Cited by 313Aldose Reductase and TaurinePain Mechanisms and TreatmentsPeripheral Neuropathies and Disorders

The DOI matches its Crossref record.

Metabolic and Vascular Factors in the Pathogenesis of Diabetic Neuropathy

Cameron, Norman E, Cotter, Mary A·1997·Diabetes

Open this paper in CoChat — free account

Abstract

Reduced nerve perfusion is an important factor in the etiology of diabetic neuropathy. Studies in streptozotocin-induced diabetic rats show that nerve conduction velocity (NCV) and blood flow deficits are corrected by treatment with vasodilator drugs, with angiotensin II and endothelin-1 antagonists being particularly important. The AT1 antagonist ZD7155 also prevents diabetic deficits in regeneration following nerve damage, indicating that hypoperfusion is an important limitation for nerve repair. Metabolic changes include high polyol pathway flux, increased advanced glycosylation, elevated oxidative stress, and impaired ω-6 essential fatty acid metabolism. Aldose reductase inhibitors (ARIs) restore NCV via their effects on perfusion. ARI action probably depends on blocking the conversion of glucose to sorbitol, thus preventing depletion of vasa nervorum glutathione, an important endogenous free radical scavenger. Free radicals cause vascular endothelium damage and reduced nitric oxide vasodilation. Inhibition of advanced glycosylation and autoxidation (autoxidative glycosylation), major sources of free radicals, by aminoguanidine or transition metal chelators, corrects neurovascular dysfunction. Evening primrose oil supplies γ-linolenic acid (GLA) to improve vasodilator eicosanoid synthesis in diabetes, correcting nerve blood flow and NCV deficits. Interactions between some of these mechanisms have therapeutic implications. Thus, combined ARI and evening primrose oil treatment produced a 10-fold amplification of NCV and blood flow responses. Similarly, GLA effects are markedly enhanced when given in combination with ascorbate as ascorbyl-GLA. Thus, metabolic abnormalities combine to produce deleterious changes in nerve perfusion that make a major contribution to the etiology of diabetic neuropathy. The potential importance of multi-action therapy is stressed.

