claim - Findingown data
At the regional level, the highest age-standardised total diabetes prevalence rate in 2021 was in Oceania, at 12·3% (95% UI 11·5-13·0).
“at the regional level, in Oceania (12·3% [11·5–13·0])”
- Also stated in: § Total diabetes prevalence · plain
“Oceania had the highest regional age-standardised prevalence, at 12·3% (11·5–13·0)”
Quote in the paperNot a substantial claim - Also stated in: § Total diabetes prevalence · plain
- Findingown data
In 2021, 52·2% (95% UI 25·5-71·8) of global type 2 diabetes DALYs were attributable to high BMI.
“In 2021, 52·2% (25·5–71·8) of global type 2 diabetes DALYs were attributable to high BMI.”
Quote in the paperNot a substantial claim - Findingown data
By 2050, more than 1·31 billion (95% UI 1·22-1·39) people are projected to have diabetes.
“By 2050, more than 1·31 billion (1·22–1·39) people are projected to have diabetes”
- Also stated in: § Funding · plain
“At the current pace, we project that more than 1·31 billion people will be living with diabetes by 2050”
Quote in the paperSubstantial claim- The authors state this as an assumption: Annual remission in the total diabetes model could be no more than 1%.
- Also stated in: § Funding · plain
- Findingown data
In people aged 30-34 years, ten countries and territories-all in Oceania-had an age-specific total diabetes prevalence that exceeded 10%.
“In people aged 30–34 years, ten countries and territories—all in Oceania—had an age-specific prevalence that exceeded 10%:”
Quote in the paperNot a substantial claim - Findingown data
At the regional level, Oceania had the highest age-specific total diabetes prevalence in the world, at 43.0% (40.7-45.9) in people aged 75-79 years.
“At the regional level, Oceania had the highest age-specific total diabetes prevalence in the world, at 43·0% (40·7–45·9) in people aged 75–79 years.”
Quote in the paperNot a substantial claim - Findingown data
In western Europe, 89.3% (87.0-91.5) of diabetes cases were due to type 2 diabetes.
“and 89·3% (87·0–91·5) in western Europe.”
Quote in the paperNot a substantial claim - Findingown data
In central Latin America, southern sub-Saharan Africa, and the Caribbean, age-standardised diabetes prevalence among females was more than 10% higher than in males.
“but prevalence among females was more than 10% higher than in males in central Latin America, southern sub-Saharan Africa, and the Caribbean.”
Quote in the paperNot a substantial claim - Findingown data
In 2021, there were 485 million (95% UI 456-517) adults aged 20-79 years with diabetes.
“We estimated there were 485 million (456–517) adults aged 20–79 years with diabetes in 2021”
Quote in the paperNot a substantial claim - Findingown data
The global male-to-female ratio of age-standardised total diabetes prevalence was 1.14 (95% UI 1.13-1.15).
“with a male-to-female sex ratio of 1·14 (1·13–1·15)”
Quote in the paperNot a substantial claim - Findingown data
Type 2 diabetes prevalence made up more than 80% of total diabetes cases in all 204 countries and territories.
“Type 2 diabetes prevalence made up more than 80% of total diabetes cases in all 204 countries and territories”
Quote in the paperNot a substantial claim - Findingown data
Type 2 diabetes cases made up 96.0% (95% UI 95.1-96.8) of all diabetes cases.
“Type 2 diabetes cases made up 96·0% (95% UI 95·1–96·8) of all diabetes cases.”
Quote in the paperNot a substantial claim - Findingown data
In 2021, age-standardised total diabetes prevalence rates were greater than 10% in 11 countries in north Africa and the Middle East: Iraq, Kuwait, Qatar, Bahrain, Afghanistan, Morocco, Jordan, Saudi Arabia, Lebanon, Libya, and Algeria.
“with country-specific rates of more than 10% in 11 countries in this region: Iraq (15·3%; 14·3–16·2), Kuwait (15·2%; 14·1–16·3), Qatar (15·1%; 14·0–16·2), Bahrain (15·0%; 14·1–15·8), Afghanistan (14·6%; 13·5–15·5), Morocco (13·8%; 12·7–14·7), Jordan (13·5%; 12·6–14·5), Saudi Arabia (11·3%; 10·6–12·0), Lebanon (11·1%; 10·3–11·8), Libya (10·6%; 9·9–11·6), and Algeria (10·0%; 9·3–10·7).”
Quote in the paperNot a substantial claim - Findingown data
In 2021, eastern sub-Saharan Africa had the lowest regional diabetes prevalence, at 2·9% (95% UI 2·7-3·1).
“Eastern sub-Saharan Africa had the lowest regional diabetes prevalence, at 2·9% (2·7–3·1).”
Quote in the paperNot a substantial claim - Findingown data
By 2050, 89 (43·6%) of 204 countries and territories will have an age-standardised diabetes prevalence rate greater than 10%.
“By 2050, 89 (43·6%) of 204 countries and territories will have an age-standardised rate greater than 10%.”
Quote in the paperNot a substantial claim- The authors state this as an assumption: Annual remission in the total diabetes model could be no more than 1%.
- Findingown data
Globally, total diabetes prevalence exceeded 20% in every age group between 65-95 years.
“Globally, total diabetes prevalence exceeded 20% in every age group between 65–95 years”
Quote in the paperNot a substantial claim - Findingown data
More than 90% of the age-standardised diabetes prevalence rate in every super-region was due to type 2 diabetes.
“More than 90% of the age-standardised diabetes prevalence rate in every super-region was due to type 2 diabetes.”
Quote in the paperNot a substantial claim - Findingown data
Of the 140 (68.6%) countries and territories where diabetes was more prevalent in males than in females, in three countries-Angola, Uganda, and Gabon-male prevalence was more than 50% higher than female prevalence.
“Of the 140 (68·6%) countries and territories where diabetes was more prevalent in males than in females, in three countries—Angola, Uganda, and Gabon—the male prevalence was more than 50% higher than the female prevalence”
Quote in the paperNot a substantial claim - Findingown data
The highest country-level age-specific total diabetes prevalence was in Qatar, at 76.1% (73.1-79.5) in people aged 75-79 years.
“The highest country-level prevalence was found in Qatar, at 76·1% (73·1–79·5) in people aged 75–79 years.”
Quote in the paperNot a substantial claim - Findingown data
The male-to-female ratio of age-standardised total diabetes prevalence varied geographically, from 1.26 (1.24-1.28) in the high-income super-region to 0.96 (0.94-0.97) in the Latin America and Caribbean super-region.
“The ratio varied geographically, from 1·26 (1·24–1·28) in the high-income super-region to 0·96 (0·94–0·97) in the Latin America and Caribbean super-region.”
Quote in the paperNot a substantial claim - Findingown data
In 2021, age-standardised diabetes prevalence exceeded 10% in 43 countries and territories.
“The age-standardised diabetes prevalence exceeded 10% in 43 countries and territories in 2021 (figure 1).”
Quote in the paperNot a substantial claim - Findingown data
Globally, total diabetes prevalence was less than 1% in age groups younger than 20 years.
“but was less than 1% in age groups younger than 20 years.”
Quote in the paperNot a substantial claim - Findingown data
Approximately 11·1% of deaths coded to diabetes were reassigned from garbage codes.
“Approximately 11·1% of deaths coded to diabetes were reassigned from garbage codes.”
Quote in the paperNot a substantial claim - Findingown data
In six countries-Azerbaijan, Haiti, Laos, Mauritania, Zimbabwe, and Belize-age-standardised diabetes prevalence in males was more than 20% lower than in females.
“and in six countries—Azerbaijan, Haiti, Laos, Mauritania, Zimbabwe, and Belize—prevalence in males was more than 20% lower than in females.”
Quote in the paperNot a substantial claim - Findingown data
Type 2 diabetes prevalence made up more than 90% of total diabetes cases in 183 (89.7%) countries and territories.
“and more than 90% of total diabetes cases in 183 (89·7%) countries and territories.”
Quote in the paperNot a substantial claim - Findingown data
More than 50% of deaths coded to diabetes did not specify a type.
“More than 50% of deaths coded to diabetes did not specify a type.”
Quote in the paperSubstantial claim - Findingown data
Global diabetes prevalence peaked between ages 75-79 years, at 24.4% (95% UI 22.3-26.2).
“Global diabetes prevalence peaked between ages 75–79 years, at 24·4% (95% UI 22·3–26·2).”
Quote in the paperNot a substantial claim - Findingown data
In 64 (31.4%) countries and territories, age-standardised diabetes prevalence was lower in males than in females.
“In 64 (31·4%) countries and territories, age-standardised diabetes prevalence was lower in males than in females”
Quote in the paperNot a substantial claim - Findingown data
In central sub-Saharan Africa, age-standardised diabetes prevalence in males was 1.40 (1.30-1.48) times higher than in females.
“At the regional level, the age-standardised diabetes prevalence in males was 1·40 (1·30–1·48) times higher than in females in central sub-Saharan Africa”
Quote in the paperNot a substantial claim - Findingown data
In Australasia, 86.4% (83.3-89.4) of diabetes cases were due to type 2 diabetes.
“In two regions, less than 90% of diabetes cases were due to type 2 diabetes: 86·4% (83·3–89·4) in Australasia”
Quote in the paperNot a substantial claim - Findingown data
In 2021, 15 of 18 countries and territories in Oceania had an age-standardised diabetes prevalence greater than 10%.
“where 15 of 18 countries and territories had a prevalence greater than 10%”
Quote in the paperNot a substantial claim - Findingown data
The age-standardised type 2 diabetes prevalence is projected to increase by more than 100% in 11 countries in three regions: seven countries (Oman, United Arab Emirates, Syria, Iran, Libya, Sudan, and Saudi Arabia) in north Africa and the Middle East, two countries (Kenya and Tanzania) in eastern sub-Saharan Africa, and two countries (Zimbabwe and Botswana) in southern sub-Saharan Africa.
“The age-standardised type 2 diabetes prevalence is projected to increase by more than 100% in 11 countries in three regions: seven countries (Oman, United Arab Emirates, Syria, Iran, Libya, Sudan, and Saudi Arabia) in north Africa and the Middle East, two countries (Kenya and Tanzania) in eastern sub-Saharan Africa, and two countries (Zimbabwe and Botswana) in southern sub-Saharan Africa.”
Quote in the paperNot a substantial claim - Findingown data
Environmental or occupational risks combined accounted for 19.6% (12.7-26.5) of type 2 diabetes DALYs.
“Among the other risk factor groups, dietary risks combined accounted for 25·7% (8·6–40·7), environmental or occupational risks combined accounted for 19·6% (12·7–26·5), tobacco use accounted for 12·1% (4·5–20·9), low physical activity accounted for 7·4% (3·0–11·2), and alcohol use accounted for 1·8% (0·3–3·9) of type 2 diabetes DALYs.”
Quote in the paperNot a substantial claim - Findingown data
The age-standardised diabetes prevalence is projected to be higher than 10% in two super-regions: north Africa and the Middle East (16.8% [16.1-17.6]) and Latin America and Caribbean (11.3% [10.8-11.9]).
“The age-standardised diabetes prevalence is projected to be higher than 10% in two super-regions: north Africa and the Middle East (16·8% [16·1–17·6]) and Latin America and Caribbean (11·3% [10·8–11·9]).”
Quote in the paperNot a substantial claim - Findingown data
Six regions (north Africa and the Middle East, high-income North America, central Asia, Oceania, Andean Latin America, and southern Latin America) showed a prevalence increase of more than 100% from 1990 to 2021.
“Six regions (north Africa and the Middle East, high-income North America, central Asia, Oceania, Andean Latin America, and southern Latin America) showed a prevalence increase of more than 100% from 1990 to 2021, while six additional regions (western Europe, southern sub-Saharan Africa, eastern Europe, south Asia, high-income Asia Pacific, and central sub-Saharan Africa) showed an increase of more”
Quote in the paperNot a substantial claim - Findingown data
In 2021, 58.9 million (95% UI 44.2-73.9) DALYs or 76.5% (58.0-87.5) of DALYs due to type 2 diabetes were attributable to risk factors.
“In 2021, 58·9 million (95% UI 44·2–73·9) DALYs or 76·5% (58·0–87·5) of DALYs due to type 2 diabetes were attributable to risk factors.”
Quote in the paperNot a substantial claim - Findingown data
High BMI contributed more than 50% of DALYs in 167 (81.9%) countries and territories.
“High BMI contributed more than 50% of DALYs in 167 (81·9%) countries and territories.”
Quote in the paperNot a substantial claim - Findingown data
Six additional regions (western Europe, southern sub-Saharan Africa, eastern Europe, south Asia, high-income Asia Pacific, and central sub-Saharan Africa) showed an increase of more than 90% from 1990 to 2021.
“Six regions (north Africa and the Middle East, high-income North America, central Asia, Oceania, Andean Latin America, and southern Latin America) showed a prevalence increase of more than 100% from 1990 to 2021, while six additional regions (western Europe, southern sub-Saharan Africa, eastern Europe, south Asia, high-income Asia Pacific, and central sub-Saharan Africa) showed an increase of more”
Quote in the paperNot a substantial claim - Findingown data
We found a positive correlation between economic development and the incidence of type 1 diabetes.
“Moreover, as with other autoimmune diseases, we found a positive correlation between economic development and the incidence of type 1 diabetes.”
Quote in the paperNot a substantial claim - Findingown data
Low physical activity accounted for 7.4% (3.0-11.2) of type 2 diabetes DALYs.
“Among the other risk factor groups, dietary risks combined accounted for 25·7% (8·6–40·7), environmental or occupational risks combined accounted for 19·6% (12·7–26·5), tobacco use accounted for 12·1% (4·5–20·9), low physical activity accounted for 7·4% (3·0–11·2), and alcohol use accounted for 1·8% (0·3–3·9) of type 2 diabetes DALYs.”
Quote in the paperNot a substantial claim - Findingown data
Between 1990 and 2021, the global age-standardised DALY rate for diabetes increased by 38.6% (29.7-45.3).
“Global | Global | 79 200 (67 800 to 92 500) | 189·8% (171·1 to 203·4) | 915·0 (782·6 to 1067·4) | 38·6% (29·7 to 45·3)”
Quote in the paperNot a substantial claim - Findingown data
Dietary risks combined accounted for 25.7% (8.6-40.7) of type 2 diabetes DALYs.
“Among the other risk factor groups, dietary risks combined accounted for 25·7% (8·6–40·7), environmental or occupational risks combined accounted for 19·6% (12·7–26·5), tobacco use accounted for 12·1% (4·5–20·9), low physical activity accounted for 7·4% (3·0–11·2), and alcohol use accounted for 1·8% (0·3–3·9) of type 2 diabetes DALYs.”
Quote in the paperNot a substantial claim - Findingown data
There are no countries and territories where diabetes prevalence rates are expected to decrease by 2050.
“There are no countries and territories where diabetes prevalence rates are expected to decrease (appendix table S23).”
Quote in the paperNot a substantial claim - Findingown data
The age-standardised global prevalence of type 1 diabetes is expected to increase by 23.9% (95% UI 17.8-32.4), from 0.2% (0.2-0.3) in 2021 to 0.3% (0.3-0.4) in 2050.
“The age-standardised global prevalence of type 1 diabetes is expected to increase by 23·9% (95% UI 17·8–32·4), from 0·2% (0·2–0·3) in 2021 to 0·3% (0·3–0·4) in 2050 (figure 4; appendix figure S26).”
Quote in the paperNot a substantial claim- The authors state this as an assumption: All individuals younger than 15 years have type 1 diabetes.
- The authors state this as an assumption: SDI is a good proxy for better access to care leading to a lower case fatality rate, and to increases in type 1 diabetes prevalence.
- Findingown data
Of the 16 risk factors analysed, high BMI was the primary risk factor for type 2 diabetes worldwide, accounting for 52.2% (25.5-71.8) of global type 2 diabetes DALYs.
“Of the 16 risk factors we analysed, high BMI was the primary risk factor for type 2 diabetes worldwide, accounting for 52·2% (25·5–71·8) of global type 2 diabetes DALYs.”
- Also stated in: § Discussion · plain
“Our estimates showed high BMI to be the primary risk factor for type 2 diabetes, contributing more than 50% of global DALYs in 2021.”
Quote in the paperSubstantial claim - Also stated in: § Discussion · plain
- Findingown data
The increase in global age-standardised diabetes prevalence between 1990 and 2021 exceeded 100% in two super-regions: north Africa and the Middle East (161.5%; 154.3-168.7) and the high-income super-region (114.8%; 109.6-119.7).
“This increase exceeded 100% in two super-regions: north Africa and the Middle East (161·5%; 154·3–168·7) and the high-income super-region (114·8%; 109·6–119·7).”
Quote in the paperNot a substantial claim - Findingown data
In south Asia, high BMI contributed less than 40% of type 2 diabetes DALYs.
“In south Asia, high BMI contributed less than 40% of type 2 diabetes DALYs.”
Quote in the paperNot a substantial claim - Findingown data
Among the 21 regions analysed, the proportion of type 2 diabetes DALYs due to high BMI ranged from 68.0% (95% UI 37.8-85.8) in north Africa and the Middle East to 39.5% (17.1-58.4) in south Asia.
“Among the 21 regions analysed, the proportion of type 2 diabetes DALYs due to high BMI ranged from 68·0% (95% UI 37·8–85·8) in north Africa and the Middle East to 39·5% (17·1–58·4) in south Asia.”
Quote in the paperNot a substantial claim - Findingown data
Alcohol use accounted for 1.8% (0.3-3.9) of type 2 diabetes DALYs.
“Among the other risk factor groups, dietary risks combined accounted for 25·7% (8·6–40·7), environmental or occupational risks combined accounted for 19·6% (12·7–26·5), tobacco use accounted for 12·1% (4·5–20·9), low physical activity accounted for 7·4% (3·0–11·2), and alcohol use accounted for 1·8% (0·3–3·9) of type 2 diabetes DALYs.”
Quote in the paperNot a substantial claim - Findingown data
High BMI contributed more than 60% of DALYs in 11 other regions: central Latin America, central Asia, southern Latin America, eastern Europe, southern sub-Saharan Africa, high-income North America, Australasia, tropical Latin America, central Europe, Andean Latin America, and Oceania.
“High BMI contributed more than 60% of DALYs in 11 other regions: central Latin America, central Asia, southern Latin America, eastern Europe, southern sub-Saharan Africa, high-income North America, Australasia, tropical Latin America, central Europe, Andean Latin America, and Oceania.”
Quote in the paperNot a substantial claim - Findingown data
The proportion of global type 2 diabetes DALYs attributable to high BMI increased by 24.3% (95% UI 18.5 to 30.4), from 42.2% (19.8 to 59.9) in 1990 to 52.2% (25.5 to 71.8) in 2021.
“The proportion of global type 2 diabetes DALYs attributable to high BMI increased by 24·3% (95% UI 18·5 to 30·4), from 42·2% (19·8 to 59·9) in 1990 to 52·2% (25·5 to 71·8) in 2021.”
- Also stated in: § Discussion · plain
“The association between high BMI and type 2 diabetes has intensified in recent decades, with the proportion of global type 2 diabetes DALYs attributable to high BMI growing by nearly 25% between 1990 and 2021.”
Quote in the paperSubstantial claim - Also stated in: § Discussion · plain
- Findingown data
Tobacco use accounted for 12.1% (4.5-20.9) of type 2 diabetes DALYs.
“Among the other risk factor groups, dietary risks combined accounted for 25·7% (8·6–40·7), environmental or occupational risks combined accounted for 19·6% (12·7–26·5), tobacco use accounted for 12·1% (4·5–20·9), low physical activity accounted for 7·4% (3·0–11·2), and alcohol use accounted for 1·8% (0·3–3·9) of type 2 diabetes DALYs.”
Quote in the paperNot a substantial claim - Findingown data
Every country and territory in three regions-Oceania, north Africa and the Middle East, and central Latin America-is projected to have a diabetes prevalence rate exceeding 10% by 2050.
“Every country and territory in three regions—Oceania, north Africa and the Middle East, and central Latin America—is projected to have a diabetes prevalence rate exceeding 10% by 2050.”
Quote in the paperNot a substantial claim - Findingown data
Between 1990 and 2021, the global age-standardised prevalence of diabetes increased by 90.5% (95% UI 85.8-93.6), from 3.2% (3.0-3.5) to 6.1% (5.8-6.5).
“Between 1990 and 2021, the global age-standardised prevalence of diabetes increased by 90·5% (95% UI 85·8–93·6), from 3·2% (3·0–3·5) to 6·1% (5·8–6·5; appendix table S22).”
Quote in the paperNot a substantial claim - Findingown data
The projected increase in age-standardised type 2 diabetes prevalence varies by super-region, from 82.7% (76.8-90.5) in north Africa and the Middle East to 30.3% (27.3-33.0) in the high-income region.
“This varies by super-region, from 82·7% (76·8–90·5) in north Africa and the Middle East to 30·3% (27·3–33·0) in the high-income region.”
Quote in the paperNot a substantial claim - Findingown data
High BMI contributed more than 60% of type 2 diabetes DALYs in three super-regions: north Africa and the Middle East; Latin America and Caribbean; and central Europe, eastern Europe, and central Asia.
“High BMI contributed more than 60% of type 2 diabetes DALYs in three super-regions: north Africa and the Middle East; Latin America and Caribbean; and central Europe, eastern Europe, and central Asia.”
