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Erythrocyte Membrane Lipid Peroxidation and Glycosylated Hemoglobin in Diabetes
Abstract
Erythrocytes of diabetic patients have abnormal membrane properties. We examined in vivo membrane lipid peroxidation in erythrocytes of diabetic subjects and its possible relationship with hyperglycemia. Lipid peroxidation was assessed in fresh, untreated erythrocytes by quantitating thiobarbituric acid reactivity and an adduct of phospholipids and malonyldialdehyde (MDA), an end product of lipid peroxidation, with thin-layer chromatography of lipid extract of diabetic erythrocytes. There was a significantly increased membrane lipid peroxidation in diabetic erythrocytes compared with nondiabetic erythrocytes. The degree of membrane lipid peroxidative damage in erythrocytes was significantly correlated with the level of glycosylated hemoglobin, an index of mean glucose level for the preceding 3–4mo. This suggests that peroxidation of membrane lipids and accumulation of MDA occurs in erythrocytes of diabetic patients.
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Cited by
Del Rio, D., Stewart, A. J., & Pellegrini, N. (2005) · Nutrition, Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2005.05.003 · Cited by 2,721
Oxidative stress, insulin signaling, and diabetes
Rains, J. L., & Jain, S. K. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2010.12.006 · Cited by 1,435
Self-citationProposed mechanisms for the induction of insulin resistance by oxidative stress
Bloch-Damti, A., & Bashan, N. (2005) · Antioxidants & Redox Signaling · doi:10.1089/ars.2005.7.1553 · Cited by 388
Hyperglycemia Can Cause Membrane Lipid Peroxidation and Osmotic Fragility in Human Red Blood Cells
Jain, S. K. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)30085-7 · Cited by 374
Self-citationAnderson, R. A., Roussel, A.-M., Zouari, N., Mahjoub, S., Matheau, J.-M., & Kerkeni, A. (2001) · Journal of the American College of Nutrition · doi:10.1080/07315724.2001.10719034 · Cited by 313
Metadata
- Authors
- Jain, S. K., McVie, R., Duett, J., & Herbst, J. J.
- Venue
- Diabetes
- Publisher
- American Diabetes Association
- Published
- 1989-12-01
- Volume
- 38
- Issue
- 12
- Pages
- 1539-1543
- ISSN
- 0012-1797 (ISSN-L)
- 1939-327X
- OpenAlex
- W2108688009
- Cited by
- 639
- References
- 0
- FWCI
- 3.85
- Type
- journal article
- Language
- en
- Open access
- closed
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- Jain, S. K., McVie, R., Duett, J., & Herbst, J. J. (1989). Erythrocyte Membrane Lipid Peroxidation and Glycosylated Hemoglobin in Diabetes. Diabetes. https://doi.org/10.2337/diab.38.12.1539
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