Cited by 79Aldose Reductase and TaurineHormonal and reproductive studiesNitric Oxide and Endothelin Effects

Effect of treatment of diabetic rats with dehydroepiandrosterone on vascular and neural function

Yorek, Mark A., Coppey, Lawrence J., Gellett, Jill S., Davidson, Eric P., Bing, Xinyu, Lund, Donald D., Dillon, Joseph S.·2002·American Journal of Physiology-Endocrinology and Metabolism

Abstract

Nutritional supplementation with dehydroepiandrosterone (DHEA) may be a candidate for treating diabetes-induced vascular and neural dysfunction. DHEA is a naturally occurring adrenal androgen that has antioxidant properties and is reportedly reduced in diabetes. Using a prevention protocol, we found that dietary supplementation of streptozotocin-induced diabetic rats with 0.1, 0.25, or 0.5% DHEA caused a concentration-dependent prevention in the development of motor nerve conduction velocity and endoneurial blood flow impairment, which are decreased in diabetes. At 0.25%, DHEA significantly prevented the diabetes-induced increase in serum thiobarbituric acid-reactive substances and sciatic nerve conjugated diene levels. This treatment also reduced the production of superoxide by epineurial arterioles of the sciatic nerve. DHEA treatment (0.25%) significantly improved vascular relaxation mediated by acetylcholine in epineurial vessels of diabetic rats. Sciatic nerve Na+-K+-ATPase activity and myoinositol content was also improved by DHEA treatment, whereas sorbitol and fructose content remained elevated. These studies suggest that DHEA, by preventing oxidative stress and perhaps improving sciatic nerve Na+-K+-ATPase activity, may improve vascular and neural dysfunction in diabetes.

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Crossref · 10.1152/ajpendo.00173.2002

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  • Generation of oxidative stress through superoxide and peroxynitrite impairs vascular function and endothelium-dependent vascular relaxation in epineural arterioles of the sciatic nerve from diabetic rats.

    “Studies in our laboratory of epineural arterioles of the sciatic nerve derived from diabetic rats have provided evidence that the generation of oxidative stress through the production of superoxide and peroxynitrite impairs vascular function and endothelium-dependent vascular relaxation (67–69, 342).”

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Authors
Yorek, M. A., Coppey, L. J., Gellett, J. S., Davidson, E. P., Bing, X., Lund, D. D., & Dillon, J. S.
Affiliations
University of Iowa (US)
Venue
American Journal of Physiology-Endocrinology and Metabolism
Published
2002-11-01
Volume
283
Issue
5
Pages
E1067-E1075
ISSN
  • 0193-1849 (ISSN-L)
  • 1522-1555
OpenAlex
W2077212501
Cited by
79
References
64
Citations by year
2024: 4 · 2021: 2 · 2020: 3 · 2019: 1 · 2018: 2 · 2017: 2 · 2016: 2 · 2015: 4 · 2014: 4 · 2012: 5
FWCI
1.09
Type
journal article
Language
en
Open access
closed
Locations
  • American Journal of Physiology-Endocrinology and Metabolism (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institute on Aging (R01AG018928, AG18928)
  • National Institute of Diabetes and Digestive and Kidney Diseases (DK-25295, DK-58005, P30DK025295)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Aldose Reductase and Taurine
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
  • Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
Keywords
dehydroepiandrosterone, diabetes mellitus, diabetic vascular dysfunction, diabetic neuropathy, nerve conduction velocity, oxidative stress, superoxide, acetylcholine-induced vasodilation, Na+/K+-ATPase, myo-inositol, sorbitol, fructose, streptozotocin-induced diabetes, antioxidant supplementation
MeSH terms
Adjuvants, Immunologic, Animals, Arterioles, Blood Glucose, Body Weight, Dehydroepiandrosterone, Diabetes Mellitus, Experimental, Diabetic Neuropathies, Estrogens, Male, Peripheral Nerves, Sciatic Nerve, Superoxides, Vasoconstriction, Rats, Sprague-Dawley, Oxidative Stress, Rats

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