Metabolism of Free Fatty Acids and Ketone Bodies During Exercise in Normal and Diabetic Man
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Early studies showed that the rate of lipolysis is a key determinant of free fatty acid uptake and oxidation in skeletal muscle and documented a linear relationship between plasma long-chain fatty acid concentration and their rate of uptake and oxidation in muscle.
“Indeed, early studies demonstrated the rate of lipolysis was a key determinant of FFA uptake and oxidation in skeletal muscle and documented a linear relationship between the plasma LCFA concentration and their rate of uptake and oxidation in the muscle [85–87].”
From Pathogenesis of insulin resistance in skeletal muscle (2010) · cites this paper as [85]
Cites
Still being checked.
Cited by
Sorted by citations
Glatz, J. F. C., Luiken, J. J. F. P., & Bonen, A. (2010) · Physiological Reviews · doi:10.1152/physrev.00003.2009 · Cited by 757 · see citing works
Pathogenesis of insulin resistance in skeletal muscle
Abdul-Ghani, M. A., & DeFronzo, R. A. (2010) · Journal of Biomedicine and Biotechnology · doi:10.1155/2010/476279 · Cited by 670 · see citing works
Skeletal Muscle Lipid Metabolism in Exercise and Insulin Resistance
Kiens, B. (2006) · Physiological Reviews · doi:10.1152/physrev.00023.2004 · Cited by 478 · see citing works
Bogardus, C., Lillioja, S., Howard, B. V., Reaven, G. M., & Mott, D. M. (1984) · Journal of Clinical Investigation · doi:10.1172/jci111533 · Cited by 397 · see citing works
New concepts in the pathogenesis and treatment of noninsulin-dependent diabetes mellitus
DeFronzo, R. A., Ferrannini, E., & Koivisto, V. A. (1983) · The American Journal of Medicine · doi:10.1016/0002-9343(83)90654-x · Cited by 263 · see citing works
Physical training and insulin sensitivity
Koivisto, V. A., Yki‐Järvinen, H., & DeFronzo, R. A. (1986) · Diabetes/Metabolism Reviews · doi:10.1002/dmr.5610010407 · Cited by 257 · see citing works
Palmitate transport and fatty acid transporters in red and white muscles
Bonen, A., Luiken, J. J. F. P., Liu, S., Dyck, D. J., Kiens, B., Kristiansen, S., Turcotte, L. P., Vusse, G. J., & Glatz, J. F. C. (1998) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1998.275.3.e471 · Cited by 228 · see citing works
Acclimatization to 4,300-m altitude decreases reliance on fat as a substrate
Roberts, A. C., Butterfield, G. E., Cymerman, A., Reeves, J. Τ., Wolfel, E. E., & Brooks, G. A. (1996) · Journal of Applied Physiology · doi:10.1152/jappl.1996.81.4.1762 · Cited by 177 · see citing works
Galster, A. D., Clutter, W. E., Cryer, P. E., Collins, J. A., & Bier, D. M. (1981) · Journal of Clinical Investigation · doi:10.1172/jci110211 · Cited by 167 · see citing works
Increased Insulin Receptors after Exercise in Patients with Insulin-Dependent Diabetes Mellitus
Pedersen, O. B., Beck‐Nielsen, H., & Hedïng, L. G. (1980) · New England Journal of Medicine · doi:10.1056/nejm198004173021603 · Cited by 166 · see citing works
Relationship between insulin-mediated glucose disposal and lipid metabolism in man.
