Effect of treatment of diabetic rats with dehydroepiandrosterone on vascular and neural function
Abstract
Nutritional supplementation with dehydroepiandrosterone (DHEA) may be a candidate for treating diabetes-induced vascular and neural dysfunction. DHEA is a naturally occurring adrenal androgen that has antioxidant properties and is reportedly reduced in diabetes. Using a prevention protocol, we found that dietary supplementation of streptozotocin-induced diabetic rats with 0.1, 0.25, or 0.5% DHEA caused a concentration-dependent prevention in the development of motor nerve conduction velocity and endoneurial blood flow impairment, which are decreased in diabetes. At 0.25%, DHEA significantly prevented the diabetes-induced increase in serum thiobarbituric acid-reactive substances and sciatic nerve conjugated diene levels. This treatment also reduced the production of superoxide by epineurial arterioles of the sciatic nerve. DHEA treatment (0.25%) significantly improved vascular relaxation mediated by acetylcholine in epineurial vessels of diabetic rats. Sciatic nerve Na+-K+-ATPase activity and myoinositol content was also improved by DHEA treatment, whereas sorbitol and fructose content remained elevated. These studies suggest that DHEA, by preventing oxidative stress and perhaps improving sciatic nerve Na+-K+-ATPase activity, may improve vascular and neural dysfunction in diabetes.
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Generation of oxidative stress through superoxide and peroxynitrite impairs vascular function and endothelium-dependent vascular relaxation in epineural arterioles of the sciatic nerve from diabetic rats.
“Studies in our laboratory of epineural arterioles of the sciatic nerve derived from diabetic rats have provided evidence that the generation of oxidative stress through the production of superoxide and peroxynitrite impairs vascular function and endothelium-dependent vascular relaxation (67–69, 342).”
From Mitochondrial Dysfunction in Diabetes: From Molecular Mechanisms to Functional Significance and Therapeutic Opportunities (2010) · cites this paper as [342]
Cites
Miller, F. J., Gutterman, D. D., Rios, C., Heistad, D. D., & Davidson, B. L. (1998) · Circulation Research · doi:10.1161/01.res.82.12.1298 · Cited by 623 · see citing works
Greene, D. A., de Jesus, P. V., & Winegrad, A. I. (1975) · Journal of Clinical Investigation · doi:10.1172/jci108052 · Cited by 471 · see citing works
Physiological importance of dehydroepiandrosterone.
Eberling, P., & Koivisto, V. A. (1994) · The Lancet · doi:10.1016/s0140-6736(94)92587-9 · Cited by 365 · see citing works
Lipoperoxidation as a vector in carbon tetrachloride hepatotoxicity.
Ro, R., & Ak, G. (1966) · PubMed · Cited by 360 · see citing works
Review of Alterations in Endothelial Nitric Oxide Production in Diabetes
Pieper, G. M. (1998) · Hypertension · doi:10.1161/01.hyp.31.5.1047 · Cited by 353 · see citing works
Therapeutic effects of dehydroepiandrosterone (DHEA) in diabetic mice.
Coleman, D. L., Leiter, E. H., & Schwizer, R. W. (1982) · Diabetes · doi:10.2337/diab.31.9.830 · Cited by 317 · see citing works
Coppey, L. J., Gellett, J. S., Davidson, E. P., Dunlap, J. A., Lund, D. D., & Yorek, M. A. (2001) · Diabetes · doi:10.2337/diabetes.50.8.1927 · Cited by 300 · see citing works
Self-citationLiu, D., & Dillon, J. S. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m200491200 · Cited by 285 · see citing works
Self-citationNerve blood flow in early experimental diabetes in rats: relation to conduction deficits
Cameron, N. E., Cotter, M. A., & Low, P. A. (1991) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1991.261.1.e1 · Cited by 283 · see citing works
Dehydroepiandrosterone (DHEA) protects hippocampal cells from oxidative stress-induced damage
Bastianetto, S., Ramassamy, C., Poirier, J., & Quirion, R. (1999) · Molecular Brain Research · doi:10.1016/s0169-328x(99)00002-9 · Cited by 257 · see citing works
DISFUNCTION OF VASCULAR ENDOTHELIUM IN DIABETES MELLITUS
Cohen, R. A. (1993) · Cited by 254 · see citing works
Greene, D. A., & Lattimer, S. A. (1983) · Journal of Clinical Investigation · doi:10.1172/jci111030 · Cited by 244 · see citing works
Cameron, N. E., Cotter, M. A., Archibald, V., Dines, K. C., & Maxfield, E. K. (1994) · Diabetologia · doi:10.1007/s001250050131 · Cited by 240 · see citing works
Mihara, M., Uchiyama, M., & Fukuzawa, K. (1980) · Biochemical Medicine · doi:10.1016/0006-2944(80)90040-x · Cited by 234 · see citing works
Cameron, N. E., & Cotter, M. A. (1994) · Diabetes/Metabolism Reviews · doi:10.1002/dmr.5610100302 · Cited by 224 · see citing works
Mayer, J. H., & Tomlinson, D. R. (1983) · Diabetologia · doi:10.1007/bf00282524 · Cited by 215 · see citing works
H2 clearance measurement of blood flow: a review of technique and polarographic principles.
