Clinical application of C18 and C20 chain length polyunsaturated fatty acids and their biotechnological production in plants

Consumption of Fish and n-3 Fatty Acids and Risk of Incident Alzheimer Disease

Morris, M. C., Evans, D. A., Bienias, J. L., Tangney, C. C., Bennett, D. A., Wilson, R. S., Aggarwal, N., & Schneider, J. (2003) · Archives of Neurology · doi:10.1001/archneur.60.7.940 · Cited by 1,135 · see citing works

STRUCTURE, FUNCTION, AND DIETARY REGULATION OF Δ6, Δ5, AND Δ9 DESATURASES

Nakamura, M., & Nara, T. (2004) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.24.121803.063211 · Cited by 1,074 · see citing works

HEALTH BENEFITS OF DOCOSAHEXAENOIC ACID (DHA)

Horrocks, L. A., & Yeo, Y. K. (1999) · Pharmacological Research · doi:10.1006/phrs.1999.0495 · Cited by 1,032 · see citing works

Maternal Supplementation With Very-Long-Chain n-3 Fatty Acids During Pregnancy and Lactation Augments Children’s IQ at 4 Years of Age

Helland, I. B., Smith, L., Saarem, K., Saugstad, O. D., & Drevon, C. A. (2003) · PEDIATRICS · doi:10.1542/peds.111.1.e39 · Cited by 928 · see citing works

Phospholipid:diacylglycerol acyltransferase: An enzyme that catalyzes the acyl-CoA-independent formation of triacylglycerol in yeast and plants

Dahlqvist, A., Ståhl, U., Lenman, M., Banaś, A., Lee, M. A., Sandager, L., Ronne, H., & Stymne, S. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.120067297 · Cited by 883 · see citing works

N-3 polyunsaturated fatty acids in coronary heart disease: a meta-analysis of randomized controlled trials.

Bucher, H. C., Hengstler, P., Schindler, C., & Meier, G. (2002) · The American Journal of Medicine · doi:10.1016/s0002-9343(01)01114-7 · Cited by 823 · see citing works

P HYTOSTEROLS IN H UMAN N UTRITION

Ostlund, R. E. (2002) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.22.020702.075220 · Cited by 633 · see citing works

Polyunsaturated fatty acids (PUFA) and eicosanoids in human health and pathologies

Tapiero, H., Ba, G. N., Couvreur, P., & Tew, K. D. (2002) · Biomedicine & Pharmacotherapy · doi:10.1016/s0753-3322(02)00193-2 · Cited by 632 · see citing works

Cloning, Expression, and Nutritional Regulation of the Mammalian Δ-6 Desaturase

Cho, H. P., Nakamura, M., & Clarke, S. D. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.1.471 · Cited by 630 · see citing works

Omega-3 fatty acids as cancer chemopreventive agents

Rose, D. P. (1999) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(99)00026-1 · Cited by 625 · see citing works

Seed-Specific Over-Expression of an Arabidopsis cDNA Encoding a Diacylglycerol Acyltransferase Enhances Seed Oil Content and Seed Weight

Jako, C., Kumar, A., Wei, Y., Zou, J., Barton, D. L., Giblin, E. M., Covello, P. S., & Taylor, D. C. (2001) · PLANT PHYSIOLOGY · doi:10.1104/pp.126.2.861 · Cited by 539 · see citing works

Microalgal mass culture systems and methods: their limitation and potential

Lee, Y.-K. (2001) · Journal of Applied Phycology · doi:10.1023/a:1017560006941 · Cited by 528 · see citing works

Are long-chain polyunsaturated fatty acids essential nutrients in infancy?

Makrides, M., Neumann, M., Simmer, K. N., Gibson, R. A., & Pater, J. (1995) · The Lancet · doi:10.1016/s0140-6736(95)91035-2 · Cited by 511 · see citing works

Seafood consumption, the DHA content of mothers’ milk and prevalence rates of postpartum depression: a cross-national, ecological analysis

Hibbeln, J. R. (2002) · Journal of Affective Disorders · doi:10.1016/s0165-0327(01)00374-3 · Cited by 508 · see citing works

Cloning, Expression, and Fatty Acid Regulation of the Human Δ-5 Desaturase

Cho, H. P., Nakamura, M., & Clarke, S. D. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.52.37335 · Cited by 501 · see citing works

Polyunsaturated Fatty Acid Regulation of Gene Expression

Sessler, A. M., & Ntambi, J. M. (1998) · Journal of Nutrition · doi:10.1093/jn/128.6.923 · Cited by 426 · see citing works

Production of very long chain polyunsaturated omega-3 and omega-6 fatty acids in plants

Qi, B., Fraser, T., Mugford, S., Dobson, G., Sayanova, O., Butler, J., Napier, J. A., Stobart, A. K., & Lazarus, C. M. (2004) · Nature Biotechnology · doi:10.1038/nbt972 · Cited by 426 · see citing works

Handbook of Food Enzymology

Finardi Filho, F. (2002) · CRC Press eBooks · doi:10.1201/9780203910450 · Cited by 380 · see citing works

A randomized double-blind, placebo-controlled study of the effects of supplementation with highly unsaturated fatty acids on ADHD-related symptoms in children with specific learning difficulties

Richardson, A. J., & Puri, B. K. (2002) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/s0278-5846(01)00254-8 · Cited by 379 · see citing works

