Gestational Diabetes Mellitus and Impaired Glucose Tolerance During Pregnancy: Long-Term Effects on Obesity and Glucose Tolerance in the Offspring
Abstract
The effects of disturbances in carbohydrate metabolism during gestation were studied in the offspring of 1049 Pima Indian women who had no previous diagnosis of diabetes. Rates of fetal and maternal complications of pregnancy among women with diabetes first diagnosed during the pregnancy were similar to those among women in whom diabetes was recognized before gestation. Offspring, aged 5-19 yr, of women with abnormal glucose tolerance during pregnancy had a higher mean percent desirable weight and a higher mean postchallenge plasma glucose concentration than did offspring of women with normal glucose tolerance. Percent desirable weight and glucose concentration, however, were both lower than found in offspring of women with diabetes diagnosed before the pregnancy. Thus, metabolic events during pregnancy, as indicated by the detection of abnormal glucose tolerance during gestation, appear to have long-term effects on obesity and glucose tolerance in the offspring.
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Impaired glucose tolerance can be detected in children of GDM pregnancies as young as five years old.
“and impaired glucose tolerance can be detected as young as five years old [69].”
From The Pathophysiology of Gestational Diabetes Mellitus (2018) · cites this paper as [69]
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- Authors
- Pettitt, D. J., Bennett, P. H., Knowler, W. C., Robert Baird, H., & Aleck, K. A.
- Affiliations
- University of New Mexico (US)
- Epidemiology and Field Studies Branch, National Institute of Arthritis, Diabetes, and Digestive and Kidney Diseases Phoenix, Arizona; Department of Pediatrics, University of New Mexico Albuquerque, New Mexico
- Venue
- Diabetes
- Publisher
- American Diabetes Association
- Published
- 1985-06-01
- Volume
- 34
- Issue
- Supplement_2
- Pages
- 119-122
- ISSN
- 0012-1797 (ISSN-L)
- 1939-327X
- OpenAlex
- W1967575964
- Cited by
- 252
- References
- 0
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 4 · 2023: 8 · 2022: 3 · 2021: 21 · 2020: 8 · 2019: 9 · 2018: 5 · 2017: 10 · 2016: 11 · 2015: 10 · 2014: 8 · 2013: 10 · 2012: 6
- FWCI
- 4.09
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Diabetes (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute of Child Health and Human Development
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD-11327-02)
- Topics
- Health Sciences › Medicine › Obstetrics and Gynecology › Gestational Diabetes Research and Management
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Keywords
- gestational diabetes mellitus, impaired glucose tolerance in pregnancy, offspring obesity, Pima Indians, maternal glucose tolerance
- MeSH terms
- Adolescent, Adult, Birth Weight, Blood Glucose, Body Weight, Child, Child, Preschool, Female, Glucose Tolerance Test, Humans, Obesity, Pregnancy, Pregnancy in Diabetics
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