Lillioja, S., Bogardus, C., Mott, D. M., Kennedy, A. L., Knowler, W. C., & Howard, B. V. (1985) · Journal of Clinical Investigation · doi:10.1172/jci111804 · Cited by 150 · see citing works
Substrate and hormonal responses to exercise in women using oral contraceptives
Bonen, A., Haynes, F. W., & Graham, T. E. (1991) · Journal of Applied Physiology · doi:10.1152/jappl.1991.70.5.1917 · Cited by 126 · see citing works
Mitchell, T. H., Abraham, G., Schiffrin, A., Leiter, L. A., & Marliss, E. B. (1988) · Diabetes Care · doi:10.2337/diacare.11.4.311 · Cited by 120 · see citing works
Richter, E. A., Ruderman, N. B., & Schneider, S. H. (1981) · The American Journal of Medicine · doi:10.1016/0002-9343(81)90427-7 · Cited by 99 · see citing works
McFarlan, J. T., Yoshida, Y., Jain, S. S., Han, X.-X., Snook, L. A., Lally, J., Smith, B. K., Glatz, J. F. C., Luiken, J. J. F. P., Sayer, R. A., et al. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.315358 · Cited by 98 · see citing works
Groscolas, R. (1986) · Journal of Comparative Physiology B · doi:10.1007/bf00691038 · Cited by 94 · see citing works
Energy metabolism of medium-chain triglycerides versus carbohydrates during exercise
Décombaz, J., Arnaud, M., Milon, H., Moesch, H. R., Philippossian, G., Thélin, A., & HOWALD, H. (1983) · European Journal of Applied Physiology · doi:10.1007/bf00429018 · Cited by 75 · see citing works
Espinal, J., Challiss, R. A. J., & Newsholme, E. A. (1983) · FEBS Letters · doi:10.1016/0014-5793(83)80685-1 · Cited by 75 · see citing works
Influence of Exercise on the Pharmacokinetics of Drugs
van Baak, M. A. (1990) · Clinical Pharmacokinetics · doi:10.2165/00003088-199019010-00003 · Cited by 73 · see citing works
Muscle triglycerides in diabetic subjects
Standl, E., Lotz, N., Dexel, T., Janka, H. U., & Kolb, H. J. (1980) · Diabetologia · doi:10.1007/bf00261702 · Cited by 69 · see citing works
Stubbe, I., Hansson, P., Gustafson, A., & Nilsson‐Ehle, P. (1983) · Metabolism · doi:10.1016/0026-0495(83)90058-6 · Cited by 65 · see citing works
Plasma fat metabolites and hunger
Carpenter, R. G., & Grossman, S. P. (1983) · Physiology & Behavior · doi:10.1016/0031-9384(83)90038-0 · Cited by 58 · see citing works
Yoshida, Y., Jain, S. S., McFarlan, J. T., Snook, L. A., Chabowski, A., & Bonen, A. (2013) · The Journal of Physiology · doi:10.1113/jphysiol.2012.238451 · Cited by 55 · see citing works
Piatti, P., Monti, L. D., Pacchioni, M., Pontiroli, A. E., & Pozza, G. (1991) · Metabolism · doi:10.1016/0026-0495(91)90068-8 · Cited by 54 · see citing works
Lipid and Carbohydrate Metabolism in IDDM During Moderate and Intense Exercise
Raguso, C. A., Coggan, A. R., Gastaldelli, A., Sidossis, L. S., Bastyr, E. J., & Wolfe, R. R. (1995) · Diabetes · doi:10.2337/diab.44.9.1066 · Cited by 50 · see citing works
Exercise training and substrate utilisation in obesity
van Baak, M. A. (1999) · International Journal of Obesity · doi:10.1038/sj.ijo.0800879 · Cited by 47 · see citing works
Kjaer, M., Dela, F., Sørensen, F. B., Secher, N., Bangsbo, J., Mohr, T., & Galbo, H. (2001) · American Journal of Physiology. Regulatory Integrative and Comparative Physiology · doi:10.1152/ajpregu.2001.281.5.r1492 · Cited by 48 · see citing works
Pyruvate ingestion for 7 days does not improve aerobic performance in well-trained individuals
Morrison, M. A., Spriet, L. L., & Dyck, D. J. (2000) · Journal of Applied Physiology · doi:10.1152/jappl.2000.89.2.549 · Cited by 45 · see citing works
Foster, D. W., & McGarry, J. (1982) · Novartis Foundation symposium · doi:10.1002/9780470720691.ch7 · Cited by 43 · see citing works
Substrate oxidation is altered in women during exercise upon acute altitude exposure
