Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade.

Mechanism of free fatty acid-induced insulin resistance in humans.

Roden, M., Price, T. B., Perseghin, G., Petersen, K. F., Rothman, D. L., Cline, G. W., & Shulman, G. I. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118742 · Cited by 1,539

Measurement of Plasma Glucose, Free Fatty Acid, Lactate, and Insulin for 24 h in Patients With NIDDM

Reaven, G. M., Hollenbeck, C., Jeng, C.-Y., Wu, M. S., & Chen, Y.-D. I. (1988) · Diabetes · doi:10.2337/diab.37.8.1020 · Cited by 753

Effects of fat on insulin-stimulated carbohydrate metabolism in normal men.

Boden, G., Jadali, F., White, J. V., Liang, Y. T., Mozzoli, M. A., Chen, X., Coleman, E., & Smith, C. R. (1991) · Journal of Clinical Investigation · doi:10.1172/jci115399 · Cited by 494

Interaction between glucose and free fatty acid metabolism in human skeletal muscle.

Kelley, D. E., Mokáň, M., Simoneau, J. A., & Mandarino, L. J. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116603 · Cited by 480

Insulin resistance and lipid metabolism

Frayn, K. N. (1993) · Current Opinion in Lipidology · doi:10.1097/00041433-199306000-00004 · Cited by 254

Resistance to Insulin but Not to Glucagon in Lean Human Hypertriglyceridemics

Steiner, G. A., Morita, S., & Vranić, M. (1980) · Diabetes · doi:10.2337/diab.29.11.899 · Cited by 80

13C and 31P NMR Studies on the Effects of Increased Plasma Free Fatty Acids on Intramuscular Glucose Metabolism in the Awake Rat

Jucker, B. M., Rennings, A. J. M., Cline, G. W., & Shulman, G. I. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.16.10464 · Cited by 77

Elevated free fatty acid levels inhibit glucose phosphorylation in slow‐twitch rat skeletal muscle

Nolte, L. A., Galuska, D., Martin, I. K., Zierath, J. R., & Wallberg‐Henriksson, H. (1994) · Acta Physiologica Scandinavica · doi:10.1111/j.1748-1716.1994.tb09720.x · Cited by 33

Rosiglitazone Inhibits Expression and Secretion of PEDF in Adipose Tissue and Liver of Male SD Rats Via a PPAR-γ Independent Mechanism

Yang, S., Luo, T., Zhou, H., Lv, Q., Liu, L., Zhang, W., Gao, R., Chen, S., Xia, W., Luo, M., et al. (2014) · Endocrinology · doi:10.1210/en.2013-1813 · Cited by 15

Alcohol extract of North American ginseng (Panax quinquefolius) reduces fatty liver, dyslipidemia, and other complications of metabolic syndrome in a mouse model

Singh, R. K., Lui, E. M. K., Wright, D. C., Taylor, A., & Bakovic, M. (2017) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/cjpp-2016-0510 · Cited by 15

Nonesterified fatty acids, cognitive decline, and dementia

Mukamal, K. J. (2019) · Current Opinion in Lipidology · doi:10.1097/mol.0000000000000656 · Cited by 16

Cardiac SNARE Expression in Health and Disease

Bowman, P. R. T., Smith, G. L., & Gould, G. W. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00881 · Cited by 16

PKCθ expression in the amygdala regulates insulin signaling, food intake and body weight

Park-York, M., Boghossian, S., Oh, H., & York, D. A. (2013) · Obesity · doi:10.1002/oby.20278 · Cited by 14

Folgeerkrankungen und Komplikationen der Adipositas

Dieterle, C. D., & Landgraf, R. (2005) · Der Internist · doi:10.1007/s00108-005-1552-0 · Cited by 14

Dietary polyunsaturated fatty acids and their metabolites: Implications for diabetes pathophysiology, prevention, and treatment

Neuman, J. C., Fenske, R. J., & Kimple, M. E. (2016) · Nutrition and Healthy Aging · doi:10.3233/nha-160004 · Cited by 15

Appropriate neck circumference cut-off points for metabolic syndrome in Turkish patients with type 2 diabetes