DGAT2 Is a New Diacylglycerol Acyltransferase Gene Family

Lardizabal, K. D., Mai, J. T., Wagner, N. W., Wyrick, A., Voelker, T., & Hawkins, D. J. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m106168200 · Cited by 371 · see citing works

Docosahexaenoic acid in the diet: its importance in maintenance and restoration of neural membrane function

Horrocks, L. A., & Farooqui, A. A. (2004) · Prostaglandins, Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2003.12.011 · Cited by 356 · see citing works

Metabolic and Vascular Factors in the Pathogenesis of Diabetic Neuropathy

Cameron, N. E., & Cotter, M. A. (1997) · Diabetes · doi:10.2337/diab.46.2.s31 · Cited by 312 · see citing works

Cloning and Functional Characterization of a Phospholipid:Diacylglycerol Acyltransferase from Arabidopsis

Ståhl, U., Carlsson, A. S., Lenman, M., Dahlqvist, A., Huang, B., Banaś, W., Banaś, A., & Stymne, S. (2004) · PLANT PHYSIOLOGY · doi:10.1104/pp.104.044354 · Cited by 306 · see citing works

Influence of Trans Fatty Acids on Health

Stender, S., & Dyerberg, J. (2003) · Annals of Nutrition and Metabolism · doi:10.1159/000075591 · Cited by 299 · see citing works

Identification and Characterization of a Sphingolipid Δ4-Desaturase Family

Ternes, P., Franke, S., Zähringer, U., Sperling, P., & Heinz, E. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m202947200 · Cited by 293 · see citing works

Essential fatty acids in mothers and their neonates

Hornstra, G. (2000) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/71.5.1262s · Cited by 283 · see citing works

Expression of a borage desaturase cDNA containing an N-terminal cytochrome b 5 domain results in the accumulation of high levels of Δ 6 -desaturated fatty acids in transgenic tobacco

Sayanova, O. V., Smith, M. A., Lapinskas, P., Stobart, A. K., Dobson, G., Christie, W. W., Shewry, P. R., & Napier, J. A. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.8.4211 · Cited by 276 · see citing works

Polyunsaturated Fatty Acid Regulation of Gene Expression

Sampath, H., & Ntambi, J. M. (2004) · Nutrition Reviews · doi:10.1111/j.1753-4887.2004.tb00058.x · Cited by 240 · see citing works

Identification of a Δ4 Fatty Acid Desaturase fromThraustochytrium sp. Involved in the Biosynthesis of Docosahexanoic Acid by Heterologous Expression inSaccharomyces cerevisiae and Brassica juncea

Qiu, X. K., Hong, H., & MacKenzie, S. L. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m102971200 · Cited by 238 · see citing works

Long chain polyunsaturated fatty acid supplementation in infant formula and blood pressure in later childhood: follow up of a randomised controlled trial

Forsyth, J. S., Willatts, P., Agostoni, C., Bissenden, J., Casaer, P., & Boehm, G. (2003) · BMJ · doi:10.1136/bmj.326.7396.953 · Cited by 232 · see citing works

Do fish oils prevent restenosis after coronary angioplasty?

Leaf, A., Jorgensen, M. B., Jacobs, A. K., Cote, G., Schoenfeld, D., Scheer, J. M., Weiner, B. H., Slack, J. D., Kellett, M. A., & Raizner, A. E. (1994) · Circulation · doi:10.1161/01.cir.90.5.2248 · Cited by 218 · see citing works

The Role of Dietary n–6 and n–3 Fatty Acids in the Developing Brain

Innis, S. M. (2000) · Developmental Neuroscience · doi:10.1159/000017478 · Cited by 217 · see citing works

Low level methylmercury exposure affects neuropsychological function in adults

Yokoo, E. M., Valente, J. G., Grattan, L. M., Schmidt, S. L., Platt, I., & Silbergeld, E. K. (2003) · Environmental Health · doi:10.1186/1476-069x-2-8 · Cited by 205 · see citing works

Crystallographic Identification and Functional Characterization of Phospholipids as Ligands for the Orphan Nuclear Receptor Steroidogenic Factor-1

Li, Y., Choi, M., Cavey, G. S., Daugherty, J., Suino, K., Kovach, A., Bingham, N. C., Kliewer, S. A., & Xu, H. E. (2005) · Molecular Cell · doi:10.1016/j.molcel.2005.02.002 · Cited by 205 · see citing works

Essential fatty acids in the plasma phospholipids of patients with atopic eczema

Manku, M. S., Horrobin, D. F., MORSE, N. L., WRIGHT, S., & Burton, J. L. (1984) · British Journal of Dermatology · doi:10.1111/j.1365-2133.1984.tb04698.x · Cited by 204 · see citing works

Contamination of rural surface and ground water by endosulfan in farming areas of the Western Cape, South Africa

Dalvie, M. A., Cairncross, E., Solomon, A., & London, L. (2003) · Environmental Health · doi:10.1186/1476-069x-2-1 · Cited by 201 · see citing works

Identification of a novel D6‐acyl‐group desaturase by targeted gene disruption in Physcomitrella patens

Girke, T., Schmidt, H., Zähringer, U., Ralf Reski, A., & Heinz, E. (1998) · The Plant Journal · doi:10.1046/j.1365-313x.1998.00178.x · Cited by 200 · see citing works

Fatty acid metabolism in neurodevelopmental disorder: a new perspective on associations between attention-deficit/hyperactivity disorder, dyslexia, dyspraxia and the autistic spectrum

