CoChat
Sign Up
Cited by 56Diabetes Management and ResearchPancreatic function and diabetesDiabetes Treatment and Management

Important role of adrenergic mechanisms in acute glucose counterregulation following insulin-induced hypoglycemia in type I diabetes. Evidence for an effect mediated by beta-adrenoreceptors

Bolli, Geremia, Feo, Pierpaolo De, Compagnucci, Pietro, Cartechini, Maria G, Angeletti, Gabriella, Santeusanio, Fausto, Brunetti, Paolo·1982·Diabetes
DOI 10.2337/diab.31.7.641
Open this paper in CoChat — free account

Abstract

Unlabelled During hypoglycemia induced by an i.v. insulin infusion for 60 min, rates of plasma glucose (PG) decrease and recovery, PG nadir, and plasma counter-regulatory hormone and free fatty acid responses were studied in eight type I uncomplicated diabetic subjects and eight nondiabetic subjects. Each subject was tested three times at two different rates of insulin infusion (25 and 32 mU/m2/min): (1) during infusion of saline, (2) during infusion of phentolamine + propranolol (combined alpha, beta-blockade), and (3) during infusion of propranolol alone (isolated beta-blockade) for 150 min. At the time of the studies, the diabetic subjects had been made euglycemic by an overnight i.v. insulin infusion. During infusion of insulin (25 mU/m2/min) and saline, the rates of PG decrease and recovery were slower (P less than 0.01) and PG nadir was delayed in the diabetic subjects. Moreover, their plasma glucagon response was blunted while plasma epinephrine, norepinephrine, growth hormone, and cortisol responses were similar in both groups. Infusion of insulin at 32 mU/m2/min caused larger decreases in PG than had been observed when insulin was infused at 25 mU/m2/min. Plasma glucagon responses increased in the nondiabetic subjects (P less than 0.05) but not in the diabetic subjects. However, in the diabetic subjects, plasma epinephrine increased more than in the nondiabetic subjects (P less than 0.05). There was an inverse correlation between the individual plasma epinephrine res…

Integrity signals

Registry

Crossref · 10.2337/diab.31.7.641

Cites

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • The adrenergic system regulates glucose recovery through activation of both alpha and beta receptors.

    “The adrenergic system regulates glucose recovery through activation of both alpha and beta receptors, as supported by delayed glucose recovery during a single episode of hypoglycemia with administration of alpha and/or beta antagonists (29-31).”

    From Plasma Epinephrine Contributes to the Development of Experimental Hypoglycemia-Associated Autonomic Failure (2020) · cites this paper as [29]

Cites

Still being checked.

Cited by

Sorted by citations

Related

Authors
Bolli, G., Feo, P. D., Compagnucci, P., Cartechini, M. G., Angeletti, G., Santeusanio, F., & Brunetti, P.
Affiliations
University of Perugia (IT)
ORCID
Venue
Diabetes
Publisher
American Diabetes Association
Published
1982-07-01
Volume
31
Issue
7
Pages
641-647
ISSN
  • 0012-1797 (ISSN-L)
  • 1939-327X
DOI
10.2337/diab.31.7.641
OpenAlex
W2133440135
Cited by
56
References
0
Citations by year
2023: 1 · 2020: 1 · 2019: 1 · 2017: 3 · 2016: 2 · 2014: 1
FWCI
5.25
Type
journal article
Language
en
Open access
closed
Locations
  • Diabetes (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
  • Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
Keywords
insulin-induced hypoglycemia, glucose counterregulation, type 1 diabetes, beta-adrenergic receptors, adrenergic mechanisms, glucagon response, epinephrine, alpha-adrenergic blockade, beta-adrenergic blockade, propranolol, phentolamine, counterregulatory hormones, free fatty acids, growth hormone, cortisol, catecholamines
MeSH terms
Blood Glucose, Diabetes Mellitus, Epinephrine, Fatty Acids, Nonesterified, Glucagon, Humans, Hydrocortisone, Hypoglycemia, Insulin, Norepinephrine, Phentolamine, Propranolol, Receptors, Adrenergic, Receptors, Adrenergic, beta, Growth Hormone

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review