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Cited by 253Diabetes, Cardiovascular Risks, and LipoproteinsHormonal and reproductive studiesAdipokines, Inflammation, and Metabolic Diseases

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Low Sex-Hormone-Binding Globulin Concentration as Independent Risk Factor for Development of NIDDM: 12-Yr Follow-Up of Population Study of Women in Gothenburg, Sweden

Lindstedt, Göran, Lundberg, Per-Arne, Lapidus, Leif, Lundgren, Hans, Bengtsson, Calle, Björntorp, Per·1991·Diabetes
DOI 10.2337/diab.40.1.123
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Abstract

Serum sex-hormone-binding globulin (SHBG) and corticosteroid-binding globulin (CBG) concentrations were evaluated as risk factors for the development of non-insulin-dependent diabetes mellitus (NIDDM), myocardial infarction, stroke, and premature death in a prospective study of 1462 randomly selected women, aged 38–60 yr, over 12 yr of observation. In multivariate analysis, taking only age into consideration as a confounding factor, low initial concentration of SHBG was significantly correlated to the incidence of NIDDM and stroke, and high initial concentration of CBG was correlated to the incidence of NIDDM. There were also significant correlations between SHBG and CBG concentrations on one hand and possible risk factors for the end points studied, such as serum triglycerides, serum cholesterol, fasting blood glucose, body mass, body mass index, waist/hip ratio, smoking habits, and systolic blood pressure, on the other. When these possible confounders, in addition to age, were taken into consideration in multivariate analyses, only the inverse significant correlation between SHBG and NIDDM remained. The increased incidence of diabetes was confined to the lowest quintile of SHBG values, where it was 5-fold higher than in the remaining group. This incidence was further increased to 8- and 11-fold in the lowest 10 and 5% of the values, respectively. We conclude that SHBG is a uniquely strong independent risk factor for the development of NIDDM in women.

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Metadata

Authors
Lindstedt, G., Lundberg, P.-A., Lapidus, L., Lundgren, H., Bengtsson, C., & Björntorp, P.
Affiliations
Sahlgrenska University Hospital (SE)
Venue
Diabetes
Publisher
American Diabetes Association
Published
1991-01-01
Volume
40
Issue
1
Pages
123-128
ISSN
  • 0012-1797 (ISSN-L)
  • 1939-327X
DOI
10.2337/diab.40.1.123
OpenAlex
W2166766026
Cited by
252
References
0
Citations by year
2026: 1 · 2025: 3 · 2024: 3 · 2023: 2 · 2022: 4 · 2021: 7 · 2020: 5 · 2019: 2 · 2018: 5 · 2017: 6 · 2016: 7 · 2015: 5 · 2014: 5 · 2013: 6 · 2012: 7
FWCI
4.94
Type
journal article
Language
en
Open access
closed
Locations
  • Diabetes (publishedVersion)
  • PubMed (publishedVersion)
Funders
Vetenskapsrådet
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Keywords
sex hormone-binding globulin, corticosteroid-binding globulin, type 2 diabetes, diabetes risk factors, women, stroke, myocardial infarction, premature mortality, serum lipids, body mass index, waist-to-hip ratio, smoking, systolic blood pressure
MeSH terms
Adult, Body Constitution, Diabetes Mellitus, Type 2, Female, Follow-Up Studies, Humans, Longitudinal Studies, Menopause, Middle Aged, Risk Factors, Sex Hormone-Binding Globulin, Sweden, Transcortin, Biomarkers, Body Mass Index, Incidence

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