Richardson, A. J., & Ross, M. A. (2000) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1054/plef.2000.0184 · Cited by 196 · see citing works

Wasting in Cancer

Tisdale, M. J. (1999) · Journal of Nutrition · doi:10.1093/jn/129.1.243s · Cited by 196 · see citing works

Essential fatty acid metabolism and its modification in atopic eczema

Horrobin, D. F. (2000) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/71.1.367s · Cited by 189 · see citing works

Intakes of essential n−6 and n−3 polyunsaturated fatty acids among pregnant Canadian women

Innis, S. M., & Elias, S. (2003) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/77.2.473 · Cited by 187 · see citing works

Evidence for the reversibility of the acyl-CoA:lysophosphatidylcholine acyltransferase in microsomal preparations from developing safflower ( Carthamus tinctorius L.) cotyledons and rat liver

Stymne, S., & Stobart, A. K. (1984) · Biochemical Journal · doi:10.1042/bj2230305 · Cited by 182 · see citing works

Placental delivery of arachidonic and docosahexaenoic acids: implications for the lipid nutrition of preterm infants

Crawford, M. A. (2000) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/71.1.275s · Cited by 182 · see citing works

Identification and characterization of an enzyme involved in the elongation of n-6 and n-3 polyunsaturated fatty acids

PARKER-BARNES, J. M., Das, T., BOBIK, E. G., Leonard, A. E., Thurmond, J. M., Chaung, L.-T., Huang, Y. S., & Mukerji, P. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.15.8284 · Cited by 177 · see citing works

Reduced levels of prostaglandin precursors in the blood of atopic patients: Defective delta-6-desaturase function as a biochemical basis for atopy

Manku, M. S., Horrobin, D. F., Morse, N. L., Kyte, V., Jenkins, K., Wright, S., & Burton, J. L. (1982) · Prostaglandins Leukotrienes and Medicine · doi:10.1016/0262-1746(82)90019-1 · Cited by 174 · see citing works

Omega‐3 fatty acids improve liver and pancreas function in postoperative cancer patients

Heller, A. R., Rössel, T., Gottschlich, B., Tiebel, O., Menschikowski, M., Litz, R. J., Zimmermann, T. P., & Koch, T. (2004) · International Journal of Cancer · doi:10.1002/ijc.20291 · Cited by 172 · see citing works

Effect of dietary advice and n-3 supplementation in newly diagnosed MS patients

Nordvik, I., Myhr, K.-M., Nyland, H., & Bjerve, K. S. (2000) · Acta Neurologica Scandinavica · doi:10.1034/j.1600-0404.2000.102003143.x · Cited by 169 · see citing works

Evening primrose oil and borage oil in rheumatologic conditions

Belch, J. J. F., & Hill, A. (2000) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/71.1.352s · Cited by 167 · see citing works

Stratum Corneum Keratin Structure, Function, and Formation: The Cubic Rod-Packing and Membrane Templating Model

Norlen, L. P. O., & Al‐Amoudi, A. (2004) · Journal of Investigative Dermatology · doi:10.1111/j.0022-202x.2004.23213.x · Cited by 165 · see citing works

Calcium metabolism, osteoporsis and essential fatty acids: A review

Kruger, M. C., & Horrobin, D. F. (1997) · Progress in Lipid Research · doi:10.1016/s0163-7827(97)00007-6 · Cited by 163 · see citing works

Increased risk of postpartum depressive symptoms is associated with slower normalization after pregnancy of the functional docosahexaenoic acid status

Otto, S. J., de Groot, R. H. M., & Hornstra, G. (2003) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/s0952-3278(03)00090-5 · Cited by 162 · see citing works

Isolation of a Δ5-Fatty Acid Desaturase Gene fromMortierella alpina

Michaelson, L. V., Lazarus, C. M., Griffiths, G. J., Napier, J. A., & Stobart, A. K. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.30.19055 · Cited by 161 · see citing works

Cloning of Δ12‐ and Δ6‐desaturases from Mortierella alpina and recombinant production of γ‐linolenic acid in Saccharomyces cerevisiae

Huang, Y. S., Chaudhary, S., Thurmond, J. M., BOBIK, E. G., Yuan, L., Chan, G. M., Kirchner, S. J., Mukerji, P., & Knutzon, D. S. (1999) · Lipids · doi:10.1007/s11745-999-0410-8 · Cited by 158 · see citing works

Identification of Acyl Coenzyme A:Monoacylglycerol Acyltransferase 3, an Intestinal Specific Enzyme Implicated in Dietary Fat Absorption

Cheng, D., Nelson, T. C., Chen, J., Walker, S. G., Wardwell-Swanson, J. A., Meegalla, R. L., Taub, R. A., Billheimer, J. T., Ramaker, M., & Feder, J. N. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.c300042200 · Cited by 157 · see citing works

Effects of α-lipoic acid on neurovascular function in diabetic rats: interaction with essential fatty acids

Cameron, N. E., Cotter, M. A., Horrobin, D. F., & Tritschler, H. (1998) · Diabetologia · doi:10.1007/s001250050921 · Cited by 156 · see citing works

Heterologous reconstitution in yeast of the polyunsaturated fatty acid biosynthetic pathway

Beaudoin, F., Michaelson, L. V., Hey, S. J., Lewis, M. J., Shewry, P. R., Sayanova, O. V., & Napier, J. A. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.110140197 · Cited by 155 · see citing works

Long-chain polyunsaturated fatty acid requirements during pregnancy and lactation