Integrity signals

Registry

Crossref · 10.2337/diab.46.2.s31

Cites

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Sorted by citations

Items 101–200 of 313

Improvement of Sensory Impairment in Patients with Peripheral Neuropathy
Prendergast, J. J., Miranda, G., & Sanchez, M. (2004) · Endocrine Practice · doi:10.4158/ep.10.1.24 · Cited by 43
Change in cutaneous perfusion following 10 weeks of aerobic training in Type 2 diabetes
Colberg, S. R., Parson, H. K., Nunnold, T., Holton, D. R., Swain, D. P., & Vinik, A. I. (2005) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2005.02.006 · Cited by 43
Toxic stress, inflammation and symptomatology of chronic complications in diabetes
Downs, C. A., & Faulkner, M. S. (2015) · World Journal of Diabetes · doi:10.4239/wjd.v6.i4.554 · Cited by 42
Therapeutic potential of PKC inhibitors in painful diabetic neuropathy
Kamei, J., Mizoguchi, H., Narita, M., & Tseng, L. F. (2001) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.10.9.1653 · Cited by 42
“Ischaemia is considered to be one of the major factors contributing to the development of diabetic neuropathy [53,54].”
Background
Prevention and partial reversal of diabetes-induced changes in enteric nerves of the rat ileum by combined treatment with α-lipoic acid and evening primrose oil
Shotton, H. R., Broadbent, S. D., & Lincoln, J. (2004) · Autonomic Neuroscience · doi:10.1016/j.autneu.2004.02.004 · Cited by 42
Transforming growth factor-β induces cellular injury in experimental diabetic neuropathy
Anjaneyulu, M., Berent‐Spillson, A., Inoue, T., Choi, J., Cherian, K., & Russell, J. W. (2008) · Experimental Neurology · doi:10.1016/j.expneurol.2008.02.011 · Cited by 41
Haemodynamics in microvascular complications in type 1 diabetes
Candido, R., & Allen, T. J. (2002) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.313 · Cited by 42
“In addition, impaired omega-6 essential fatty acid and carnitine metabolism may be involved in the pathogenesis of diabetic neuropathy [20].”
Background
Cutaneous Manifestations of Diabetes Mellitus and Prediabetes
Sanches, M. M., Roda, Â., Pimenta, R., et al. (2019) · Acta Médica Portuguesa · doi:10.20344/amp.10738 · Cited by 40
The Function of Endogenous Protective Systems in Patients with Insulin-Dependent Diabetes Mellitus and Polyneuropathy: Effect of Antioxidant Therapy
Strokov, I. A., Manukhina, E. B., Bakhtina, L. Y., et al. (2000) · Bulletin of Experimental Biology and Medicine · doi:10.1023/a:1002874125993 · Cited by 39
Naringin Attenuates the Diabetic Neuropathy in STZ-Induced Type 2 Diabetic Wistar Rats
Ahmad, M. F., Naseem, N., Rahman, I., Imam, N., Younus, H., Pandey, S. K., & Siddiqui, W. A. (2022) · Life · doi:10.3390/life12122111 · Cited by 46
“Diabetic neuropathy may be prevented and/or treated using the regulatory functions of cytokines in nerve regeneration and degeneration [51].”
Background
A Current Update on the Use of Alpha Lipoic Acid in the Management of Type 2 Diabetes Mellitus
Poh, Z., & Goh, K. (2009) · Endocrine Metabolic & Immune Disorders - Drug Targets · doi:10.2174/187153009789839147 · Cited by 38
Nerve Growth Factor Blocks the Glucose-induced Down-regulation of Caveolin-1 Expression in Schwann Cells via p75 Neurotrophin Receptor Signaling
Tan, W., Rouen, S., Barkus, K., Dremina, Y. S., Hui, D., Christianson, J. A., Wright, D. E., Yoon, S. O., & Dobrowsky, R. T. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m212986200 · Cited by 38
Diabetic Foot Ulcer: A Review
Zubair, M. (2015) · American Journal of Internal Medicine · doi:10.11648/j.ajim.20150302.11 · Cited by 37
“The pathogenesis of diabetic neuropathy includes various factors, like hyperglycemia [1, 69, 70], pre-diabetes neuropathy [71, 72], Vaso Nervorum [73], Protein Kinase C pathway activation [74, 75], abnormal fatty acid metabolism [76], Polyol pathway [77], Myo-inositol [78], advanced glycated end product [79], antibody…”
Background
Enriching the diet with menhaden oil improves peripheral neuropathy in streptozotocin-induced type 1 diabetic rats
Coppey, L. J., Davidson, E. P., Obrosov, A. A., & Yorek, M. A. (2014) · Journal of Neurophysiology · doi:10.1152/jn.00718.2014 · Cited by 38
Altered theta rhythm and hippocampal-cortical interactions underlie working memory deficits in a hyperglycemia risk factor model of Alzheimer’s disease
Wirt, R. A., Crew, L. A., Ortiz, A. A., McNeela, A. M., Flores, E., Kinney, J. W., & Hyman, J. M. (2021) · Communications Biology · doi:10.1038/s42003-021-02558-4 · Cited by 41
“The modi ﬁ ed protocol of staggered STZ injections on days 1, 2, 3, 14, and 15, followed by supplemental injections of STZ on days 35 and 36, achieved the criteria for sustained hyperglycemia consistent with Murtishaw et al. 10 .”
Continuous Inhibition of Excessive Polyol Pathway Flux in Peripheral Nerves by Aldose Reductase Inhibitor Fidarestat Leads to Improvement of Diabetic Neuropathy
Mizuno, K., Kato, N., Makino, M., et al. (1999) · Journal of Diabetes and its Complications · doi:10.1016/s1056-8727(99)00038-0 · Cited by 36
Diabetic Neuropathy: Pathogenesis and Treatment