Özkaya, İ., Yardımcı, B., & Tunçkale, A. (2017) · Endocrinología Diabetes y Nutrición · doi:10.1016/j.endinu.2017.07.006 · Cited by 15

Chronic exposure to high fatty acids impedes receptor agonist-induced nitric oxide production and increments of cytosolic Ca2+ levels in endothelial cells

Tang, Y., & Li, G. (2011) · Journal of Molecular Endocrinology · doi:10.1530/jme-11-0082 · Cited by 15

Activation of G proteins by GIV-GEF is a pivot point for insulin resistance and sensitivity

Ma, G. S., López-Sánchez, I., Aznar, N., Kalogriopoulos, N. A., Pedram, S., Midde, K., Ciaraldi, T. P., Henry, R. R., & Ghosh, P. (2015) · Molecular Biology of the Cell · doi:10.1091/mbc.e15-08-0553 · Cited by 14

Natural products targeting cancer cell dependency

Shi, C., Yang, E. J., Tao, S., Ren, G., Mou, P. K., & Shim, J. S. (2021) · The Journal of Antibiotics · doi:10.1038/s41429-021-00438-x · Cited by 15

Revisiting the contribution of mitochondrial biology to the pathophysiology of skeletal muscle insulin resistance

Frangos, S. M., Bishop, D. J., & Holloway, G. P. (2021) · Biochemical Journal · doi:10.1042/bcj20210145 · Cited by 14

Fat and Protein Combat Triggers Immunological Weapons of Innate and Adaptive Immune Systems to Launch Neuroinflammation in Parkinson’s Disease

Hatton, S. L., & Pandey, M. K. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23031089 · Cited by 15

The role of key adipokines in obesity and insulin resistance in cats

Lusby, A. L., Kirk, C. A., & Bartges, J. W. (2009) · Journal of the American Veterinary Medical Association · doi:10.2460/javma.235.5.518 · Cited by 13

Genetic variants and clinical relevance associated with gestational diabetes mellitus in Chinese women: a case-control study

Yan, J., Su, R., Ao, D., Wang, Y., Wang, H., & Yang, H. (2017) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.1080/14767058.2017.1336225 · Cited by 13

Vascular endothelial growth factor B promotes transendothelial fatty acid transport into skeletal muscle via histone modifications during catch-up growth

Lü, X., Hu, S., Liao, Y., Zheng, J., Zeng, T., Zhong, X., Liu, G., Gou, L., & Chen, L. (2020) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00090.2020 · Cited by 14

Pathogenesis of Type 2 Diabetes Mellitus

DeFronzo, R. A. (2018) · Endocrinology · doi:10.1007/978-3-319-45015-5_8 · Cited by 14

Insulin Sensitivity is Related to Fat Oxidation and Protein Kinase C Activity in Children With Acute Burn Injury

Cree‐Green, M., Zwetsloot, J. J., Herndon, D. N., Newcomer, B. R., Fram, R. Y., Angel, C. A., Green, J. M., Dohm, G. L., Sun, D., Aarsland, A. A., et al. (2008) · Journal of Burn Care & Research · doi:10.1097/bcr.0b013e31817db88f · Cited by 14

Fatty Acids Differentially Modulate Insulin-Stimulated Endothelial Nitric Oxide Production by an Akt-Independent Pathway

Lynn, M. A., Rupnow, H. L., Kleinhenz, D. J., Kanner, W. A., Dudley, S. C., & Hart, C. M. (2004) · Journal of Investigative Medicine · doi:10.1136/jim-52-02-22 · Cited by 14

Pathogenesis of type 2 diabetes mellitus

DeFronzo, R. A. (2015) · Wiley eBooks · doi:10.1002/9781118387658.ch25 · Cited by 17

Insulin‐Mediated PI3K and AKT Signaling

Kwon, H., & Pessin, J. E. (2020) · Wiley eBooks · doi:10.1002/9781119436812.ch39 · Cited by 14

Triglycerides, Glucose Metabolism, and Type 2 Diabetes

Wang, Y. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26209910 · Cited by 20

Bioactive lipids and metabolic syndrome—a symposium report

DeVito, L. M., Dennis, E. A., Kahn, B. B., Shulman, G. I., Witztum, J. L., Sadhu, S., Nickels, J. T., Spite, M. R., Smyth, S. S., & Spiegel, S. (2022) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.14752 · Cited by 12