Quote in the paperNot a substantial claim - Findingown data
The age-standardised diabetes prevalence increased by less than 30% in only two countries: Mexico (19.7% [16.7-22.4]) and the Philippines (29.1% [24.3-33.8]).
“The age-standardised diabetes prevalence increased by less than 30% in only two countries: Mexico (19·7% [16·7–22·4]) and the Philippines (29·1% [24·3–33·8]; appendix table S22).”
Quote in the paperNot a substantial claim - Findingown data
Age-standardised type 2 diabetes prevalence will increase by more than 70% in six regions: north Africa and the Middle East (82.7%; 76.8-90.5), east Asia (80.1%; 72.1-89.2), central sub-Saharan Africa (79.9%; 72.4-89.9), southern sub-Saharan Africa (74.7%; 67.9-83.7), central Latin America (74.7%; 68.5-80.2), and Australasia (71.9%; 63.6-81.8).
“Age-standardised type 2 diabetes prevalence will increase by more than 70% in six regions: north Africa and the Middle East (82·7%; 76·8–90·5), east Asia (80·1%; 72·1–89·2), central sub-Saharan Africa (79·9%; 72·4–89·9), southern sub-Saharan Africa (74·7%; 67·9–83·7), central Latin America (74·7%; 68·5–80·2), and Australasia (71·9%; 63·6–81·8).”
Quote in the paperNot a substantial claim - Interpretationown data
Total diabetes prevalence, especially among older adults, primarily reflects type 2 diabetes.
“Total diabetes prevalence—especially among older adults—primarily reflects type 2 diabetes”
Quote in the paperNot a substantial claim- The authors state this as an assumption: All deaths due to diabetes in people younger than 15 years were from type 1 diabetes.
- The authors state this as an assumption: There was no remission (no cure) in the type 1 diabetes model.
- The authors state this as an assumption: All diabetes cases in people aged younger than 15 years were type 1 diabetes.
- The authors state this as an assumption: All patients aged younger than 15 years with diabetes had sought hospital care due to their insulin dependence.
- Study design and conductnone given
Ensembles in the CODEm mortality model were selected on the basis of out-of-sample predictive validity testing.
“Ensembles were selected on the basis of out-of-sample predictive validity testing.”
Quote in the paperNot a substantial claim - Study design and conductown data
The present analysis does not reflect the potential impact of the COVID-19 pandemic on diabetes prevalence and burden.
“The present analysis does not reflect the potential impact of the COVID-19 pandemic on diabetes prevalence and burden since these data were not available at the time of the analysis.”
Quote in the paperNot a substantial claim - Study design and conductreasoning
Our GBD analysis deliberately excluded sources that rely on self-reported diabetes data.
“For example, our GBD analysis deliberately excluded sources that rely on self-reported diabetes data because we assumed that reporting bias would change over time and across location (eg, due to variability in diagnostic and screening efficacy), thus making bias adjustment challenging.”
Quote in the paperSubstantial claim- The authors state this as an assumption: Reporting bias in self-reported diabetes data changes over time and across location.
- Study design and conductown data
Our estimates and forecasts do not reflect a potential impact of the COVID-19 pandemic on diabetes prevalence and burden in 2020 and 2021.
“Additionally, our estimates and forecasts do not reflect a potential impact of the COVID-19 pandemic on diabetes prevalence and burden in 2020 and 2021.”
Quote in the paperNot a substantial claim - Interpretationown data
The projected increase in total diabetes prevalence is expected to be driven by type 2 diabetes.
“The projected increase in total diabetes prevalence is expected to be driven by type 2 diabetes.”
Quote in the paperNot a substantial claim - Study design and conductown data
The process of reallocating deaths coded as diabetes to type 1 or type 2 relied on data from high-income and high-middle-income locations that might not have been valid for dissimilar locations.
“However, this process relied on data from high-income and high-middle-income locations that might not have been valid for dissimilar locations.”
Quote in the paperNot a substantial claim - Interpretationreasoning
Diabetes is set to become an even greater public health issue over the coming three decades.
“Diabetes was already a substantial concern in 2021 and is set to become an even greater public health issue over the coming three decades”
Quote in the paperSubstantial claim - Study design and conductnone given
Many deaths that are coded as being caused by diabetes do not specify the diabetes type.
“Second, many deaths that are coded as being caused by diabetes do not specify the diabetes type.”
Quote in the paperNot a substantial claim
- May combine two claims. 31
- Classified as probably not a substantial claim. 44
- The quote only partly states this claim. 1
May combine two claims.
PremisecitationAll risk factors modelled have been shown to be associated with type 2 diabetes, but high air temperature and low air temperature are the only risk factors associated with type 1 diabetes.
“All risk factors have been shown to be associated with type 2 diabetes, but high air temperature and low air temperature are the only risk factors associated with type 1 diabetes.28”
Quote in the paperNot a substantial claim1 of 1 sources checked- cites [28] 2020, Global burden of 87 risk factors in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019, Lancet source
The Methods section (‘Determining the inclusion of risk–outcome pairs in GBD’; page unavailable) says high and low temperatures were evaluated against disease outcomes, but does not identify type 1 diabetes among them. Searches for type 1 diabetes, type 2 diabetes, and diabetes–temperature risk–outcome pairs found no passage establishing the claimed distinction or that all the relevant risk factors are associated with type 2 diabetes. (LLM, conf=0.72)
Experimental — accuracy not yet measured
Probably not a substantial claim: may not pass S3 (load-bearing).
PremisecitationAccording to IDF estimates, 537 million people worldwide had diabetes in 2021.
“estimates by the International Diabetes Federation (IDF) indicating that 537 million people worldwide had diabetes in 2021”
Quote in the paperNot a substantial claim1 of 2 sources checked- cites [4] 2021
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
- cites [10] Sun, 2022, IDF Diabetes Atlas: Global, regional and country-level diabetes prevalence estimates for 2021 and projections for 2045, Diabetes Res Clin Pract source
Probably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.
PremisecitationAccording to IDF estimates, diabetes resulted in health expenditures of US$966 billion globally in 2021, forecast to reach more than $1054 billion by 2045.
“resulting in health expenditures of US$966 billion globally, forecast to reach more than $1054 billion by 2045.4, 10”
Quote in the paperNot a substantial claim1 of 2 sources checked- cites [4] 2021
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
- cites [10] Sun, 2022, IDF Diabetes Atlas: Global, regional and country-level diabetes prevalence estimates for 2021 and projections for 2045, Diabetes Res Clin Pract source
The Results (Health expenditure) report global diabetes-related healthcare expenditure of USD 966 billion in 2021 and predict USD 1,054 billion for 2045. The source does not say the 2045 figure will be more than USD 1,054 billion; it gives that figure as the estimate. (LLM, conf=0.87)
Experimental — accuracy not yet measured
Probably not a substantial claim: may not pass S3 (load-bearing).
PremisecitationAccording to GBD 2019, diabetes was the eighth leading cause of death and disability combined in the world in 2019.
“According to estimates from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019, diabetes was the eighth leading cause of death and disability combined in the world”
Quote in the paperNot a substantial claim1 of 1 sources checked- cites [6] 2020, Global burden of 369 diseases and injuries in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019, Lancet source
The Results (Global trends; page unavailable) place diabetes among the ten leading causes of disability-adjusted life-years (DALYs) in both older age groups in 2019, and the Discussion describes it as a major contributor to disease burden. The passages in our copy do not establish that diabetes ranked eighth worldwide across all ages; searches for “eighth” and the global diabetes ranking did not find that rank. (LLM, conf=0.79)
Experimental — accuracy not yet measured
Probably not a substantial claim: may not pass S3 (load-bearing).
PremisecitationThe comparative risk assessment approach is predicated on a causal web of hierarchically organised, potentially overlapping health risks.
“the comparative risk assessment approach, a framework used by GBD since 2002 that is predicated on a causal web of hierarchically organised, potentially overlapping health risks.29, 37”
Quote in the paperNot a substantial claim1 of 2 sources checked- cites [29] Murray, 1997, Global mortality, disability, and the contribution of risk factors: Global Burden of Disease Study, Lancet source
- cites [37] Murray, 2003, Comparative quantification of health risks conceptual framework and methodological issues, Popul Health Metr source
The Introduction (page unavailable) identifies comparative risk assessment as a GBD framework and says it considers multiple stages in a causal network, including interactions and joint effects of risk factors. The Risk Quantification Models section (page unavailable) describes layers of a causal web, supporting the claim about hierarchically organised, potentially overlapping risks. The paper identifies the framework with the GBD 2000 study but does not establish that GBD has used it since 2002. (LLM, conf=0.85)
Experimental — accuracy not yet measured
Probably not a substantial claim: may not pass S3 (load-bearing).
PremisecitationIn 2019, nearly 460 million people across every country and age group were living with diabetes.
“with nearly 460 million people across every country and age group living with the disease in 2019.6”
Quote in the paperNot a substantial claim1 of 1 sources checked- cites [6] 2020, Global burden of 369 diseases and injuries in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019, Lancet source
The Discussion (Main findings; page unavailable) describes rising diabetes prevalence globally, and the Results (Global trends; page unavailable) identify diabetes as a major contributor to disease burden in 2019. Neither passage gives a count of nearly 460 million people living with diabetes or establishes the claim for every country and age group. (LLM, conf=0.78)
Experimental — accuracy not yet measured
Probably not a substantial claim: may not pass S3 (load-bearing).
PremisecitationThe 2016 NCD-RisC Study projected that the probability of meeting global targets to halt the rising diabetes prevalence by 2025 was lower than 1% for women and even lower for men.
“The 2016 NCD Risk Factor Collaboration (NCD-RisC) Study projected that the probability of meeting global targets to halt the rising diabetes prevalence by 2025 was lower than 1% for women and even lower for men.11”
Quote in the paperNot a substantial claim1 of 1 sources checked- cites [11] Zhou, 2016, Worldwide trends in diabetes since 1980: a pooled analysis of 751 population-based studies with 4·4 million participants, Lancet source
The Results state that, if post-2000 trends continue, the worldwide probability of meeting the 2025 diabetes target is lower than 1% for men but is 1% for women. The claim gets the ordering right, but incorrectly says the probability for women is lower than 1%. (LLM, conf=0.94)
Experimental — accuracy not yet measured
Probably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.
PremisecitationType 1 diabetes often develops during childhood, while type 2 diabetes has a strong genetic component and a robust association with obesity and a sedentary lifestyle.
“Type 1 diabetes often develops during childhood, while type 2 diabetes has a strong genetic component and a robust association with obesity and a sedentary lifestyle.10, 13”
Quote in the paperNot a substantial claim1 of 2 sources checked- cites [10] Sun, 2022, IDF Diabetes Atlas: Global, regional and country-level diabetes prevalence estimates for 2021 and projections for 2045, Diabetes Res Clin Pract source
The Discussion > Limitations passage says type 1 diabetes incidence peaks in childhood and links type 2 diabetes to excess body weight and sedentary behaviour. It does not describe a strong genetic component of type 2 diabetes; its discussion of genetic factors concerns type 1 diabetes. (LLM, conf=0.88)
Experimental — accuracy not yet measured - cites [13] Ahmad, 2022, Type 2 diabetes, Lancet source
Probably not a substantial claim: may not pass S3 (load-bearing).
PremisecitationDiabetes is a major risk factor for ischaemic heart disease and stroke.
“Diabetes is also a major risk factor for ischaemic heart disease and stroke,12”
Quote in the paperNot a substantial claim1 of 1 sources checked- cites [12] 2010, Diabetes mellitus, fasting blood glucose concentration, and risk of vascular disease: a collaborative meta-analysis of 102 prospective studies, Lancet source
Probably not a substantial claim: may not pass S2 (checkable), S3 (load-bearing).
InterpretationcitationEfforts that succeed in halting the rise in diabetes could mitigate or delay associated health complications if implemented early.
“Furthermore, efforts that succeed in halting the rise in diabetes could mitigate or delay associated health complications if implemented early.76, 77, 78, 79, 80”
Quote in the paperNot a substantial claim1 of 3 sources checked- cites [76] Aggarwal, 2020, Diabetes mellitus association with coronavirus disease 2019 (COVID-19) severity and mortality: a pooled analysis, J Diabetes source
- cites [77] Feldman, 2020, COVID-19 and diabetes: a collision and collusion of two diseases, Diabetes source
The Glycemic Control section reports better COVID-19 outcomes among people with diabetes whose blood glucose was well controlled. The Conclusions discuss improving care, but neither section addresses whether early efforts to halt the rise in diabetes could mitigate or delay its associated health complications; searches for diabetes prevention and early intervention found no such passage. (LLM, conf=0.75)
Experimental — accuracy not yet measured - cites [78] Kissela, 2005, Epidemiology of ischemic stroke in patients with diabetes: the greater Cincinnati/Northern Kentucky Stroke Study, Diabetes Care source
Probably not a substantial claim: may not pass S3 (load-bearing).
InterpretationcitationThe regional variation in sex differences in age-standardised diabetes prevalence rates revealed by our estimates is probably also related to variation in patterns in and the impact of obesity on type 2 diabetes, socioeconomic factors, and biological and hormonal differences.
“The regional variation in sex differences in age-standardised diabetes prevalence rates revealed by our estimates is probably also related to variation in patterns in and the impact of obesity on type 2 diabetes, socioeconomic factors, and biological and hormonal differences.48”
Quote in the paperNot a substantial claim1 of 1 sources checked- cites [48] Kautzky-Willer, 2016, Sex and gender differences in risk, pathophysiology and complications of type 2 diabetes mellitus, Endocr Rev source
May combine two claims.
PremisecitationVarious interventions and policies to address obesity have been developed and studied, but no programme to date has shown long-term, sustained, population-level reductions in obesity.
“Various interventions and policies to address obesity have been developed and studied,53, 54, 55, 56 but no programme to date has shown long-term, sustained, population-level reductions in obesity.57”
Quote in the paperNot a substantial claim2 of 3 sources checked- cites [53] Maniadakis, 2013, A systematic review of the effectiveness of taxes on nonalcoholic beverages and high-in-fat foods as a means to prevent obesity trends, Clinicoecon Outcomes Res source
The Discussion (page unavailable) says the evidence for pricing and tax policies reducing obesity rates is inconsistent. That supports a narrower concern about those policies, but the review does not establish that no obesity programme of any kind has achieved long-term, sustained, population-level reductions. (LLM, conf=0.84)
Experimental — accuracy not yet measured - cites [54] Puzziferri, 2014, Long-term follow-up after bariatric surgery: a systematic review, JAMA source
Citation 57 is attached to the claim that no programme has achieved sustained, population-level reductions in obesity. The Discussion and Abstract Conclusions address long-term follow-up and possible overestimation of outcomes after bariatric surgery, not population-level obesity trends or the effectiveness of programmes generally. Searches for sustained population-level reductions and obesity programmes found no passage addressing that claim; page numbers were unavailable in our copy. (LLM, conf=0.77)
Experimental — accuracy not yet measured - cites [55] Sun, 2017, The effectiveness and cost of lifestyle interventions including nutrition education for diabetes prevention: a systematic review and meta-analysis, J Acad Nutr Diet source
May combine two claims.
PremisecitationAlthough obesity is theoretically reversible and addressing it could provide the biggest opportunity to limit the advance of diabetes, current trends suggest that obesity rates are likely to continue to climb.
“Although obesity is theoretically reversible28, 51, 52 and addressing it could provide the biggest opportunity to limit the advance of diabetes, current trends suggest that obesity rates are likely to continue to climb.45”
Quote in the paperNot a substantial claim2 of 3 sources checked- cites [28] 2020, Global burden of 87 risk factors in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019, Lancet source
- cites [51] Afshin, 2017, Health effects of overweight and obesity in 195 countries, N Engl J Med source
- cites [52] Teufel, 2021, Body-mass index and diabetes risk in 57 low-income and middle-income countries: a cross-sectional study of nationally representative, individual-level data in 685 616 adults, Lancet source
May combine two claims.
Study design and conductcitationThere is growing evidence of type 2 diabetes occurring in younger individuals in many parts of the world, but we do not have population-based studies that distinguish type 1 diabetes from type 2 diabetes among people younger than 15 years across time, age, and location.
“Although there is growing evidence of type 2 diabetes occurring in younger individuals in many parts of the world,91, 92 we do not have population-based studies that distinguish type 1 diabetes from type 2 diabetes among people younger than 15 years across time, age, and location.”
Quote in the paperSubstantial claim1 of 2 sources checked- cites [91] Kao, 2016, Type 2 diabetes mellitus in children and adolescents, Aust Fam Physician
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
- cites [92] Nadeau, 2016, Youth-onset type 2 diabetes consensus report: current status, challenges, and priorities, Diabetes Care source
Probably not a substantial claim: may not pass S3 (load-bearing).
Findingown dataIn 2010, there were 321 million (95% UI 304-341) people aged 18 years and older with diabetes.
“and 321 million (304–341) people aged 18 years and older with diabetes in 2010”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
Findingown dataIn the 75-79 year age group, diabetes prevalence was lowest in central Europe, eastern Europe, and central Asia, at 19.8% (18.3-21.6).
“and lowest in central Europe, eastern Europe, and central Asia, at 19·8% (18·3–21·6; figure 2).”
Quote in the paperNot a substantial claimMay combine two claims.
Findingown dataGlobally in 2021, age-standardised total diabetes prevalence was 6.5% (95% UI 6.2-7.0) in males and 5.8% (5.4-6.1) in females.
“The global age-standardised total diabetes prevalence was higher in males than in females (6·5% [95% UI 6·2–7·0] vs 5·8% [5·4–6·1])”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
Findingnone givenThere was no difference in type-specific breakdown by sex.
“There was no difference in type-specific breakdown by sex.”
Quote in the paperNot a substantial claimMay combine two claims.
Findingown dataBy 2050, expected age-standardised total diabetes prevalence rates will be greater than 10% in two super-regions: 16·8% (95% UI 16·1-17·6) in north Africa and the Middle East and 11·3% (95% UI 10·8-11·9) in Latin America and Caribbean.
“with expected age-standardised total diabetes prevalence rates greater than 10% in two super-regions: 16·8% (16·1–17·6) in north Africa and the Middle East and 11·3% (10·8–11·9) in Latin America and Caribbean.”
Quote in the paperSubstantial claim- The authors state this as an assumption: Annual remission in the total diabetes model could be no more than 1%.
Probably not a substantial claim: may not pass S3 (load-bearing).
Findingown dataIn the 75-79 year age group, diabetes prevalence was highest in the north Africa and Middle East super-region, at 39.4% (36.3-42.3).
“In this age group, prevalence was highest in the north Africa and Middle East super-region, at 39·4% (36·3–42·3)”
Quote in the paperNot a substantial claimMay combine two claims.
Findingown dataIn 2021, age-standardised diabetes prevalence rates were greater than 20% in the Marshall Islands (22·2%; 95% UI 20·7-23·9) and American Samoa (21·4%; 95% UI 19·9-22·7).
“age-standardised prevalence rates were greater than 20% in the Marshall Islands, at 22·2% (20·7–23·9), and American Samoa, at 21·4% (19·9–22·7).”
Quote in the paperNot a substantial claimMay combine two claims.
Findingown dataDiabetes prevalence rates are driven almost entirely by type 2 diabetes, which accounted for more than 96% of diabetes cases worldwide in 2021.
“Because diabetes prevalence rates are driven almost entirely by type 2 diabetes, which accounted for more than 96% of diabetes cases worldwide in 2021, much of the following discussion will focus on type 2 diabetes.”
Quote in the paperSubstantial claimMay combine two claims.
Findingown dataThe age-standardised diabetes prevalence increased by more than 100% in 97 (47.5%) of 204 countries and territories and by more than 200% in three countries and one territory: Egypt (284.3%; 262.7-305.9), Greenland (263.6%; 236.8-296.3), Timor-Leste (225.3%; 206.7-243.7), and Seychelles (211.5%; 193.5-230.7).
“The age-standardised diabetes prevalence increased by more than 100% in 97 (47·5%) of 204 countries and territories and by more than 200% in three countries and one territory: Egypt (284·3%; 262·7–305·9), Greenland (263·6%; 236·8–296·3), Timor-Leste (225·3%; 206·7–243·7), and Seychelles (211·5%; 193·5–230·7).”
Quote in the paperNot a substantial claimMay combine two claims.
Findingown dataThe age-standardised global prevalence of type 2 diabetes is projected to rise by 61.2% (95% UI 56.2-68.1), from 5.9% (5.5-6.3) in 2021 to 9.5% (9.0-9.9) in 2050, affecting more than 1.27 billion (1.19-1.35) people.
“The age-standardised global prevalence of type 2 diabetes is projected to rise by 61·2% (95% UI 56·2–68·1), from 5·9% (5·5–6·3) in 2021 to 9·5% (9·0–9·9) in 2050, affecting more than 1·27 billion (1·19–1·35) people.”
- Also stated in: § Discussion · plain
“By 2050, we project a global increase in age-standardised type 2 diabetes prevalence of more than 60%, with increases of more than 70% in six regions: north Africa and the Middle East, east Asia, central sub-Saharan Africa, southern sub-Saharan Africa, central Latin America, and Australasia.”
Quote in the paperSubstantial claim- Also stated in: § Discussion · plain
Probably not a substantial claim: may not pass S3 (load-bearing).
Findingown dataThe global age-standardised diabetes DALY rate was 915.0 (782.6-1067.5) per 100,000.
“The global age-standardised diabetes DALY rate was 915·0 (782·6–1067·5) per 100 000”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
Findingown dataIn 47 (23.0%) countries and territories, age-standardised DALY rates were greater than 2000 per 100 000.