Siemionow, M., Külahçı, Y., & Agaoglu, G. (2007) · Elsevier eBooks · doi:10.1016/b978-044452809-4/50165-4 · Cited by 37
Chinese herbal medicine in treatment of diabetic peripheral neuropathy: A systematic review and meta-analysis
Xu, H., Jiang, R.-H., Chen, X., et al. (2012) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2012.07.034 · Cited by 35
Longitudinal assessment of the development of diabetic polyneuropathy and associated risk factors
van de Poll-Franse, L. V., Valk, G. D., Renders, C. M., et al. (2002) · Diabetic Medicine · doi:10.1046/j.1464-5491.2002.00778.x · Cited by 35
Cardiac autonomic function in children with type 1 diabetes
Metwalley, K. A., Hamed, S. A., & Farghaly, H. S. (2018) · European Journal of Pediatrics · doi:10.1007/s00431-018-3122-1 · Cited by 33
“The suggested mechanisms or pathogenesis of DAN including CAN are similar to those for diabetic peripheral neuropathy which include metabolic insult to nerves, increased formation of advanced glycation end products (AGE), oxidative stress, vitamin deficiencies, neurovascular insufficiency, immune-mediated, hormonal an…”
Background
Cardiorespiratory Fitness and Cardiac Autonomic Function in Diabetes
Röhling, M., Strom, A., Bönhof, G. J., Roden, M., & Ziegler, D. (2017) · Current Diabetes Reports · doi:10.1007/s11892-017-0959-z · Cited by 34
Functional and structural abnormalities in the nerves of Type I diabetic baboons: aminoguanidine treatment does not improve nerve function
Birrell, A., Heffernan, S. J., Ansselin, A. D., et al. (2000) · Diabetologia · doi:10.1007/s001250050014 · Cited by 34
Induction of vascular endothelial growth factor release by transcutaneous frequency modulated neural stimulation in diabetic polyneuropathy
Bevilacqua, M. T., Dominguez, L. J., Barrella, M., & Barbagallo, M. (2007) · Journal of Endocrinological Investigation · doi:10.1007/bf03349242 · Cited by 33
Minocycline with aspirin: a therapeutic approach in the treatment of diabetic neuropathy
Bhatt, L. K., & Veeranjaneyulu, A. (2010) · Neurological Sciences · doi:10.1007/s10072-010-0243-3 · Cited by 33
“These results are in accordance with the other reports, wherein similar reduction of motor nerve conduction velocity in streptozotocin-induced diabetic rats was reported [31, 32].”
Result
Determination of membrane lipid differences in insulin resistant diabetes mellitus type 2 in whites and blacks
Allen, H. G., Allen, J. C., Boyd, L. C., Alston‐Mills, B., & Fenner, G. P. (2006) · Nutrition · doi:10.1016/j.nut.2006.07.007 · Cited by 33
The Effectiveness of Treatments of Diabetic Autonomic Neuropathy Is Not the Same in Autonomic Nerves Supplying Different Organs
Shotton, H. R., Clarke, S., & Lincoln, J. (2003) · Diabetes · doi:10.2337/diabetes.52.1.157 · Cited by 33
“Oxidative stress occurs in diabetes by a variety of mechanisms including auto-oxidation of glucose, production of advanced glycation end products, and reductions in anti oxidant defense mechanisms caused by activation of the polyol pathway (9,10).”
Background
New method for evaluation of cutaneous sensibility in diabetic feet: preliminary report
Ferreira, M. C., Rodrigues, L., & Fels, K. W. (2004) · Revista do Hospital das Clínicas · doi:10.1590/s0041-87812004000500011 · Cited by 32
Cutaneous Blood Flow in Type 2 Diabetic Individuals After an Acute Bout of Maximal Exercise
Colberg, S. R., Parson, H. K., Holton, D. R., Nunnold, T., & Vinik, A. I. (2003) · Diabetes Care · doi:10.2337/diacare.26.6.1883 · Cited by 32
Vascular Impairment of Epineurial Arterioles of the Sciatic Nerve: Implications for Diabetic Peripheral Neuropathy
Yorek, M. A. (2015) · The Review of Diabetic Studies · doi:10.1900/rds.2015.12.13 · Cited by 31
“Inhibition of these radicals by angiotensin-converting enzyme (ACE) inhibitors/angiotensin receptor blockers, aminoguanidine, transition metal chelators, antioxidants, or free radical scavengers have been shown to improve the diabetes-induced decrease in vascular function of epineurial arterioles, endoneurial blood fl…”
Background
Effect of evening primrose oil supplementation on lipid profile: A systematic review and meta‐analysis of randomized clinical trials
Khorshidi, M., Zarezadeh, M., Moghaddam, O. M., Emami, M. R., Kord‐Varkaneh, H., Mousavi, S. M., Alizadeh, S., Heshmati, J., Olang, B., & Aryaeian, N. (2020) · Phytotherapy Research · doi:10.1002/ptr.6716 · Cited by 31
“Therefore, EPO is known as a rich source of GLA which has a beneficial effect on diseases like systemic sclerosis (Senapati, Banerjee, & Gangopadhyay, 2008), rheumatoid arthritis (Jäntti, Seppälä, Vapaatalo, & Isomäki, 1989), and diabetes (Cameron & Cotter, 1997).”
Background
Effects of adenosine and adenosine A2Areceptor agonist on motor nerve conduction velocity and nerve blood flow in experimental diabetic neuropathy
Kumar, S., Arun, K., Kaul, C. L., et al. (2005) · Neurological Research · doi:10.1179/016164105x18278 · Cited by 31
Diabetic neuropathy and heart failure: role of neuropeptides
Ejaz, A., LoGerfo, F. W., & Pradhan, L. (2011) · Expert Reviews in Molecular Medicine · doi:10.1017/s1462399411001979 · Cited by 31