Makrides, M., & Gibson, R. A. (2000) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/71.1.307s · Cited by 150 · see citing works

Acyl Carriers Used as Substrates by the Desaturases and Elongases Involved in Very Long-chain Polyunsaturated Fatty Acids Biosynthesis Reconstituted in Yeast

Domergue, F., Abbadi, A., Ott, C., Zank, T. K., Zähringer, U., & Heinz, E. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m305990200 · Cited by 149 · see citing works

A Family of Fatty Acid Binding Receptors

Brown, A. J., Jupe, S., & Briscoe, C. P. (2005) · DNA and Cell Biology · doi:10.1089/dna.2005.24.54 · Cited by 149 · see citing works

Identification of a Caenorhabditis elegans Δ6-fatty-acid-desaturase by heterologous expression in Saccharomyces cerevisiae

Napier, J. A., HEY, J. S., LACEY, J. D., & SHEWRY, R. P. (1998) · Biochemical Journal · doi:10.1042/bj3300611 · Cited by 142 · see citing works

Identification of a cDNA encoding a novel C18‐Δ9 polyunsaturated fatty acid‐specific elongating activity from the docosahexaenoic acid (DHA)‐producing microalga, Isochrysis galbana1

Qi, B., Beaudoin, F., Fraser, T. C. M., Stobart, A. K., Napier, J. A., & Lazarus, C. M. (2001) · FEBS Letters · doi:10.1016/s0014-5793(01)03247-1 · Cited by 138 · see citing works

The Δ8-Desaturase ofEuglena gracilis:An Alternate Pathway for Synthesis of 20-Carbon Polyunsaturated Fatty Acids

Wallis, J. G., & Browse, J. (1999) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1999.1167 · Cited by 138 · see citing works

Effects of supplementation with fish oil–derived n−3 fatty acids and γ-linolenic acid on circulating plasma lipids and fatty acid profiles in women

Laidlaw, M., & Holub, B. J. (2003) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/77.1.37 · Cited by 128 · see citing works

Triacylglycerols are synthesised and utilized by transacylation reactions in microsomal preparations of developing safflower ( Carthamus tinctorius L.) seeds

Stobart, K., Mancha, M., Lenman, M., Dahlqvist, A., & Stymne, S. (1997) · Planta · doi:10.1007/s00050165 · Cited by 126 · see citing works

Deficiencies of polyunsaturated fatty acids and replacement by nonessential fatty acids in plasma lipids in multiple sclerosis.

Holman, R. T., Johnson, S. B., & Kokmen, E. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.12.4720 · Cited by 121 · see citing works

Δ6-Fatty acid desaturase from an arachidonic acid-producing Mortierella fungus

Sakuradani, E., Kobayashi, M., & Shimizu, S. (1999) · Gene · doi:10.1016/s0378-1119(99)00359-5 · Cited by 113 · see citing works

Cloning and functional characterisation of an enzyme involved in the elongation of Δ6‐polyunsaturated fatty acids from the moss Physcomitrella patens

Zank, T. K., Zähringer, U., Beckmann, C., Pohnert, G., Boland, W., Holtorf, H., Ralf Reski, A., Lerchl, J., & Heinz, E. (2002) · The Plant Journal · doi:10.1046/j.1365-313x.2002.01354.x · Cited by 111 · see citing works

Photodynamic therapy of vulvar intraepithelial neoplasia using 5-aminolevulinic acid

Hillemanns, P., Untch, M., Dannecker, C., Baumgartner, R., Stepp, H. G., Diebold, J., Weingandt, H., Pr�ve, F., & Korell, M. (2000) · International Journal of Cancer · doi:10.1002/(sici)1097-0215(20000301)85:5 · Cited by 110 · see citing works

A lipoic acid-gamma linolenic acid conjugate is effective against multiple indices of experimental diabetic neuropathy

Hounsom, L., Horrobin, D. F., Tritschler, H., Corder, R., & Tomlinson, D. R. (1998) · Diabetologia · doi:10.1007/s001250050996 · Cited by 105 · see citing works

Red blood cell fatty acid compositions in a patient with autistic spectrum disorder: a characteristic abnormality in neurodevelopmental disorders?

Bell, J. G., SARGENT, J. R., Tocher, D. R., & Dick, J. R. (2000) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1054/plef.2000.0186 · Cited by 103 · see citing works

MRI and neuropsychological improvement in Huntington disease following ethyl-EPA treatment

Puri, B. K., Bydder, G. M., Counsell, S. J., Corridan, B., Richardson, A. J., Hajnal, J. V., Appel, C., McKee, H. M., Vaddadi, K. S., & Horrobin, D. F. (2002) · Neuroreport · doi:10.1097/00001756-200201210-00029 · Cited by 100 · see citing works

The acylation of sn-glycerol 3-phosphate and the metabolism of phosphatidate in microsomal preparations from the developing cotyledons of safflower (Carthamus tinctorius L.) seed

Griffiths, G. J., Stobart, A. K., & Stymne, S. (1985) · Biochemical Journal · doi:10.1042/bj2300379 · Cited by 100 · see citing works

Metabolic engineering of fatty acids for breeding of new oilseed crops: strategies, problems and first results

Drexler, H. H. S., Spiekermann, P., Meyer, A., Domergue, F., Zank, T. K., Sperling, P., Abbadi, A., & Heinz, E. (2003) · Journal of Plant Physiology · doi:10.1078/0176-1617-01025 · Cited by 95 · see citing works