Beidleman, B. A., Rock, P. B., Muza, S. R., Fulco, C. S., GIBSON, L. L., Kamimori, G. H., & Cymerman, A. (2002) · Medicine & Science in Sports & Exercise · doi:10.1097/00005768-200203000-00008 · Cited by 38 · see citing works
Lipid Mobilization and Utilization
B�low, J. (2003) · KARGER eBooks · doi:10.1159/000074369 · Cited by 36 · see citing works
Influence of a 3.5 day fast on physical performance
Knapik, J. J., Jones, B. H., Meredith, C., & Evans, W. J. (1987) · European Journal of Applied Physiology · doi:10.1007/bf00417770 · Cited by 35 · see citing works
Ventura, J. L., Estruch, A., Rodas, G., & Segura, R. (1994) · European Journal of Applied Physiology · doi:10.1007/bf00571455 · Cited by 25 · see citing works
Walker, M., Agius, L., Ørskov, H., & Alberti, K. G. M. M. (1993) · Metabolism · doi:10.1016/0026-0495(93)90219-e · Cited by 23 · see citing works
Williams, R. S., & Bishop, D. T. (1982) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1982.243.5.e345 · Cited by 22 · see citing works
Metabolic response to moderate exercise in obese man during prolonged fasting
Minuk, H. L., Hanna, A. K., Marliss, E. B., Vranić, M., & Zinman, B. (1980) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1980.238.4.e322 · Cited by 22 · see citing works
Palmitate oxidation by intact preparations of skeletal muscle
Glatz, J. F. C., & Veerkamp, J. H. (1982) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(82)90240-5 · Cited by 22 · see citing works
Heterogeneity of response to exercise of rat muscle pyruvate dehydrogenase complex
Denyer, G. S., Cooney, G. J., Storlien, L. H., Jenkins, A. B., Kraegen, E. W., Kusunoki, M., & Caterson, I. D. (1991) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/bf00372995 · Cited by 21 · see citing works
Therapy and better quality of life: The dichotomous role of exercise in diabetes mellitus
Kemmer, F. W., & Berger, M. (1986) · Diabetes/Metabolism Reviews · doi:10.1002/dmr.5610020104 · Cited by 21 · see citing works
Utilization of long‐chain fatty acids in human skeletal muscle during exercise
Kiens, B., & Roepstorff, C. (2003) · Acta Physiologica Scandinavica · doi:10.1046/j.1365-201x.2003.01156.x · Cited by 20 · see citing works
Hough, D. O. (1994) · Medical Clinics of North America · doi:10.1016/s0025-7125(16)30168-7 · Cited by 19 · see citing works
Palmitate incorporation into lipids pools of contracting red and white muscles
Górski, J., & Bonen, A. (1997) · Molecular and Cellular Biochemistry · doi:10.1023/a:1006882515938 · Cited by 18 · see citing works
Skeletal Muscle Fatty Acid Transport and Transporters
Luiken, J. J. F. P., Miskovic, D., Arumugam, Y., Glatz, J. F. C., & Bonen, A. (2001) · International Journal of Sport Nutrition and Exercise Metabolism · doi:10.1123/ijsnem.11.s1.s92 · Cited by 18 · see citing works
Diabetes, Insulin and Exercise
Richter, E. A., & Galbo, H. (1986) · Sports Medicine · doi:10.2165/00007256-198603040-00004 · Cited by 18 · see citing works
The effect of chronic fatty acid treatment on lipolysis in 3T3-L1 adipocytes
Fong, J. C. (1990) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(90)91354-u · Cited by 16 · see citing works
Early streptozotocin diabetes and hunger
Carpenter, R. G., & Grossman, S. P. (1983) · Physiology & Behavior · doi:10.1016/0031-9384(83)90115-4 · Cited by 15 · see citing works
Exercise and the management of diabetes mellitus
Franz, M. J. (1987) · Journal of the American Dietetic Association · doi:10.1016/s0002-8223(21)03208-9 · Cited by 15 · see citing works
2Biochemistry and differential diagnosis of metabolic acidoses
Sestoft, L., & Bartels, P. D. (1983) · Clinics in Endocrinology and Metabolism · doi:10.1016/s0300-595x(83)80042-5 · Cited by 13 · see citing works
Lickley, H. L. A., Kemmer, F. W., Wasserman, D. H., & Vranić, M. (1983) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-69019-8_16 · Cited by 12 · see citing works