Oxidative stress in the latissimus dorsi muscle of diabetic rats
Angelis, K. D., Cestari, I. A., Barp, J., Lago, P. D., Fernandes, T. R. G., de Bittencourt, P. I. H., Belló‐Klein, A., Belló, A. A., Llesuy, S., & Irigoyen, M. C. (2000) · Brazilian Journal of Medical and Biological Research · doi:10.1590/s0100-879x2000001100016 · Cited by 31
Relationship Between Electroneurographic Changes and Serum Ubiquitin Levels in Patients With Type 2 Diabetes
Akarsu, E., Pirim, İ., Çapoğlu, İ., et al. (2001) · Diabetes Care · doi:10.2337/diacare.24.1.100 · Cited by 31
Centella asiatica triterpenes for diabetic neuropathy: a randomized, double-blind, placebo-controlled, pilot clinical study
Lou, J., Dimitrova, D. M., Murchison, C., Arnold, G. C., Belding, H., Seifer, N., Le, N., Andrea, S. B., Gray, N. E., Wright, K. M., et al. (2018) · Esperienze Dermatologiche · doi:10.23736/s1128-9155.18.00455-7 · Cited by 31
Ghrelin reverses experimental diabetic neuropathy in mice.
Kyoraku, I., Shiomi, K., Kangawa, K., & Nakazato, M. (2009) · Biochemical and Biophysical Research Communications - BBRC · doi:10.1016/j.bbrc.2009.08.171 · Cited by 28
Effects of aminoguanidine and desferrioxamine on some vascular and biochemical changes associated with streptozotocin-induced hyperglycaemia in rats
El-Khatib, A. S., Moustafa, A. M., Abdel‐Aziz, A. H., Al‐Shabanah, O. A., & El‐Kashef, H. A. (2001) · Pharmacological Research · doi:10.1006/phrs.2000.0772 · Cited by 29
Combined Therapy of Diabetic Peripheral Neuropathy with Breviscapine and Mecobalamin: A Systematic Review and a Meta-Analysis of Chinese Studies
Zheng, C., Ou, W., Shen, H., Zhou, Z., & Wang, J. (2015) · BioMed Research International · doi:10.1155/2015/680756 · Cited by 28
“The pathogenesis of DPN is very complicated and is currently regarded as a result of interaction among multiple factors under a hyperglycemic state including suppressions of glycation end products generation, changes in protein kinase C signaling pathway [45], activation of polyol pathway [46], and increases in cytoki…”
Background
Gosha‐jinki‐gan (a Herbal Complex) Corrects Abnormal Insulin Signaling
Qin, B., Nagasaki, M., Ren, M., Bajotto, G., Oshida, Y., & Sato, Y. (2004) · Evidence-based Complementary and Alternative Medicine · doi:10.1093/ecam/neh028 · Cited by 28
Effect of an 8-week resistance training program on cutaneous perfusion in type 2 diabetes
Colberg, S. R., Parson, H. K., Nunnold, T., Herriott, M. T., & Vinik, A. I. (2006) · Microvascular Research · doi:10.1016/j.mvr.2005.11.005 · Cited by 28
The Effect of an Aerobic Exercise Training Program on Quality of Life in Type 2 Diabetes
Holton, D. R., Colberg, S. R., Nunnold, T., Parson, H. K., & Vinik, A. I. (2003) · The Science of Diabetes Self-Management and Care · doi:10.1177/014572170302900513 · Cited by 27
Clinical trials for drugs against diabetic neuropathy: Can we combine scientific needs with clinical practicalities?
Ziegler, D., & Luff, D. (2002) · International review of neurobiology · doi:10.1016/s0074-7742(02)50085-4 · Cited by 26
Fluid shear stress as a regulator of gene expression in vascular cells: possible correlations with diabetic abnormalities
Papadaki, M., Eskin, S. G., Ruef, J., et al. (1999) · Diabetes Research and Clinical Practice · doi:10.1016/s0168-8227(99)00036-4 · Cited by 26
The effect of α‐lipoic acid on symptoms and skin blood flow in diabetic neuropathy
Jin, H. Y., Joung, S. J., Park, J. H., Baek, H. S., & Park, T. S. (2007) · Diabetic Medicine · doi:10.1111/j.1464-5491.2007.02179.x · Cited by 26
Assessment of erectile dysfunction in diabetic patients
Hamdan, F. B., & Al‐Matubsi, H. Y. (2008) · International Journal of Andrology · doi:10.1111/j.1365-2605.2008.00873.x · Cited by 25
“…(Cameron & Cotter, 1997; Low et al., 1997) and formation of advanced glycosylation end products (localized in endoneurial blood vessels) (Brownlee, 1992) also result in reduced endoneurial blood flow and nerve hypoxia with altered nerve function (Cameron & Cotter, 1997; Vinik, 1999).”
Blockade of sigma 1 receptors alleviates sensory signs of diabetic neuropathy in rats
Paniagua, N., Girón, R., Goicoechea, C., López‐Miranda, V., Vela, J. M., Merlos, M., & Fontelles, M. I. M. (2016) · European Journal of Pain · doi:10.1002/ejp.897 · Cited by 25
“Finally, as reduced nerve perfusion is an important factor in the aetiology of diabetic neuropathy (Cameron and Cotter, 1997) and decreased nerve blood flow and hypoxia in neuropathic diabetes patients have been related to the neurovascular dysfunction (Cameron and Cotter, 1992, 1994), the vascular…”
BackgroundInfluential
Transition metals and polyol pathway in the development of diabetic neuropathy in rats
Nakamura, J., Hamada, Y., Chaya, S., Nakashima, E., Naruse, K., Kato, K., Yasuda, Y., Kamiya, H., Sakakibara, F., Koh, N., et al. (2002) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.319 · Cited by 24
“hyperglycemia-induced metabolic changes [4,5].”
Effects of zinc deficiency on immune functions