“In 47 (23·0%) countries and territories, age-standardised DALY rates were greater than 2000 per 100 000 (table).”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
Findingown dataGlobally in 2021, there were 37.8 million (95% UI 35.4-40.2) total diabetes-related YLLs.
“Globally, there were 37·8 million (95% UI 35·4–40·2) total diabetes-related YLLs”
Quote in the paperNot a substantial claimMay combine two claims.
Findingown dataBetween 2021 and 2050, the global age-standardised total diabetes prevalence is expected to increase by 59.7% (95% UI 54.7-66.0), from 6.1% (5.8-6.5) to 9.8% (9.4-10.2), resulting in 1.31 billion (1.22-1.39) people living with diabetes in 2050, or an annualised rate of change of 3.31%.
“Between 2021 and 2050, the global age-standardised total diabetes prevalence is expected to increase by 59·7% (95% UI 54·7–66·0), from 6·1% (5·8–6·5) to 9·8% (9·4–10·2), resulting in 1·31 billion (1·22–1·39) people living with diabetes in 2050, or an annualised rate of change of 3·31%.”
Quote in the paperSubstantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
Findingown dataType 2 diabetes made up 96.6% (96.0-97.3) of diabetes YLDs.
“96·6% (96·0–97·3) of YLDs”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
Findingown dataThe age-standardised DALY rate was more than 1000 per 100 000 in four GBD super-regions: Latin America and Caribbean, sub-Saharan Africa, north Africa and the Middle East, and south Asia.
“The age-standardised DALY rate was more than 1000 per 100 000 in four GBD super-regions: Latin America and Caribbean, sub-Saharan Africa, north Africa and the Middle East, and south Asia.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
Findingown dataThe global age-standardised diabetes YLD rate was 477.6 (340.7-637.4) per 100,000.
“and the YLD rate was 477·6 (340·7–637·4) per 100 000.”
Quote in the paperNot a substantial claimMay combine two claims.
Findingown dataAt the regional level, the increase in type 2 diabetes DALYs attributable to high BMI between 1990 and 2021 was greater than 45% in south Asia (58.0%; 44.0 to 75.4), central sub-Saharan Africa (48.8%; 35.8 to 61.2), and east Asia (45.7%; 33.5 to 57.3).
“At the regional level, the increase in type 2 diabetes DALYs attributable to high BMI between 1990 and 2021 was greater than 45% in south Asia (58·0%; 44·0 to 75·4), central sub-Saharan Africa (48·8%; 35·8 to 61·2), and east Asia (45·7%; 33·5 to 57·3).”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
Findingown dataType 2 diabetes made up 94.0% (93.6-94.6) of diabetes YLLs.
“Type 2 diabetes made up 94·0% (93·6–94·6) of diabetes YLLs”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
Findingown dataGlobally in 2021, there were 41.4 million (29.5-55.4) YLDs due to diabetes.
“and 41·4 million (29·5–55·4) YLDs”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
Findingown dataThe global age-standardised diabetes YLL rate was 437.4 (409.2-464.1) per 100,000.
“the YLL rate was 437·4 (409·2–464·1) per 100 000”
Quote in the paperNot a substantial claimMay combine two claims.
Findingown dataOf the projected increase in total diabetes prevalence between 2021 and 2050, 49.6% is driven by trends in obesity, and the remaining 50.4% is driven by demographic shifts.
“Of this increase, 49·6% is driven by trends in obesity, and the remaining 50·4% is driven by demographic shifts.”
Quote in the paperNot a substantial claimMay combine two claims.
Findingown dataDiabetes was especially prevalent in people aged 65 years and older in every location, but in some locations prevalence rates were high even in younger adults, exceeding 10% among those aged 30-34 years in ten countries, all in Oceania.
“Diabetes was especially prevalent in people aged 65 years and older in every location, but in some locations the prevalence rates were high even in younger adults, exceeding 10% among those aged 30–34 years in ten countries, all in Oceania.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
Findingown dataBetween 1990 and 2021, the global DALY count for diabetes increased by 189.8% (171.1-203.4).
“Global | Global | 79 200 (67 800 to 92 500) | 189·8% (171·1 to 203·4) | 915·0 (782·6 to 1067·4) | 38·6% (29·7 to 45·3)”
Quote in the paperNot a substantial claimMay combine two claims.
Findingown dataThere were an estimated 529 million people living with diabetes in 2021, a number projected to more than double to about 1.31 billion by 2050.
“There were an estimated 529 million people living with diabetes in 2021, a number we project will more than double to about 1·31 billion by 2050.”
Quote in the paperSubstantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
Findingown dataGlobally in 2021, there were 79.2 million (67.8-92.5) DALYs due to diabetes.
“yielding 79·2 million (67·8–92·5) DALYs due to diabetes in 2021”
Quote in the paperNot a substantial claimMay combine two claims.
Findingown dataAlthough there were increases in every super-region, the largest change in the proportion of type 2 diabetes DALYs attributable to high BMI occurred in south Asia, with an increase of 58.0% (44.0 to 75.4).
“Although there were increases in every super-region, the largest change occurred in south Asia, with an increase of 58·0% (44·0 to 75·4).”
Quote in the paperNot a substantial claimMay combine two claims.
Findingown dataIn 13 of 18 countries and territories in Oceania, ten of 21 countries in north Africa and the Middle East, and one country in the Caribbean, the diabetes prevalence will be greater than 20% by 2050.
“In 13 of 18 countries and territories in Oceania, ten of 21 countries in north Africa and the Middle East, and one country in the Caribbean, the diabetes prevalence will be greater than 20% by 2050.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
Findingown dataRegionally, the age-standardised DALY rate varied from a high of 3577.0 (95% UI 3157.0-4120.5) per 100 000 in Oceania to a low of 511.8 (402.0-648.3) per 100 000 in western Europe.
“Regionally, the age-standardised DALY rate varied from a high of 3577·0 (95% UI 3157·0–4120·5) per 100 000 in Oceania to a low of 511·8 (402·0–648·3) per 100 000 in western Europe.”
Quote in the paperNot a substantial claimMay combine two claims. The quote only partly states this claim.
Findingown dataOver 1990-2021, the proportion of DALYs due to high BMI increased in every country and territory, ranging from an increase of 77.2% (52.2 to 107.9) in Viet Nam to 1.3% (-1.5 to 4.1) in Czechia.
“Over this period, the proportion of DALYS due to high BMI increased in every country and territory, ranging from an increase of 77·2% (52·2 to 107·9) in Viet Nam to 1·3% (–1·5 to 4·1) in Czechia (figure 3).”
Quote in the paperNot a substantial claimMay combine two claims.
Findingown dataThe age-standardised diabetes prevalence rate is projected to exceed 10% in 89 (43.6%) countries and territories and to surpass 20% in 24 (11.8%) countries and territories by 2050.
“The age-standardised diabetes prevalence rate is projected to exceed 10% in 89 (43·6%) countries and territories and to surpass 20% in 24 (11·8%) countries and territories.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
Findingown dataAt the country level, Fiji had the highest age-standardised DALY rate, at 7333.9 (6066.7-8776.7) per 100 000.
“At the country level, Fiji had the highest age-standardised DALY rate, at 7333·9 (6066·7–8776·7) per 100 000.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
Findingown dataType 2 diabetes made up 95.4% (94.9-95.9) of diabetes DALYs.
“and 95·4% (94·9–95·9) of DALYs.”
Quote in the paperNot a substantial claimMay combine two claims.
Findingown dataThe global age-standardised diabetes prevalence rate in 2021 was 6.1%, with highs of 9.3% in the north Africa and Middle East super-region and 12.3% in the Oceania region.
“The global age-standardised diabetes prevalence rate in 2021 was 6·1%, with highs of 9·3% in the north Africa and Middle East super-region and 12·3% in the Oceania region.”
Quote in the paperNot a substantial claimMay combine two claims.
Findingnone givenDiabetes prevalence continues to increase in every country and territory, age group, and in both males and females.
“diabetes prevalence continues to increase in every country and territory, age group, and in both males and females.”
Quote in the paperSubstantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
PremisecitationThe Lancet Commission on diabetes reported that 80% of diabetes cases occur in low-income and middle-income countries.
“The Lancet Commission on diabetes published in 2020 highlights the unequal burden of the disease on people in low-income and middle-income countries (LMICs), reporting that 80% of diabetes cases occur in LMICs.2”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [2] Chan, 2021, The Lancet Commission on diabetes: using data to transform diabetes care and patient lives, Lancet source
Probably not a substantial claim: may not pass S3 (load-bearing), S4 (based). May combine two claims.
Interpretationnone givenType 2 diabetes is largely preventable and, in some cases, potentially reversible if identified and managed early in the disease course.
“Type 2 diabetes, which makes up the bulk of diabetes cases, is largely preventable and, in some cases, potentially reversible if identified and managed early in the disease course.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
Study design and conductown dataThere were 1527 location-years of data from 172 countries (84·3% of the 204 countries and territories included in GBD) used in the diabetes modelling process.
“There were 1527 location-years of data from 172 countries (84·3% of the 204 countries and territories included in GBD) used in the diabetes modelling process (appendix section 4.1.1).”
Quote in the paperNot a substantial claimMay combine two claims.
Interpretationown dataAll evidence indicates that diabetes prevalence is increasing worldwide, primarily due to a rise in obesity caused by multiple factors.
“However, all evidence indicates that diabetes prevalence is increasing worldwide, primarily due to a rise in obesity caused by multiple factors.”
Quote in the paperSubstantial claimProbably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.
PremisecitationType 1 and type 2 diabetes are the most common forms of diabetes and are diagnosed through well established criteria.
“Type 1 and type 2 diabetes are the most common forms of the disease and are diagnosed through well established criteria.1, 2, 4”
Quote in the paperNot a substantial claim0 of 3 sources checked- cites [1]
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
- cites [2] Chan, 2021, The Lancet Commission on diabetes: using data to transform diabetes care and patient lives, Lancet source
- cites [4] 2021
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
Probably not a substantial claim: may not pass S3 (load-bearing).
Study design and conductnone givenThe funder of the study had no role in study design, data collection, data analysis, data interpretation, or the writing of the report.
“The funder of the study had no role in study design, data collection, data analysis, data interpretation, or the writing of the report.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
Study design and conductown dataThere were 25 666 location-years of death data included in the fatal model.
“There were 25 666 location-years of death data included in the fatal model (appendix section 3.1).”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
Study design and conductnone givenAll codes used for these analyses are publicly available online.
“All codes used for these analyses are publicly available online.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
Study design and conductown dataFor this study, 27 193 data sources were identified to which the methodological and evidentiary framework provided by GBD was applied.
“For this study, we identified 27 193 data sources to which we applied the methodological and evidentiary framework provided by GBD.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
Study design and conductcitationThis study complies with the Guidelines for Accurate and Transparent Health Estimates Reporting (GATHER) statement.
“This study complies with the Guidelines for Accurate and Transparent Health Estimates Reporting (GATHER) statement (appendix table S1).30”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [30] Stevens, 2016, Guidelines for accurate and transparent health estimates reporting: the GATHER statement, PLoS Med
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
Probably not a substantial claim: may not pass S2 (checkable), S3 (load-bearing).
InterpretationreasoningThe lack of long-term, sustained, population-level reductions in obesity is probably because no strategy has attempted to deal with the multiple factors that potentially contribute to obesity.
“This is probably because no strategy has attempted to deal with the multiple factors that potentially contribute to obesity.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S2 (checkable).
Study design and conductreasoningThe robust location-specific, age-specific, and sex-specific diabetes estimates produced by our analysis are largely due to our ability to leverage the rigorous evidentiary and methodological framework provided by the larger GBD enterprise.
“The robust location-specific, age-specific, and sex-specific diabetes estimates produced by our analysis are largely due to our ability to leverage the rigorous evidentiary and methodological framework provided by the larger GBD enterprise.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S2 (checkable), S3 (load-bearing), S4 (based).
Interpretationnone givenFew countries have health-care systems that are positioned to take a proactive approach or possess the infrastructure to prioritise early interventions.
“Few countries have health-care systems, however, that are positioned to take a proactive approach or possess the infrastructure to prioritise early interventions.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
InterpretationcitationDespite methodological and reporting differences, our estimates of particularly high total diabetes prevalence rates in the north Africa and the Middle East super-region are supported by similar estimates reported in the 2021 IDF Atlas.
“Despite methodological and reporting differences, our estimates of particularly high total diabetes prevalence rates in the north Africa and the Middle East super-region are supported by similar estimates reported in the 2021 IDF Atlas.4”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [4] 2021
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
May combine two claims.
InterpretationcitationRelying on a single glucose test could overestimate diabetes prevalence; however, the magnitude of error depends on the distribution of blood sugar concentrations as the reliability of a single glucose test increases with higher blood sugar values.
“Relying on a single glucose test could overestimate diabetes prevalence; however, the magnitude of error depends on the distribution of blood sugar concentrations as the reliability of a single glucose test increases with higher blood sugar values.87”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [87] Selvin, 2007, Short-term variability in measures of glycemia and implications for the classification of diabetes, Arch Intern Med source
Probably not a substantial claim: may not pass S3 (load-bearing).
Study design and conductreasoningDue to limitations inherent in the available literature and the comparative risk factor framework, we were unable to account for cohort effects apart from those pertaining to tobacco exposure.
“Finally, due to limitations inherent in the available literature and the comparative risk factor framework, we were unable to account for cohort effects apart from those pertaining to tobacco exposure.”
Quote in the paperNot a substantial claimMay combine two claims.
Study design and conductreasoningOur analysis did not estimate gestational diabetes explicitly since this diagnosis is captured in another GBD disease category, "Other maternal disorders", nor did our study include rarer forms of diabetes such as monogenic diabetes, due to the paucity of relevant data.
“Fifth, our analysis did not estimate gestational diabetes explicitly since this diagnosis is captured in another GBD disease category, “Other maternal disorders”, nor did our study include rarer forms of diabetes such as monogenic diabetes,1 due to the paucity of relevant data.”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [1]
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
May combine two claims.
Study design and conductnone givenAlthough our forecasts do not incorporate all known risk factors, they capture the principal driver of type 2 diabetes, high BMI.
“Although our forecasts do not incorporate all known risk factors, here we capture the principal driver of type 2 diabetes, high BMI.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.
Study design and conductnone givenGBD generates risk factor analyses for modifiable risk-outcome pairs; each risk factor is identified by a review of the literature, and the risk-outcome association is quantified through a rules-based assessment of existing evidence.
“Seventh, GBD generates risk factor analyses for modifiable risk–outcome pairs. Each risk factor is identified by a review of the literature, and we regularly revisit the possibility of adding additional risk factors. The risk–outcome association is quantified through a rules-based assessment of existing evidence.”
Quote in the paperNot a substantial claimClassified as probably not a substantial claim.
InterpretationreasoningNo effective mitigation strategy is currently in place.
“with no effective mitigation strategy currently in place”
Quote in the paperSubstantial claimMay combine two claims.
PremisecitationAlthough clinical diagnostic criteria for diabetes require more than one abnormal glucose concentration in the absence of symptoms, very few population-based epidemiological studies require these diagnostic criteria.
“Third, although clinical diagnostic criteria for diabetes require more than one abnormal glucose concentration in the absence of symptoms,1 very few population-based epidemiological studies require these diagnostic criteria.”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [1]
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
The authors state this as an assumption.
All deaths due to diabetes in people younger than 15 years were from type 1 diabetes.
“We assumed that all deaths due to diabetes in people younger than 15 years were from type 1 diabetes.”
The authors state this as an assumption.
There was no remission (no cure) in the type 1 diabetes model.
“We assumed there was no remission (ie, no cure).”
The authors state this as an assumption.
Annual remission in the total diabetes model could be no more than 1%.
“and assumed that annual remission could be no more than 1% (appendix sections 4.3.1 and 4.3.2).”
The authors state this as an assumption.
All diabetes cases in people aged younger than 15 years were type 1 diabetes.
“For data from people aged younger than 15 years, we assumed that all diabetes cases were type 1 diabetes”
The authors state this as an assumption.
All patients aged younger than 15 years with diabetes had sought hospital care due to their insulin dependence.
“and that all patients had sought hospital care due to their insulin dependence.”
The authors state this as an assumption.
Reporting bias in self-reported diabetes data changes over time and across location.
“we assumed that reporting bias would change over time and across location (eg, due to variability in diagnostic and screening efficacy), thus making bias adjustment challenging.”
The authors state this as an assumption.
All individuals younger than 15 years have type 1 diabetes.
“GBD currently assumes that all individuals younger than 15 years have type 1 diabetes.”
The authors state this as an assumption.
SDI is a good proxy for better access to care leading to a lower case fatality rate, and to increases in type 1 diabetes prevalence.
“However, we believe that SDI is a good proxy for better access to care leading to a lower case fatality rate, and to increases in type 1 diabetes prevalence.”
The paper relies on this without support.
Type 1 and type 2 diabetes differ with respect to risk factor profiles and underlying pathophysiology.
“Differences between type 1 and type 2 diabetes with respect to risk factor profiles and underlying pathophysiology”
The paper relies on this without support.
Hyperglycaemia leads to similar complications for both type 1 and type 2 diabetes.
“given that hyperglycaemia leads to similar complications for both types”
The paper relies on this without support.
Type 2 diabetes can in some cases be prevented.
“Although type 2 diabetes can in some cases be prevented”
The paper relies on this without support.
Management of hyperglycaemia has the potential to improve outcomes.
“management of hyperglycaemia has the potential to improve outcomes”
The paper relies on this without support.
Type 2 diabetes continues to be a major public health problem due to high rates of obesity.
“the disease continues to be a major public health problem due to high rates of obesity that place an increasing burden on individuals and health-care systems alike”
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The non-communicable disease burden was distributed widely across the world's populations, irrespective of age, sex, or socioeconomic circumstance.
“The non-communicable disease burden was distributed widely across the world's populations, irrespective of age, sex, or socioeconomic circumstance”
From Global incidence, prevalence, years lived with disability (YLDs), disability-adjusted life-years (DALYs), and healthy life expectancy (HALE) for 371 diseases and injuries in 204 countries and territories and 811 subnational locations, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021 (2024) · cites this paper as [33]
The Introduction says diabetes affected people in every country and age group, and the Results report diabetes prevalence in both sexes. But the paper examines diabetes, not the burden of non-communicable diseases as a whole. Its Introduction also describes substantial socioeconomic disparities rather than establishing that the burden is distributed irrespective of socioeconomic circumstance. (LLM, conf=0.85)
Experimental — accuracy not yet measuredType 2 diabetes is preventable and, in some instances, reversible with early detection and adequate care.
“Type 2 diabetes is preventable and, in some instances, reversible with early detection and adequate care.33, 45, 46”
From Global incidence, prevalence, years lived with disability (YLDs), disability-adjusted life-years (DALYs), and healthy life expectancy (HALE) for 371 diseases and injuries in 204 countries and territories and 811 subnational locations, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021 (2024) · cites this paper as [33]
The Discussion (page not specified) says early interventions can prevent or delay type 2 diabetes and reports successful outcomes from weight-loss interventions in people who have it. It does not establish in the non-abstract passages that early detection and care can reverse the disease; that part is stated only in the abstract, which is excluded as evidence under this rubric. (LLM, conf=0.78)
Experimental — accuracy not yet measuredA separate GBD 2021 analysis has forecast that more than 1.31 billion people worldwide will have diabetes by 2050 without global intervention.
“however, without global intervention, a separate GBD 2021 analysis has forecast that more than 1·31 billion people worldwide will have diabetes by 2050.33”
From Global incidence, prevalence, years lived with disability (YLDs), disability-adjusted life-years (DALYs), and healthy life expectancy (HALE) for 371 diseases and injuries in 204 countries and territories and 811 subnational locations, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021 (2024) · cites this paper as [33]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
Each contradiction between two passages listed here was confirmed by an independent check.
Australasia has a lower DALY rate than the stated regional minimum
MinorThe text calls western Europe's rate of 511·8 per 100 000 the lowest among regions, but the table gives Australasia a lower rate of 469·2.
“Regionally, the age-standardised DALY rate varied from a high of 3577·0 (95% UI 3157·0–4120·5) per 100 000 in Oceania to a low of 511·8 (402·0–648·3) per 100 000 in western Europe.”
“| Australasia | Australasia | 226 (183 to 288) | 140·8% (122·2 to 164·8) | 469·2 (378·1 to 602·4) | 15·3% (5·5 to 27·1) |”
Global DALY-rate uncertainty interval differs between text and table
MinorThe upper bound of the same global age-standardised DALY-rate uncertainty interval is 1067·5 in the text but 1067·4 in the table.
“The global age-standardised diabetes DALY rate was 915·0 (782·6–1067·5) per 100 000”
“| Global | Global | 79 200 (67 800 to 92 500) | 189·8% (171·1 to 203·4) | 915·0 (782·6 to 1067·4) | 38·6% (29·7 to 45·3) |”
Cites
Vos, T., Lim, S. S., Abbafati, C., Abbas, K. M., Abbasi, M., Abbasifard, M., Abbasi-Kangevari, M., Abbastabar, H., Abd-Allah, F., Abdelalim, A., et al. (2020) · The Lancet · doi:10.1016/s0140-6736(20)30925-9 · Cited by 19,358 · see citing works
Self-citationReduction in the incidence of type 2 diabetes with lifestyle intervention or metformin
(2002) · New England Journal of Medicine · doi:10.1056/nejmoa012512 · Cited by 19,011 · cited 1× · see citing works
“71,72 75 Few countries have health-care systems, however, that are positioned to take a proactive approach or possess the infrastructure to prioritise early interventions.”