The Endocrine System: Metabolic Effects of the Pancreatic, Adrenal, Thyroidal, and Growth Hormones
Riddell, M. C., Ruderman, N. B., Tsiani, E., & Vranić, M. (2003) · Springer eBooks · doi:10.1007/978-1-4614-7543-9_9 · Cited by 12 · see citing works
Transport of fatty acids by myoglobin—An hypothesis
Yackzan, K., & Wingo, W. J. (1982) · Medical Hypotheses · doi:10.1016/0306-9877(82)90042-1 · Cited by 12 · see citing works
Role of Fat Metabolism in Exercise
Askew, E. W. (1984) · Clinics in Sports Medicine · doi:10.1016/s0278-5919(20)31307-7 · Cited by 11 · see citing works
Auclair, E., Satabin, P., Servan, E., & Guezennec, C. Y. (1988) · European Journal of Applied Physiology · doi:10.1007/bf00691251 · Cited by 11 · see citing works
Christopher, M., Rantzau, C., McConell, G. K., Kemp, B. E., & ALFORD, F. P. (2005) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00687.2004 · Cited by 10 · see citing works
Hoyt, C. J. (1982) · Plastic & Reconstructive Surgery · doi:10.1097/00006534-198204000-00141 · Cited by 11 · see citing works
Physiologic Responses of Elite Paraplegic Road Racers to Prolonged Exercise
Hooker, S. P., & Wells, C. L. (1990) · The Journal of The American Paraplegia Society · doi:10.1080/01952307.1990.11735823 · Cited by 9 · see citing works
Fong, J. C., Leu, S.-J. J., & Chai, S. (1997) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/s0005-2760(96)00133-6 · Cited by 9 · see citing works
Monti, L., Piatti, P. M., Home, P. D., Tomson, C., & Alberti, K. G. M. M. (1992) · Diabetes Research and Clinical Practice · doi:10.1016/0168-8227(92)90030-u · Cited by 8 · see citing works
Glucose and lactate kinetics during a short exercise bout in pregnancy
Cowett, R. M., Carpenter, M. W., Carr, S., Kalhan, S. C., Maguire, C., Sady, M. A., Haydon, B., Sady, S. P., & Dorcus, B. (1996) · Metabolism · doi:10.1016/s0026-0495(96)90142-0 · Cited by 8 · see citing works
Physiological Effects of Exercise in the Diabetic
Jette, D. U. (1984) · Physical Therapy · doi:10.1093/ptj/64.3.339 · Cited by 7 · see citing works
Palmitate oxidation in suspended skeletal muscle fibers from the rat
Zuurveld, J. G. E. M., & Veerkamp, J. H. (1984) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(84)90235-2 · Cited by 7 · see citing works
van Dijk, G., Vissing, J., Steffens, A. B., & Galbo, H. (1994) · Acta Physiologica Scandinavica · doi:10.1111/j.1748-1716.1994.tb09734.x · Cited by 6 · see citing works
The effect of NH4Cl induced chronic metabolic acidosis on work capacity in man
Bulbulian, R., Girandola, R. N., & WISWELL, R. A. (1983) · European Journal of Applied Physiology · doi:10.1007/bf00952533 · Cited by 5 · see citing works
Norepinephrine mobilization of free fatty acids in endurance trained rats
Thibault, M. C., Vallières, J., & LEBLANC, J. (1981) · European Journal of Applied Physiology · doi:10.1007/bf02332958 · Cited by 5 · see citing works
Cerasola, G., Donatelli, M., Cottone, S., D'Ignoto, G., Grasso, L., Morici, M. L., Terrizzi, C., Verga, S., & Bompiani, G. (1987) · Acta Diabetologica · doi:10.1007/bf02732046 · Cited by 5 · see citing works
Hetzler, R. K., KNOWLTON, R. G., Kaminsky, L. A., & Kamimori, G. H. (1986) · Research Quarterly for Exercise and Sport · doi:10.1080/02701367.1986.10605401 · Cited by 4 · see citing works
Child and Adolescent Athletes With Diabetes
Blackett, P. R., & Eichner, E. R. (1988) · The Physician and Sportsmedicine · doi:10.1080/00913847.1988.11709459 · Cited by 3 · see citing works
Competitive sport and the insulin-dependent diabetic patient
Greenhalgh, P. M. (1990) · Postgraduate Medical Journal · doi:10.1136/pgmj.66.780.803 · Cited by 3 · see citing works
Hormonal and metabolic changes in starving obese patients during exhaustive physical exercise
