The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Method for the Isolation of Intact Islets of Langerhans from the Rat Pancreas
Abstract
A simple method for the isolation of intact islets from the normal rat pancreas is described. The method is based upon disruption of the acinar parenchyma by injecting Hanks solution into the pancreatic duct system followed by incubation of the pancreas in collagenase. Islets can be separated rapidly from this mixture by sedimentation. The isolated islets release insulin in vitro and appear normal by light and electron microscopy after incubation. A centrifugation method is also described for isolation of large quantities of islets for biochemical studies.
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Citations
Cites
A MODIFIED PROCEDURE FOR LEAD STAINING OF THIN SECTIONS
Millonig, G. (1961) · The Journal of Cell Biology · doi:10.1083/jcb.11.3.736 · Cited by 1,377
Aldehyde-Fuchsin: A New Stain for Elastic Tissue*
George, G. (1950) · American Journal of Clinical Pathology · doi:10.1093/ajcp/20.7_ts.665 · Cited by 744
Regulation of insulin secretion studied with pieces of rabbit pancreas incubated in vitro
Coore, H., & Randle, P. (1964) · Biochemical Journal · doi:10.1042/bj0930066 · Cited by 540
Electron microscopy of the beta cell of the pancreas
Lacy, P. E. (1961) · The American Journal of Medicine · doi:10.1016/0002-9343(61)90024-9 · Cited by 182
Self-citationSimple Method for in Vitro Metabolic Studies Using Small Volumes of Tissue and Medium
KEEN, H., Field, J. B., & Pastan, I. H. (1963) · JAMA · doi:10.1001/jama.1963.03700120137105 · Cited by 88
Cited by
Microencapsulated Islets as Bioartificial Endocrine Pancreas
Lim, F., & Sun, A. M. (1980) · Science · doi:10.1126/science.6776628 · Cited by 2,377
Free fatty acids regulate insulin secretion from pancreatic β cells through GPR40
Itoh, Y., Kawamata, Y., Harada, M., Kobayashi, M., Fujii, R., Fukusumi, S., Ogi, K., Hosoya, M., Tanaka, Y., Uejima, H., et al. (2003) · Nature · doi:10.1038/nature01478 · Cited by 1,538
Chronic high-fat diet in fathers programs β-cell dysfunction in female rat offspring
Ng, S.-F., Lin, R. C. Y., Laybutt, D. R., Barres, R., Owens, J. A., & Morris, M. J. (2010) · Nature · doi:10.1038/nature09491 · Cited by 1,327
Veiseh, O., Doloff, J. C., Ma, M., Vegas, A. J., Tam, H. H., Bader, A. R., Li, J., Langan, E., Wyckoff, J., Loo, W. S., et al. (2015) · Nature Materials · doi:10.1038/nmat4290 · Cited by 897
Clinical pancreatic islet transplantation
Shapiro, A. M. J., Pokrywczynska, M., & Ricordi, C. (2017) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2016.178 · Cited by 747
Metadata
- Authors
- Lacy, P. E., & Kostianovsky, M.
- Venue
- Diabetes
- Publisher
- American Diabetes Association
- Published
- 1967-01-01
- Volume
- 16
- Issue
- 1
- Pages
- 35-39
- ISSN
- 0012-1797 (ISSN-L)
- 1939-327X
- OpenAlex
- W2157865424
- Cited by
- 2,751
- References
- 5
- FWCI
- 65.70
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Method for the Isolation of Intact Islets of Langerhans from the Rat Pancreas. https://app.cochat.ai/papers/10.2337/diab.16.1.35
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- Lacy, P. E., & Kostianovsky, M. (1967). Method for the Isolation of Intact Islets of Langerhans from the Rat Pancreas. Diabetes. https://doi.org/10.2337/diab.16.1.35
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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