Sun, H., Saeedi, P., Karuranga, S., Pinkepank, M., Ogurtsova, K., Duncan, B. B., Stein, C., Basit, A., Chan, J. C. N., Mbanya, J. C., et al. (2022) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2021.109119 · Cited by 10,123 · cited 2× · see citing works
“47 A high diabetes burden in LMICs is also related to economic and sociopolitical challenges, including limited health spending on diabetes 10 and inadequate or incomplete coverage for pharmacological treatment.”
Self-citationMurray, C. J. L., Aravkin, A. Y., Zheng, P., Abbafati, C., Abbas, K. M., Abbasi-Kangevari, M., Abd-Allah, F., Abdelalim, A., Abdollahi, M., Abdollahpour, I., et al. (2020) · The Lancet · doi:10.1016/s0140-6736(20)30752-2 · Cited by 9,854 · see citing works
Self-citationHealth effects of overweight and obesity in 195 countries over 25 years
Collaborators, T. G. 2. O. (2017) · New England Journal of Medicine · doi:10.1056/nejmoa1614362 · Cited by 7,918 · see citing works
Obesity: global epidemiology and pathogenesis
Blüher, M. (2019) · Nature Reviews Endocrinology · doi:10.1038/s41574-019-0176-8 · Cited by 5,126 · cited 1× · see citing works
“57 This is probably because no strategy has attempted to deal with the multiple factors that potentially contribute to obesity.”
The Emerging Risk Factors Collaboration (2010) · The Lancet · doi:10.1016/s0140-6736(10)60484-9 · Cited by 5,125 · see citing works
Global mortality, disability, and the contribution of risk factors: Global Burden of Disease Study
Murray, C. J., & Lopez, A. D. (1997) · The Lancet · doi:10.1016/s0140-6736(96)07495-8 · Cited by 4,492 · cited 3× · see citing works
“29,37 For each risk factor analysed here, we estimated the relative risk of diabetes as a function of risk exposure, using the following methods, which have been extensively detailed elsewhere.”
InfluentialGlobal nutrition transition and the pandemic of obesity in developing countries
Popkin, B. M., Adair, L. S., & Ng, S. W. (2012) · Nutrition Reviews · doi:10.1111/j.1753-4887.2011.00456.x · Cited by 4,313 · cited 2× · see citing works
“45 Various interventions and policies to address obesity have been developed and studied, 53–56 but no programme to date has shown long-term, sustained, population-level reductions in obesity.”
Zhou, B., Lu, Y., Hajifathalian, K., Bentham, J., Di Cesare, M., Danaei, G., Bixby, H., Cowan, M., Ali, M., Taddei, C., et al. (2016) · The Lancet · doi:10.1016/s0140-6736(16)00618-8 · Cited by 4,311 · see citing works
Self-citationForeman, K. J., Marquez, N., Dolgert, A. J., Fukutaki, K. G., Fullman, N., McGaughey, M., Pletcher, M. A., Smith, A. E., Tang, K., Yuan, C.-W., et al. (2018) · The Lancet · doi:10.1016/s0140-6736(18)31694-5 · Cited by 3,048 · cited 3× · see citing works
“We used forecasted Socio-demographic Index (SDI) 39 as a predictor in a regression model to estimate the prevalence of type 1 diabetes and forecasted BMI as the predictor for estimating the prevalence of type 2 diabetes.”
Self-citationBariatric Surgery versus Intensive Medical Therapy for Diabetes — 5-Year Outcomes
Schauer, P. R., Bhatt, D. L., Kirwan, J. P., Wolski, K., Aminian, A., Brethauer, S. A., Navaneethan, S. D., Singh, R. P., Pothier, C. E., Nissen, S. E., et al. (2017) · New England Journal of Medicine · doi:10.1056/nejmoa1600869 · Cited by 2,934 · cited 1× · see citing works
“64 68 Both options involve close oversight and are unlikely to be scalable at a population level globally.”
Chatterjee, S., Khunti, K., & Davies, M. J. (2017) · The Lancet · doi:10.1016/s0140-6736(17)30058-2 · Cited by 2,577 · see citing works
Sex and Gender Differences in Risk, Pathophysiology and Complications of Type 2 Diabetes Mellitus
Kautzky-Willer, A., Harreiter, J., & Pacini, G. (2016) · Endocrine Reviews · doi:10.1210/er.2015-1137 · Cited by 2,043 · cited 2× · see citing works
“16 Conversely, obesity tends to be more common in females, 48 and diabetes treatments rarely account for reported differences in the risk of developing diabetes at different ages between males and females, which are likely to be due to the impact of a combination of genetic, hormonal, and…”
Wang, H., Abbas, K. M., Abbasifard, M., Abbasi-Kangevari, M., Abbastabar, H., Abd-Allah, F., Abdelalim, A., Abolhassani, H., Abreu, L. G., Abrigo, M. R. M., et al. (2020) · The Lancet · doi:10.1016/s0140-6736(20)30977-6 · Cited by 1,971 · see citing works
Self-citationGuidelines for accurate and transparent health estimates reporting: the GATHER statement
Stevens, G. A., Alkema, L., Black, R. E., Boerma, J. T., Collins, G. S., Ezzati, M., Grove, J. T., Hogan, D. R., Hogan, M. C., Horton, R., et al. (2016) · The Lancet · doi:10.1016/s0140-6736(16)30388-9 · Cited by 1,798 · see citing works
Self-citationSocial determinants of health and diabetes: A scientific review
Hill-Briggs, F., Adler, N. E., Berkowitz, S. A., Chin, M. H., Gary-Webb, T. L., Navas-Acien, A., Thornton, P. L., & Haire-Joshu, D. (2021) · Diabetes Care · doi:10.2337/dci20-0053 · Cited by 1,732 · see citing works
Disease control priorities in developing countries
Frenk, J. M. (2006) · Salud Pública de México · doi:10.1590/s0036-36342006000600011 · Cited by 1,615 · see citing works
Vollset, S. E., Goren, E., Yuan, C.-W., Cao, J., Smith, A. E., Hsiao, T., Bisignano, C., Azhar, G. S., Castro, E., Chalek, J., et al. (2020) · The Lancet · doi:10.1016/s0140-6736(20)30677-2 · Cited by 1,506 · cited 1× · see citing works
“40 For each location ( l ), age ( a ), sex ( s ), and year ( y ), we logit-transformed the GBD 2019 diabetes prevalence estimates logit ( Y l,a,s,y ) and used a fixed coefficient (β 1 ) on SDI only for type 1 diabetes (equation 1) and BMI for type 2 diabetes (equation 2) over time, and a random…”
Self-citationUS Health Care Spending by Payer and Health Condition, 1996-2016
Dieleman, J. L., Cao, J., Chapin, A., Chen, C., Li, Z., Liu, A., Horst, C., Kaldjian, A., Matyasz, T., Scott, K. W., et al. (2020) · JAMA · doi:10.1001/jama.2020.0734 · Cited by 1,313 · see citing works
Self-citationDisability weights for the Global Burden of Disease 2013 study
Salomon, J. A., Haagsma, J. A., Davis, A., de Noordhout, C. M., Polinder, S., Havelaar, A. H., Cassini, A., Devleesschauwer, B., Kretzschmar, M., Speybroeck, N., et al. (2015) · The Lancet Global Health · doi:10.1016/s2214-109x(15)00069-8 · Cited by 1,217 · cited 1× · see citing works
“36 We included estimates for four diabetic sequelae for each type of diabetes: neuropathy, diabetic foot, lower limb amputation, and vision loss due to retinopathy.”
Self-citationAhmad, E., Lim, S., Lamptey, R., Webb, D. R., & Davies, M. J. (2022) · The Lancet · doi:10.1016/s0140-6736(22)01655-5 · Cited by 1,120 · cited 1× · see citing works
“10,13 Although prevention and management approaches differ between diabetes types, there are well established strategies to reduce the disease burden, including limiting risk factors for type 2 diabetes, 2 increasing access to treatment such as insulin, 14 and enhancing the health-system…”
Self-citation(2015) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(15)00291-0 · Cited by 1,029 · see citing works
Fullman, N., Yearwood, J., Abay, S. M., Abbafati, C., Abd-Allah, F., Abdela, J., Abdelalim, A., Abebe, Z., Abebo, T. A., Aboyans, V., et al. (2018) · The Lancet · doi:10.1016/s0140-6736(18)30994-2 · Cited by 1,013 · see citing works
Self-citationSalminen, P., Helmiö, M., Ovaska, J., Juuti, A., Leivonen, M., Peromaa-Haavisto, P., Hurme, S., Soinio, M., Nuutila, P., & Victorzon, M. (2018) · JAMA · doi:10.1001/jama.2017.20313 · Cited by 946 · see citing works
Comparative quantification of health risks conceptual framework and methodological issues
Murray, C. J., Ezzati, M., Lopez, A. D., Rodgers, A., & Vander Hoorn, S. (2003) · Population Health Metrics · doi:10.1186/1478-7954-1-1 · Cited by 887 · cited 1× · see citing works
“29,37 For each risk factor analysed here, we estimated the relative risk of diabetes as a function of risk exposure, using the following methods, which have been extensively detailed elsewhere.”
Self-citationLong-term Follow-up After Bariatric Surgery: A Systematic Review
Puzziferri, N., Roshek, T. B., Mayo, H. G., Gallagher, R., Belle, S. H., & Livingston, E. H. (2014) · JAMA · doi:10.1001/jama.2014.10706 · Cited by 819 · see citing works
The Lancet Commission on diabetes: using data to transform diabetes care and patient lives
Chan, J. C. N., Lim, L.-L., Wareham, N. J., Shaw, J. E., Orchard, T. J., Zhang, P., Lau, E. S. H., Eliasson, B., Kong, A. P. S., Ezzati, M., et al. (2020) · The Lancet · doi:10.1016/s0140-6736(20)32374-6 · Cited by 793 · see citing works
Self-citationLozano, R., Fullman, N., Mumford, J. E., Knight, M., Barthelemy, C. M., Abbafati, C., Abbastabar, H., Abd-Allah, F., Abdollahi, M., Abedi, A., et al. (2020) · The Lancet · doi:10.1016/s0140-6736(20)30750-9 · Cited by 719 · see citing works
Self-citationTrends in diabetes treatment and control in U.S. adults, 1999-2018
Fang, M., Wang, D., Coresh, J., & Selvin, E. (2021) · New England Journal of Medicine · doi:10.1056/nejmsa2032271 · Cited by 690 · see citing works
Complications of Diabetes 2017
Papatheodorou, K., Banach, M., Bekiari, E., Rizzo, M., & EDMONDS, M. E. (2018) · Journal of Diabetes Research · doi:10.1155/2018/3086167 · Cited by 686 · cited 1× · see citing works
“28,51,52 80 These are important considerations given that in many places in the world, increases in disability due to diabetes have outpaced diabetes mortality.”
Environmental risk factors for type 1 diabetes
Rewers, M., & Ludvigsson, J. (2016) · The Lancet · doi:10.1016/s0140-6736(16)30507-4 · Cited by 676 · see citing works
Race/Ethnic Difference in Diabetes and Diabetic Complications
Spanakis, E. K., & Golden, S. H. (2013) · Current Diabetes Reports · doi:10.1007/s11892-013-0421-9 · Cited by 636 · see citing works
Gong, Q., Zhang, P., Wang, J., Ma, J., An, Y., Chen, Y., Zhang, B., Feng, X., Li, H., Chen, X., et al. (2019) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(19)30093-2 · Cited by 615 · see citing works
Self-citationGenetic risk factors for type 1 diabetes
Pociot, F., & Lernmark, Å. (2016) · The Lancet · doi:10.1016/s0140-6736(16)30582-7 · Cited by 553 · cited 1× · see citing works
“93,94 However, we believe that SDI is a good proxy for better access to care leading to a lower case fatality rate, and to increases in type 1 diabetes prevalence.”
(DPS), F. T. F. D. P. S., Lindström, J., Peltonen, M., Eriksson, J. G., Ilanne-Parikka, P., Aunola, S., Keinänen-Kiukaanniemi, S., Uusitupa, M., & Tuomilehto, J. (2013) · Diabetologia · doi:10.1007/s00125-012-2752-5 · Cited by 551 · see citing works
Equity, social determinants and public health programmes
Mukhopadhyay, A. (2011) · The Indian Journal of Medical Research · Cited by 545 · see citing works
Guidelines for accurate and transparent health estimates reporting: the GATHER statement
Stevens, G. A., Alkema, L., Black, R. E., Boerma, J. T., Collins, G. S., Ezzati, M., Grove, J. T., Hogan, D. R., Hogan, M. C., Horton, R., et al. (2016) · PLOS Medicine · doi:10.1371/journal.pmed.1002056 · Cited by 424 · see citing works
Self-citationShort-term variability in measures of glycemia and implications for the classification of diabetes
Selvin, E. (2007) · Archives of Internal Medicine · doi:10.1001/archinte.167.14.1545 · Cited by 402 · cited 1× · see citing works
“87 90 We plan to address this issue in upcoming GBD cycles.”
Taheri, S., Zaghloul, H., Chagoury, O., Elhadad, S., Ahmed, S. H., El Khatib, N., Amona, R. A., El Nahas, K., Suleiman, N., Alnaama, A., et al. (2020) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(20)30117-0 · Cited by 393 · see citing works
Self-citationYouth-Onset Type 2 Diabetes Consensus Report: Current Status, Challenges, and Priorities
Nadeau, K. J., Anderson, B. J., Berg, E. G., Chiang, J. L., Chou, H., Copeland, K. C., Hannon, T. S., Huang, T. T.-K., Lynch, J. L., Powell, J., et al. (2016) · Diabetes Care · doi:10.2337/dc16-1066 · Cited by 381 · cited 1× · see citing works
“Although there is growing evidence of type 2 diabetes occurring in younger individuals in many parts of the world, 91,92 we do not have population-based studies that distinguish type 1 diabetes from type 2 diabetes among people younger than 15 years across time, age, and location.”
Mechanisms of Recovery From Type 2 Diabetes After Malabsorptive Bariatric Surgery
Guidone, C., Manco, M., Valera-Mora, E., Iaconelli, A., Gniuli, D., Mari, A., Nanni, G., Castagneto, M., Calvani, M., & Mingrone, G. (2006) · Diabetes · doi:10.2337/db06-0068 · Cited by 367 · see citing works
Type 2 diabetes mellitus in children and adolescents
Reinehr, T. (2013) · World Journal of Diabetes · doi:10.4239/wjd.v4.i6.270 · Cited by 363 · see citing works
Sex differences in the burden of type 2 diabetes and cardiovascular risk across the life course
Huebschmann, A. G., Huxley, R., Kohrt, W. M., Zeitler, P. S., Regensteiner, J. G., & Reusch, J. E. B. (2019) · Diabetologia · doi:10.1007/s00125-019-4939-5 · Cited by 354 · see citing works
The Lancet Commission on diabetes: using data to transform diabetes care and patient lives
Chan, J. C. N., Lim, L., Wareham, N. J., Shaw, J. E., Orchard, T. J., Zhang, P., Lau, E. S. H., Eliasson, B., Kong, A. P. S., Ezzati, M., et al. (2020) · Figshare · Cited by 337 · see citing works
Self-citationEpidemiology of Ischemic Stroke in Patients With Diabetes
Kissela, B. M., Khoury, J., Kleindorfer, D., Woo, D., Schneider, A., Alwell, K., Miller, R., Ewing, I., Moomaw, C. J., Szaflarski, J. P., et al. (2005) · Diabetes Care · doi:10.2337/diacare.28.2.355 · Cited by 330 · see citing works
Manne‐Goehler, J., Geldsetzer, P., Agoudavi, K., Andall‐Brereton, G., Aryal, K. K., Bicaba, B. W., Bovet, P., Brian, G. R., Dorobanţu, M., Gathecha, G. K., et al. (2019) · PLoS Medicine · doi:10.1371/journal.pmed.1002751 · Cited by 325 · cited 1× · see citing works
“17 As our forecasts suggest that nearly 50% of the increases in diabetes prevalence will be due to changing demographic profiles, countries will need to invest in health systems to handle the surge in expected patients.”
Self-citationFlood, D., Seiglie, J. A., Dunn, M. R., Tschida, S., Theilmann, M., Marcus, M. E., Brian, G. R., Норов, Б., Mayige, M. T., Gurung, M. S., et al. (2021) · The Lancet Healthy Longevity · doi:10.1016/s2666-7568(21)00089-1 · Cited by 290 · see citing works
Self-citationSemaglutide for the treatment of overweight and obesity: A review
Bergmann, N. C., Davies, M. J., Lingvay, I., & Knop, F. K. (2023) · Diabetes, Obesity and Metabolism · doi:10.1111/dom.14863 · Cited by 265 · cited 1× · see citing works
“Pharmacological agents such as SGLT2 inhibitors and GLP1 agonists have shown some promising results in weight reduction and cardiovascular protection in individuals with type 2 diabetes, 69,70 but the viability of these interventions at the population level remains unclear.”
Health Effects of Overweight and Obesity in 195 Countries
(2017) · New England Journal of Medicine · doi:10.1056/nejmc1710026 · Cited by 219 · cited 2× · see citing works
“28,51,52 80 These are important considerations given that in many places in the world, increases in disability due to diabetes have outpaced diabetes mortality.”
Socioeconomic inequalities and type 2 diabetes complications: A systematic review
Tatulashvili, S., Fagherazzi, G., Dow, C., Cohen, R., Fosse‐Edorh, S., & Bihan, H. (2019) · Diabetes & Metabolism · doi:10.1016/j.diabet.2019.11.001 · Cited by 196 · see citing works
Sun, Y., You, W., Almeida, F., Estabrooks, P., & Davy, B. (2017) · Journal of the Academy of Nutrition and Dietetics · doi:10.1016/j.jand.2016.11.016 · Cited by 186 · see citing works
Public health utility of cause of death data: applying empirical algorithms to improve data quality
Johnson, S. C., Cunningham, M., Dippenaar, I. N., Sharara, F., Wool, E. E., Agesa, K. M., Han, C., Miller-Petrie, M. K., Wilson, S., Fuller, J. E., et al. (2021) · BMC Medical Informatics and Decision Making · doi:10.1186/s12911-021-01501-1 · Cited by 175 · cited 1× · see citing works
“Codes for causes that either did not lead to death or were intermediate causes, but for which diabetes could have been the underlying cause—referred to as garbage codes 31 —were eligible for inclusion in the diabetes model 6 (appendix section 3.2.1).”
InfluentialSelf-citationTrimmed constrained mixed effects models: formulations and algorithms
Zheng, P., Barber, R., Sorensen, R. J. D., Murray, C. J. L., & Aravkin, A. Y. (2021) · Journal of Computational and Graphical Statistics · doi:10.1080/10618600.2020.1868303 · Cited by 174 · cited 3× · see citing works
“We used the meta-regression Bayesian, regularised, trimmed (MR-BRT) 33 tool to generate coefficients that were used to adjust estimates from studies that did not define diabetes with the reference definition (appendix section 4.2.2).”
InfluentialSelf-citationDiabetes: The Pandemic and Potential Solutions
Narayan, K. M. V., Zhang, P., Kanaya, A. M., Williams, D. E., Engelgau, M. M., Imperatore, G., & Ramachandran, A. (2006) · Europe PMC (PubMed Central) · Cited by 167 · see citing works
Delpino, F. M., Figueiredo, L. M., Bielemann, R. M., da Silva, B. G. C., dos Santos, F. S., Mintem, G. C., Flores, T. R., Arcêncio, R. A., & Nunes, B. P. (2021) · International Journal of Epidemiology · doi:10.1093/ije/dyab247 · Cited by 166 · cited 1× · see citing works
“…greater availability of shelf-stable and high-calorie products; limited financial and proximal access to healthy food options; increased consumption of ultra-processed foods 44 and fat, sugar, and animal products; and reductions in physical activity related to global work and transportation trends.”
Diabetes mellitus, race, and socioeconomic status a population-based study
Brancati, F. L., Whelton, P. K., Kuller, L. H., & Klag, M. J. (1996) · Annals of Epidemiology · doi:10.1016/1047-2797(95)00095-x · Cited by 159 · see citing works
Teufel, F., Seiglie, J. A., Geldsetzer, P., Theilmann, M., Marcus, M. E., Ebert, C., Arboleda, W. A. L., Agoudavi, K., Andall-Brereton, G., Aryal, K. K., et al. (2021) · The Lancet · doi:10.1016/s0140-6736(21)00844-8 · Cited by 159 · cited 2× · see citing works
“28,51,52 80 These are important considerations given that in many places in the world, increases in disability due to diabetes have outpaced diabetes mortality.”
Socioeconomic gradients and distribution of diabetes, hypertension, and obesity in India
Corsi, D. J., & Subramanian, S. V. (2019) · JAMA Network Open · doi:10.1001/jamanetworkopen.2019.0411 · Cited by 152 · see citing works
Scott, A., Chambers, D., Goyder, E., & O’Cathain, A. (2017) · PLoS ONE · doi:10.1371/journal.pone.0177210 · Cited by 145 · cited 1× · see citing works
“,20–26 The Lancet Commission on diabetes published in 2020 highlights the unequal burden of the disease on people in low-income and middle-income countries (LMICs), reporting that 80% of diabetes cases occur in LMICs.”