Prasad, A. S. (2000) · The Journal of Trace Elements in Experimental Medicine · doi:10.1002/(sici)1520-670x(2000)13:1 · Cited by 87
NEUROPATHIC PROBLEMS OF THE LOWER LIMBS IN DIABETIC PATIENTS
Tanenberg, R. J., & Donofrio, P. D. (2008) · Elsevier eBooks · doi:10.1016/b978-0-323-04145-4.50010-7 · Cited by 27
Treatment for Diabetic Peripheral Neuropathy: What have we Learned from Animal Models?
Yorek, M. A. (2021) · Current Diabetes Reviews · doi:10.2174/1573399817666210504101609 · Cited by 26
Elevated coronary endothelin-1 but not Nitric Oxide in diabetics during CABG
Sharma, A. C., Fogelson, B. G., Nawas, S. I., et al. (1999) · The Annals of Thoracic Surgery · doi:10.1016/s0003-4975(99)00287-8 · Cited by 23
“Nitric oxide has been widely accepted as one of the potent vasoactive mediators implicated in cardiovascular and diabetic pathophysiology [1, 20, 25].”
Background
The effect of insulin and sulodexide (Vessel Due F) on diabetic foot syndrome
Koblik, T., Sieradzki, J., Sendur, R., Biernat, J., Czarnobilski, K., Gryz, E. A., Ww, P., Szczudlik, A., & Gaddi, A. V. (2001) · Journal of Diabetes and its Complications · doi:10.1016/s1056-8727(00)00134-3 · Cited by 23
Cardio-Ankle Vascular Index and Indices of Diabetic Polyneuropathy in Patients with Type 2 Diabetes
Ando, A., Miyamoto, M., Kotani, K., Okada, K., Nagasaka, S., & Ishibashi, S. (2017) · Journal of Diabetes Research · doi:10.1155/2017/2810914 · Cited by 22
Association of the SOD2 Ala(–9)Val and SOD3 Arg213Gly Polymorphisms with Diabetic Polyneuropathy in Diabetes Mellitus Type 1
Zotova, E., Chistyakov, D. A., Savost'yanov, E. V., et al. (2003) · Molecular Biology · doi:10.1023/a:1024222907542 · Cited by 22
“At high concentrations, free radicals and peroxides directly damage neurons and affect the endothelium of nerve-supplying blood vessels, as demonstrated with experimental DM in rat [3, 4].”
Ca2+-Mg2+-ATPase activity and ionized calcium in Type 2 diabetic patients with neuropathy
Migdalis, I. N., Xenos, K., Chairopoulos, K., et al. (2000) · Diabetes Research and Clinical Practice · doi:10.1016/s0168-8227(00)00150-9 · Cited by 22
“Vascular as well as metabolic factors have been invoked to explain the structural lesions of human diabetic neuropathy [3,5,6].”
Background
The function of endogenous protective systems in patients with insulin-dependent diabetes mellitus and polyneuropathy: Effect of antioxidant therapy
Strokov, I. A., Manukhina, E. B., Bakhtina, L. Y., et al. (2000) · Bulletin of Experimental Biology and Medicine · doi:10.1007/bf02682046 · Cited by 22
EFFECT OF MUSTARD (BRASSICA JUNCEA) LEAF EXTRACT ON STREPTOZOTOCIN-INDUCED DIABETIC CATARACT IN WISTAR RATS
Kumar, V. V., Vangipurapu, R., BANAM, V. R., PULUKURTHI, U. M. R., & Turlapati, N. R. (2010) · Journal of Food Biochemistry · doi:10.1111/j.1745-4514.2010.00369.x · Cited by 20
Vascular Complications in Diabetes
Rosen, P., Tritschler, H., & Packer, L. (2001) · CRC Press eBooks · doi:10.1201/9780203904046.ch25 · Cited by 21
Traumatic brain injury, diabetic neuropathy and altered-psychiatric health: The fateful triangle
Abou‐El‐Hassan, H., Dia, B., Choucair, K., Eid, S., Najdi, F., Baki, L., Talih, F. R., Eid, A. A., & Kobeissy, F. H. (2017) · Medical Hypotheses · doi:10.1016/j.mehy.2017.08.008 · Cited by 20
Research progress on 2,4-thiazolidinedione and 2-thioxo-4-thiazolidinone analogues as aldose reductase inhibitors
Kharyal, A., Ranjan, S. K., Jaswal, S., Parveen, D., Gupta, G. D., Thareja, S., & Verma, S. K. (2022) · Journal of Molecular Structure · doi:10.1016/j.molstruc.2022.133742 · Cited by 19
Histopathological Study of Evening Primrose Oil Effects on Experimental Diabetic Neuropathy
Omran, O. M. (2012) · Ultrastructural Pathology · doi:10.3109/01913123.2012.662268 · Cited by 19
“The first step in the conversion of the essential fatty acid linoleic acid to gamma linolenic acid (GLA) is broken in diabetics, leading to shortage of GLA and its metabolites; prostaglandins (PGs), especially prostacyclin [3].”
Background
Pharmacologic Targets and Peritoneal Membrane Remodeling
Farhat, K., Stavenuiter, A. W. D., Beelen, R. H. J., & ter Wee, P. M. (2014) · Peritoneal Dialysis International · doi:10.3747/pdi.2011.00332 · Cited by 19
“In the polyol pathway (important for intracellular glucose metabolism), glucose is reduced to sorbitol by aldose reductase, with the eventual formation of AGEs (45).”
Background
Neuropatía diabética periférica
Gadea, N. H. (2000) · Medicine - Programa de Formación Médica Continuada Acreditado · doi:10.1016/s0304-5412(00)70189-2 · Cited by 19
High Glucose Restraint of Acetylcholine-Induced Keratinocyte Epithelial-Mesenchymal Transition Is Mitigated by p38 Inhibition
Tan, M. W. Y., Tan, W., Kong, Z. Q., Toh, J. H., Wee, J. W. K., Teo, E. M. L., Cheng, H. S., Wang, X., & Tan, N. S. (2020) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2020.10.026 · Cited by 18
Is there a role for endothelin antagonists in diabetic renal disease?
Jandeleit-Dahm, K. A. M., Allen, T. J., Youssef, S., et al. (2000) · Diabetes Obesity and Metabolism · doi:10.1046/j.1463-1326.2000.00045.x · Cited by 18
