Cited by 2,377Pancreatic function and diabetesTissue Engineering and Regenerative MedicineDiabetes and associated disorders

Microencapsulated Islets as Bioartificial Endocrine Pancreas

Lim, Franklin, Sun, Anthony M.·1980·Science

Abstract

Single implantation of microencapsulated islets into rats with streptozotocin-induced diabetes corrected the diabetic state for 2 to 3 weeks. The microencapsulated islets remained morphologically and functionally intact throughout long-term culture studies lasting over 15 weeks.

Integrity signals

Registry

Crossref · 10.1126/science.6776628

Cites

17 of 17 references verified0 citation errors · 0 not checkable

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Authors
Lim, F., & Sun, A. M.
Affiliations
  • Virginia Commonwealth University (US)
  • Connaught Research Institute, Willowdale, Ontario, Canada M2N 5T8
Venue
Science
Published
1980-11-21
Volume
210
Issue
4472
Pages
908-910
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
OpenAlex
W2022282748
Cited by
2,377
References
17
Citations by year
2026: 30 · 2025: 27 · 2024: 39 · 2023: 42 · 2022: 51 · 2021: 64 · 2020: 56 · 2019: 83 · 2018: 63 · 2017: 81 · 2016: 86 · 2015: 90 · 2014: 80 · 2013: 90 · 2012: 90
FWCI
12.09
Type
journal article
Language
en
Open access
closed
Locations
  • Science (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
  • Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
Keywords
bioartificial pancreas, islet transplantation, streptozotocin-induced diabetes, islet viability, endocrine pancreas
MeSH terms
Alginates, Animals, Cell Survival, Diabetes Mellitus, Experimental, Permeability, Transplantation, Homologous, Islets of Langerhans Transplantation, Rats

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