CoChat
Sign Up
Cited by 253Diabetes, Cardiovascular Risks, and LipoproteinsHormonal and reproductive studiesAdipokines, Inflammation, and Metabolic Diseases

The DOI matches its Crossref record.

Low Sex-Hormone-Binding Globulin Concentration as Independent Risk Factor for Development of NIDDM: 12-Yr Follow-Up of Population Study of Women in Gothenburg, Sweden

Lindstedt, Göran, Lundberg, Per-Arne, Lapidus, Leif, Lundgren, Hans, Bengtsson, Calle, Björntorp, Per·1991·Diabetes
DOI 10.2337/diab.40.1.123
Open this paper in CoChat — free account

Abstract

Serum sex-hormone-binding globulin (SHBG) and corticosteroid-binding globulin (CBG) concentrations were evaluated as risk factors for the development of non-insulin-dependent diabetes mellitus (NIDDM), myocardial infarction, stroke, and premature death in a prospective study of 1462 randomly selected women, aged 38–60 yr, over 12 yr of observation. In multivariate analysis, taking only age into consideration as a confounding factor, low initial concentration of SHBG was significantly correlated to the incidence of NIDDM and stroke, and high initial concentration of CBG was correlated to the incidence of NIDDM. There were also significant correlations between SHBG and CBG concentrations on one hand and possible risk factors for the end points studied, such as serum triglycerides, serum cholesterol, fasting blood glucose, body mass, body mass index, waist/hip ratio, smoking habits, and systolic blood pressure, on the other. When these possible confounders, in addition to age, were taken into consideration in multivariate analyses, only the inverse significant correlation between SHBG and NIDDM remained. The increased incidence of diabetes was confined to the lowest quintile of SHBG values, where it was 5-fold higher than in the remaining group. This incidence was further increased to 8- and 11-fold in the lowest 10 and 5% of the values, respectively. We conclude that SHBG is a uniquely strong independent risk factor for the development of NIDDM in women.

Overview

Integrity signals

Registry

Crossref · 10.2337/diab.40.1.123

Cites

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Still being checked.

Cited by

Sorted by citations

Items 201–253 of 253

Related

See all

Metadata

Authors
Lindstedt, G., Lundberg, P.-A., Lapidus, L., Lundgren, H., Bengtsson, C., & Björntorp, P.
Affiliations
Sahlgrenska University Hospital (SE)
Venue
Diabetes
Publisher
American Diabetes Association
Published
1991-01-01
Volume
40
Issue
1
Pages
123-128
ISSN
  • 0012-1797 (ISSN-L)
  • 1939-327X
DOI
10.2337/diab.40.1.123
OpenAlex
W2166766026
Cited by
252
References
0
Citations by year
2026: 1 · 2025: 3 · 2024: 3 · 2023: 2 · 2022: 4 · 2021: 7 · 2020: 5 · 2019: 2 · 2018: 5 · 2017: 6 · 2016: 7 · 2015: 5 · 2014: 5 · 2013: 6 · 2012: 7
FWCI
4.94
Type
journal article
Language
en
Open access
closed
Locations
  • Diabetes (publishedVersion)
  • PubMed (publishedVersion)
Funders
Vetenskapsrådet
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Keywords
sex hormone-binding globulin, corticosteroid-binding globulin, type 2 diabetes, diabetes risk factors, women, stroke, myocardial infarction, premature mortality, serum lipids, body mass index, waist-to-hip ratio, smoking, systolic blood pressure
MeSH terms
Adult, Body Constitution, Diabetes Mellitus, Type 2, Female, Follow-Up Studies, Humans, Longitudinal Studies, Menopause, Middle Aged, Risk Factors, Sex Hormone-Binding Globulin, Sweden, Transcortin, Biomarkers, Body Mass Index, Incidence

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review