Review: Autonomic neuropathy: a marker of cardiovascular risk
Kempler, P. (2003) · The British Journal of Diabetes · doi:10.1177/14746514030030020201 · Cited by 18
Diabetic Autonomic Neuropathy: Pathogenesis to Pharmacological Management
Kaur, N. (2014) · Journal of Diabetes & Metabolism · doi:10.4172/2155-6156.1000402 · Cited by 17
“The metabolic hypotheses for diabetic complications include polyol pathway hyperactivity and its related myo-inositol deletion, increased diacylglycerol-protein kinase C cascade, oxidative stress, and nonenzymatic glycation [4].”
Background
Exploring the interactional details between aldose reductase (AKR1B1) and 3-Mercapto-5H-1,2,4-triazino[5,6-b]indole-5-acetic acid through molecular dynamics simulations
Zhan, J., Ma, K., Zheng, Q., et al. (2018) · Journal of Biomolecular Structure and Dynamics · doi:10.1080/07391102.2018.1465851 · Cited by 17
“…et al., 2015), diabetic retinopathy(Azab, Abdel-Aziz, Ahmed, & El-deen, 2016; G Obrosova & F Kador, 2011), cardiac contractile dysfunction(Tang et al., 2010), and diabetic neuropathy (Cameron & Cotter, 1997), are attributed to the glucose entering into the polyol pathway in a high glucose level.”
Background
A cardiac risk score based on sudomotor function to evaluate cardiovascular autonomic neuropathy in asymptomatic Chinese patients with diabetes mellitus
Yuan, T., Li, J., Fu, Y., Xu, T., Li, J., Wang, X., Zhou, Y., Dong, Y., & Zhao, W. (2018) · PLoS ONE · doi:10.1371/journal.pone.0204804 · Cited by 18
Ocular surface changes in mice with streptozotocin-induced diabetes and diabetic polyneuropathy
Schicht, M., Farger, J., Wedel, S., Sisignano, M., Scholich, K., Geißlinger, G., Perumal, N., Grus, F. H., Singh, S., Şahin, A., et al. (2023) · The Ocular Surface · doi:10.1016/j.jtos.2023.12.006 · Cited by 17
Mechanical stimulation enhances endothelin-1 hyperalgesia
Joseph, E. K., Gear, R. W., & Levine, J. D. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.01.043 · Cited by 16
“To further elucidate the sensitization induced by ET-1, we studied ET-1-induced mechanical hyperalgesia in the skin, a tissue in which neurovascular interactions are known to be important (Cameron and Cotter, 1996, 1997).”
Background
Structural Remodeling in the Limb Circulation: Impact of Obesity and Diabetes
Stepp, D. W., & de Chantemèle, E. J. B. (2007) · Microcirculation · doi:10.1080/10739680701285609 · Cited by 16
The potential of esculin in ameliorating Type-2 diabetes mellitus induced neuropathy in Wistar rats and probing its inhibitory mechanism of insulin aggregation
Naseem, N., Ahmad, M. F., Malik, S., et al. (2023) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2023.124760 · Cited by 15
Azithromycin in an Older Woman With Diabetic Gastroparesis
Sutera, L., Dominguez, L. J., Belvedere, M., Putignano, E., Vernuccio, L., Ferlisi, A., Fazio, G., Costanza, G., & Barbagallo, M. (2008) · American Journal of Therapeutics · doi:10.1097/mjt.0b013e31814daff6 · Cited by 15
Glycation and Glycoxidation in Diabetic Vascular Disease
Thorpe, S. R., Lyons, T. J., & Baynes, J. (2000) · Developments in cardiovascular medicine · doi:10.1007/978-1-4615-4649-8_14 · Cited by 15
Impact of visceral obesity on cardiac parasympathetic activity in type 2 diabetics after coronary artery bypass graft surgery
Salamin, G., Pelletier, C., Poirier, P., Després, J., Bertrand, O. F., Alméras, N., Costerousse, O., & Brassard, P. (2013) · Obesity · doi:10.1002/oby.20089 · Cited by 15
Diabetic Peripheral and Autonomic Neuropathy
Feldman, E. L., Stevens, M. J., & Russell, J. W. (2003) · Humana Press eBooks · doi:10.1007/978-1-59259-310-1_24 · Cited by 16
Pathogenesis and management of diabetic gastroparesis: An updated clinically oriented review
Uppaluri, S., Jain, M. A., Ali, H., Shingala, J., Amin, D., Ajwani, T., Fatima, I., Patel, N., Kaka, N., Sethi, Y., et al. (2024) · Diabetes & Metabolic Syndrome: Clinical Research & Reviews · doi:10.1016/j.dsx.2024.102994 · Cited by 14
Interactions between cannabinoid and opioid receptors in a mouse model of diabetic neuropathy
Toniolo, E. F., Gupta, A., Franciosi, A. C., Gomes, I., Devi, L. A., & Dale, C. S. (2021) · Pain · doi:10.1097/j.pain.0000000000002527 · Cited by 15
Exercise status affects skin perfusion via prostaglandin, nitric oxide, and EDHF pathways in diabetes
Colberg, S. R., Azoury, K. R., Parson, H. K., & Vinik, A. I. (2008) · Microvascular Research · doi:10.1016/j.mvr.2008.11.004 · Cited by 14
A Randomized, Double-Blind Study of the Effects of a Sustained Release Formulation of Sodium Nitrite (SR-nitrite) on Patients with Diabetic Neuropathy
Soin, A. (2018) · Pain Physician · doi:10.36076/ppj.2018.2.179 · Cited by 14
Effects of the 5-HT2A Receptor Antagonist Sarpogrelate in Diabetic Patients with Complications
Hotta, N., Nakamura, J., Sumita, Y., Yasuda, K., Ito, M., Takeuchi, T., Hara, T., & Sakamoto, N. (1999) · Clinical Drug Investigation · doi:10.2165/00044011-199918030-00004 · Cited by 14
Navigating Preclinical Models and Medications for Peripheral Neuropathy: A Review
