The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
Potential Antioxidant Effects of Zinc and Chromium Supplementation in People with Type 2 Diabetes Mellitus
Abstract
OBJECTIVE: To determine the effects of combined zinc (Zn) and chromium (Cr) supplementation on oxidative stress and glucose homeostasis of people with type 2 diabetes. DESIGN: Tunisian adult subjects with HbA1C > 7.5% were supplemented for 6 months with 30 mg/d of Zn as Zn gluconate or 400 microg/d of Cr as Cr pidolate or combined Zn/Cr supplementation or placebo. The effects of supplementation on plasma zinc (Zn), copper (Cu), selenium (Se), urinary Zn, Cr, plasma thiobarbituric acid reactive substances (TBARS), Cu-Zn superoxide dismutase (SOD) and Se glutathione peroxidase (GPx) in red blood cells, blood lipids and lipoproteins, HbA1C and fasting glucose were measured at the beginning of the study and after six months. RESULTS: At the beginning of the study, more than 30% of the subjects may have been Zn deficient with plasma Zn values less than 10.7 mircomol/L, whereas levels of plasma Cu, Se and antioxidant RBC enzyme activities were in the normal ranges. Following supplementation, there were significant decreases of plasma TBARS in the Cr (13.6%), Zn (13.6%) and Zn/Cr (18.2%) groups with no significant changes in the placebo group. The value for the TBARS of the control healthy Tunisian subjects was 2.08 +/- 0.04 micromol/L and that of the Tunisian subjects with diabetes was 3.32 +/- 0.05 micromol/L. This difference of 1.24 micromol/L between the control group and the subjects with diabetes was reduced from 36% to 50% in the three supplemented groups. Supplementation did not modify significantly HbAIC nor glucose homeostasis. No adverse effects of Zn supplementation were observed on Cu status. HDL cholesterol nor interactions in Zn or Cr. CONCLUSIONS: These data suggest the potential beneficial antioxidant effects of the individual and combined supplementation of Zn and Cr in people with type 2 DM. These results are particularly important in light of the deleterious consequences of oxidative stress in people with diabetes.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
MARKLUND, S., & MARKLUND, G. (1974) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1974.tb03714.x · Cited by 10,354
Role of Oxidative Stress in Development of Complications in Diabetes
Baynes, J. W. (1991) · Diabetes · doi:10.2337/diab.40.4.405 · Cited by 3,793
Oberley, L. W. (1988) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(88)90036-6 · Cited by 1,105
The physiological role of zinc as an antioxidant
Bray, T. M., & Bettger, W. J. (1990) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(90)90076-u · Cited by 892
Protein glycation and oxidative stress in diabetes mellitus and ageing
Wolff, S. P., Jiang, Z. Y., & Hunt, J. V. (1991) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(91)90040-a · Cited by 883
Chausmer, A. B. (1998) · Journal of the American College of Nutrition · doi:10.1080/07315724.1998.10718735 · Cited by 734
Erythrocyte Membrane Lipid Peroxidation and Glycosylated Hemoglobin in Diabetes
Jain, S. K., McVie, R., Duett, J., & Herbst, J. J. (1989) · Diabetes · doi:10.2337/diab.38.12.1539 · Cited by 639
Anderson, R. A., Cheng, N., Bryden, N. A., Polansky, M. M., Cheng, N., Chi, J., & Feng, J. (1997) · Diabetes · doi:10.2337/diab.46.11.1786 · Cited by 609
Self-citationChromium, Glucose Intolerance and Diabetes
Anderson, R. A. (1998) · Journal of the American College of Nutrition · doi:10.1080/07315724.1998.10718802 · Cited by 442
Self-citationMAXWELL, S. R. J., THOMASON, H., SANDLER, D., LEGUEN, C., BAXTER, M. A., THORPE, G. H. G., JONES, A. F., & BARNETT, A. H. (1997) · European Journal of Clinical Investigation · doi:10.1046/j.1365-2362.1997.1390687.x · Cited by 403
Cited by
Chimienti, F., Devergnas, S., Pattou, F., Schuit, F., Garcia-Cuenca, R., Vandewalle, B., Kerr-Conte, J., Van Lommel, L., Grunwald, D., Favier, A., et al. (2006) · Journal of Cell Science · doi:10.1242/jcs.03164 · Cited by 349
Effects of zinc supplementation on diabetes mellitus: A systematic review and meta-analysis
Jayawardena, R., Ranasinghe, P., Galappatthy, P., Malkanthi, R., Constantine, G., & Katulanda, P. (2012) · Diabetology & Metabolic Syndrome · doi:10.1186/1758-5996-4-13 · Cited by 346
Suksomboon, N., Poolsup, N., & Yuwanakorn, A. (2014) · Journal of Clinical Pharmacy and Therapeutics · doi:10.1111/jcpt.12147 · Cited by 154
Chromium picolinate for reducing body weight: Meta-analysis of randomized trials
Pittler, M. H., Stevinson, C., & Ernst, E. (2003) · International Journal of Obesity · doi:10.1038/sj.ijo.0802262 · Cited by 131
Zinc, pancreatic islet cell function and diabetes: new insights into an old story
Chimienti, F. (2013) · Nutrition Research Reviews · doi:10.1017/s0954422412000212 · Cited by 125
Metadata
- Authors
- Anderson, R. A., Roussel, A.-M., Zouari, N., Mahjoub, S., Matheau, J.-M., & Kerkeni, A.
- Venue
- Journal of the American College of Nutrition
- Publisher
- Informa UK Limited
- Published
- 2001-06
- Volume
- 20
- Issue
- 3
- Pages
- 212-218
- ISSN
- 0731-5724 (ISSN-L)
- 1541-1087
- OpenAlex
- W2062229551
- Cited by
- 313
- References
- 33
- FWCI
- 9.16
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Potential Antioxidant Effects of Zinc and Chromium Supplementation in People with Type 2 Diabetes Mellitus. https://app.cochat.ai/papers/10.1080/07315724.2001.10719034
- The paper
- Anderson, R. A., Roussel, A.-M., Zouari, N., Mahjoub, S., Matheau, J.-M., & Kerkeni, A. (2001). Potential Antioxidant Effects of Zinc and Chromium Supplementation in People with Type 2 Diabetes Mellitus. Journal of the American College of Nutrition. https://doi.org/10.1080/07315724.2001.10719034
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