The Burden of Proof studies: assessing the evidence of risk
Zheng, P., Afshin, A., Biryukov, S., Bisignano, C., Brauer, M., Bryazka, D., Burkart, K., Cercy, K. M., Cornaby, L., Dai, X., et al. (2022) · Nature Medicine · doi:10.1038/s41591-022-01973-2 · Cited by 142 · see citing works
Self-citationAfroz, A., Alramadan, M. J., Hossain, M. N., Romero, L., Alam, K., Magliano, D. J., & Billah, B. (2018) · BMC Health Services Research · doi:10.1186/s12913-018-3772-8 · Cited by 139 · see citing works
Self-citationCOVID-19 and Diabetes: A Collision and Collusion of Two Diseases
Feldman, E. L., Savelieff, M. G., Hayek, S. S., Pennathur, S., Kretzler, M., & Pop-Busui, R. (2020) · Diabetes · doi:10.2337/dbi20-0032 · Cited by 136 · see citing works
Diabetes Prevention Program Research Group, Nathan, D. M., Knowler, W. C., Edelstein, S., Crandall, J. P., Dabelea, D., Goldberg, R. B., Kahn, S. E., Mather, K. J., Trandafirescu, G., et al. (2019) · Diabetes Care · doi:10.2337/dc18-1970 · Cited by 128 · cited 1× · see citing works
“71,72 75 Few countries have health-care systems, however, that are positioned to take a proactive approach or possess the infrastructure to prioritise early interventions.”
Diabetes Reporting as a Cause of Death
McEwen, L. N., Kim, C., Haan, M., Ghosh, D., Lantz, P. M., Mangione, C. M., Safford, M. M., Marrero, D., Thompson, T. J., Herman, W. H., et al. (2006) · Diabetes Care · doi:10.2337/diacare.29.02.06.dc05-0998 · Cited by 127 · see citing works
Cousin, E., Schmidt, M. I., Ong, K. L., Lozano, R., Afshin, A., Abushouk, A. I., Agarwal, G., Agudelo‐Botero, M., Al‐Aly, Z., Rabanal, J. E. A., et al. (2022) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(22)00186-3 · Cited by 116 · see citing works
Self-citationOwolabi, M. O., Yaria, J. O., Daivadanam, M., Makanjuola, A., Parker, G., Oldenburg, B. F., Vedanthan, R., Norris, S. A., Oguntoye, A. R., Osundina, M. A., et al. (2018) · Diabetes Care · doi:10.2337/dc17-1795 · Cited by 114 · cited 1× · see citing works
“Although 77 countries, representing every region and socioeconomic level, have created recommendations, guidelines, and targets to monitor and control diabetes in their populations, 60–62 preparedness varies considerably between countries.”
Self-citationMisra, A., Ramchandran, A., Jayawardena, R., Shrivastava, U., & Snehalatha, C. (2014) · Diabetic Medicine · doi:10.1111/dme.12540 · Cited by 112 · cited 1× · see citing works
“47 A high diabetes burden in LMICs is also related to economic and sociopolitical challenges, including limited health spending on diabetes 10 and inadequate or incomplete coverage for pharmacological treatment.”
Self-citationCapillary versus venous bedside blood glucose estimations
Boyd, R. (2005) · Emergency Medicine Journal · doi:10.1136/emj.2003.011619 · Cited by 112 · see citing works
Diet, Genetics, and Disease: A Focus on the Middle East and North Africa Region
Fahed, A. C., Sleiman, K., Farhat, T., & Nemer, G. M. (2012) · Journal of Nutrition and Metabolism · doi:10.1155/2012/109037 · Cited by 102 · cited 2× · see citing works
“46 In some instances, high type 2 diabetes prevalence rates might also be partly associated with a population-specific genetic disposition to developing diabetes.”
Whyte, M., Hinton, W., McGovern, A. P., van Vlymen, J. N., Ferreira, F. M., Calderara, S., Mount, J., Munro, N. M., & de Lusignan, S. (2019) · PLoS Medicine · doi:10.1371/journal.pmed.1002942 · Cited by 102 · see citing works
Comparability of venous and capillary glucose measurements in blood
Colagiuri, S., Sandbaek, A., Carstensen, B., Christensen, J. O., Glümer, C., Lauritzen, T., & Borch‐Johnsen, K. (2003) · Diabetic Medicine · doi:10.1046/j.1464-5491.2003.01048.x · Cited by 101 · see citing works
Rampatige, R., Mikkelsen, L., Hernandez, B., Riley, I., & Lopez, A. D. (2014) · Bulletin of the World Health Organization · doi:10.2471/blt.14.137935 · Cited by 98 · cited 1× · see citing works
“86 Second, many deaths that are coded as being caused by diabetes do not specify the diabetes type.”
Magliano, D. J., Chen, L., Carstensen, B., Gregg, E. W., Pavkov, M. E., Salim, A., Andes, L. J., Balicer, R., Baviera, M., Chan, J. C. N., et al. (2022) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(21)00327-2 · Cited by 91 · cited 1× · see citing works
“81,82 In addition to the estimates presented here, previous studies have reported global diabetes estimates from earlier rounds of GBD, and two other organisations, the IDF and NCD-RisC, have also generated global and multi-country estimates of diabetes for specific age groups.”
Self-citationMutyambizi, C., Booysen, F., Stokes, A. C., Pavlova, M., & Groot, W. N. J. (2019) · PLoS ONE · doi:10.1371/journal.pone.0211208 · Cited by 85 · see citing works
Aggarwal, G., Lippi, G., Lavie, C. J., Henry, B. M., & Sanchis‐Gomar, F. (2020) · Journal of Diabetes · doi:10.1111/1753-0407.13091 · Cited by 78 · see citing works
Diabetes: equity and social determinants.
Whiting, D. R., Unwin, N. C., Roglić, G., Blas, E., & Kurup, A. S. (2010) · Cited by 69 · see citing works
Maniadakis, N., Kapaki, V., Damianidi, L., & Kourlaba, G. (2013) · ClinicoEconomics and Outcomes Research · doi:10.2147/ceor.s49659 · Cited by 62 · cited 1× · see citing works
“45 Various interventions and policies to address obesity have been developed and studied, 53–56 but no programme to date has shown long-term, sustained, population-level reductions in obesity.”
Type 1 Diabetes Mellitus in Children and Adolescents
Kao, K., & Sabin, M. A. (2013) · PsycEXTRA Dataset · doi:10.1037/e619582012-001 · Cited by 58 · see citing works
Bhutta, Z. A., Salam, R. A., Gomber, A., Lewis-Watts, L., Narang, T., Mbanya, J. C., & Alleyne, G. A. O. (2021) · The Lancet · doi:10.1016/s0140-6736(21)02247-9 · Cited by 58 · cited 2× · see citing works
“2,14,15 However, social determinants of health have led to considerable disparities across populations in risk factor profiles,”
Effectiveness of Policies and Programs to Combat Adult Obesity: a Systematic Review
Tseng, E., Zhang, A. W., Shogbesan, O., et al. (2018) · Journal of General Internal Medicine · doi:10.1007/s11606-018-4619-z · Cited by 55 · cited 1× · see citing works
“45 Various interventions and policies to address obesity have been developed and studied, 53–56 but no programme to date has shown long-term, sustained, population-level reductions in obesity.”
JOUGLA, E., PAPOZ, L., BALKAU, B., MAGUIN, P., & HATTON, F. (1992) · International Journal of Epidemiology · doi:10.1093/ije/21.2.343 · Cited by 53 · see citing works
Health Care Spending on Diabetes in the U.S., 1996–2013
Squires, E., Duber, H. C., Campbell, M., Cao, J., Chapin, A., Horst, C., Li, Z., Matyasz, T., Reynolds, A., Hirsch, I. B., et al. (2018) · Diabetes Care · doi:10.2337/dc17-1376 · Cited by 40 · see citing works
New directions for diabetes prevention and management in behavioral medicine
Stetson, B. A., Minges, K. E., & Richardson, C. R. (2016) · Journal of Behavioral Medicine · doi:10.1007/s10865-016-9802-2 · Cited by 36 · cited 1× · see citing works
“58 This is clearly not a simple challenge.”
Home, P., HADDAD, J. A., Latif, Z. A., Soewondo, P., Benabbas, Y., Litwak, L., Güler, S., Chen, J.-W., & Zilov, A. V. (2013) · Diabetes Therapy · doi:10.1007/s13300-013-0022-2 · Cited by 33 · see citing works
Hill, K. E., Ward, P., Grace, B. S., & Gleadle, J. (2017) · BMC Public Health · doi:10.1186/s12889-017-4807-5 · Cited by 23 · see citing works
Mukonda, E. E., & Lesosky, M. (2021) · Journal of Global Health · doi:10.7189/jogh.11.04055 · Cited by 15 · see citing works
Chakhtoura, M., & Mantzoros, C. S. (2023) · Metabolism · doi:10.1016/j.metabol.2023.155531 · Cited by 15 · cited 1× · see citing works
“Pharmacological agents such as SGLT2 inhibitors and GLP1 agonists have shown some promising results in weight reduction and cardiovascular protection in individuals with type 2 diabetes, 69,70 but the viability of these interventions at the population level remains unclear.”
A Potential Issue with Screening Prediabetes or Diabetes Using Serum Glucose: A Delay in Diagnosis
Kang, J. G., Park, C., Ihm, S., & Park, S. W. (2016) · Diabetes & Metabolism Journal · doi:10.4093/dmj.2016.40.5.414 · Cited by 13 · see citing works
Type 2 Diabetes in Women: Differences and Difficulties
Kesavadev, J., Abraham, G., Chandni, R., CHAWLA, P. M., Nambiar, A., Deshpande, N., Joshi, S., Jothydev, S., Krishnan, G., & Das, A. K. (2021) · Current Diabetes Reviews · doi:10.2174/1573399818666211208110759 · Cited by 4 · cited 1× · see citing works
“50 Although obesity is theoretically reversible 28,51,52 and addressing it could provide the biggest opportunity to limit the advance of diabetes, current trends suggest that obesity rates are likely to continue to climb.”
Flagged first, then by citations
1 of the 91 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Ferrari, A. J., Santomauro, D. F., Aali, A., Abate, Y. H., Abbafati, C., Abbastabar, H., Abd ElHafeez, S., Abdelmasseh, M., Abd-Elsalam, S., Abdollahi, A., et al. (2024) · The Lancet · doi:10.1016/s0140-6736(24)00757-8 · Cited by 5,112 · see citing works
Self-citationNaghavi, M., Vollset, S. E., Ikuta, K. S., Swetschinski, L. R., Gray, A. P., Wool, E. E., Robles Aguilar, G., Mestrovic, T., Smith, G., Han, C., et al. (2024) · The Lancet · doi:10.1016/s0140-6736(24)01867-1 · Cited by 3,791 · see citing works
Self-citationBrauer, M., Roth, G. A., Aravkin, A. Y., Zheng, P., Abate, K. H., Abate, Y. H., Abbafati, C., Abbasgholizadeh, R., Abbasi, M. A., Abbasian, M., et al. (2024) · The Lancet · doi:10.1016/s0140-6736(24)00933-4 · Cited by 2,884 · see citing works
“We generally assumed that the TMREL is 0 for harmful risks with monotonically increasing risk functions.”
BackgroundSelf-citationSteinmetz, J. D., Seeher, K. M., Schiess, N., Nichols, E. L., Cao, B., Servili, C., Cavallera, V., Cousin, E., Hagins, H., Moberg, M. E., et al. (2024) · The Lancet Neurology · doi:10.1016/s1474-4422(24)00038-3 · Cited by 2,093 · see citing works
“…fifth-ranked cause of global age-standardised DALYs due to neurological conditions and its fast-increasing burden is in line with the observed increase in the global prevalence of diabetes, 38 particularly type 2 diabetes, which constitutes 96% of all diabetic cases and is a preventable condition.”
BackgroundSelf-citationFeigin, V. L., Abate, M. D., Abate, Y. H., ElHafeez, S. A., Abd-Allah, F., Abdelalim, A., Abdelkader, A. F. I., Abdelmasseh, M., Abd-Elsalam, S. M., Abdi, P., et al. (2024) · The Lancet Neurology · doi:10.1016/s1474-4422(24)00369-7 · Cited by 2,060 · see citing works
Self-citationNg, M., Gakidou, E., Lo, J., Abate, Y. H., Abbafati, C., Abbas, N., Abbasian, M., Abd ElHafeez, S., Abdel-Rahman, W. M., Abd-Elsalam, S., et al. (2025) · The Lancet · doi:10.1016/s0140-6736(25)00355-1 · Cited by 1,151 · see citing works
Self-citationFindings from the Global Burden of Disease Study 2021
Murray, C. J. L. (2024) · The Lancet · doi:10.1016/s0140-6736(24)00769-4 · Cited by 1,069 · see citing works
Self-citationVollset, S. E., Ababneh, H., Abate, Y. H., Abbafati, C., Abbasgholizadeh, R., Abbasian, M., Abbastabar, H., Magied, A. H. A. A. A., ElHafeez, S. A., Abdelkader, A. F. I., et al. (2024) · The Lancet · doi:10.1016/s0140-6736(24)00685-8 · Cited by 1,152 · see citing works
Self-citationZhou, B., Rayner, A. W., Gregg, E. W., Sheffer, K. E., Carrillo-Larco, R. M., Bennett, J. E., Shaw, J. E., Paciorek, C. J., Singleton, R. K., Barradas Pires, A., et al. (2024) · The Lancet · doi:10.1016/s0140-6736(24)02317-1 · Cited by 1,013 · see citing works
Self-citationHossain, M. J., Al‐Mamun, M., & Islam, M. R. (2024) · Health Science Reports · doi:10.1002/hsr2.2004 · Cited by 953 · see citing works
Self-citationHay, S. I., Ong, K. L., Santomauro, D. F., A, B., Aalipour, M. A., Aalruz, H., Ababneh, H. S., Abaraogu, U. O., Abate, B. B., Abbafati, C., et al. (2025) · The Lancet · doi:10.1016/s0140-6736(25)01637-x · Cited by 916 · see citing works
Self-citationType 2 diabetes mellitus in adults: pathogenesis, prevention and therapy
Lu, X., Xie, Q., Pan, X., Zhang, R., Zhang, X., Peng, G., Zhang, Y., Shen, S., & Tong, N. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01951-9 · Cited by 788 · see citing works
Su, D., Cui, Y., He, C., Yin, P., Bai, R., Zhu, J., Lam, J. S. T., Zhang, J., Yan, R., Zheng, X., et al. (2025) · BMJ · doi:10.1136/bmj-2024-080952 · Cited by 698 · see citing works
Self-citationGenitsaridi, I., Salpea, P., Salim, A., Sajjadi, S. F., Tomic, D., James, S., Thirunavukkarasu, S., Issaka, A., Chen, L., Basit, A., et al. (2025) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(25)00299-2 · Cited by 717 · see citing works
Self-citationMark, P. B., Stafford, L. K., Grams, M. E., Aalruz, H., ElHafeez, S. A., Abdelgalil, A. A., Abdulkader, R. S., Abeywickrama, H. M., Abiodun, O. O., Abramov, D., et al. (2025) · The Lancet · doi:10.1016/s0140-6736(25)01853-7 · Cited by 573 · see citing works
Self-citationAdvance in peptide-based drug development: delivery platforms, therapeutics and vaccines
Xiao, W., Jiang, W., Chen, Z., Huang, Y., Mao, J., Zheng, W., Hu, Y., & Shi, J. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-02107-5 · Cited by 449 · see citing works
Nascimento, G. G., Costa, S. A., & Romandini, M. (2024) · Journal of Periodontal Research · doi:10.1111/jre.13337 · Cited by 415 · see citing works
Li, X., Kong, X.-M., Yang, C., Cheng, Z., Lv, J.-J., Guo, H. Y., & Liu, X. (2024) · EClinicalMedicine · doi:10.1016/j.eclinm.2024.102758 · Cited by 408 · see citing works
“12 These approaches enabled us to model exposure distributions for each risk factor across various demographics and locations.”
Self-citationGlobal burden of metabolic diseases, 1990–2021
Zhang, H., Zhou, X., Shapiro, M. D., Lip, G. Y. H., Tilg, H., Valenti, L. V. C., Somers, V. K., Byrne, C. D., Targher, G., Yang, W., et al. (2024) · Metabolism · doi:10.1016/j.metabol.2024.155999 · Cited by 382 · see citing works
Israelsen, M. E., Francque, S., Tsochatzis, E. A., & Krag, A. A. (2024) · The Lancet · doi:10.1016/s0140-6736(24)01811-7 · Cited by 370 · see citing works
Ng, M., Dai, X., Cogen, R. M., Abdelmasseh, M., Abdollahi, A., Abdullahi, A., Aboagye, R. G., Abukhadijah, H. J., Adeyeoluwa, T. E., Afolabi, A. A., et al. (2024) · The Lancet · doi:10.1016/s0140-6736(24)01548-4 · Cited by 370 · see citing works
Self-citationBadve, S. V., Bilal, A., Lee, M. M. Y., Sattar, N., Gerstein, H. C., Ruff, C. T., McMurray, J. J. V., Rossing, P., Bakris, G., Mahaffey, K. W., et al. (2025) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(24)00271-7 · Cited by 359 · see citing works
Self-citationMłynarska, E., Czarnik, W., Kurys, N., Jędraszak, W., Majchrowicz, G., Prusinowski, F., Stabrawa, M., Rysz, J., & Franczyk, B. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26031094 · Cited by 421 · see citing works
Diabetes mellitus—Progress and opportunities in the evolving epidemic
Abel, E. D., Gloyn, A. L., Evans‐Molina, C., Joseph, J. J., Misra, S., Pajvani, U. B., Simcox, J., Suszták, K., & Drucker, D. J. (2024) · Cell · doi:10.1016/j.cell.2024.06.029 · Cited by 330 · see citing works
Ma, Z., Zuo, T., Frey, N., & Rangrez, A. Y. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01946-6 · Cited by 297 · see citing works
Multidrug-resistant tuberculosis
Dheda, K. U. J., Mirzayev, F., Cirillo, D. M., Udwadia, Z. F., Dooley, K. E., Chang, K. C., Omar, S. V., Reuter, A., Perumal, T., Horsburgh, C. R., et al. (2024) · Nature Reviews Disease Primers · doi:10.1038/s41572-024-00504-2 · Cited by 255 · see citing works
“27), diabetes mellitus is expected to have an increasingly important role in the epidemiology of TB in the coming decades.”
InfluentialZhou, X., Chen, Q., Yang, W., Zuluaga, M., Targher, G., Byrne, C. D., Valenti, L. V. C., Luo, F., Katsouras, C. S., Thaher, O., et al. (2024) · EClinicalMedicine · doi:10.1016/j.eclinm.2024.102848 · Cited by 259 · see citing works
“38 In recent decades, there has been a growing correlation between high BMI and type 2 diabetes, with exposure increased considerably between 2000 and 2021.”
Diabetic neuropathy: cutting-edge research and future directions
Yang, Y., Zhao, B. T., Wang, Y., Lan, H. H., Liu, X., Hu, Y., & Cao, P. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02175-1 · Cited by 285 · see citing works
Self-citationMesenchymal stem cells in treating human diseases: molecular mechanisms and clinical studies
Han, X., Liao, R., Li, X., Zhang, C., Huo, S., Qin, L., Xiong, Y., He, T., Xiao, G., & Zhang, T. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02313-9 · Cited by 251 · see citing works
Alfaris, N., Waldrop, S., Johnson, V., Boaventura, B., Kendrick, K., & Stanford, F. C. (2024) · EClinicalMedicine · doi:10.1016/j.eclinm.2024.102782 · Cited by 224 · see citing works
Tobias, D. K., Merino, J., Ahmad, A., Aiken, C., Benham, J. L., Bodhini, D., Clark, A. L., Colclough, K., Corcoy, R., CROMER, S. J., et al. (2023) · Nature Medicine · doi:10.1038/s41591-023-02502-5 · Cited by 229 · see citing works
Self-citationDiabetes in China part 1: epidemiology and risk factors
Xu, Y., Lu, J., Li, M., Wang, T., Wang, K., Cao, Q., Ding, Y., Xiang, Y., Wang, S., Yang, Q., et al. (2024) · The Lancet Public Health · doi:10.1016/s2468-2667(24)00250-0 · Cited by 235 · see citing works
Self-citationReligioni, U., Barrios‐Rodríguez, R., Requena, P., Borowska, M. W., & Ostrowski, J. (2025) · Medicina · doi:10.3390/medicina61010153 · Cited by 271 · see citing works
The Lancet Commission on rethinking coronary artery disease: moving from ischaemia to atheroma
Zaman, S. J., Wasfy, J. H., Kapil, V., Ziaeian, B., Parsonage, W. A., Sriswasdi, S., Chico, T., Capodanno, D., Colleran, R., Sutton, N. R., et al. (2025) · The Lancet · doi:10.1016/s0140-6736(25)00055-8 · Cited by 228 · see citing works
Self-citationA Heart-Healthy and Stroke-Free World
Mensah, G. A., Fuster, V., & Roth, G. A. (2023) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2023.11.003 · Cited by 195 · see citing works
Machine learning in precision diabetes care and cardiovascular risk prediction
Oikonomou, E. K., & Khera, R. (2023) · Cardiovascular Diabetology · doi:10.1186/s12933-023-01985-3 · Cited by 190 · see citing works
“It is estimated that nearly 529 million people worldwide and 35 million Americans currently have diabetes, with cardiovascular disease (CVD) representing the leading cause of morbidity and mortality [3, 4].”