Jali, A. M., Banji, D., Banji, O. J. F., Hurubi, K. Y., Tawhari, F. Y., Alameer, A. A., Dohal, A. S., & Zanqoti, R. A. (2024) · Pharmaceuticals · doi:10.3390/ph17081010 · Cited by 13
“The STZ-induced diabetic rat model is a valuable instrument for investigating diabetic neuropathy, as it reproduces crucial functional and biochemical irregularities observed in humans [17,18].”
Background
Hyperbaric oxygen therapy and promoting neurological recovery following nerve trauma.
Nazario, J., & Kuffler, D. P. (2011) · PubMed · Cited by 13
Structural and Chemical Organization of the Autonomic Neuroeffector System
Burnstock, G. (2002) · CRC Press eBooks · doi:10.1201/9780203908891.ch1 · Cited by 12
A smartphone-based tool for screening diabetic neuropathies: A mHealth and 3D printing approach
Piaggio, D., Castaldo, R., Garibizzo, G., Iadanza, E., & Pecchia, L. (2023) · Biomedical Signal Processing and Control · doi:10.1016/j.bspc.2023.105807 · Cited by 12
Impaired regulation function in cardiovascular neurons of nucleus tractus solitarii in streptozotocin-induced diabetic rats
Chen, H., Wu, J., Chen, J. J., & Cheng, J. (2007) · Neuroscience Letters · doi:10.1016/j.neulet.2007.11.035 · Cited by 12
Which is responsible for cardiac autonomic dysfunction in non-diabetic patients with metabolic syndrome: Prediabetes or the syndrome itself?
Balcıoğlu, A. S., Akıncı, S., Çiçek, D., Eldem, H. O., Çoner, A., Bal, U. A., & Müderrisoğlu, H. (2015) · Diabetes & Metabolic Syndrome Clinical Research & Reviews · doi:10.1016/j.dsx.2015.09.001 · Cited by 12
Treatment of diabetic neuropathy with baicalein: Intervention at multiple sites
Yorek, M. A. (2011) · Experimental Neurology · doi:10.1016/j.expneurol.2011.08.017 · Cited by 12
“…aminoguanidine and transition metal chelators, or antioxidants and free radical scavengers improves endoneurial blood flow and neural dysfunction (Cameron et al., 1993; Cameron and Cotter, 1995; 1997; 1999; Coppey et al., 2001a,b, 2002; Karasu et al., 1995; Keegan et al., 1999; Yorek et al., 2002).”
Background
Effects of Inhibition of the Polyol Pathway during Chronic Peritoneal Exposure to a Dialysis Solution
van Westrhenen, R., Aten, J., Aberra, M., et al. (2005) · Peritoneal Dialysis International · doi:10.1177/089686080502503s05 · Cited by 12
The Effect of Omega-3 Fatty Acids on Nerve Conduction Velocity (NCV) and F-wave Latency in Patients with Diabetic polyneuropathy
Zangiabadi, N., Ahrari, M. N., & Nakhaee, N. (2007) · American Journal of Pharmacology and Toxicology · doi:10.3844/ajptsp.2007.1.3 · Cited by 11
Exercise as Treatment for Neuropathy in the Setting of Diabetes and Prediabetic Metabolic Syndrome: A Review of Animal Models and Human Trials
Singleton, J. R., Foster-Palmer, S. C., & Marcus, R. L. (2021) · Current Diabetes Reviews · doi:10.2174/1573399817666210923125832 · Cited by 14
Changes in the Basal Membrane of Dorsal Root Ganglia Schwann Cells Explain the Biphasic Pattern of the Peripheral Neuropathy in Streptozotocin-Induced Diabetic Rats
Becker, M., Benromano, T., Shahar, A., Nevo, Z., & Pick, C. G. (2014) · Journal of Molecular Neuroscience · doi:10.1007/s12031-014-0424-2 · Cited by 11
“In addition, hyperglycemia causes oxidative stress (Cameron and Cotter, 1997), non-enzymatic glycation (Ryle et al., 1997; Cameron and Cotter, 1999), and abnormal neurotropism (Tomlinson and Fernyhough, 1999), which lead to nerve damage.”
Activation of IL‐1 Signaling Pathway in Schwann Cells during Diabetic Neuropathy
Skundric, D. S., Dai, R., JAMES, J., & Lisak, R. P. (2002) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2002.tb03011.x · Cited by 11
Acute effects of adrenergic-mediated ischemia on nerve conduction in subjects with type 2 diabetes
Hogikyan, R. V., Wald, J. J., Feldman, E. L., Greene, D. A., Halter, J. B., & Supiano, M. A. (1999) · Metabolism · doi:10.1016/s0026-0495(99)90110-5 · Cited by 11
Diabetic Hyperglycemia: A Facilitating Factor in Systemic Capillary Leak
Lawson, S., Ward, D. T., Conner, C., et al. (2002) · Journal of Surgical Research · doi:10.1006/jsre.2002.6370 · Cited by 11
“The deficiency in nitric oxide reflects the competition for NADPH, a cofactor used by both NOS and aldose reductase [18].”
Background
Clinical application of C18 and C20 chain length polyunsaturated fatty acids and their biotechnological production in plants
Griffiths, G., & Morse, N. (2006) · Journal of the American Oil Chemists Society · doi:10.1007/s11746-006-1191-1 · Cited by 10
β2-adrenoceptor agonists as potential therapeutic drugs in diabetic peripheral neuropathy
Baraka, A., Darwish, I. E., Ghoneim, M. T., & Korayem, H. K. (2014) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2014.11.004 · Cited by 10
Effect of Twelve Weeks Supervised Aerobic Exercise on Ulcer Healing and Changes in Selected Biochemical Profiles of Diabetic Foot Ulcer Subjects
Nwankwo, M. J., Okoye, C. G., Victor, E. A., & Ezeukwu, A. O. (2014) · Cited by 10
Role of protein kinase C in diabetic complications
King, G. L., & Daş-Evcimen, N. (2010) · Expert Review of Endocrinology & Metabolism · doi:10.1586/eem.09.74 · Cited by 9

