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Action of Sorbinil in Diabetic Peripheral Nerve: Relationship of Polyol (Sorbitol) Pathway Inhibition to a myo-Inositol-mediated Defect in Sodium-Potassium ATPase Activity
Abstract
The small, but statistically significant, improvement in nerve conduction after treatment of diabetic patients with the aldose reductase inhibitor, sorbinil, suggests that increased polyol (sorbitol) pathway activity may contribute to diabetic nerve conduction slowing. Although classically viewed solely in terms of sorbitol-induced osmotic swelling, polyol pathway inhibition is now speculated to influence a concomitant myo-inositol-mediated alteration in nerve sodium-potassium ATPase activity in diabetic nerve. Therefore, we directly examined the effect of sorbinil treatment on sodium-potassium ATPase activity in crude homogenates of sciatic nerve from streptozotocin-diabetic and non-diabetic rats. We demonstrate that sorbinil treatment, which preserves normal nerve myo-inositol content, prevents the fall in nerve sodium-potassium ATPase activity that has been linked to conduction slowing in the diabetic rat.
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Cited by
Metabolism and Function of myo-Inositol and Inositol Phospholipids
Holub, B. J. (1986) · Annual Review of Nutrition · doi:10.1146/annurev.nu.06.070186.003023 · Cited by 317
Reduced Phosphoinositide Concentrations in Anterior Temporal Cortex of Alzheimer‐Diseased Brains
Stokes, C. E., & Hawthorne, J. N. (1987) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1987.tb05619.x · Cited by 206
Effect of treatment of diabetic rats with dehydroepiandrosterone on vascular and neural function
Yorek, M. A., Coppey, L. J., Gellett, J. S., Davidson, E. P., Bing, X., Lund, D. D., & Dillon, J. S. (2002) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00173.2002 · Cited by 79
Metadata
- Authors
- Greene, D. A., & Lattimer, S. A.
- Venue
- Diabetes
- Publisher
- American Diabetes Association
- Published
- 1984-08-01
- Volume
- 33
- Issue
- 8
- Pages
- 712-716
- ISSN
- 0012-1797 (ISSN-L)
- 1939-327X
- OpenAlex
- W2111578630
- Cited by
- 179
- References
- 0
- FWCI
- 9.34
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Action of Sorbinil in Diabetic Peripheral Nerve: Relationship of Polyol (Sorbitol) Pathway Inhibition to a myo-Inositol-mediated Defect in Sodium-Potassium ATPase Activity. https://app.cochat.ai/papers/10.2337/diab.33.8.712
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- Greene, D. A., & Lattimer, S. A. (1984). Action of Sorbinil in Diabetic Peripheral Nerve: Relationship of Polyol (Sorbitol) Pathway Inhibition to a myo-Inositol-mediated Defect in Sodium-Potassium ATPase Activity. Diabetes. https://doi.org/10.2337/diab.33.8.712
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