BackgroundBlüher, M. (2025) · Diabetes Obesity and Metabolism · doi:10.1111/dom.16263 · Cited by 215 · see citing works
The impact of population ageing on the burden of chronic kidney disease
Chesnaye, N. C., Ortíz, A., Zoccali, C., Stel, V. S., & Jager, K. J. (2024) · Nature Reviews Nephrology · doi:10.1038/s41581-024-00863-9 · Cited by 185 · see citing works
“As diabetes mainly affects older individuals 59 and kidney damage typically occurs 5–15 years after diabetes onset, the rise in the burden of diabetes is expected to lead to a parallel rise in the burden of CKD, unless the implementation of preventive measures is substantially increased.”
Animal models for type 1 and type 2 diabetes: advantages and limitations
Singh, R. K., Gholipourmalekabadi, M., & Shafikhani, S. H. (2024) · Frontiers in Endocrinology · doi:10.3389/fendo.2024.1359685 · Cited by 166 · see citing works
Singh, A. P., Shadangi, S., Gupta, P. K., & Rana, S. (2025) · Comprehensive physiology · doi:10.1002/cph4.70003 · Cited by 183 · see citing works
Zi, H., Liu, M.-Y., Luo, L.-S., Huang, Q. Y., Luo, P.-C., Luan, H., Huang, J., Wang, D., Wang, Y., Zhang, Y., et al. (2024) · Military Medical Research · doi:10.1186/s40779-024-00569-w · Cited by 163 · see citing works
“Furthermore, transitioning from a traditional diet to an industrialized one, heightened exposure to environmental pollutants, and lifestyle changes such as reduced physical activity, can all contribute to an elevated risk of chronic diseases [17–19].”
BackgroundSelf-citationLu, Y., Shang, Z., Zhang, W., Hu, X., Shen, R., Zhang, L., Zhang, Y., Zhang, L., Liu, B., Pang, M., et al. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102598 · Cited by 159 · see citing works
Angiogenesis during diabetic wound repair: from mechanism to therapy opportunity
Huang, K., Mi, B., Xiong, Y., Fu, Z., Zhou, W., Liu, W., Liu, G., & Dai, G. (2024) · Burns & Trauma · doi:10.1093/burnst/tkae052 · Cited by 165 · see citing works
Acute respiratory distress syndrome
Wick, K. D., Ware, L. B., & Matthay, M. A. (2024) · BMJ · doi:10.1136/bmj-2023-076612 · Cited by 166 · see citing works
Ledesma, J. R., Ma, J., Zhang, M., Basting, A. V. L., Chu, H. T., Vongpradith, A., Novotney, A., LeGrand, K. E., Xu, Y. Y., Dai, X., et al. (2024) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(24)00007-0 · Cited by 146 · see citing works
Self-citationYu, B., Li, M., Yu, Z., Zheng, T., Feng, X., Gao, A., Zhang, H., & Gao, R. (2024) · BMC Medicine · doi:10.1186/s12916-024-03536-3 · Cited by 148 · see citing works
Self-citationThe global and regional burden of diabetic peripheral neuropathy
Savelieff, M. G., Elafros, M. A., Viswanathan, V., Jensen, T. S., Bennett, D., & Feldman, E. L. (2024) · Nature Reviews Neurology · doi:10.1038/s41582-024-01041-y · Cited by 163 · see citing works
Self-citationRafferty, Q., Stafford, L. K., Vos, T., Thomé, F. S., Aalruz, H., Abate, Y. H., Abbafati, C., ElHafeez, S. A., Abedi, A., Abiodun, O. O., et al. (2025) · The Lancet Global Health · doi:10.1016/s2214-109x(25)00198-6 · Cited by 159 · see citing works
Self-citationCaturano, A., Rocco, M. P., Tagliaferri, G., Piacevole, A., Nilo, D., Lorenzo, G. D., Iadicicco, I., Donnarumma, M., Galiero, R., Acierno, C., et al. (2025) · Antioxidants · doi:10.3390/antiox14010072 · Cited by 162 · see citing works
Huang, D., Lai, H., Shi, X., et al. (2024) · Journal of Infection · doi:10.1016/j.jinf.2024.106250 · Cited by 134 · see citing works
Global burden of metabolic dysfunction-associated steatotic liver disease, 2010 to 2021
Feng, G., Targher, G., Byrne, C. D., Yilmaz, Y. N., Wong, V. W., Lesmana, C. R. A., Adams, L. A., Boursier, J., Papatheodoridis, G., El‐Kassas, M., et al. (2024) · JHEP Reports · doi:10.1016/j.jhepr.2024.101271 · Cited by 122 · see citing works
Physical exercise, cognition, and brain health in aging
Silva, N. C. B. S., Barha, C. K., Erickson, K. I., Kramer, A. F., & Liu-Ambrose, T. Y. L. (2024) · Trends in Neurosciences · doi:10.1016/j.tins.2024.04.004 · Cited by 124 · see citing works
Apperloo, E. M., Gorriz, J. L., Soler, M. J., Cigarrán Guldris, S., Cruzado, J. M., Puchades, M. J., López-Martínez, M., Waanders, F., Laverman, G. D., van der Aart-van der Beek, A., et al. (2025) · Nature Medicine · doi:10.1038/s41591-024-03327-6 · Cited by 120 · see citing works
“Many patients with obesity develop type 2 diabetes 3 .”
Self-citationAdvances and challenges in kidney fibrosis therapeutics
Abbad, L., Estève, E., & Chatziantoniou, C. (2025) · Nature Reviews Nephrology · doi:10.1038/s41581-025-00934-5 · Cited by 125 · see citing works
“…(CKD) is a leading cause of disability worldwide owing to an ageing population, improved survival from cardiovascular disease, the increased prevalence of type 2 diabetes and a rise in autoimmune disorders driven by environmental changes (including pollution and industrialized food systems) 1 .”
Chen, Y., Meng, Z., Li, Y., Liu, S., Hu, P. L., & Luo, E. (2024) · Molecular Medicine · doi:10.1186/s10020-024-00905-9 · Cited by 113 · see citing works
Self-citationLara-Castor, L., O’Hearn, M., Cudhea, F., Miller, V., Shi, P., Zhang, J., Sharib, J. R., Cash, S. B., Barquera, S., Micha, R., et al. (2025) · Nature Medicine · doi:10.1038/s41591-024-03345-4 · Cited by 113 · see citing works
Self-citationLombardi, L., Genio, V. D., Alberício, F., & Williams, D. R. (2025) · Chemical Reviews · doi:10.1021/acs.chemrev.4c00989 · Cited by 126 · see citing works
Qi, X., Li, J., Caussy, C., Teng, G., & Loomba, R. (2024) · Hepatology · doi:10.1097/hep.0000000000000913 · Cited by 109 · see citing works
“[8] The presence of T2DM adversely affects glucose and lipid metabolism, leading to multiple systemic disturbances and organ dysfunction.”
Artificial intelligence for diabetes care: current and future prospects
Sheng, B., Pushpanathan, K., Guan, Z., Lim, Q. H., Lim, Z. W., Yew, S. M. E., Goh, J. H. L., Bee, Y. M., Sabanayagam, C., Sevdalis, N., et al. (2024) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(24)00154-2 · Cited by 106 · see citing works
Self-citationDiabetes in China: epidemiology, pathophysiology and multi-omics
Jia, W., Chan, J. C. N., Wong, T. Y., & Fisher, E. B. (2025) · Nature Metabolism · doi:10.1038/s42255-024-01190-w · Cited by 106 · see citing works
Global burden of MAFLD, MAFLD related cirrhosis and MASH related liver cancer from 1990 to 2021
Guo, Z., Wu, D., Mao, R., Yao, Z., Wu, Q., & Lv, W. (2025) · Scientific Reports · doi:10.1038/s41598-025-91312-5 · Cited by 100 · see citing works
The role of structural racism and geographical inequity in diabetes outcomes
Agarwal, S., Wade, A. N., Mbanya, J. C., Yajnik, C., Thomas, N., Egede, L. E., Campbell, J. A., Walker, R. J., Maple-Brown, L., & Graham, S. (2023) · The Lancet · doi:10.1016/s0140-6736(23)00909-1 · Cited by 97 · see citing works
Self-citationPan, Y., He, M., Wu, J., Qi, H., & Cheng, Y. (2023) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2023.135055 · Cited by 98 · see citing works
Mackenzie, S. C., Sainsbury, C. A. R., & Wake, D. J. (2023) · Diabetologia · doi:10.1007/s00125-023-06038-8 · Cited by 97 · see citing works
“In parallel, future diabetes projections look bleak; forecasts estimate that by 2050, 1.31 billion people will be living with diabetes [77].”
BackgroundInfluentialLiu, H., Yin, P., Qi, J., & Zhou, M. (2024) · Chinese Medical Journal · doi:10.1097/cm9.0000000000003270 · Cited by 101 · see citing works
A review of healthy role of dietary fiber in modulating chronic diseases
Li, M., & Ma, S. (2024) · Food Research International · doi:10.1016/j.foodres.2024.114682 · Cited by 101 · see citing works
Self-citationCardiovascular Effects and Tolerability of GLP-1 Receptor Agonists
Galli, M., Benenati, S., Laudani, C., Simeone, B., Sarto, G., Ortega‐Paz, L., Rocco, E., Bernardi, M., Spadafora, L., D’Amario, D., et al. (2025) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2025.08.027 · Cited by 113 · see citing works
Microenvironmental dynamics of diabetic wounds and insights for hydrogel-based therapeutics
Zhao, Y., Zhao, Y., Xu, B., Liu, H., & Chang, Q. (2024) · Journal of Tissue Engineering · doi:10.1177/20417314241253290 · Cited by 96 · see citing works
Li, C., Bishop, T. R. P., Imamura, F., Sharp, S. J., Pearce, M., Brage, S., Ong, K. K., Ahsan, H., Bes‐Rastrollo, M., Beulens, J. W. J., et al. (2024) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(24)00179-7 · Cited by 96 · see citing works
Self-citationHe, K., Wang, H., Xu, J., Gong, G., Liu, X., & Guan, H. (2024) · Frontiers in Endocrinology · doi:10.3389/fendo.2024.1501690 · Cited by 121 · see citing works
Self-citationEstatística Cardiovascular – Brasil 2023
de Oliveira, G. M. M., Brant, L. C. C., Polanczyk, C. A., Malta, D. C., Biolo, A., Nascimento, B. R., de Souza, M. D. F. M., Lorenzo, A. D., Fagundes, A. A. D. P., Schaan, B. D., et al. (2024) · Arquivos Brasileiros de Cardiologia · doi:10.36660/abc.20240079 · Cited by 97 · see citing works
Self-citationPeriodontitis and metabolic diseases (diabetes and obesity): Tackling multimorbidity
Marruganti, C., Suvan, J. E., & D’Aiuto, F. (2023) · Periodontology 2000 · doi:10.1111/prd.12536 · Cited by 96 · see citing works
Liang, B., Xiao, D., Wang, S., et al. (2024) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2024.116595 · Cited by 90 · see citing works
Self-citationGlobal Burden of the Key Components of Cardiovascular-Kidney-Metabolic Syndrome
Xie, Z., Yu, C., Cui, Q., Zhao, X., Zhuang, J., Chen, S., Guan, H., & Li, J. (2025) · Journal of the American Society of Nephrology · doi:10.1681/asn.0000000658 · Cited by 99 · see citing works
Self-citationOculomics: Current concepts and evidence
Zhu, Z., Wang, Y., Qi, Z., Hu, W., Zhang, X., Wagner, S. K., Wang, Y., Ran, A. R., Ong, J., Waisberg, E., et al. (2025) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2025.101350 · Cited by 94 · see citing works
“With 529 million people living with diabetes globally (Collaborators, 2023), early detection through retinal imaging could not only predict diabetes risk but also address DR, diabetic kidney disease, and cardio-vascular risk (Fox et al., 2007; Vujosevic et al., 2020; Zhang et al., 2021a).”
Self-citationLi, J., Wang, X., Jia, W., Wang, K., Wang, W., Diao, W.-B., Ou, F., Ma, J., & Yang, Y. (2024) · Frontiers in Endocrinology · doi:10.3389/fendo.2024.1367376 · Cited by 92 · see citing works
Redox signaling in the pancreas in health and disease
Sastre, J., Pérez, S., Sabater-Orti, L., & Rius‐Pérez, S. (2024) · Physiological Reviews · doi:10.1152/physrev.00044.2023 · Cited by 92 · see citing works
Cao, Y., Wang, W., Xie, S., Xu, Y., & Lin, Z. (2025) · BMC Public Health · doi:10.1186/s12889-024-21131-2 · Cited by 81 · see citing works
Self-citationCell migration in diabetic wound healing: Molecular mechanisms and therapeutic strategies (Review)
Song, J., Zhao, T., Wang, C., Sun, X., Sun, J., & Zhang, Z. (2025) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2025.5567 · Cited by 86 · see citing works
Self-citationObesity-Driven Metabolic Disorders: The Interplay of Inflammation and Mitochondrial Dysfunction
Choi, W., Woo, G. H., Kwon, T., & Jeon, J. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26199715 · Cited by 112 · see citing works
“T2DM accounts for the vast majority of diabetes cases worldwide and has reached epidemic proportions, closely linked to rising obesity prevalence [19,20].”
Understanding the cause of type 2 diabetes
Taylor, R. (2024) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(24)00157-8 · Cited by 83 · see citing works
Diabetes and its complications: molecular mechanisms, prevention and treatment
Zhao, L., Yuan, J., Yang, Q., Ma, J., Yang, F., Zou, Y., Liu, K., & Liu, F. (2026) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02401-w · Cited by 80 · see citing works
“2 The number of cases is projected to exceed 1.31 billion by 2050 3 , thus imposing a signi fi cant burden on both healthcare and the global economy.”
InfluentialInterventions to address global inequity in diabetes: international progress
Walker, A. F., Graham, S., Maple-Brown, L. J., Egede, L. E., Campbell, J. A., Walker, R. J., Wade, A. N., Mbanya, J. C., Long, J. A., Yajnik, C. S., et al. (2023) · The Lancet · doi:10.1016/s0140-6736(23)00914-5 · Cited by 79 · see citing works
Self-citationInsulin resistance as the molecular link between diabetes and Alzheimer's disease
Abdalla, M. M. I. (2024) · World Journal of Diabetes · doi:10.4239/wjd.v15.i7.1430 · Cited by 82 · see citing works
Type 2 diabetes mellitus – conventional therapies and future perspectives in innovative treatment
Gieroba, B., Kryska, A., & Sroka‐Bartnicka, A. (2025) · Biochemistry and Biophysics Reports · doi:10.1016/j.bbrep.2025.102037 · Cited by 104 · see citing works
“Importantly, T2DM accounts for over 96 % of all diabetes cases [1].”
Digital twins and artificial intelligence in metabolic disease research
MOSQUERA-LOPEZ, C. M., & Jacobs, P. G. (2024) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2024.04.019 · Cited by 77 · see citing works
FoxO1 as a tissue-specific therapeutic target for type 2 diabetes
Teaney, N. A., & Cyr, N. E. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1286838 · Cited by 81 · see citing works
Nandi, S., Nag, A., Khatua, S., Sen, S., Chakraborty, N., Naskar, A., Acharya, K., Călina, D. C., & Sharifi‐Rad, J. (2023) · Phytotherapy Research · doi:10.1002/ptr.8061 · Cited by 77 · see citing works
Huang, X., Wu, Y., Ni, Y., Xu, H., & He, Y. (2025) · Frontiers in Public Health · doi:10.3389/fpubh.2025.1515797 · Cited by 76 · see citing works
Self-citationChen, X., Zhang, L., & Chen, W. (2025) · BMC Medicine · doi:10.1186/s12916-025-03890-w · Cited by 73 · see citing works
Early-onset type 2 diabetes: the next major diabetes transition
Luk, A. O. Y., Wild, S. H., Jones, S., Anjana, R. M., Hivert, M., McCaffrey, J., Gregg, E. W., & Misra, S. (2025) · The Lancet · doi:10.1016/s0140-6736(25)00830-x · Cited by 85 · see citing works
Self-citationChen, W., Cai, P., Zou, W., & Fu, Z. (2024) · Frontiers in Endocrinology · doi:10.3389/fendo.2024.1330936 · Cited by 84 · see citing works
MOF-based platforms on diabetic disease: Advanced and prospect of effective diagnosing and therapy
Ma, D., Liang, T., Zheng, J., Chen, G., Ye, Y., Nezamzadeh‐Ejhieh, A., Lu, L., Song, Z., & Huang, Y. (2025) · Reactive and Functional Polymers · doi:10.1016/j.reactfunctpolym.2025.106520 · Cited by 71 · see citing works
Plant-derived nanovesicles: harnessing nature's power for tissue protection and repair
Chen, X., Xing, X., Lin, S., Huang, L., He, L., Zou, Y., Zhang, X., Su, B.-H., Lu, Y., & Zheng, D. (2023) · Journal of Nanobiotechnology · doi:10.1186/s12951-023-02193-7 · Cited by 72 · see citing works
Macrophages and T cells in metabolic disorder-associated cancers
Taranto, D., Kloosterman, D., & Akkari, L. (2024) · Nature Reviews. Cancer · doi:10.1038/s41568-024-00743-1 · Cited by 67 · see citing works
Interplay between periodontitis and chronic kidney disease
Chapple, I., Hirschfeld, J., Cockwell, P., Dietrich, T., & Sharma, P. (2024) · Nature Reviews Nephrology · doi:10.1038/s41581-024-00910-5 · Cited by 79 · see citing works
Zhou, Y.-C., Liu, J.-M., Zhao, Z., Zhou, M., & Ng, M. (2025) · Military Medical Research · doi:10.1186/s40779-025-00615-1 · Cited by 70 · see citing works
“The age-standardized rate (ASR) of prevalence of diabetes has doubled, increasing from 3% in 1990 to 6.2% in 2021 [2].”