Jakober, B., Schmülling, R. M., Müller, P., & Eggstein, M. (1983) · Journal of Endocrinological Investigation · doi:10.1007/bf03348344 · Cited by 3 · see citing works
The Therapeutic Role of Exercise in Diabetes Mellitus
Brown, S. P., & Thompson, W. R. (1988) · The Science of Diabetes Self-Management and Care · doi:10.1177/014572178801400311 · Cited by 2 · see citing works
Donatelli, M., Verga, S., Terrizzi, C., Russo, V., Bucalo, M. L., Scarpinato, A., & Cerasola, G. (1987) · La Ricerca in Clinica e in Laboratorio · doi:10.1007/bf02886917 · Cited by 2 · see citing works
Logesh, R., Hari, B., Chidambaram, K., & Das, N. (2024) · Gene · doi:10.1016/j.gene.2024.148216 · Cited by 1 · see citing works
Donatelli, M., Verga, S., Russo, V., Terrizzi, C., Bucalo, M. L., Scarpinato, A., Vaccaro, M., & Cerasola, G. (1988) · Acta Diabetologica · doi:10.1007/bf02581380 · Cited by 1 · see citing works
Sonnenburg, R. (2018) · UWSpace (University of Waterloo) · Cited by 1 · see citing works
Effect of Exercise on Fuel Utilization and Insulin Requirements
McLane, M. P., & Horwitz, D. L. (1988) · Springer eBooks · doi:10.1007/978-1-4684-5499-4_9
Exercise in the Therapy of Diabetes Mellitus
Vergano, S., Bhambri, R., & Schneider, S. H. (2009) · Springer eBooks · doi:10.1007/978-0-387-09841-8_42
The contribution of myofibers and fibrocytes to palmitate oxidation in skeletal muscle
Zuurveld, J. G. E. M., & Veerkamp, J. H. (1985) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(85)90158-3
Recent developments in the management of diabetes mellitus
Kalhan, S. C. (1982) · The Indian Journal of Pediatrics · doi:10.1007/bf02834568
Epinephrine Plasma Thresholds for Lipolytic Effects in Man MEASUREMENTS OF FATTY ACID TRANSPORT WITH
Galster, A. D., Clutter, W. E., Cryer, P. E., Collins, J. A., & Bier, D. M. (1981)
Chapter 4. Exercise in the Therapy of Diabetes Mellitus
Schneider, S. H., & Bhambri, R. (2004)
The Effects of Metabolic Perturbations on Fatty Acid Transport Protein Cellular Location
Stefanyk, L. E. (2012) · The Atrium (University of Guelph)
Exercise in the Therapy of Diabetes Mellitus
Ohri, A., Vergano, S., Bhambri, R., & Schneider, S. H. (2017) · Springer eBooks · doi:10.1007/978-3-319-18741-9_42
Exercise in the Therapy of Diabetes Mellitus
Ohri, A., Vergano, S., Bhambri, R., & Schneider, S. H. (2016) · Springer eBooks · doi:10.1007/978-3-319-20797-1_42-1
Exercise in the Therapy of Diabetes Mellitus
Ohri, A., Vergano, S., Bhambri, R., & Schneider, S. H. (2016) · Springer eBooks · doi:10.1007/978-3-319-20797-1_42-2
Exercise in the Therapy of Diabetes Mellitus
Schneider, S. H., & Bhambri, R. (2004) · Springer eBooks · doi:10.1007/978-1-4757-6260-0_30
- Authors
- Hagenfeldt, L.
- Affiliations
- Karolinska University Hospital (SE)
- Corresponding author
- Hagenfeldt, L
- Venue
- Diabetes
- Publisher
- American Diabetes Association
- Published
- 1979-01-01
- Volume
- 28
- Issue
- Supplement_1
- Pages
- 66-70
- ISSN
- 0012-1797 (ISSN-L)
- 1939-327X
- OpenAlex
- W2334828387
- Cited by
- 86
- References
- 0
- Citations by year
- 2024: 1 · 2018: 1 · 2017: 1 · 2016: 2 · 2012: 3
- FWCI
- 4.85
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Diabetes (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Vetenskapsrådet
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Health Sciences › Medicine › Physiology › Diet and metabolism studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
- Keywords
- free fatty acid metabolism, ketone bodies, physical activity, diabetes mellitus, diabetic patients, fatty acid oxidation, ketogenesis
- MeSH terms
- Diabetes Mellitus, Physical Exertion, Fatty Acids, Nonesterified, Humans, Ketone Bodies, Lactates, Muscles, Oxygen Consumption, Diabetic Ketoacidosis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review