Young, W. (1980) · Stroke · doi:10.1161/01.str.11.5.552 · Cited by 212 · see citing works
Greene, D. A., Lattimer, S. A., & Sima, A. A. F. (1988) · Diabetes · doi:10.2337/diab.37.6.688 · Cited by 199 · see citing works
Greene, D. A., & LATTIMER, S. A. (1984) · Diabetes · doi:10.2337/diab.33.8.712 · Cited by 176 · see citing works
Effects of antioxidants on nerve and vascular dysfunction in experimental diabetes
Cameron, N. E., & Cotter, M. A. (1999) · Diabetes Research and Clinical Practice · doi:10.1016/s0168-8227(99)00043-1 · Cited by 173 · see citing works
The Epidemiology of DHEAS and Cardiovascular Disease
Barrett-Connor, E. L., & Goodman‐Gruen, D. (1995) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1995.tb17386.x-i1 · Cited by 167 · see citing works
Oxygen Free Radical Effects in Sciatic Nerve in Experimental Diabetes
Low, P. A., & Nickander, K. K. (1991) · Diabetes · doi:10.2337/diab.40.7.873 · Cited by 160 · see citing works
The Estrogen Trinity: Membrane, Cytosolic, and Nuclear Effects
Nadal, Ã., Díaz, M. L., & Valverde, M. A. (2001) · Physiology · doi:10.1152/physiologyonline.2001.16.6.251 · Cited by 159 · see citing works
Dehydroepiandrosterone Sulfate and Aging
Vermeulen, A. (1995) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1995.tb17376.x · Cited by 157 · see citing works
Simán, C. M., & Eriksson, U. J. (1997) · Diabetologia · doi:10.1007/s001250050844 · Cited by 146 · see citing works
Glutathione depletion in the lens of galactosemic and diabetic rats
Lou, M. F., Dickerson, J. E., Garadi, R., & York, B. M. (1988) · Experimental Eye Research · doi:10.1016/s0014-4835(88)80009-5 · Cited by 145 · see citing works
Coppey, L. J., Davidson, E. P., Dunlap, J. A., Lund, D. D., & Yorek, M. A. (2000) · Journal of Diabetes Research · doi:10.1155/edr.2000.131 · Cited by 142 · see citing works
Self-citationAragno, M., Brignardello, E., Tamagno, E., Gatto, V., Danni, O., & Boccuzzi, G. (1997) · Journal of Endocrinology · doi:10.1677/joe.0.1550233 · Cited by 140 · see citing works
Dehydroepiandrosterone protects tissues of streptozotocin-treated rats against oxidative stress
Aragno, M., Tamagno, E., Gatto, V., Brignardello, E., Parola, S., Danni, O., & Boccuzzi, G. (1999) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(99)00012-x · Cited by 128 · see citing works
Dehydroepiandrosterone (DHEA)–the Multifunctional Steroid
Regelson, W., & Kalimi, M. (1994) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1994.tb56860.x · Cited by 126 · see citing works
Aragno, M., Parola, S., Brignardello, E., Mauro, A., Tamagno, E., Manti, R., Danni, O., & Boccuzzi, G. (2000) · Diabetes · doi:10.2337/diabetes.49.11.1924 · Cited by 121 · see citing works
Dehydroepiandrosterone Retards Atherosclerosis Formation Through Its Conversion to Estrogen
Hayashi, T., Esaki, T., Muto, E., Kano, H., Asai, Y., Thakur, N. K., Sumi, D., Jayachandran, M., & Iguchi, A. (2000) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.20.3.782 · Cited by 98 · see citing works
Therapeutic Effects of Dehydroepiandrosterone Metabolites in Diabetes Mutant Mice (C57BL/KsJ-db/db)*
Coleman, D., Leiter, E. H., & APPLEZWEIG, N. (1984) · Endocrinology · doi:10.1210/endo-115-1-239 · Cited by 92 · see citing works
Coppey, L. J., Gellett, J. S., Davidson, E. P., Dunlap, J. A., Lund, D. D., Salvemini, D., & Yorek, M. A. (2001) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0704216 · Cited by 91 · see citing works
Self-citationLee, K., Finnigan-Bunick, C., Bahr, J. M., & Bunick, D. (2001) · Biology of Reproduction · doi:10.1095/biolreprod65.5.1534 · Cited by 86 · see citing works
Aragno, M., Parola, S., Tamagno, E., Brignardello, E., Manti, R., Danni, O., & Boccuzzi, G. (2000) · Biochemical Pharmacology · doi:10.1016/s0006-2952(00)00327-0 · Cited by 85 · see citing works