A combination of ascorbic acid and α-tocopherol to test the effectiveness and safety in the fragile X syndrome: study protocol for a phase II, randomized, placebo-controlled trial

de Diego‐Otero, Y., Medina, R. C., Quintero-Navarro, C., Salido, L. S., García-Guirado, F., del Arco, I., Fernández-Carvajal, I., Ferrando-Lucas, T., Caballero‐Andaluz, R., & Pérez-Costillas, L. (2014) · Trials · doi:10.1186/1745-6215-15-345 · Cited by 14

Impact of Acipimox Therapy on Free Fatty Acid Efflux and Endothelial Function in the Metabolic Syndrome: A Randomized Trial

Aday, A. W., Goldfine, A. B., Gregory, J. M., & Beckman, J. A. (2019) · Obesity · doi:10.1002/oby.22602 · Cited by 13

Site dependency of fatty acid composition in adipose triacylglycerol in rats and its absence as a result of high-fat feeding

Sato, D., Nakamura, T., Tsutsumi, K., Shinzawa, G., Karimata, T., Okawa, T., Feng, Z., & Kusunoki, M. (2011) · Metabolism · doi:10.1016/j.metabol.2011.05.012 · Cited by 13

Oleate regulates genes controlled by signaling pathways of mitogen-activated protein kinase, insulin, and hypoxia

Vock, C., Gleissner, M., Klapper, M., & Döring, F. (2008) · Nutrition Research · doi:10.1016/j.nutres.2008.06.010 · Cited by 13

The effect of an acute elevation of NEFA concentrations on glucagon-stimulated hepatic glucose output

Grueter, C. A., Edgerton, D. S., Donahue, E. P., Vaughan, S., Chu, C. A., Sindelar, D. K., & Cherrington, A. D. (2006) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00043.2006 · Cited by 13

Immunohistochemical identification and fiber type specific localization of protein kinase C isoforms in equine skeletal muscle

van Ginneken, M. M. E., KEIZER, H. A., Wijnberg, I. D., van Dam, K. G., Schaart, G., de Graaf‐Roelfsema, E., van der Kolk, J. H., & van Breda, E. (2004) · American Journal of Veterinary Research · doi:10.2460/ajvr.2004.65.69 · Cited by 13

Effects of Lifestyle Intervention in Tissue-Specific Lipidomic Profile of Formerly Obese Mice

Dahdah, N., González-Franquesa, A., Samino, S., Gama-Pérez, P., Herrero, L., Perales, J. C., Yanes, Ó., Malagón, M. M., & García-Rovés, P. M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22073694 · Cited by 13

Fatty acids induce increased granulocyte macrophage‐colony stimulating factor secretion through protein kinase C‐activation in THP‐1 macrophages

Bahramian, N., Östergren‐Lundén, G., Bondjers, G., & Olsson, U. (2004) · Lipids · doi:10.1007/s11745-004-1226-2 · Cited by 12

Expression of subcutaneous adipose tissue phosphoenolpyruvate carboxykinase correlates with body mass index in nondiabetic women

Chang, T., Lee, W., Chang, H., Lee, K., & Chuang, L. (2008) · Metabolism · doi:10.1016/j.metabol.2007.10.012 · Cited by 12

Inhibition of cellular responses to insulin in a rat liver cell line. A role for PKC in insulin resistance

Puljak, L., Pagliassotti, M. J., Wei, Y., Qadri, I., Parameswara, V., Esser, V., Fitz, J., & Kilic, G. (2005) · The Journal of Physiology · doi:10.1113/jphysiol.2004.080333 · Cited by 12

Dietary Diacyiglycerol-Rich Oil Stimulation of Glucose Intolerance in Genetically Obese Rats

Sugimoto, T., Fukuda, H., Kimura, T., & Iritani, N. (2003) · Journal of Nutritional Science and Vitaminology · doi:10.3177/jnsv.49.139 · Cited by 12

Protective Effects of Curcumin and its Analogues via the Nrf2 Pathway in Metabolic Syndrome