Essential Fatty Acids in Serum Lecithin of Children with Atopic Dermatitis and in Umbilical Cord Serum of Infants with High or Low IgE Levels

Strannegård, I., Svennerholm, L., & Strannegård, Ö. O. (2009) · International Archives of Allergy and Applied Immunology · doi:10.1159/000234245 · Cited by 95 · see citing works

Isolation and Characterization of a Δ5-Fatty Acid Desaturase fromCaenorhabditis elegans

Watts, J. L., & Browse, J. (1999) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1998.1024 · Cited by 87 · see citing works

Functional identification of a fatty acid Δ 5 desaturase gene from Caenorhabditis elegans

Michaelson, L. V., Napier, J. A., Lewis, M. J., Griffiths, G. J., Lazarus, C. M., & Stobart, A. K. (1998) · FEBS Letters · doi:10.1016/s0014-5793(98)01385-4 · Cited by 87 · see citing works

Diets could prevent many diseases

Lands, W. E. M. (2003) · Lipids · doi:10.1007/s11745-003-1066-0 · Cited by 87 · see citing works

Identification of a very long chain polyunsaturated fatty acid Δ4‐desaturase from the microalga Pavlova lutheri1

Tonon, T., Harvey, D., Larson, T. R., & Graham, I. A. (2003) · FEBS Letters · doi:10.1016/s0014-5793(03)01078-0 · Cited by 86 · see citing works

Differential sensitivity of cancer cells to docosahexaenoic acid–induced cytotoxicity: The potential importance of down-regulation of superoxide dismutase 1 expression

Ding, W., Vaught, J. L., Yamauchi, H., & Lind, S. E. (2004) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.1109.3.9 · Cited by 84 · see citing works

The possible role of gradual accumulation of copper, cadmium, lead and iron and gradual depletion of zinc, magnesium, selenium, vitamins B2, B6, D, and E and essential fatty acids in multiple sclerosis

Johnson, S. (2000) · Medical Hypotheses · doi:10.1054/mehy.2000.1051 · Cited by 81 · see citing works

Fish oil supplementation enhanced CPT-11 (irinotecan) efficacy against MCF7 breast carcinoma xenografts and ameliorated intestinal side-effects

Hardman, W. E., Moyer, M. P., & Cameron, I. L. (1999) · British Journal of Cancer · doi:10.1038/sj.bjc.6690713 · Cited by 81 · see citing works

Cytotoxic drugs efficacy correlates with adipose tissue docosahexaenoic acid level in locally advanced breast carcinoma

Bougnoux, P., Germain, E., Chajès, V., Hubert, B., Lhuillery, C., Floch, O. L., Body, G., & Calais, G. (1999) · British Journal of Cancer · doi:10.1038/sj.bjc.6690281 · Cited by 77 · see citing works

Metabolic and health effects of isomeric fatty acids

Mensink, R. P. (2005) · Current Opinion in Lipidology · doi:10.1097/00041433-200502000-00006 · Cited by 77 · see citing works

Essential Fatty Acids in the Management of Impaired Nerve Function in Diabetes

Horrobin, D. F. (1997) · Diabetes · doi:10.2337/diab.46.2.s90 · Cited by 77 · see citing works

Δ 6- and Δ12-desaturase activities and phosphatidic acid formation in microsomal preparations from the developing cotyledons of common borage (Borago officinalis)

Griffiths, G. J., Stobart, A. K., & Stymne, S. (1988) · Biochemical Journal · doi:10.1042/bj2520641 · Cited by 73 · see citing works

Synergistic Interaction Between Vinorelbine and Gamma-Linolenic Acid in Breast Cancer Cells

Menéndez, J. A., Ropero, S., Barbacid, M. D. M., Montero, S., Solanas, M., Escrich, E., Cortés-Funes, H., & Colomer, R. (2002) · Breast Cancer Research and Treatment · doi:10.1023/a:1014968415759 · Cited by 71 · see citing works

Novel lipid mixtures based on synthetic ceramides reproduce the unique stratum corneum lipid organization

de Jager, M. W., Gooris, G. S., Dolbnya, I. P., Bras, W., Ponec, M., & Bouwstra, J. A. (2004) · Journal of Lipid Research · doi:10.1194/jlr.m300484-jlr200 · Cited by 69 · see citing works

The lipids that matter from infant nutrition to insulin resistance

Das, U. N. (2002) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1054/plef.2002.0374 · Cited by 67 · see citing works

1‐Acyl‐sn‐glycerol‐3‐phosphate acyltransferase in maturing safflower seeds and its contribution to the non‐random fatty acid distribution of triacylglycerol

ICHIHARA, K.-I., Asahi, T., & Fujii, S. (1987) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1987.tb13342.x · Cited by 61 · see citing works

Abnormal essential fatty acid levels in plasma of women with premenstrual syndrome

Brush, M. G., Watson, S., Horrobin, D. F., & Manku, M. S. (1984) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(84)80139-8 · Cited by 60 · see citing works

Cancer cachexia and its treatment with fish-oil-enriched nutritional supplementation

Barber, M. D. (2001) · Nutrition · doi:10.1016/s0899-9007(01)00631-1 · Cited by 59 · see citing works

The interconversion of diacylglycerol and phosphatidylcholine during triacylglycerol production in microsomal preparations of developing cotyledons of safflower (Carthamus tinctorius L.)

