Impact of Excessive Weight Gain on Cardiovascular Outcomes in Type 1 Diabetes: Results From the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) Study

Purnell, Jonathan Q.; Braffett, Barbara H.; Zinman, Bernard; Gubitosi-Klug, Rose A.; Sivitz, William; Bantle, John P.; Ziegler, Georgia; Cleary, Patricia A.; Brunzell, John D.; DCCT/EDIC Research Group; Nathan, D.M.; Zinman, B.; Crofford, O.; Genuth, S.; Brown-Friday, J.; Crandall, J.; Engel, H.; Engel, S.; Martinez, H.; Phillips, M.; Reid, M.; Shamoon, H.; Sheindlin, J.; Gubitosi-Klug, R.; Mayer, L.; Pendegast, S.; Zegarra, H.; Miller, D.; Singerman, L.; Smith-Brewer, S.; Novak, M.; Quin, J.; Genuth, Saul; Palmert, M.; Brown, E.; McConnell, J.; Pugsley, P.; Crawford, P.; Dahms, W.; Gregory, N.S.; Lackaye, M.E.; Kiss, S.; Chan, R.; Orlin, A.; Rubin, M.; Brillon, D.; Reppucci, V.; Lee, T.; Heinemann, M.; Chang, S.

doi:10.2337/dc16-2523

Impact of Excessive Weight Gain on Cardiovascular Outcomes in Type 1 Diabetes: Results From the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) Study

OBJECTIVE Intensive treatment (INT) of type 1 diabetes reduces the incidence of cardiovascular disease (CVD) events compared with conventional treatment (CONV), but it also results in more weight gain. Our objective was to examine whether excessive weight gain from INT of type 1 diabetes is indep…