Counterregulatory hormone release and glucose recovery after hypoglycemia in non-insulin-dependent diabetic patients
Abstract
An increasing number of patients with non-insulin-dependent diabetes mellitus (NIDDM) is presently being treated with insulin, some aggressively with intensified treatment schedules. However, there is little information on the ability of these patients to recover from insulin-induced hypoglycemia. We have, therefore, determined glucose recovery and counterregulatory hormone secretion in response to insulin-induced hypoglycemia in 10 NIDDM patients without autonomic neuropathy and in 6 age- and weight-matched normal controls. Recovery of plasma glucose concentration and hypoglycemia-induced increments of plasma concentrations of glucagon, epinephrine, norepinephrine, and HGH were similar in the NIDDM patients and the age- and weight-matched nondiabetic controls. It appears likely, therefore, that these NIDDM patients, if treated aggressively with insulin, may be at lesser risk for severe and prolonged hypoglycemia than insulin-dependent diabetic patients, particularly those with autonomic neuropathy or those treated with beta-adrenergic antagonists.
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In type 2 diabetes, the glucagon response to hypoglycemia has been diversely reported as being either modestly diminished or preserved.
“In type 2 diabetes, the glucagon response to hypoglycemia has been diversely reported as being either modestly diminished (16, 30,50) or preserved (33,34,37,38).”
From Hypoglycemia in Type 2 Diabetes (2005) · cites this paper as [34]
Most investigators reporting preservation of the glucagon response have studied people with type 2 diabetes who were unlikely to be insulin deficient, and, with one exception, all of these studies have examined counterregulatory responses in middle-aged subjects in their 5th or 6th decade.
“Most investigators reporting preservation of the glucagon response have studied people with type 2 diabetes who were unlikely to be insulin deficient (33,34,36,38), and, with one exception (16), all of these studies have examined counterregulatory responses in middle-aged subjects in their 5th or 6th decade.”
From Hypoglycemia in Type 2 Diabetes (2005) · cites this paper as [34]
Cited by
Sorted by citations
Hypoglycaemia: the limiting factor in the glycaemic management of type I and type II diabetes.
Cryer, P. (2002) · Diabetologia · doi:10.1007/s00125-002-0822-9 · Cited by 794 · see citing works
Hypoglycemia in Type 2 Diabetes
Zammitt, N. N., & Frier, B. M. (2005) · Diabetes Care · doi:10.2337/diacare.28.12.2948 · Cited by 435 · see citing works
Hypoglycemia-associated autonomic failure in advanced type 2 diabetes.
Segel, S. A., Paramore, D. S., & Cryer, P. E. (2002) · Diabetes · doi:10.2337/diabetes.51.3.724 · Cited by 337 · see citing works
- Authors
- Boden, G., Soriano, M., Hoeldtke, R. D., & Owen, O. E.
- Affiliations
- Temple University (US)
- Venue
- Diabetes
- Publisher
- American Diabetes Association
- Published
- 1983-11-01
- Volume
- 32
- Issue
- 11
- Pages
- 1055-1059
- ISSN
- 0012-1797 (ISSN-L)
- OpenAlex
- W2156281997
- Cited by
- 43
- References
- 0
- Citations by year
- 2025: 1 · 2024: 1 · 2020: 1 · 2018: 4 · 2015: 1 · 2013: 1 · 2012: 1
- FWCI
- 1.40
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Diabetes (publishedVersion)
- PubMed (publishedVersion)
- Funders
- U.S. Public Health Service
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Keywords
- type 2 diabetes, insulin-induced hypoglycemia, glucose recovery, glucagon, epinephrine, norepinephrine, growth hormone, autonomic neuropathy, beta-blockers, hypoglycemia risk
- MeSH terms
- Adult, Aged, Catecholamines, Diabetes Mellitus, Type 2, Epinephrine, Female, Glucagon, Humans, Hypoglycemia, Insulin, Male, Middle Aged, Norepinephrine, Growth Hormone
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