Stobart, A. K., & Stymne, S. (1985) · Biochemical Journal · doi:10.1042/bj2320217 · Cited by 59 · see citing works

Interactions between n-3 and n-6 essential fatty acids (EFAs) in the regulation of cardiovascular disorders and inflammation

Horrobin, D. F. (1991) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/0952-3278(91)90196-c · Cited by 58 · see citing works

Tolerance and incorporation of a high‐dose eicosapentaenoic acid diester emulsion by patients with pancreatic cancer cachexia

Barber, M. D., & Fearon, K. C. H. (2001) · Lipids · doi:10.1007/s11745-001-0726-4 · Cited by 56 · see citing works

Relationship between ω3 long‐chain polyunsaturated fatty acid status during early infancy and neurodevelopmental status at 1 year of age

Voigt, R. G., Jensen, C. L., Fraley, J. K., Rozelle, J. C., Brown, F. R., & Heird, W. C. (2002) · Journal of Human Nutrition and Dietetics · doi:10.1046/j.1365-277x.2002.00341.x · Cited by 56 · see citing works

Prostanoids and blood pressure: which way is up?

Francois, H., & Coffman, T. M. (2004) · Journal of Clinical Investigation · doi:10.1172/jci200422929 · Cited by 56 · see citing works

Cloning and molecular characterization of the Fatty Acid Elongase 1 (FAE 1) gene from high and low erucic acid lines of Brassica campestris and Brassica oleracea

Das, S., Roscoe, T. J., Delseny, M., Srivastava, P. S., & Lakshmikumaran, M. (2002) · Plant Science · doi:10.1016/s0168-9452(01)00556-8 · Cited by 55 · see citing works

Food components and immune function

Plat, J., & Mensink, R. P. (2005) · Current Opinion in Lipidology · doi:10.1097/00041433-200502000-00007 · Cited by 53 · see citing works

Comparison of the effects of ascorbyl ?-linolenic acid and ?-linolenic acid in the correction of neurovascular deficits in diabetic rats

Cameron, N. E., & Cotter, M. A. (1996) · Diabetologia · doi:10.1007/bf00400653 · Cited by 52 · see citing works

Impaired Arachidonic (20:4n-6) and Docosahexaenoic (22:6n-3) Acid Synthesis by Phenylalanine Metabolites as Etiological Factors in the Neuropathology of Phenylketonuria

Infante, J. P., & Huszagh, V. A. (2001) · Molecular Genetics and Metabolism · doi:10.1006/mgme.2001.3148 · Cited by 52 · see citing works

Identification, Purification, and Characterization of Monoacylglycerol Acyltransferase from Developing Peanut Cotyledons

Tumaney, A. W., Shekar, S., & Rajasekharan, R. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m100005200 · Cited by 50 · see citing works

Essential fatty acid and lipid profiles in plasma and erythrocytes in patients with multiple sclerosis

Cunnane, S. C., Ho, S. Y., Dore‐Duffy, P., Ells, K., & Horrobin, D. F. (1989) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/50.4.801 · Cited by 46 · see citing works

γ-linolenic acid therapy of human gliomas

Bakshi, A., Mukherjee, D., Bakshi, A., Banerji, A. K., & Das, U. N. (2003) · Nutrition · doi:10.1016/s0899-9007(02)00862-6 · Cited by 46 · see citing works

Premenstrual syndrome and premenstrual breast pain (cyclical mastalgia): Disorders of essential fatty acid (EFA) metabolism

Horrobin, D. F., & Manku, M. S. (1989) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/0952-3278(89)90036-7 · Cited by 45 · see citing works

The modulation of radiation-induced damage to pig skin by essential fatty acids

Hopewell, J. W., Robbins, M., van den Aardweg, G., Gm, M., Ross, G. A., Whitehouse, E. M., Horrobin, D. F., & Scott, C. (1993) · British Journal of Cancer · doi:10.1038/bjc.1993.276 · Cited by 45 · see citing works

Randomized, dose-finding phase III study of lithium gamolenate in patients with advanced pancreatic adenocarcinoma

Johnson, C. D., Puntis, M. C. A., Davidson, N. G. P., Todd, S., & Bryce, R. P. (2001) · British journal of surgery · doi:10.1046/j.0007-1323.2001.01770.x · Cited by 45 · see citing works

Amelioration of both early and late radiation-induced damage to pig skin by essential fatty acids

Hopewell, J. W., van den Aardweg, G. J. M. J., Morris, G. M., Rezvani, M., Robbins, M. E. C., Ross, G. A., Whitehouse, E. M., Scott, C. A., & Horrobin, D. F. (1994) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/0360-3016(94)90318-2 · Cited by 43 · see citing works

Abnormal fatty acid pattern in rheumatoid arthritis. A rationale for treatment with marine and botanical lipids.

Navarro, E., Esteve, M., Olivé, A., Klaassen, J., Cabré, E., Tena, X., Fernández‐Bañares, F., Pastor, C., & Gassull, M. À. (2000) · PubMed · Cited by 42 · see citing works

Prostanoids and blood pressure: which way is up?