InfluentialPrioritising the primary prevention of heart failure
Khan, S. S., Berwanger, O., Fiuzat, M., McMurray, J. J. V., Narula, J., Prabhakaran, D., Sliwa, K. S., Tromp, J., & Vaduganathan, M. (2025) · The Lancet · doi:10.1016/s0140-6736(25)01393-5 · Cited by 74 · see citing works
Prevention of cardiorenal complications in people with type 2 diabetes and obesity
Drucker, D. J. (2024) · Cell Metabolism · doi:10.1016/j.cmet.2023.12.018 · Cited by 68 · see citing works
Glycaemic control is still central in the hierarchy of priorities in type 2 diabetes management
Khunti, K., Zaccardi, F., Amod, A., Aroda, V., Aschner, P., Colagiuri, S., Mohan, V., & Chan, J. C. (2024) · Diabetologia · doi:10.1007/s00125-024-06254-w · Cited by 71 · see citing works
- Authors
- Ong, K. L., Stafford, L. K., McLaughlin, S. A., Boyko, E. J., Vollset, S. E., Smith, A. E., Dalton, B. E., Duprey, J., Cruz, J. A., Hagins, H., Lindstedt, P. A., Aali, A., Abate, Y. H., Abate, M. D., Abbasian, M., Abbasi-Kangevari, Z., Abbasi-Kangevari, M., Abd ElHafeez, S., Abd-Rabu, R., Abdulah, D. M., Abdullah, A. Y. M., Abedi, V., Abidi, H., Aboagye, R. G., Abolhassani, H., Abu-Gharbieh, E., Abu-Zaid, A., Adane, T. D., Adane, D. E., Addo, I. Y., Adegboye, O. A., Adekanmbi, V., Adepoju, A. V., Adnani, Q. E. S., Afolabi, R. F., Agarwal, G., Aghdam, Z. B., Agudelo-Botero, M., Aguilera Arriagada, C. E., Agyemang-Duah, W., Ahinkorah, B. O., Ahmad, D., Ahmad, R., Ahmad, S., Ahmad, A., Ahmadi, A., Ahmadi, K., Ahmed, A., Ahmed, A., Ahmed, L. A., Ahmed, S. A., Ajami, M., Akinyemi, R. O., Al Hamad, H., Al Hasan, S. M., AL-Ahdal, T. M. A., Alalwan, T. A., Al-Aly, Z., AlBataineh, M. T., Alcalde-Rabanal, J. E., Alemi, S., Ali, H., Alinia, T., Aljunid, S. M., Almustanyir, S., Al-Raddadi, R. M., Alvis-Guzman, N., Amare, F., Ameyaw, E. K., Amiri, S., Amusa, G. A., Andrei, C. L., Anjana, R. M., Ansar, A., Ansari, G., Ansari-Moghaddam, A., Anyasodor, A. E., Arabloo, J., Aravkin, A. Y., Areda, D., Arifin, H., Arkew, M., Armocida, B., Ärnlöv, J., Artamonov, A. A., Arulappan, J., Aruleba, R. T., Arumugam, A., Aryan, Z., Asemu, M. T., Asghari-Jafarabadi, M., Askari, E., Asmelash, D., Astell-Burt, T., Athar, M., Athari, S. S., Atout, M. M. W., Avila-Burgos, L., Awaisu, A., Azadnajafabad, S., B, D. B., Babamohamadi, H., Badar, M., Badawi, A., Badiye, A. D., Baghcheghi, N., Bagheri, N., Bagherieh, S., Bah, S., Bahadory, S., Bai, R., Baig, A. A., Baltatu, O. C., Baradaran, H. R., Barchitta, M., Bardhan, M., Barengo, N. C., Bärnighausen, T. W., Barone, M. T. U., Barone-Adesi, F., Barrow, A., Bashiri, H., Basiru, A., Basu, S., Basu, S., Batiha, A.-M. M., Batra, K., Bayih, M. T., Bayileyegn, N. S., Behnoush, A. H., Bekele, A. B., Belete, M. A., Belgaumi, U. I., Belo, L., Bennett, D. A., Bensenor, I. M., Berhe, K., Berhie, A. Y., Bhaskar, S., Bhat, A. N., Bhatti, J. S., Bikbov, B., Bilal, F., Bintoro, B. S., Bitaraf, S., Bitra, V. R., Bjegovic-Mikanovic, V., Bodolica, V., Boloor, A., Brauer, M., Brazo-Sayavera, J., Brenner, H., Butt, Z. A., Calina, D., Campos, L. A., Campos-Nonato, I. R., Cao, Y., Cao, C., Car, J., Carvalho, M., Castañeda-Orjuela, C. A., Catalá-López, F., Cerin, E., Chadwick, J., Chandrasekar, E. K., Chanie, G. S., Charan, J., Chattu, V. K., Chauhan, K., Cheema, H. A., Chekol Abebe, E., Chen, S., Cherbuin, N., Chichagi, F., Chidambaram, S. B., Cho, W. C. S., Choudhari, S. G., Chowdhury, R., Chowdhury, E. K., Chu, D.-T., Chukwu, I. S., Chung, S.-C., Coberly, K., Columbus, A., Contreras, D., Cousin, E., Criqui, M. H., Cruz-Martins, N., Cuschieri, S., Dabo, B., Dadras, O., Dai, X., Damasceno, A. A. M., Dandona, R., Dandona, L., Das, S., Dascalu, A. M., Dash, N. R., Dashti, M., Dávila-Cervantes, C. A., De la Cruz-Góngora, V., Debele, G. R., Delpasand, K., Demisse, F. W., Demissie, G. D., Deng, X., Denova-Gutiérrez, E., Deo, S. V., Dervišević, E., Desai, H. D., Desale, A. T., Dessie, A. M., Desta, F., Dewan, S. M. R., Dey, S., Dhama, K., Dhimal, M., Diao, N., Diaz, D., Dinu, M., Diress, M., Djalalinia, S., Doan, L. P., Dongarwar, D., dos Santos Figueiredo, F. W., Duncan, B. B., Dutta, S., Dziedzic, A. M., Edinur, H. A., Ekholuenetale, M., Ekundayo, T. C., Elgendy, I. Y., Elhadi, M., El-Huneidi, W., Elmeligy, O. A. A., Elmonem, M. A., Endeshaw, D., Esayas, H. L., Eshetu, H. B., Etaee, F., Fadhil, I., Fagbamigbe, A. F., Fahim, A., Falahi, S., Faris, M. E. M., Farrokhpour, H., Farzadfar, F., Fatehizadeh, A., Fazli, G., Feng, X., Ferede, T. Y., Fischer, F., Flood, D., Forouhari, A., Foroumadi, R., Foroutan Koudehi, M., Gaidhane, A. M., Gaihre, S., Gaipov, A., Galali, Y., Ganesan, B., Garcia-Gordillo, M., Gautam, R. K., Gebrehiwot, M., Gebrekidan, K. G., Gebremeskel, T. G., Getacher, L., Ghadirian, F., Ghamari, S.-H., Ghasemi Nour, M., Ghassemi, F., Golechha, M., Goleij, P., Golinelli, D., Gopalani, S. V., Guadie, H. A., Guan, S.-Y., Gudayu, T. W., Guimarães, R. A., Guled, R. A., Gupta, R., Gupta, K., Gupta, V. B., Gupta, V. K., Gyawali, B., Haddadi, R., Hadi, N. R., Haile, T. G., Hajibeygi, R., Haj-Mirzaian, A., Halwani, R., Hamidi, S., Hankey, G. J., Hannan, M. A., Haque, S., Harandi, H., Harlianto, N. I., Hasan, S. M. M., Hasan, S. S., Hasani, H., Hassanipour, S., Hassen, M. B., Haubold, J., Hayat, K., Heidari, G., Heidari, M., Hessami, K., Hiraike, Y., Holla, R., Hossain, S., Hossain, M. S., Hosseini, M.-S., Hosseinzadeh, M., Hosseinzadeh, H., Huang, J., Huda, M. N., Hussain, S., Huynh, H.-H., Hwang, B.-F., Ibitoye, S. E., Ikeda, N., Ilic, I. M., Ilic, M. D., Inbaraj, L. R., Iqbal, A., Islam, S. M. S., Islam, R. M., Ismail, N. E., Iso, H., Isola, G., Itumalla, R., Iwagami, M., Iwu, C. C. D., Iyamu, I. O., Iyasu, A. N., Jacob, L., Jafarzadeh, A., Jahrami, H., Jain, R., Jaja, C., Jamalpoor, Z., Jamshidi, E., Janakiraman, B., Jayanna, K., Jayapal, S. K., Jayaram, S., Jayawardena, R., Jebai, R., Jeong, W., Jin, Y., Jokar, M., Jonas, J. B., Joseph, N., Joseph, A., Joshua, C. E., Joukar, F., Jozwiak, J. J., Kaambwa, B., Kabir, A., Kabthymer, R. H., Kadashetti, V., Kahe, F., Kalhor, R., Kandel, H., Karanth, S. D., Karaye, I. M., Karkhah, S., Katoto, P. D., Kaur, N., Kazemian, S., Kebede, S. A., Khader, Y. S., Khajuria, H., Khalaji, A., Khan, M. A., Khan, M., Khan, A., Khanal, S., Khatatbeh, M. M., Khater, A. M., Khateri, S., khorashadizadeh, F., Khubchandani, J., Kibret, B. G., Kim, M. S., Kimokoti, R. W., Kisa, A., Kivimäki, M., Kolahi, A.-A., Komaki, S., Kompani, F., Koohestani, H. R., Korzh, O., Kostev, K., Kothari, N., Koyanagi, A., Krishan, K., Krishnamoorthy, Y., Kuate Defo, B., Kuddus, M., Kuddus, M. A., Kumar, R., Kumar, H., Kundu, S., Kurniasari, M. D., Kuttikkattu, A., La Vecchia, C., Lallukka, T., Larijani, B., Larsson, A. O., Latief, K., Lawal, B. K., Le, T. T. T., Le, T. T. B., Lee, S. W. H., Lee, M., Lee, W.-C., Lee, P. H., Lee, S.-W., Lee, S. W., Legesse, S. M., Lenzi, J., Li, Y., Li, M.-C., Lim, S. S., Lim, L.-L., Liu, X., Liu, C., Lo, C.-H., Lopes, G., Lorkowski, S., Lozano, R., Lucchetti, G., Maghazachi, A. A., Mahasha, P. W., Mahjoub, S., Mahmoud, M. A., Mahmoudi, R., Mahmoudimanesh, M., Mai, A. T., Majeed, A., Majma Sanaye, P., Makris, K. C., Malhotra, K., Malik, A. A., Malik, I., Mallhi, T. H., Malta, D. C., Mamun, A. A., Mansouri, B., Marateb, H. R., Mardi, P., Martini, S., Martorell, M., Marzo, R. R., Masoudi, R., Masoudi, S., Mathews, E., Maugeri, A., Mazzaglia, G., Mekonnen, T., Meshkat, M., Mestrovic, T., Miao Jonasson, J., Miazgowski, T., Michalek, I. M., Minh, L. H. N., Mini, G., Miranda, J. J., Mirfakhraie, R., Mirrakhimov, E. M., Mirza-Aghazadeh-Attari, M., Misganaw, A., Misgina, K. H., Mishra, M., Moazen, B., Mohamed, N. S., Mohammadi, E., Mohammadi, M., Mohammadian-Hafshejani, A., Mohammadshahi, M., Mohseni, A., Mojiri-forushani, H., Mokdad, A. H., Momtazmanesh, S., Monasta, L., Moniruzzaman, M., Mons, U., Montazeri, F., Moodi Ghalibaf, A., Moradi, Y., Moradi, M., Moradi Sarabi, M., Morovatdar, N., Morrison, S. D., Morze, J., Mossialos, E., Mostafavi, E., Mueller, U. O., Mulita, F., Mulita, A., Murillo-Zamora, E., Musa, K. I., Mwita, J. C., Nagaraju, S. P., Naghavi, M., Nainu, F., Nair, T. S., Najmuldeen, H. H. R., Nangia, V., Nargus, S., Naser, A. Y., Nassereldine, H., Natto, Z. S., Nauman, J., Nayak, B. P., Ndejjo, R., Negash, H., Negoi, R. I., Nguyen, H. T. H., Nguyen, D. H., Nguyen, P. T., Nguyen, V. T., Nguyen, H. Q., Niazi, R. K., Nigatu, Y. T., Ningrum, D. N. A., Nizam, M. A., Nnyanzi, L. A., Noreen, M., Noubiap, J. J., Nzoputam, O. J., Nzoputam, C. I., Oancea, B., Odogwu, N. M., Odukoya, O. O., Ojha, V. A., Okati-Aliabad, H., Okekunle, A. P., Okonji, O. C., Okwute, P. G., Olufadewa, I. I., Onwujekwe, O. E., Ordak, M., Ortiz, A., Osuagwu, U. L., Oulhaj, A., Owolabi, M. O., Padron-Monedero, A., Padubidri, J. R., Palladino, R., Panagiotakos, D., Panda-Jonas, S., Pandey, A., Pandey, A., Pandi-Perumal, S. R., Pantea Stoian, A. M., Pardhan, S., Parekh, T., Parekh, U., Pasovic, M., Patel, J., Patel, J. R., Paudel, U., Pepito, V. C. F., Pereira, M., Perico, N., Perna, S., Petcu, I.-R., Petermann-Rocha, F. E., Podder, V., Postma, M. J., Pourali, G., Pourtaheri, N., Prates, E. J. S., Qadir, M. M. F., Qattea, I., Raee, P., Rafique, I., Rahimi, M., Rahimifard, M., Rahimi-Movaghar, V., Rahman, M. O., Rahman, M. A., Rahman, M. H. U., Rahman, M., Rahman, M. M., Rahmani, M., Rahmani, S., Rahmanian, V., Rahmawaty, S., Rahnavard, N., Rajbhandari, B., Ram, P., Ramazanu, S., Rana, J., Rancic, N., Ranjha, M. M. A. N., Rao, C. R., Rapaka, D., Rasali, D. P., Rashedi, S., Rashedi, V., Rashid, A. M., Rashidi, M.-M., Ratan, Z. A., Rawaf, S., Rawal, L., Redwan, E. M. M., Remuzzi, G., Rengasamy, K. R., Renzaho, A. M. N., Reyes, L. F., Rezaei, N., Rezaei, N., Rezaeian, M., Rezazadeh, H., Riahi, S. M., Rias, Y. A., Riaz, M., Ribeiro, D., Rodrigues, M., Rodriguez, J. A. B., Roever, L., Rohloff, P., Roshandel, G., Roustazadeh, A., Rwegerera, G. M., Saad, A. M. A., Saber-Ayad, M. M., Sabour, S., Sabzmakan, L., Saddik, B., Sadeghi, E., Saeed, U., Saeedi Moghaddam, S., Safi, S., Safi, S. Z., Saghazadeh, A., Saheb Sharif-Askari, N., Saheb Sharif-Askari, F., Sahebkar, A., Sahoo, S. S., Sahoo, H., Saif-Ur-Rahman, K., Sajid, M. R., Salahi, S., Salahi, S., Saleh, M. A., Salehi, M. A., Salomon, J. A., Sanabria, J., Sanjeev, R. K., Sanmarchi, F., Santric-Milicevic, M. M., Sarasmita, M. A., Sargazi, S., Sathian, B., Sathish, T., Sawhney, M., Schlaich, M. P., Schmidt, M. I., Schuermans, A., Seidu, A.-A., Senthil Kumar, N., Sepanlou, S. G., Sethi, Y., Seylani, A., Shabany, M., Shafaghat, T., Shafeghat, M., Shafie, M., Shah, N. S., Shahid, S., Shaikh, M. A., Shanawaz, M., Shannawaz, M., Sharfaei, S., Shashamo, B. B., Shiri, R., Shittu, A., Shivakumar, K. M., Shivalli, S., Shobeiri, P., Shokri, F., Shuval, K., Sibhat, M. M., Silva, L. M. L. R., Simpson, C. R., Singh, J. A., Singh, P., Singh, S., Siraj, M. S., Skryabina, A. A., Sohag, A. A. M., Soleimani, H., Solikhah, S., Soltani-Zangbar, M. S., Somayaji, R., Sorensen, R. J. D., Starodubova, A. V., Sujata, S., Suleman, M., Sun, J., Sundström, J., Tabarés-Seisdedos, R., Tabatabaei, S. M., Tabatabaeizadeh, S.-A., Tabish, M., Taheri, M., Taheri, E., Taki, E., Tamuzi, J. J. L., Tan, K.-K., Tat, N. Y., Taye, B. T., Temesgen, W. A., Temsah, M.-H., Tesler, R., Thangaraju, P., Thankappan, K. R., Thapa, R., Tharwat, S., Thomas, N., Ticoalu, J. H. V., Tiyuri, A., Tonelli, M., Tovani-Palone, M. R., Trico, D., Trihandini, I., Tripathy, J. P., Tromans, S. J., Tsegay, G. M., Tualeka, A. R., Tufa, D. G., Tyrovolas, S., Ullah, S., Upadhyay, E., Vahabi, S. M., Vaithinathan, A. G., Valizadeh, R., van Daalen, K. R., Vart, P., Varthya, S. B., Vasankari, T. J., Vaziri, S., Verma, M. V., Verras, G.-I., Vo, D. C., Wagaye, B., Waheed, Y., Wang, Z., Wang, Y., Wang, C., Wang, F., Wassie, G. T., Wei, M. Y. W., Weldemariam, A. H., Westerman, R., Wickramasinghe, N. D., Wu, Y., Wulandari, R. D., Xia, J., Xiao, H., Xu, S., Xu, X., Yada, D. Y., Yang, L., Yatsuya, H., Yesiltepe, M., Yi, S., Yohannis, H. K., Yonemoto, N., You, Y., Zaman, S. B., Zamora, N., Zare, I., Zarea, K., Zarrintan, A., Zastrozhin, M. S., Zeru, N. G., Zhang, Z.-J., Zhong, C., Zhou, J., Zielińska, M., Zikarg, Y. T., Zodpey, S., Zoladl, M., Zou, Z., Zumla, A., Zuniga, Y. M. H., Magliano, D. J., Murray, C. J. L., Hay, S. I., & Vos, T.
- Affiliations
- University of Washington (US)
- ORCID
- Ong, Kanyin Liane
- Stafford, Lauryn K
- Boyko, Edward J
- Smith, Amanda E
- Lindstedt, Paulina A
- Aali, Amirali
- Abate, Melsew Dagne
- Abbasian, Mohammadreza
- Abbasi-Kangevari, Zeinab
- Abdulah, Deldar Morad
- Abdullah, Abu Yousuf Md
- Abedi, Vida
- Abidi, Hassan
- Aboagye, Richard Gyan
- Abolhassani, Hassan
- Adane, Tigist Demssew
- Addo, Isaac Yeboah
- Adegboye, Oyelola A
- Adekanmbi, Victor
- Adnani, Qorinah Estiningtyas Sakilah
- Afolabi, Rotimi Felix
- Agarwal, Gina
- Aghdam, Zahra Babaei
- Ahinkorah, Bright Opoku
- Ahmad, Danish
- Ahmad, Rizwan
- Ahmad, Aqeel
- Ahmadi, Ali
- Ahmadi, Keivan
- Ahmed, Ayman
- Ahmed, Ali
- Ahmed, Luai A
- Ahmed, Syed Anees
- Ajami, Marjan
- Akinyemi, Rufus Olusola
- AL-Ahdal, Tareq Mohammed Ali
- Alalwan, Tariq A
- Alemi, Sharifullah
- Ali, Hassam
- Alinia, Tahereh
- Aljunid, Syed Mohamed
- Almustanyir, Sami
- Al-Raddadi, Rajaa M
- Amare, Firehiwot
- Ameyaw, Edward Kwabena
- Amiri, Sohrab
- Anjana, Ranjit Mohan
- Ansar, Adnan
- Anyasodor, Anayochukwu Edward
- Arabloo, Jalal
- Aravkin, Aleksandr Y
- Arifin, Hidayat
- Arkew, Mesay
- Armocida, Benedetta
- Ärnlöv, Johan
- Artamonov, Anton A
- Arulappan, Judie
- Aruleba, Raphael Taiwo
- Arumugam, Ashokan
- Aryan, Zahra
- Asmelash, Daniel
- Athar, Mohammad
- Athari, Seyyed Shamsadin
- Atout, Maha Moh'd Wahbi
- Awaisu, Ahmed
- Azadnajafabad, Sina
- Babamohamadi, Hassan
- Badar, Muhammad
- Badawi, Alaa
- Badiye, Ashish D
- Baghcheghi, Nayereh
- Bagheri, Nasser
- Bagherieh, Sara
- Bah, Sulaiman
- Bahadory, Saeed
- Bai, Ruhai
- Baig, Atif Amin
- Baltatu, Ovidiu Constantin
- Baradaran, Hamid Reza
- Barchitta, Martina
- Bardhan, Mainak
- Bärnighausen, Till Winfried
- Barone, Mark Thomaz Ugliara
- Barrow, Amadou
- Basiru, Afisu
- Basu, Sanjay
- Basu, Saurav
- Batiha, Abdul-Monim Mohammad
- Batra, Kavita
- Bayih, Mulat Tirfie
- Bayileyegn, Nebiyou Simegnew
- Behnoush, Amir Hossein
- Bekele, Alehegn Bekele
- Belete, Melaku Ashagrie
- Belgaumi, Uzma Iqbal
- Bennett, Derrick A
- Berhe, Kidanemaryam
- Berhie, Alemshet Yirga
- Bhaskar, Sonu
- Bhatti, Jasvinder Singh
- Bikbov, Boris
- Bintoro, Bagas Suryo
- Bitaraf, Saeid
- Bitra, Veera R
- Bjegovic-Mikanovic, Vesna
- Boloor, Archith
- Brauer, Michael
- Brenner, Hermann
- Butt, Zahid A
- Campos, Luciana Aparecida
- Cao, Yin
- Cao, Chao
- Car, Josip
- Carvalho, Márcia
- Castañeda-Orjuela, Carlos A
- Catalá-López, Ferrán
- Cerin, Ester
- Chadwick, Joshua
- Chandrasekar, Eeshwar K
- Chanie, Gashaw Sisay
- Charan, Jaykaran
- Chattu, Vijay Kumar
- Chauhan, Kirti
- Cheema, Huzaifa Ahmad
- Chen, Simiao
- Cherbuin, Nicolas
- Chichagi, Fatemeh
- Chidambaram, Saravana Babu
- Cho, William C S
- Choudhari, Sonali Gajanan
- Chowdhury, Rajiv
- Chowdhury, Enayet Karim
- Chu, Dinh-Toi
- Chukwu, Isaac Sunday
- Chung, Sheng-Chia
- Columbus, Alyssa
- Contreras, Daniela
- Cousin, Ewerton
- Criqui, Michael H
- Cuschieri, Sarah
- Dadras, Omid
- Dai, Xiaochen
- Damasceno, Albertino Antonio Moura
- Dandona, Rakhi
- Dandona, Lalit
- Dash, Nihar Ranjan
- Dashti, Mohsen
- Dávila-Cervantes, Claudio Alberto
- Debele, Gebiso Roba
- Delpasand, Kourosh
- Demissie, Getu Debalkie
- Deo, Salil V
- Dervišević, Emina
- Desai, Hardik Dineshbhai
- Dessie, Anteneh Mengist
- Desta, Fikreab
- Dewan, Syed Masudur Rahman
- Dhama, Kuldeep
- Dhimal, Meghnath
- Dinu, Monica
- Diress, Mengistie
- Djalalinia, Shirin
- Doan, Linh Phuong
- Dongarwar, Deepa
- Duncan, Bruce B
- Dutta, Siddhartha
- Dziedzic, Arkadiusz Marian
- Edinur, Hisham Atan
- Ekholuenetale, Michael
- Ekundayo, Temitope Cyrus
- Elgendy, Islam Y
- Elhadi, Muhammed
- Elmonem, Mohamed A
- Endeshaw, Destaw
- Eshetu, Habitu Birhan
- Fadhil, Ibtihal
- Fagbamigbe, Adeniyi Francis
- Fahim, Ayesha
- Falahi, Shahab
- Faris, MoezAlIslam Ezzat Mahmoud
- Farrokhpour, Hossein
- Farzadfar, Farshad
- Fatehizadeh, Ali
- Fazli, Ghazal
- Feng, Xiaoqi
- Fischer, Florian
- Flood, David
- Forouhari, Ali
- Foroumadi, Roham
- Gaidhane, Abhay Motiramji
- Gaihre, Santosh
- Gaipov, Abduzhappar
- Galali, Yaseen
- Ganesan, Balasankar
