Microencapsulated Islets as Bioartificial Endocrine Pancreas
Abstract
Single implantation of microencapsulated islets into rats with streptozotocin-induced diabetes corrected the diabetic state for 2 to 3 weeks. The microencapsulated islets remained morphologically and functionally intact throughout long-term culture studies lasting over 15 weeks.
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In humans, host recognition and fibrosis of alginate capsules, regardless of donor tissue, is the main obstacle to using encapsulated donor islets to treat type-1 diabetes.
“Host recognition and fibrosis of alginate capsules in humans, independent of donor tissue, is the key barrier to the clinical translation of encapsulated donor islets for treatment of type-1 diabetes26, 27, 28.”
From Size- and shape-dependent foreign body immune response to materials implanted in rodents and non-human primates (2015) · cites this paper as [26]
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- Authors
- Lim, F., & Sun, A. M.
- Affiliations
- Virginia Commonwealth University (US)
- Connaught Research Institute, Willowdale, Ontario, Canada M2N 5T8
- Venue
- Science
- Published
- 1980-11-21
- Volume
- 210
- Issue
- 4472
- Pages
- 908-910
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2022282748
- Cited by
- 2,377
- References
- 17
- Citations by year
- 2026: 30 · 2025: 27 · 2024: 39 · 2023: 42 · 2022: 51 · 2021: 64 · 2020: 56 · 2019: 83 · 2018: 63 · 2017: 81 · 2016: 86 · 2015: 90 · 2014: 80 · 2013: 90 · 2012: 90
- FWCI
- 12.09
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
- Keywords
- bioartificial pancreas, islet transplantation, streptozotocin-induced diabetes, islet viability, endocrine pancreas
- MeSH terms
- Alginates, Animals, Cell Survival, Diabetes Mellitus, Experimental, Permeability, Transplantation, Homologous, Islets of Langerhans Transplantation, Rats
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