Francois, H., & Coffman, T. M. (2004) · Journal of Clinical Investigation · doi:10.1172/jci22929 · Cited by 41 · see citing works

Essential fatty acids in relation to pregnancy complications and fetal development

Sattar, N. A., Berry, C., & Greer, I. A. (1998) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.1998.tb10002.x · Cited by 41 · see citing works

Treatment of multiple sclerosis with lofepramine, l-phenylalanine and vitamin B12: mechanism of action and clinical importance: roles of the locus coeruleus and central noradrenergic systems

Loder, C., Allawi, J., & Horrobin, D. F. (2002) · Medical Hypotheses · doi:10.1016/s0306-9877(02)00261-x · Cited by 40 · see citing works

Expression of the Isochrysis C18-Δ9 Polyunsaturated Fatty Acid Specific Elongase Component Alters Arabidopsis Glycerolipid Profiles

Fraser, T., Qi, B., Elhussein, S. A., Chatrattanakunchai, S., Stobart, A. K., & Lazarus, C. M. (2004) · PLANT PHYSIOLOGY · doi:10.1104/pp.104.038984 · Cited by 40 · see citing works

Triacylglycerols are synthesised and utilized by transacylation reactions in microsomal preparations of developing safflower ( Carthamus tinctorius L.) seeds

Stobart, K., Mancha, M., Lenman, M., et al. (1997) · Planta · doi:10.1007/s004250050165 · Cited by 38 · see citing works

Intracellular translocation of phosphatidate phosphatase in maturing safflower seeds: a possible mechanism of feedforward control of triacylglycerol synthesis by fatty acids

ICHIHARA, K.-I., 室田, 直., & Fujii, S. (1990) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(90)90021-o · Cited by 37 · see citing works

A novel pathway for lipid biosynthesis: the direct acylation of glycerol

Lee, D. P., Deonarine, A. S., Kienetz, M., Zhu, Q., Skrzypczak, M., Chan, M., & Choy, P. C. (2001) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)31526-1 · Cited by 37 · see citing works

Effect of n-3 fatty acids on the antitumour effects of cytotoxic drugs.

Wynter, M. P., Russell, S. T., & Tisdale, M. J. (2005) · PubMed · Cited by 36 · see citing works

Molecular profiling of embryonal carcinoma cells following retinoic acid or histone deacetylase inhibitor treatment

Sangster‐Guity, N., Yu, L., & McCormick, P. J. (2004) · Cancer Biology & Therapy · doi:10.4161/cbt.3.11.1190 · Cited by 33 · see citing works

n-6 andn-3 Essential fatty acids in rheumatoid arthritis and other rheumatic conditions

Belch, J. J. F., & Muir, A. H. (1998) · Proceedings of The Nutrition Society · doi:10.1079/pns19980082 · Cited by 33 · see citing works

MANAGEMENT OF CYCLICAL MASTALGIA IN ORIENTAL WOMEN: PIONEER EXPERIENCE OF USING GAMOLENIC ACID (EFAMAST®) IN ASIA

Cheung, K. (1999) · Australian and New Zealand Journal of Surgery · doi:10.1046/j.1440-1622.1999.01609.x · Cited by 32 · see citing works

Treatment of Diabetic Neuropathy, A New Approach

Taylor, R. (1993) · Postgraduate Medical Journal · doi:10.1136/pgmj.69.817.900-a · Cited by 31 · see citing works

Expression of human delta-6-desaturase is associated with aggressiveness of human breast cancer

Lane, J., Mansel, R. E., & Jiang, W. G. (2003) · International Journal of Molecular Medicine · doi:10.3892/ijmm.12.2.253 · Cited by 28 · see citing works

Differential effects of dietary Oenothera, Zizyphus mistol, and corn oils, and essential fatty acid deficiency on the progression of a murine mammary gland adenocarcinoma

Muñoz, S. E., Piegari, M., Guzmán, C. A., & Eynard, A. R. (1999) · Nutrition · doi:10.1016/s0899-9007(98)00181-6 · Cited by 27 · see citing works

A new category of psychotropic drugs: neuroactive lipids as exemplified by ethyl eicosapentaenoate (E-E)

Horrobin, D. F. (2002) · Birkhäuser Basel eBooks · doi:10.1007/978-3-0348-8171-5_6 · Cited by 24 · see citing works

Omega-6 and Omega-3 Essential Fatty Acids in Atherosclerosis

Horrobin, D. F. (1993) · Seminars in Thrombosis and Hemostasis · doi:10.1055/s-2007-994016 · Cited by 24 · see citing works

Epirubicin and meglumine γ‐linolenic acid

Harris, N. M., Anderson, W. R., Lwaleed, B. A., Cooper, A. J., Birch, B. R., & SOLOMON, L. Z. (2002) · Cancer · doi:10.1002/cncr.11055 · Cited by 23 · see citing works

Prostaglandins

FitzGerald, G. A. (2004) · JCR Journal of Clinical Rheumatology · doi:10.1097/01.rhu.0000130685.73681.8b · Cited by 23 · see citing works

Stereotactic radiosurgery XII. Large AVM and the failure of the radiation response modifier gamma linolenic acid to improve the therapeutic ratio

Plowman, P. N. (2001) · British Journal of Neurosurgery · doi:10.1080/026886901300004058 · Cited by 22 · see citing works

EPA in the Prevention of Restenosis Post PTCA

Bowles, M. H., Klonis, D., Plavac, T. G., Gonzales, B., Francisco, D., Roberts, R. W., Boxberger, G. R., Poliner, L. R., & Galichia, J. P. (1991) · Angiology · doi:10.1177/000331979104200302 · Cited by 16 · see citing works

Back to Boston!

