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Glucagonostatic and Insulinotropic Action of Glucagonlike Peptide I-(7–36)-Amide
Abstract
We examined the effect of glucagonlike peptides (GLPs), which are cleaved from preproglucagon in the enteroglucagon cells, on rat endocrine pancreas with the isolated perfused system. GLP-I-(7–36)-amide, a truncated form of full-sequence GLP-I-(1–37), showed a potent inhibitory effect on glucagon secretion. This inhibitory effect of GLP-I-(7–36)-amide was demonstrated at concentrations of 0.25, 2.5, and 25 nM in 11.2 and 2.8 mM glucose. In contrast, insulin release was significantly stimulated by GLP-I-(7–36)-amide at its concentration from 0.025 to 25 nM in a high glucose concentration, whereas in a low glucose concentration, the stimulation was seen only at the highest concentration (25 nM). Neither GLP-I-(1–37) nor GLP-II showed any effect on glucagon and insulin release. Although several gastrointestinal hormones have been nominated as incretins, none of them may suppress the glucagon secretion. A truncated form of GLP-I, GLP-I-(7–36)-amide thus seems to be a unique incretin that exerts glucagonostatic action.
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Citations
Cited by
Glucagon-like peptide 1 (GLP-1)
Müller, T. D., Finan, B., Bloom, S. R., D'Alessio, D., Drucker, D. J., Flatt, P. R., Fritsche, A., Gribble, F., Grill, H. J., Habener, J. F., et al. (2019) · Molecular Metabolism · doi:10.1016/j.molmet.2019.09.010 · Cited by 1,868
Nauck, M. A., Heimesaat, M. M., Orskov, C., Holst, J. J., Ebert, R., & Creutzfeldt, W. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116186 · Cited by 1,651
Nauck, M. A., Kleine, N., �rskov, C., Holst, J. J., Willms, B., & Creutzfeldt, W. (1993) · Diabetologia · doi:10.1007/bf00401145 · Cited by 1,092
The role of incretins in glucose homeostasis and diabetes treatment
Kim, W., & Egan, J. M. (2008) · Pharmacological Reviews · doi:10.1124/pr.108.000604 · Cited by 824
Glucagon‐like peptide‐1 cells in the gastrointestinal tract and pancreas of rat, pig and man
EISSELE, R., GÖKE, R., WILLEMER, S., HARTHUS, H. ‐., VERMEER, H., ARNOLD, R., & GÖKE, B. (1992) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.1992.tb01464.x · Cited by 654
Metadata
- Authors
- Komatsu, R., Matsuyama, T., Namba, M., Watanabe, N., Itoh, H., Kono, N., & Tarui, S.
- Venue
- Diabetes
- Publisher
- American Diabetes Association
- Published
- 1989-07-01
- Volume
- 38
- Issue
- 7
- Pages
- 902-905
- ISSN
- 0012-1797 (ISSN-L)
- 1939-327X
- OpenAlex
- W2161923520
- Cited by
- 234
- References
- 0
- FWCI
- 5.19
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Glucagonostatic and Insulinotropic Action of Glucagonlike Peptide I-(7–36)-Amide. https://app.cochat.ai/papers/10.2337/diab.38.7.902
- The paper
- Komatsu, R., Matsuyama, T., Namba, M., Watanabe, N., Itoh, H., Kono, N., & Tarui, S. (1989). Glucagonostatic and Insulinotropic Action of Glucagonlike Peptide I-(7–36)-Amide. Diabetes. https://doi.org/10.2337/diab.38.7.902
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