Dehydroepiandrosterone and coronary atherosclerosis
HERRINGTON, D. M. (1995) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1995.tb17387.x-i1 · Cited by 75 · see citing works
Dopamine regulates Na-K-ATPase in alveolar epithelial cells via MAPK-ERK-dependent mechanisms
Guerrero, C., Lecuona, E., Pesce, L. M., Ridge, K. M., & Sznajder, J. I. (2001) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.2001.281.1.l79 · Cited by 66 · see citing works
Relaxant Effects of 17-β-Estradiol in Cerebral Arteries through Ca 2+ Entry Inhibition
Salom, J. B., Burguete, M. C., Pérez-Asensio, F. J., Torregrosa, G., & Alborch, E. (2001) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-200104000-00011 · Cited by 64 · see citing works
Thompson, L. P., Pinkas, G. A., & Weiner, C. P. (2000) · Circulation · doi:10.1161/01.cir.102.4.445 · Cited by 64 · see citing works
Cancer prevention with dehydroepiandrosterone and non-androgenic structural analogs
Schwartz, A. G., & Pashko, L. L. (1995) · Journal of Cellular Biochemistry · doi:10.1002/jcb.240590826 · Cited by 61 · see citing works
Effect of Estrogen Replacement on Vasoconstrictor Responses in Rat Mesenteric Arteries
Zhang, Y., & Davidge, S. T. (1999) · Hypertension · doi:10.1161/01.hyp.34.5.1117 · Cited by 61 · see citing works
Terata, K., Coppey, L. J., Davidson, E. P., Dunlap, J. A., Gutterman, D. D., & Yorek, M. A. (1999) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0702856 · Cited by 59 · see citing works
Self-citationKim, J., Kyriazi, H. T., & Greene, D. A. (1991) · Diabetes · doi:10.2337/diab.40.5.558 · Cited by 59 · see citing works
Dillon, J. S., Yaney, G. C., Zhou, Y., Voilley, N., Bowen, S., Chipkin, S. R., Bliss, C. R., Schultz, V., Schuit, F. C., Prentki, M., et al. (2000) · Diabetes · doi:10.2337/diabetes.49.12.2012 · Cited by 58 · see citing works
Self-citation17β-Estradiol increases nitric oxide-dependent dilation in rat pulmonary arteries and thoracic aorta
Gonzales, R. J., Walker, B. R., & Kanagy, N. L. (2001) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.2001.280.3.l555 · Cited by 52 · see citing works
β‐Agonists regulate Na,K‐ATPase via novel MAPK/ERK and rapamycin‐sensitive pathways
Pesce, L. M., Guerrero, C., Comellas, A. P., Ridge, K. M., & Sznajder, J. I. (2000) · FEBS Letters · doi:10.1016/s0014-5793(00)02298-5 · Cited by 51 · see citing works
Mechanism of Cancer Preventive Action of DHEA
Schwartz, A. G., & Pashko, L. L. (1995) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1995.tb17381.x · Cited by 50 · see citing works
Serum Levels of Testosterone Precursors, Testosterone and Estradiol in 10 Animal Species
Wichmann, U., Wichmann, G., & Kŕause, W. (2009) · Experimental and Clinical Endocrinology & Diabetes · doi:10.1055/s-0029-1210342 · Cited by 49 · see citing works
Oxygen free radical scavenger properties of dehydroepiandrosterone
Tamagno, E., Aragno, M., Boccuzzi, G., Gallo, M., Parola, S., Fubini, B., Poli, G., & Danni, O. (1998) · Cell Biochemistry and Function · doi:10.1002/(sici)1099-0844(199803)16:1 · Cited by 47 · see citing works
Greene, D. A., & Mackway, A. M. (1986) · Diabetes · doi:10.2337/diab.35.10.1106 · Cited by 42 · see citing works
Teoh, H., & Man, R. Y. K. (2000) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0703252 · Cited by 40 · see citing works
7 Diabetes and adrenal disease
Nestler, J. E., & McClanahan, M. A. (1992) · Baillière s Clinical Endocrinology and Metabolism · doi:10.1016/s0950-351x(05)80169-7 · Cited by 40 · see citing works
Narkar, V. A., Hussain, T., & Lokhandwala, M. F. (2002) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00126.2001 · Cited by 36 · see citing works
The pharmacology of diabetic neuropathy
Tomlinson, D. R. (1992) · Diabetes/Metabolism Reviews · doi:10.1002/dmr.5610080107 · Cited by 34 · see citing works