Rajabi, S., Darroudi, M., Naseri, K., Farkhondeh, T., & Samarghandian, S. (2023) · Current Medicinal Chemistry · doi:10.2174/0929867330666230510101150 · Cited by 11

Genetic Susceptibility of Type 2 Diabetes and Metabolic Syndrome

Ercegović, V., Džimbeg, M., & Gelemanović, A. (2025) · Diabetology · doi:10.3390/diabetology6020011 · Cited by 15

Proteomic analysis of adipose tissue: informing diabetes research

Murri, M., Insenser, M. R., Luque‐Ramírez, M., Tinahones, F. J., & Escobar-Morreale, H. F. (2014) · Expert Review of Proteomics · doi:10.1586/14789450.2014.903158 · Cited by 11

Intramyocellular lipid levels are associated with peripheral, but not hepatic, insulin sensitivity in normal healthy subjects

Salgin, B., Sleigh, A., Williams, R. M., Jackson, S. J., Bluck, L. J. C., Murgatroyd, P. R., Humphreys, S. M., Harding, S. G., Carpenter, T. A., & Dunger, D. B. (2008) · Clinical Science · doi:10.1042/cs20080563 · Cited by 11

Intrinsic disorder in biomarkers of insulin resistance, hypoadiponectinemia, and endothelial dysfunction among the type 2 diabetic patients

Al-Jiffri, O. H., Al-Sharif, F. M., Jiffri, E. H., & Uversky, V. N. (2016) · Intrinsically Disordered Proteins · doi:10.1080/21690707.2016.1171278 · Cited by 11

Sleep-Disordered Breathing and Free Fatty Acid Metabolism

Stefanovski, D., Boston, R., & Punjabi, N. M. (2020) · CHEST Journal · doi:10.1016/j.chest.2020.05.600 · Cited by 12

Fasting and Postload Nonesterified Fatty Acids and Glucose Dysregulation in Older Adults

Shitole, S. G., Biggs, M. L., Ix, J. H., Fretts, A. M., Tracy, R. P., Siscovick, D. S., Djoussé, L., Mukamal, K. J., & Kizer, J. R. (2022) · American Journal of Epidemiology · doi:10.1093/aje/kwac044 · Cited by 11

A Skeletal Muscle-Centric View on Time-Restricted Feeding and Obesity under Various Metabolic Challenges in Humans and Animals

Livelo, C., Guo, Y., & Melkani, G. C. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms24010422 · Cited by 11

Marine Bromophenol Derivative 3,4-Dibromo-5-(2-bromo-3,4-dihydroxy-6-isopropoxymethyl benzyl)benzene-1,2-diol Protects Hepatocytes from Lipid-Induced Cell Damage and Insulin Resistance via PTP1B Inhibition

Luo, J., Wu, N., Jiang, B., Wang, L., Wang, S., Li, X., Wang, B., Wang, C., & Shi, D. (2015) · Marine Drugs · doi:10.3390/md13074452 · Cited by 11

Trans Fatty Acid‐Induced NF‐κB Activation Does Not Induce Insulin Resistance in Cultured Murine Skeletal Muscle Cells

Hommelberg, P. P. H., LANGEN, R. C. J., Schols, A. M. W. J., van Essen, A. L. M., Snepvangers, F. J. M., Mensink, R. P., & Plat, J. (2010) · Lipids · doi:10.1007/s11745-010-3388-1 · Cited by 11

Studying progression from glucose intolerance to type 2 diabetes in obese children

Dubinina, I. A., Chistiakov, D. A., Eremina, I. A., Бровкин, А. Н., Zilberman, L. I., Nikitin, A. G., Кураева, Т. Л., Nosikov, V. V., Peterkova, V. A., & Dedov, I. I. (2014) · Diabetes & Metabolic Syndrome Clinical Research & Reviews · doi:10.1016/j.dsx.2014.07.002 · Cited by 11

Chronic Inflammation in the Metabolic Syndrome: Emphasis on Adipose Tissue

Monteiro, R. (2009) · Springer eBooks · doi:10.1007/978-1-4020-9701-0_4 · Cited by 11

Mechanical signals protect stem cell lineage selection, preserving the bone and muscle phenotypes in obesity

Frechette, D. M., Krishnamoorthy, D., Pamon, T., Chan, M. E., Patel, V. S., & Rubin, C. T. (2017) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.13442 · Cited by 12

The Influence of Age and Cardiorespiratory Fitness on Bioactive Lipids in Muscle

Søgaard, D., Baranowski, M., Dela, F., & Helge, J. W. (2018) · The Journals of Gerontology Series A · doi:10.1093/gerona/gly214 · Cited by 12

Targeting PKCθ in skeletal muscle and muscle diseases: good or bad?