Weir, G. C. (1997) · Diabetes · doi:10.2337/diab.46.1.1 · Cited by 14 · see citing works

Effects of Exogenous Lipids on Cancer and Cancer Chemotherapy

Burns, C. P., & Wagner, B. A. (1993) · Drug Safety · doi:10.2165/00002018-199308010-00007 · Cited by 13 · see citing works

Multiple Sclerosis: Effect of Gamma Linolenate Administration upon Membranes and the Need for Extended Clinical Trials of Unsaturated Fatty Acids

Field, E. J., & Joyce, G. (2008) · European Neurology · doi:10.1159/000115540 · Cited by 10 · see citing works

In vivo and in vitro biotransformation of the lithium salt of gamma-linolenic acid by three human carcinomas

de Antueno, R., Elliot, M. L., Ells, G., Quiroga, P., Jenkins, K., & Horrobin, D. F. (1997) · British Journal of Cancer · doi:10.1038/bjc.1997.309 · Cited by 9 · see citing works

The effect of evening primrose oil on the radiation response and blood flow of mouse normal and tumour tissue

Rahbeeni, A. S. H. F. (2000) · International Journal of Radiation Biology · doi:10.1080/09553000050029039 · Cited by 8 · see citing works

Tissue distribution and metabolism of gamma-linolenoyl-3-eicosapentaenoyl propane diol enterally or intravenously administered to mice bearing human pancreatic carcinomas.

De Antueno, R., Bai, M., & Elliot, M. L. (1999) · PubMed · Cited by 7 · see citing works

A low toxicity maintenance regime, using eicosapentaenoic acid and readily available drugs, for mantle cell lymphoma and other malignancies with excess cyclin D1 levels

Horrobin, D. F. (2003) · Medical Hypotheses · doi:10.1016/s0306-9877(03)00075-6 · Cited by 6 · see citing works

Key Targets for Improving Algal Biofuel Production

Griffiths, G., Hossain, A. K., Sharma, V., & Duraisamy, G. (2021) · Clean Technologies · doi:10.3390/cleantechnol3040043 · Cited by 49 · see citing works

Fatty Acids in Fish and Shellfish

ACKMAN, R. G. (2007) · Food science and technology · doi:10.1201/9781420006902.ch8 · Cited by 22 · see citing works

Safety and efficacy of hemp-derived products in animal feeds—a narrative review

Neijat, M., & House, J. D. (2024) · Canadian Journal of Animal Science · doi:10.1139/cjas-2023-0133 · Cited by 10 · see citing works

Synthesis and evaluation of 2,3-dinorprostaglandins: Dinor-PGD1 and 13-epi-dinor-PGD1 are peroxisome proliferator-activated receptor α/γ dual agonists

Sato, A., Dodo, K., Makishima, M., Hashimoto, Y., & Sodeoka, M. (2013) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2013.03.024 · Cited by 5 · see citing works

Protein, Fatty acid, and Isoflavone Contents of Soybean Lines Tolerant to Acid Soil

Ginting, E., Yulifianti, R., Kuswantoro, H., Lee, B. W., & Baek, I. Y. (2018) · Journal of the Korean Society of International Agriculture · doi:10.12719/ksia.2018.30.3.167 · Cited by 4 · see citing works

A Method for Identifying Germplasm that Exhibit Multiple Mutations in the Fatty Acid Synthetic Pathway of Perilla frutescens

Zhang, X., Feng, S., Yang, W., Shen, Q., & Chen, S. (2020) · Journal of the American Oil Chemists Society · doi:10.1002/aocs.12417 · Cited by 1 · see citing works

11. Egg fortification with n-3 polyunsaturated fatty acids

House, J. D., Goldberg, E. M., & Neijat, M. (2015) · Wageningen Academic Publishers eBooks · doi:10.3920/978-90-8686-804-9_11 · Cited by 1 · see citing works

Probing the limits of very long chain polyunsaturated fatty acid accumulation in transgenic Brassica napus

Snyder, C. L. (2010) · ERA: Education and Research Archive (University of Alberta) · doi:10.7939/r3vm0t · Cited by 1 · see citing works

Estudio de la conservación de la leche humana y de los preparados para lactantes

Nadal, M. R. (2006) · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas)

Advances in Technology to Generate Cardiovascular-Friendly Functional Food Products

Eskin, N. A. M., Rempel, C., Aliani, M., & University Manitoba (2012) · CRC Press eBooks · doi:10.1201/b11562-3

acids and their biotechnological production in plants.

Griffiths, G., & Morse, N. (2013)

Future directions in polyunsaturated fatty acid technology and product development

Jafari, S., Ebrahimi, M., Mishra, D., & Assatarakul, K. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-43810-3.00024-5

Engineering production of C18 conjugated fatty acids in developing seeds of oil crops

Mietkiewska, E., Lin, Y., & Weselake, R. J. (2013) · Biocatalysis and Agricultural Biotechnology · doi:10.1016/j.bcab.2013.11.003 · Cited by 11 · see citing works

Plant Unsaturated Fatty Acids: Biosynthesis and Regulation

He, M., Qin, C.-X., Wang, X., & Ding, N. (2020) · Frontiers in Plant Science · doi:10.3389/fpls.2020.00390 · Cited by 310 · see citing works

Progress toward the production of long‐chain polyunsaturated fatty acids in transgenic plants

Napier, J. A., Sayanova, O. V., Qi, B., & Lazarus, C. M. (2004) · Lipids · doi:10.1007/s11745-004-1332-1 · Cited by 35 · see citing works