Dehydroepiandrosterone and Body Fat
Clore, J. N. (1995) · Obesity Research · doi:10.1002/j.1550-8528.1995.tb00234.x · Cited by 32 · see citing works
Omawari, N., Dewhurst, M., Vo, P. A., Mahmood, S., Stevens, E. J., & Tomlinson, D. R. (1996) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1996.tb15384.x · Cited by 32 · see citing works
Aragno, M., Parola, S., Brignardello, E., Manti, R., Betteto, S., Tamagno, E., Danni, O., & Boccuzzi, G. (2001) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(01)00669-4 · Cited by 31 · see citing works
Tummala, S., & Svec, F. (1999) · Clinical Biochemistry · doi:10.1016/s0009-9120(99)00021-1 · Cited by 31 · see citing works
The Role of Dehydroepiandrosterone in Diabetes Mellitus
Wellman, M., Shane‐McWhorter, L., Orlando, P. L., & Jennings, J. P. (1999) · Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy · doi:10.1592/phco.19.8.582.31533 · Cited by 21 · see citing works
Biochemical and vascular factors in the pathogenesis of diabetic neuropathy.
Ward, J. D. (1995) · PubMed · Cited by 13 · see citing works
Byrne, J. J., & Bradlow, H. L. (2001) · Diabetes Technology & Therapeutics · doi:10.1089/152091501300209570 · Cited by 12 · see citing works
Dehydroepiandrosterone: Fountain of Youth or Snake Oil?
Nestler, J. E. (1997) · The Endocrinologist · doi:10.1097/00019616-199707060-00003 · Cited by 8 · see citing works
Analysis: Potential Therapeutic Use of Dehydroepiandrosterone and Structural Analogs
Schwartz, A. G., & Pashko, L. L. (2001) · Diabetes Technology & Therapeutics · doi:10.1089/152091501300209589 · Cited by 3 · see citing works
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Sivitz, W. I., & Yorek, M. A. (2010) · Antioxidants & Redox Signaling · doi:10.1089/ars.2009.2531 · Cited by 742 · see citing works
Self-citationNeuroactive steroids: State of the art and new perspectives
Melcangi, R. C., García‐Segura, L. M., & Mensah‐Nyagan, A. G. (2007) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-007-7403-5 · Cited by 232 · see citing works
Leonelli, E., Bianchi, R., Cavaletti, G., Caruso, D., Crippa, D., García‐Segura, L. M., Lauria, G., Magnaghi, V., Roglio, I., & Melcangi, R. C. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.11.014 · Cited by 187 · see citing works
Simoncini, T., Mannella, P., Fornari, L., Varone, G. L., Caruso, A., & Genazzani, A. R. (2003) · Endocrinology · doi:10.1210/en.2003-0044 · Cited by 185 · see citing works
DHEA, Important Source of Sex Steroids in Men and Even More in Women
Labrie, F. (2010) · Progress in brain research · doi:10.1016/s0079-6123(10)82004-7 · Cited by 183 · see citing works
Oxidative Stress Triggers Cardiac Fibrosis in the Heart of Diabetic Rats
Aragno, M., Mastrocola, R., Alloatti, G., Vercellinatto, I., Bardini, P., Geuna, S., Catalano, M. G., Danni, O., & Boccuzzi, G. (2007) · Endocrinology · doi:10.1210/en.2007-0877 · Cited by 177 · see citing works
Aragno, M., Mastrocola, R., Medana, C., Catalano, M. G., Vercellinatto, I., Danni, O., & Boccuzzi, G. (2006) · Endocrinology · doi:10.1210/en.2006-0728 · Cited by 146 · see citing works
Labrie, F., Martel, C., & Balser, J. (2011) · Menopause · doi:10.1097/gme.0b013e3181e195a6 · Cited by 143 · see citing works
Lipids in the nervous system: From biochemistry and molecular biology to patho-physiology
Cermenati, G., Mitro, N., Audano, M., Melcangi, R. C., Crestani, M., De Fabiani, E., & Caruso, D. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2014.08.011 · Cited by 137 · see citing works
Liu, D., & Dillon, J. S. (2004) · Steroids · doi:10.1016/j.steroids.2004.02.004 · Cited by 132 · see citing works
Self-citationMuscle wasting in diabetic and in tumor-bearing rats: Role of oxidative stress
Mastrocola, R., Reffo, P., Penna, F., Tomasinelli, C. E., Boccuzzi, G., Baccino, F. M., Aragno, M., & Costelli, P. (2007) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.10.047 · Cited by 115 · see citing works