Authors: Cameron, N. E., & Cotter, M. A.
Affiliations: University of Aberdeen (GB)
ORCID: Cameron, Norman E
Cotter, Mary A
Venue: Diabetes
Publisher: American Diabetes Association
Published: 1997-09-01
Volume: 46
Issue: Supplement_2
Pages: S31-S37
ISSN: 0012-1797 (ISSN-L)
1939-327X
DOI: 10.2337/diab.46.2.s31
OpenAlex: W2151689386
Cited by: 312
References: 0
Citations by year: 2026: 1 · 2025: 4 · 2024: 5 · 2023: 7 · 2022: 5 · 2021: 7 · 2020: 11 · 2019: 9 · 2018: 7 · 2017: 9 · 2016: 7 · 2015: 12 · 2014: 12 · 2013: 10 · 2012: 8
FWCI: 4.82
Type: journal article
Language: en
Open access: closed
Locations: Diabetes (publishedVersion)
PubMed (publishedVersion)
Funders: Wellcome Trust
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Aldose Reductase and Taurine
Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
Health Sciences › Medicine › Clinical Neurology › Peripheral Neuropathies and Disorders
Keywords: diabetic neuropathy, nerve blood flow, nerve conduction velocity, polyol pathway, advanced glycation end products, oxidative stress, aldose reductase inhibitors, sorbitol, glutathione, vasa nervorum, angiotensin receptor blockers, nerve regeneration, aminoguanidine, evening primrose oil, gamma-linolenic acid, nitric oxide, vasodilation, free radicals, endothelial injury
MeSH terms: Animals, Carnitine, Diabetes Mellitus, Experimental, Diabetic Neuropathies, Endothelium, Vascular, Fatty Acids, Essential, Glycosylation, Humans, Nerve Tissue, Oxidation-Reduction, Regional Blood Flow, Sugar Alcohols, Vasodilator Agents, Reactive Oxygen Species, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Metabolic and Vascular Factors in the Pathogenesis of Diabetic Neuropathy

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cited by

Related

Metadata

Record

About these checks