- Gautam, Rupesh K
- Gebrehiwot, Mesfin
- Gebrekidan, Kahsu Gebrekirstos
- Gebremeskel, Teferi Gebru
- Getacher, Lemma
- Ghamari, Seyyed-Hadi
- Ghassemi, Fariba
- Golechha, Mahaveer
- Goleij, Pouya
- Golinelli, Davide
- Gopalani, Sameer Vali
- Guadie, Habtamu Alganeh
- Guan, Shi-Yang
- Gudayu, Temesgen Worku
- Guimarães, Rafael Alves
- Guled, Rashid Abdi
- Gupta, Kartik
- Gupta, Veer Bala
- Gupta, Vivek Kumar
- Gyawali, Bishal
- Haddadi, Rasool
- Haile, Teklehaimanot Gereziher
- Hajibeygi, Ramtin
- Halwani, Rabih
- Hamidi, Samer
- Hankey, Graeme J
- Hannan, Md Abdul
- Haque, Shafiul
- Harandi, Hamid
- Harlianto, Netanja I
- Hasan, S M Mahmudul
- Hasan, Syed Shahzad
- Hassanipour, Soheil
- Haubold, Johannes
- Hayat, Khezar
- Heidari, Golnaz
- Heidari, Mohammad
- Hessami, Kamran
- Holla, Ramesh
- Hossain, Sahadat
- Hossain, Md Shakhaoat
- Hosseini, Mohammad-Salar
- Hosseinzadeh, Mehdi
- Hosseinzadeh, Hassan
- Huang, Junjie
- Huda, Md Nazmul
- Hussain, Salman
- Huynh, Hong-Han
- Hwang, Bing-Fang
- Ibitoye, Segun Emmanuel
- Ikeda, Nayu
- Inbaraj, Leeberk Raja
- Iqbal, Afrin
- Islam, Sheikh Mohammed Shariful
- Islam, Rakibul M
- Ismail, Nahlah Elkudssiah
- Iso, Hiroyasu
- Isola, Gaetano
- Itumalla, Ramaiah
- Iwagami, Masao
- Iyamu, Ihoghosa Osamuyi
- Iyasu, Assefa N
- Jacob, Louis
- Jafarzadeh, Abdollah
- Jahrami, Haitham
- Jain, Rajesh
- Jamshidi, Elham
- Janakiraman, Balamurugan
- Jayanna, Krishnamurthy
- Jayapal, Sathish Kumar
- Jayawardena, Ranil
- Jebai, Rime
- Jeong, Wonjeong
- Jin, Yinzi
- Jokar, Mohammad
- Jonas, Jost B
- Joseph, Nitin
- Joseph, Abel
- Jozwiak, Jacek Jerzy
- Kaambwa, Billingsley
- Kabir, Ali
- Kabthymer, Robel Hussen
- Kalhor, Rohollah
- Kandel, Himal
- Karanth, Shama D
- Karaye, Ibraheem M
- Karkhah, Samad
- Katoto, Patrick DMC
- Kaur, Navjot
- Kazemian, Sina
- Kebede, Sewnet Adem
- Khader, Yousef Saleh
- Khajuria, Himanshu
- Khalaji, Amirmohammad
- Khan, Moien AB
- Khan, Maseer
- Khan, Ajmal
- Khanal, Saval
- Khatatbeh, Moawiah Mohammad
- Khateri, Sorour
- khorashadizadeh, Fatemeh
- Khubchandani, Jagdish
- Kim, Min Seo
- Kimokoti, Ruth W
- Kolahi, Ali-Asghar
- Kompani, Farzad
- Koohestani, Hamid Reza
- Korzh, Oleksii
- Kostev, Karel
- Kothari, Nikhil
- Koyanagi, Ai
- Krishan, Kewal
- Krishnamoorthy, Yuvaraj
- Kuddus, Mohammed
- Kuddus, Md Abdul
- Kundu, Satyajit
- Kurniasari, Maria Dyah
- Lallukka, Tea
- Larijani, Bagher
- Larsson, Anders O
- Latief, Kamaluddin
- Lawal, Basira Kankia
- Le, Trang Thi Bich
- Lee, Shaun Wen Huey
- Lee, Munjae
- Lee, Wei-Chen
- Lee, Paul H
- Lee, Seung Won
- Legesse, Samson Mideksa
- Lenzi, Jacopo
- Li, Yongze
- Li, Ming-Chieh
- Lim, Stephen S
- Lim, Lee-Ling
- Liu, Xuefeng
- Liu, Chaojie
- Lo, Chun-Han
- Lopes, Graciliana
- Lozano, Rafael
- Lucchetti, Giancarlo
- Maghazachi, Azzam A
- Mahasha, Phetole Walter
- Majeed, Azeem
- Makris, Konstantinos Christos
- Malhotra, Kashish
- Malik, Ahmad Azam
- Malik, Iram
- Mallhi, Tauqeer Hussain
- Mamun, Abdullah A
- Mansouri, Borhan
- Marateb, Hamid Reza
- Mardi, Parham
- Martini, Santi
- Martorell, Miquel
- Marzo, Roy Rillera
- Masoudi, Sahar
- Mathews, Elezebeth
- Maugeri, Andrea
- Mazzaglia, Giampiero
- Mekonnen, Teferi
- Miazgowski, Tomasz
- Minh, Le Huu Nhat
- Mini, GK
- Miranda, J Jaime
- Mirfakhraie, Reza
- Mirrakhimov, Erkin M
- Misgina, Kebede Haile
- Mishra, Manish
- Moazen, Babak
- Mohamed, Nouh Saad
- Mohammadi, Esmaeil
- Mohammadian-Hafshejani, Abdollah
- Mohammadshahi, Marita
- Mojiri-forushani, Hoda
- Mokdad, Ali H
- Momtazmanesh, Sara
- Monasta, Lorenzo
- Mons, Ute
- Moradi, Yousef
- Moradi, Maryam
- Morovatdar, Negar
- Morrison, Shane Douglas
- Morze, Jakub
- Mossialos, Elias
- Mostafavi, Ebrahim
- Mueller, Ulrich Otto
- Mulita, Francesk
- Mulita, Admir
- Musa, Kamarul Imran
- Mwita, Julius C
- Nagaraju, Shankar Prasad
- Naghavi, Mohsen
- Nainu, Firzan
- Nair, Tapas Sadasivan
- Najmuldeen, Hastyar Hama Rashid
- Nargus, Shumaila
- Naser, Abdallah Y
- Nassereldine, Hasan
- Natto, Zuhair S
- Nauman, Javaid
- Nayak, Biswa Prakash
- Ndejjo, Rawlance
- Negoi, Ruxandra Irina
- Nguyen, Dang H
- Nguyen, Phat Tuan
- Nguyen, Hien Quang
- Nigatu, Yeshambel T
- Ningrum, Dina Nur Anggraini
- Nnyanzi, Lawrence Achilles
- Noreen, Mamoona
- Noubiap, Jean Jacques
- Nzoputam, Ogochukwu Janet
- Nzoputam, Chimezie Igwegbe
- Oancea, Bogdan
- Odogwu, Nkechi Martina
- Odukoya, Oluwakemi Ololade
- Okekunle, Akinkunmi Paul
- Okonji, Osaretin Christabel
- Olufadewa, Isaac Iyinoluwa
- Onwujekwe, Obinna E
- Osuagwu, Uchechukwu Levi
- Owolabi, Mayowa O
- Padubidri, Jagadish Rao
- Palladino, Raffaele
- Panagiotakos, Demosthenes
- Pandey, Ashok
- Pandey, Anamika
- Pandi-Perumal, Seithikurippu R
- Pardhan, Shahina
- Parekh, Tarang
- Parekh, Utsav
- Pasovic, Maja
- Patel, Jay
- Patel, Jenil R
- Paudel, Uttam
- Pepito, Veincent Christian Filipino
- Pereira, Marcos
- Perico, Norberto
- Perna, Simone
- Petcu, Ionela-Roxana
- Petermann-Rocha, Fanny Emily
- Podder, Vivek
- Postma, Maarten J
- Pourali, Ghazaleh
- Prates, Elton Junio Sady
- Qadir, Mirza Muhammad Fahd
- Qattea, Ibrahim
- Raee, Pourya
- Rahimi, Mehran
- Rahimifard, Mahban
- Rahman, Muhammad Aziz
- Rahman, Mohammad Hifz Ur
- Rahman, Mosiur
- Rahman, Md Mosfequr
- Rahmanian, Vahid
- Rahmawaty, Setyaningrum
- Rajbhandari, Bibek
- Ram, Pradhum
- Ramazanu, Sheena
- Rana, Juwel
- Ranjha, Muhammad Modassar Ali Nawaz
- Rao, Chythra R
- Rapaka, Deepthi
- Rasali, Drona Prakash
- Rashedi, Sina
- Rashedi, Vahid
- Rashid, Ahmed Mustafa
- Rashidi, Mohammad-Mahdi
- Ratan, Zubair Ahmed
- Rawaf, Salman
- Rawal, Lal
- Remuzzi, Giuseppe
- Rengasamy, Kannan RR
- Reyes, Luis Felipe
- Rezaei, Nima
- Rezaei, Nazila
- Rezaeian, Mohsen
- Rezazadeh, Hossein
- Riahi, Seyed Mohammad
- Rias, Yohanes Andy
- Riaz, Muhammad
- Rodrigues, Mónica
- Roever, Leonardo
- Rohloff, Peter
- Roshandel, Gholamreza
- Roustazadeh, Abazar
- Rwegerera, Godfrey M
- Saad, Aly M A
- Saber-Ayad, Maha Mohamed
- Sabour, Siamak
- Sabzmakan, Leila
- Saddik, Basema
- Sadeghi, Erfan
- Saeed, Umar
- Safi, Sare
- Safi, Sher Zaman
- Saghazadeh, Amene
- Sahebkar, Amirhossein
- Sahoo, Soumya Swaroop
- Sahoo, Harihar
- Sajid, Mirza Rizwan
- Saleh, Mohamed A
- Salehi, Mohammad Amin
- Salomon, Joshua A
- Sanabria, Juan
- Sanjeev, Rama Krishna
- Sanmarchi, Francesco
- Santric-Milicevic, Milena M
- Sarasmita, Made Ary
- Sargazi, Saman
- Sathian, Brijesh
- Schlaich, Markus P
- Schuermans, Art
- Sepanlou, Sadaf G
- Sethi, Yashendra
- Shafaghat, Tahereh
- Shafeghat, Melika
- Shafie, Mahan
- Shah, Nilay S
- Shahid, Samiah
- Shaikh, Masood Ali
- Shanawaz, Mohd
- Shannawaz, Mohammed
- Sharfaei, Sadaf
- Shashamo, Bereket Beyene
- Shiri, Rahman
- Shittu, Aminu
- Shivakumar, K M
- Shivalli, Siddharudha
- Shobeiri, Parnian
- Shokri, Fereshteh
- Shuval, Kerem
- Sibhat, Migbar Mekonnen
- Simpson, Colin R
- Singh, Paramdeep
- Singh, Surjit
- Siraj, Md Shahjahan
- Skryabina, Anna Aleksandrovna
- Sohag, Abdullah Al Mamun
- Soleimani, Hamidreza
- Solikhah, Solikhah
- Somayaji, Ranjani
- Sorensen, Reed J D
- Starodubova, Antonina V
- Sujata, Sujata
- Suleman, Muhammad
- Sun, Jing
- Sundström, Johan
- Tabatabaei, Seyyed Mohammad
- Tabatabaeizadeh, Seyed-Amir
- Tabish, Mohammad
- Taheri, Majid
- Taki, Elahe
- Tan, Ker-Kan
- Tat, Nathan Y
- Taye, Birhan Tsegaw
- Temesgen, Worku Animaw
- Temsah, Mohamad-Hani
- Tesler, Riki
- Thangaraju, Pugazhenthan
- Thapa, Rajshree
- Tharwat, Samar
- Thomas, Nihal
- Tiyuri, Amir
- Tonelli, Marcello
- Trihandini, Indang
- Tripathy, Jaya Prasad
- Tromans, Samuel Joseph
- Tualeka, Abdul Rohim
- Tyrovolas, Stefanos
- Ullah, Sana
- Upadhyay, Era
- Vahabi, Seyed Mohammad
- Vaithinathan, Asokan Govindaraj
- Vart, Priya
- Varthya, Shoban Babu
- Vasankari, Tommi Juhani
- Verma, Madhur verma
- Verras, Georgios-Ioannis
- Wagaye, Birhanu
- Waheed, Yasir
- Wang, Ziyue
- Wang, Yanqing
- Wang, Cong
- Wang, Fang
- Wassie, Gizachew Tadesse
- Wei, Melissa Y Wei
- Westerman, Ronny
- Wickramasinghe, Nuwan Darshana
- Wu, YiFan
- Wulandari, Ratna DWI
- Xiao, Hong
- Xu, Suowen
- Xu, Xiaoyue
- Yada, Dereje Y
- Yang, Lin
- Yatsuya, Hiroshi
- Yi, Siyan
- Yohannis, Hunachew Kibret
- Yonemoto, Naohiro
- You, Yuyi
- Zaman, Sojib Bin
- Zarea, Kourosh
- Zarrintan, Armin
- Zhang, Zhi-Jiang
- Zielińska, Magdalena
- Zikarg, Yossef Teshome
- Zodpey, Sanjay
- Zoladl, Mohammad
- Zumla, Alimuddin
- Magliano, Dianna J
- Murray, Christopher J L
- Hay, Simon I
- Vos, Theo
- Venue
- The Lancet
- Publisher
- Elsevier BV
- Published
- 2023-07
- Volume
- 402
- Issue
- 10397
- Pages
- 203-234
- ISSN
- 0099-5355 (ISSN-L)
- 0140-6736
- PMC
- PMC10364581
- OpenAlex
- W4381799391
- Cited by
- 4,681
- References
- 91
- Citations by year
- 2026: 1296 · 2025: 1970 · 2024: 1249 · 2023: 162 · 2022: 2 · 2021: 1 · 2018: 1
- FWCI
- 773.24
- Type
- journal article
- Language
- en
- Update notices
- Open access
- hybrid
- doi.org
- Licence
- Locations
- The Lancet (publishedVersion, cc-by)
- UWA Profiles and Research Repository (UWA) (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Institutional Repository University of Antioquia (University of Antioquia) (publishedVersion, cc-by-nc-nd)
- Research at the University of Copenhagen (University of Copenhagen) (publishedVersion, cc-by)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (publishedVersion, cc-by)
- Monash University Research Portal (Monash University) (acceptedVersion, cc-by)
- London School of Economics and Political Science Research Online (London School of Economics and Political Science) (acceptedVersion)
- ePrints Soton (University of Southampton) (acceptedVersion)
- LSHTM Research Online (London School of Hygiene and Tropical Medicine) (acceptedVersion)
- UEA Digital Repository (University of East Anglia) (acceptedVersion)
- DSPACE System - Metalibrary (University of the Coast) (submittedVersion, cc-by)
- ResearchOnline at James Cook University (James Cook University) (submittedVersion)
- UNSWorks (University of New South Wales, Sydney, Australia) (submittedVersion, cc-by-nc-nd)
- UPCommons institutional repository (Universitat Politècnica de Catalunya) (submittedVersion, cc-by-nc-nd)
- OAR@UM (University of Malta) (submittedVersion, other-oa)
- Diva portal (Dalarna University Library) (submittedVersion, other-oa)
- Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano) (submittedVersion, other-oa)
- CINECA IRIS Institutial research information system (University of Pisa) (submittedVersion, cc-by)
- BOA (University of Milano-Bicocca) (submittedVersion, cc-by)
- Archivio istituzionale della ricerca (Alma Mater Studiorum Università di Bologna) (submittedVersion, cc-by)
- Econstor (Econstor) (submittedVersion, cc-by)
- UCL Discovery (University College London) (submittedVersion, cc-by)
- eScholarship (California Digital Library) (submittedVersion, cc-by)
- Florence Research (University of Florence) (submittedVersion, cc-by-nc-nd)
- Lirias (KU Leuven) (submittedVersion, cc-by)
- PubMed Central (submittedVersion, cc-by)
- UpSpace Institutional Repository (University of Pretoria) (submittedVersion, cc-by)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, cc-by-nc-sa)
- AJOU Open Repository (Ajou University) (submittedVersion)
- Digital Scholarship - UNLV (University of Nevada Reno) (submittedVersion, cc-by)
- Charles Sturt University Research Output (CRO) (submittedVersion, cc-by)
- Kharkiv National Medical University Repository (Kharkiv National Medical University) (submittedVersion)
- Research Online (University of Wollongong) (submittedVersion)
- National University of Singapore (submittedVersion)
- FedUni ResearchOnline (Federation University Australia) (submittedVersion, cc-by)
- KTH Publication Database DiVA (KTH Royal Institute of Technology) (submittedVersion, other-oa)
- Aberdeen University Research Archive (Aberdeen University) (submittedVersion, cc-by)
- Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion, cc-by)
- DR-NTU (Nanyang Technological University) (submittedVersion)
- Utrecht University Repository (Utrecht University) (submittedVersion, cc-by)
- Estudo Geral (Universidad de Coimbra) (submittedVersion, cc-by)
- Figshare (submittedVersion, cc-by)
- Figshare (submittedVersion)
- Työväentutkimus Vuosikirja (submittedVersion)
- TeesRep (Teesside University) (submittedVersion, cc-by)
- Intellectum (Universidad de La Sabana) (submittedVersion, cc-by-nc-nd)
- NORA - Norwegian Open Research Archives (submittedVersion, other-oa)
- Huddersfield Research Portal (University of Huddersfield) (submittedVersion, cc-by)
- Qatar University QSpace (Qatar University) (submittedVersion, cc-by-nc-nd)
- Griffith Research Online (submittedVersion, cc-by)
- Spiral (Imperial College London) (submittedVersion, other-oa)
- Tampere University Institutional Repository (Tampere University) (submittedVersion, cc-by)
- Funders
- Heart Foundation
- European Commission
- Fundação de Amparo à Pesquisa do Estado de Minas Gerais
- National Health and Medical Research Council
- Taibah University
- International Medical University
- Ministry of Education
- McGill University
- Universitätsklinikum Essen
- National Institute of Biomedical Innovation
- King Abdulaziz City for Science and Technology
- Universidad de La Sabana
- University of Aberdeen
- Manipal Academy of Higher Education
- Public Health Agency of Canada
- Ministero della Salute (34/2017)
- Academy of Scientific Research and Technology
- University of Sydney
- Medical Research Council
- Ateneo de Manila University
- Deutsche Forschungsgemeinschaft (FU 356/12-2)
- Wellcome Trust (221854/Z/20/Z, R024227)
- Ministarstvo Prosvete, Nauke i Tehnološkog Razvoja (2011-2023)
- Office of the Secretary of Transportation
- China Medical University, Taiwan (CMU111-MF-55)
- National Heart, Lung, and Blood Institute (CENTRO-04-3559-FSE-000162, K23HL157766)
- Horizon 2020 Framework Programme (EDCTP-RIA2016E-1609)
- Central University of Kerala
- European and Developing Countries Clinical Trials Partnership
- Belgian American Educational Foundation
- JSS Academy of Higher Education and Research
- Universiti Kebangsaan Malaysia
- Chandigarh University
- Korea Institute for Advancement of Technology
- University Grants Commission
- Marga und Walter Boll-Stiftung
- Ministry of Higher Education, Malaysia (FRGS/1/2020/STG03/USM/03/5)
- National Research Foundation of Korea (NRF-2021R1I1A4A01057428)
- Ministry of Trade, Industry and Energy (P0017805)
- National Natural Science Foundation of China (72204112)
- National Institute on Aging (R01AG062553)
- Conselho Nacional de Desenvolvimento Científico e Tecnológico (304224/2022-7)
- Instituto de Salud Carlos III (RD21/0005/0001)
- National Science and Technology Council (NSTC 111-2410-H-003-100-SSS)
- Bundesministerium für Bildung und Forschung (01EA1808A)
- Research Council of Finland (350426)
- Wellcome Trust DBT India Alliance (IA/CPHE/17/1/503345)
- Applied Molecular Biosciences Unit (LA/P/0140/2020)
- National Heart Foundation of Australia (102597)
- Bill and Melinda Gates Foundation
- Department of Biotechnology, Ministry of Science and Technology, India
- King Abdulaziz University
- Jazan University
- Social Science Foundation of Jiangsu Province (21GLD008)
- Fundação para a Ciência e a Tecnologia (UIDB/04084/2020, UIDP/04378/2020, UIDB/04378/2020)
- Science and Technology Development Fund
- Università ta' Malta
- Australian Research Council (FT220100857)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Health Sciences › Health Professions › Health Information Management › Global Health and Epidemiology
- Keywords
- diabetes mellitus, type 1 diabetes, type 2 diabetes, diabetes prevalence, diabetes mortality, disability-adjusted life years, years of life lost, years lived with disability, risk factors, body mass index, physical activity, tobacco use, alcohol consumption, dietary factors, sex differences, age differences, global burden of disease
- MeSH terms
- Global Burden of Disease, Aged, Bayes Theorem, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, Female, Humans, Life Expectancy, Male, Risk Factors, Global Health, Prevalence, Quality-Adjusted Life Years
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Claims read by deepseek-v4.1-flash under definition version 3 (extract-v3) on 2026-10-16.
Classified by jev-1.13-20260917 (gold-guideline-v0.2) on 2026-10-16.
Cited sources are checked by gpt-6-sol.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review