Pesaresi, M., Maschi, O., Giatti, S., García‐Segura, L. M., Caruso, D., & Melcangi, R. C. (2009) · Hormones and Behavior · doi:10.1016/j.yhbeh.2009.04.008 · Cited by 114 · see citing works
Aragno, M., Cutrìn, J. C., Mastrocola, R., Perrelli, M.-G., Restivo, F., Poli, G., Danni, O., & Boccuzzi, G. (2003) · Kidney International · doi:10.1046/j.1523-1755.2003.00152.x · Cited by 109 · see citing works
Neuroactive steroids, neurosteroidogenesis and sex
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Caruso, D., Scurati, S., Maschi, O., Angelis, L. D., Roglio, I., Giatti, S., García‐Segura, L. M., & Melcangi, R. C. (2007) · Neurochemistry International · doi:10.1016/j.neuint.2007.06.004 · Cited by 102 · see citing works
Diabetes, oxidative stress, molecular mechanism, and cardiovascular disease – an overview
Selvaraju, V., Joshi, M., Suresh, S. C., Sánchez, J. A., Maulik, N., & Maulik, G. (2012) · Toxicology Mechanisms and Methods · doi:10.3109/15376516.2012.666648 · Cited by 93 · see citing works
Melcangi, R. C., Giatti, S., & García‐Segura, L. M. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.09.023 · Cited by 94 · see citing works
Neuroactive steroids and peripheral neuropathy
Roglio, I., Giatti, S., Pesaresi, M., Bianchi, R., Cavaletti, G., Lauria, G., García‐Segura, L. M., & Melcangi, R. C. (2007) · Brain Research Reviews · doi:10.1016/j.brainresrev.2007.04.010 · Cited by 92 · see citing works
Giatti, S., Pesaresi, M., Cavaletti, G., Bianchi, R., Carozzi, V., Lombardi, R., Maschi, O., Lauria, G., García‐Segura, L. M., Caruso, D., et al. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.08.005 · Cited by 89 · see citing works
Liu, D., Iruthayanathan, M., Homan, L. L., Wang, Y., Yang, L., Wang, Y., & Dillon, J. S. (2007) · Endocrinology · doi:10.1210/en.2007-1125 · Cited by 90 · see citing works
Self-citationZangiabadi, N., Asadi‐Shekaari, M., Sheibani, V., Jafari, M., Shabani, M., Asadi, A. R., Tajadini, H., & Jarahi, M. (2011) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2011/976948 · Cited by 89 · see citing works
Morimoto, S., Mendoza-Rodríguez, C. A., Hiriart, M., Larrieta, M. E., Vital, P., & Cerbón, M. A. (2005) · Journal of Endocrinology · doi:10.1677/joe.1.06357 · Cited by 88 · see citing works
Camporez, J. P., Akamine, E. H., Davel, A. P., Franci, C. R., Rossoni, L. V., & Carvalho, C. R. D. O. (2011) · The Journal of Physiology · doi:10.1113/jphysiol.2011.206078 · Cited by 83 · see citing works
Testosterone derivatives are neuroprotective agents in experimental diabetic neuropathy
Roglio, I., Bianchi, R., Giatti, S., Cavaletti, G., Caruso, D., Scurati, S., Crippa, D., García‐Segura, L. M., Camozzi, F., Lauria, G., et al. (2007) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-007-7002-5 · Cited by 67 · see citing works
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Aragno, M., Mastrocola, R., Medana, C., Restivo, F., Catalano, M. G., Pons, N., Danni, O., & Boccuzzi, G. (2005) · Endocrinology · doi:10.1210/en.2005-0712 · Cited by 64 · see citing works
Sharma, S. S., Kumar, A., Arora, M., & Kaundal, R. K. (2009) · Free Radical Research · doi:10.1080/10715760902801509 · Cited by 58 · see citing works
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Neuroactive steroids and the peripheral nervous system: An update
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DHEAS improves learning and memory in aged SAMP8 mice but not in diabetic mice
Farr, S. A., Banks, W. A., Uezu, K., Gaskin, F. S., & Morley, J. E. (2004) · Life Sciences · doi:10.1016/j.lfs.2004.05.026 · Cited by 39 · see citing works
Matsumoto, T., Kakami, M., Kobayashi, T., & Kamata, K. (2008) · Peptides · doi:10.1016/j.peptides.2008.04.001 · Cited by 38 · see citing works
Martín, M. D. C., Balfagón, G., Minoves, N., Blanco‐Rivero, J., & Ferrer, M. (2005) · Nitric Oxide · doi:10.1016/j.niox.2005.02.003 · Cited by 35 · see citing works
Regression of diabetic complications by islet transplantation in the rat
Remuzzi, A., Cornolti, R., Bianchi, R., Figliuzzi, M., Porretta‐Serapiglia, C., Oggioni, N., Carozzi, V., Crippa, L., Avezza, F., Fiordaliso, F., et al. (2009) · Diabetologia · doi:10.1007/s00125-009-1537-y · Cited by 34 · see citing works
Therapeutic potential of Mesenchymal Stem Cells for the treatment of diabetic peripheral neuropathy
Monfrini, M., Donzelli, E., Rodriguez‐Menendez, V., Ballarini, E., Carozzi, V., Chiorazzi, A., Meregalli, C., Canta, A., Oggioni, N., Crippa, L., et al. (2016) · Experimental Neurology · doi:10.1016/j.expneurol.2016.11.006 · Cited by 34 · see citing works
Neuroactive steroids and diabetic complications in the nervous system
Giatti, S., Mastrangelo, R., D’Antonio, M., Pesaresi, M., Romano, S., Diviccaro, S., Caruso, D., Mitro, N., & Melcangi, R. C. (2017) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2017.07.006 · Cited by 32 · see citing works
Fokidis, H. B., Adomat, H. H., Kharmate, G., Beheshti, E. H., Guns, E. S. T., & Soma, K. K. (2014) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2014.08.005 · Cited by 31 · see citing works
Yorek, M. A. (2015) · The Review of Diabetic Studies · doi:10.1900/rds.2015.12.13 · Cited by 31 · see citing works
Self-citationPesaresi, M., Giatti, S., Cavaletti, G., Abbiati, F., Calabrese, D., Bianchi, R., Caruso, D., García‐Segura, L. M., & Melcangi, R. C. (2011) · Experimental Neurology · doi:10.1016/j.expneurol.2011.01.005 · Cited by 31 · see citing works
Effects of Melatonin in Prevention of Neuropathy in STZ-Induced Diabetic Rats
Zangiabadi (2011) · American Journal of Pharmacology and Toxicology · doi:10.3844/ajptsp.2011.59.67 · Cited by 31 · see citing works
Effect of mitoquinone (Mito-Q) on neuropathic endpoints in an obese and type 2 diabetic rat model
Fink, B. D., Coppey, L. J., Davidson, E. P., Shevalye, H., Obrosov, A. A., Chheda, P. R., Kerns, R. J., Sivitz, W. I., & Yorek, M. A. (2020) · Free Radical Research · doi:10.1080/10715762.2020.1754409 · Cited by 29 · see citing works
Self-citationMartorell, A., Blanco‐Rivero, J., Aras‐López, R., Sagredo, A., Balfagón, G., & Ferrer, M. (2007) · Cardiovascular Research · doi:10.1093/cvr/cvm059 · Cited by 28 · see citing works
Romano, S., Mitro, N., Giatti, S., Diviccaro, S., Pesaresi, M., Spezzano, R., Audano, M., García‐Segura, L. M., Caruso, D., & Melcangi, R. C. (2017) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2017.11.009 · Cited by 27 · see citing works
Short-term effects of diabetes on neurosteroidogenesis in the rat hippocampus
Romano, S., Mitro, N., Diviccaro, S., Spezzano, R., Audano, M., García‐Segura, L. M., Caruso, D., & Melcangi, R. C. (2016) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2016.11.019 · Cited by 25 · see citing works
Huang, Y.-J., Chen, M.-T., Fang, C.-L., Lee, W., Yang, S.-C., & Kuo, C. (2006) · International Journal of Medical Sciences · doi:10.7150/ijms.3.141 · Cited by 25 · see citing works
The effect of dehydroepiandrosterone (DHEA) on renal function and metabolism in diabetic rats
Jahn, M. P., Gomes, L. F., Jacob, M., Janner, D. D. R., Araújo, A. S. D. R., Belló‐Klein, A., Ribeiro, M. F. M., & Kucharski, L. C. (2011) · Steroids · doi:10.1016/j.steroids.2011.02.006 · Cited by 24 · see citing works
Physiopathological Role of Neuroactive Steroids in the Peripheral Nervous System
Falvo, E., Diviccaro, S., Melcangi, R. C., & Giatti, S. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21239000 · Cited by 24 · see citing works
Treatment for Diabetic Peripheral Neuropathy: What have we Learned from Animal Models?
Yorek, M. A. (2021) · Current Diabetes Reviews · doi:10.2174/1573399817666210504101609 · Cited by 23 · see citing works
Self-citationSex-dimorphic effects of dehydroepiandrosterone in diabetic neuropathy
Pesaresi, M., Giatti, S., Cavaletti, G., Abbiati, F., Calabrese, D., Lombardi, R., Bianchi, R., Lauria, G., Caruso, D., García‐Segura, L. M., et al. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.09.013 · Cited by 23 · see citing works
DHEA Alleviates Oxidative Stress of Muscle Cells via Activation of Nrf2 Pathway
Jeon, S., Hur, J., & Kim, J. (2015) · Applied Biochemistry and Biotechnology · doi:10.1007/s12010-015-1500-y · Cited by 23 · see citing works
Blanco‐Rivero, J., Sagredo, A., Balfagón, G., & Ferrer, M. (2007) · Journal of Endocrinology · doi:10.1677/joe.1.07079 · Cited by 23 · see citing works
Potential role of resveratrol in prevention and therapy of diabetic complications: a critical review
Koushki, M., Farahani, M., Yekta, R. F., Frazizadeh, N., Bahari, P., Parsamanesh, N., Chiti, H., Chahkandi, S., Fridoni, M., & Dashatan, N. A. (2024) · Food & Nutrition Research · doi:10.29219/fnr.v68.9731 · Cited by 22 · see citing works
Blanco-Rivero, J., Sagredo, A., Balfagón, G., & Ferrer, M. (2006) · Journal of Endocrinology · doi:10.1677/joe.1.06887 · Cited by 21 · see citing works
Clinical uses and misuses of dehydroepiandrosterone
Binello, E., & GORDON, C. (2003) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2003.07.006 · Cited by 22 · see citing works
Jia, C., Chen, X., Li, X., Li, M., Miao, C., Sun, B., Fan, Z., & Ren, L. (2011) · Journal of Trace Elements in Medicine and Biology · doi:10.1016/j.jtemb.2011.04.001 · Cited by 20 · see citing works
Jahn, M. P., Jacob, M., Gomes, L. F., Duarte, R. F., Araújo, A. S. D. R., Belló‐Klein, A., Ribeiro, M. F. M., & Kucharski, L. C. (2010) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2010.03.015 · Cited by 19 · see citing works
The Neuroprotective Effects of Progesterone on Experimental Diabetic Neuropathy in Rats
Sameni, H., Panahi, M., Sarkaki, A., Saki, G., & Makvandi, M. (2008) · Pakistan Journal of Biological Sciences · doi:10.3923/pjbs.2008.1994.2000 · Cited by 17 · see citing works
Bruno, C., Silvestrini, A., Calarco, R., Favuzzi, A. M. R., Vergani, E., Nicolazzi, M. A., d’Abate, C., Meucci, E., Mordente, A., Landolfi, R., et al. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.00281 · Cited by 14 · see citing works
Treatment of diabetic neuropathy with baicalein: Intervention at multiple sites
Yorek, M. A. (2011) · Experimental Neurology · doi:10.1016/j.expneurol.2011.08.017 · Cited by 12 · see citing works
Self-citationSameni, H., & Panahi, M. (2011) · PubMed Central · Cited by 9 · see citing works
Neuroactive Steroids and Sex-Dimorphic Nervous Damage Induced by Diabetes Mellitus
Giatti, S., Diviccaro, S., & Melcangi, R. C. (2018) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-018-0613-6 · Cited by 9 · see citing works
Mishra, D., Yadav, P., Iqbal, H., Parashar, S., Negi, A. S., & Chanda, D. (2024) · Microvascular Research · doi:10.1016/j.mvr.2024.104758 · Cited by 6 · see citing works
Peredo, H. A., Mayer, M. A., Faya, I. R., Puyó, A. M., & Carranza, A. (2008) · European Journal of Nutrition · doi:10.1007/s00394-008-0734-7 · Cited by 6 · see citing works
Conservative Treatment of Peripheral Neuropathy and Neuropathic Pain
Francis, D. A., Christopher, A. T., & Beasley, B. D. (2006) · Clinics in Podiatric Medicine and Surgery · doi:10.1016/j.cpm.2006.04.004 · Cited by 6 · see citing works
Isidoro-García, L., Villalpando, D. M., & Ferrer, M. (2021) · PLoS ONE · doi:10.1371/journal.pone.0246254 · Cited by 5 · see citing works
Y1R control of sciatic nerve blood flow in the Wistar Kyoto rat
Twynstra, J., Medeiros, P. J., Lacefield, J. C., Jackson, D. N., & Shoemaker, J. K. (2012) · Microvascular Research · doi:10.1016/j.mvr.2012.06.005 · Cited by 5 · see citing works
Effect of 5β-dihydrotestosterone on vasodilator function and on cell proliferation
Sánchez-Fernández, D., Eguibar, A., López, C., Cuesta, Á. M., Albiñana, V., Rogers-Ezewuike, S., Rivas, J. G., Saldaña, L., Botella, L. M., & Ferrer, M. (2024) · PLoS ONE · doi:10.1371/journal.pone.0312080 · Cited by 4 · see citing works
Shibli-Rahhal, A. A., Haynes, W. G., Sinkey, C. A., & Dillon, J. S. (2012) · journal of Diabetes Research and Clinical Metabolism · doi:10.7243/2050-0866-1-13 · Cited by 2 · see citing works
Self-citationChapter 22 Dehydroepiandrosterone
Schiechl, G., & Straub, R. H. (2008) · Technical report · doi:10.1016/s1571-5078(07)00222-x · Cited by 1 · see citing works
Androgens and Vascular Function
Ferrer, M. (2011) · InTech eBooks · doi:10.5772/18603 · Cited by 1 · see citing works
Neuroactive Steroids and Peripheral Neuropathy
Melcangi, R. C., Giatti, S., Pesaresi, M., Caruso, D., & Tetel, M. J. (2011) · doi:10.1002/9783527633968.ch7 · Cited by 1 · see citing works
Efeitos da ooforectomia e do desidroepiandrosterona (DHEA) sobre a massa cardíaca de ratas.
Teixeira, K. S. (2012) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/d.42.2012.tde-24072012-152439
Sistemas, P. D., Sinalização, A. E. D., Mecanismos, I. N., Lesão, C. A., Periférica, N., Mestrado, D. D., Bosco, L. D., Sabino, F., Marques, M. F., & Lovatel, G. A. (2010)
ROLE OF LIVER X RECEPTOR ACTIVATION ON DIABETIC PERIPHERAL NEUROPATHY
Abbiati, F. (2014) · Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano) · doi:10.13130/abbiati-federico_phd2014-02-27
Mitochondria and Oxidative Stress in Diabetes
Sivitz, W. I. (2014) · Oxidative stress in applied basic research and clinical practice · doi:10.1007/978-1-4899-8035-9_5
Anti-Aging Medicine LiteratureWatch
(2003) · Rejuvenation Research · doi:10.1089/109454503765361588
Haghi‐Aminjan, H., Kouhestani, M., & Hosseini, A. (2024) · Metabolic Brain Disease · doi:10.1007/s11011-024-01480-y
- Authors
- Yorek, M. A., Coppey, L. J., Gellett, J. S., Davidson, E. P., Bing, X., Lund, D. D., & Dillon, J. S.
- Affiliations
- University of Iowa (US)
- Venue
- American Journal of Physiology-Endocrinology and Metabolism
- Publisher
- American Physiological Society
- Published
- 2002-11-01
- Volume
- 283
- Issue
- 5
- Pages
- E1067-E1075
- ISSN
- 0193-1849 (ISSN-L)
- 1522-1555
- OpenAlex
- W2077212501
- Cited by
- 79
- References
- 64
- Citations by year
- 2024: 4 · 2021: 2 · 2020: 3 · 2019: 1 · 2018: 2 · 2017: 2 · 2016: 2 · 2015: 4 · 2014: 4 · 2012: 5
- FWCI
- 1.09
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Physiology-Endocrinology and Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging (R01AG018928, AG18928)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK-25295, DK-58005, P30DK025295)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Aldose Reductase and Taurine
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Keywords
- dehydroepiandrosterone, diabetes mellitus, diabetic vascular dysfunction, diabetic neuropathy, nerve conduction velocity, oxidative stress, superoxide, acetylcholine-induced vasodilation, Na+/K+-ATPase, myo-inositol, sorbitol, fructose, streptozotocin-induced diabetes, antioxidant supplementation
- MeSH terms
- Adjuvants, Immunologic, Animals, Arterioles, Blood Glucose, Body Weight, Dehydroepiandrosterone, Diabetes Mellitus, Experimental, Diabetic Neuropathies, Estrogens, Male, Peripheral Nerves, Sciatic Nerve, Superoxides, Vasoconstriction, Rats, Sprague-Dawley, Oxidative Stress, Rats
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