Marrocco, V., Fiore, P. F., Madaro, L., Crupi, A. N., Lozanoska‐Ochser, B., & Bouché, M. (2014) · Biochemical Society Transactions · doi:10.1042/bst20140207 · Cited by 11

Valsartan Alleviates Insulin Resistance in Skeletal Muscle of Chronic Renal Failure Rats

Wang, Y., Wei, R., Yang, Y., Su, T.-Y., Huang, M., Li, P., & Chen, X. (2018) · Medical Science Monitor · doi:10.12659/msm.909910 · Cited by 11

Pathogenesis of Type 2 Diabetes Mellitus

DeFronzo, R. A. (2018) · Endocrinology · doi:10.1007/978-3-319-27317-4_8-1 · Cited by 11

Targeting Type 2 Diabetes

Schwanstecher, C., & Schwanstecher, M. (2011) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-17214-4_1 · Cited by 11

Rôle des acides gras libres dans la sécrétion et l’action de l’insuline: mécanismes de la lipotoxicité

Girard, J. R. (2003) · Érudit (Université de Montréal) · doi:10.7202/007112ar · Cited by 11

Peroxisome proliferator activated receptors, fatty acids and muscle insulin resistance.

Kraegen, E. W., Cooney, G. J., Ye, J., & Furler, S. M. (2002) · Europe PMC (PubMed Central) · Cited by 11

Effect of hepatic glucose production on acute insulin resistance induced by lipid-infusion in awake rats

Li, L. (2004) · World Journal of Gastroenterology · doi:10.3748/wjg.v10.i21.3208 · Cited by 11

Human placental mesenchymal stromal cell therapy restores the cytokine efflux and insulin signaling in the skeletal muscle of obesity-induced type 2 diabetes rat model

Kotikalapudi, N., Sampath, S. J. P., Sinha, S. N., Bhonde, R. R., Mungamuri, S. K., & Venkatesan, V. (2022) · Human Cell · doi:10.1007/s13577-021-00664-3 · Cited by 10

Acetyl Co-A Carboxylase Inhibition Halts Hyperglycemia Induced Upregulation of De Novo Lipogenesis in Podocytes and Proximal Tubular Cells

Kayampilly, P. P., Roeser, N. F., Rajendiran, T. M., Pennathur, S., & Afshinnia, F. (2022) · Metabolites · doi:10.3390/metabo12100940 · Cited by 10

Sex Differences in Energy Balance, Body Composition, and Body Fat Distribution

Tchernof, A. (2009) · Humana Press eBooks · doi:10.1007/978-1-60327-250-6_1 · Cited by 10

Global analysis of protein phosphorylation networks in insulin signaling by sequential enrichment of phosphoproteins and phosphopeptides

Fedjaev, M., Parmar, A., Xu, Y., Vyetrogon, K., DiFalco, M. R., Ashmarina, M., Nifant'ev, I. E., Posner, B. I., & Pshezhetsky, A. V. (2012) · Molecular BioSystems · doi:10.1039/c2mb05440j · Cited by 10

Mice lacking PKC-θ in skeletal muscle have reduced intramyocellular lipid accumulation and increased insulin responsiveness in skeletal muscle

Peck, B. D., Huot, J. R., Renzi, T., Arthur, S. T., Turner, M. J., & Marino, J. S. (2017) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00521.2016 · Cited by 11

The diabetic phenotype is preserved in myotubes established from type 2 diabetic subjects: a critical appraisal

Gaster, M. (2018) · Apmis · doi:10.1111/apm.12908 · Cited by 12

Increased Endothelin-1-Mediated Vasoconstrictor Tone in Human Obesity: Effects of Gut Hormones

Schinzari, F., Tesauro, M., & Cardillo, C. (2018) · Physiological Research · doi:10.33549/physiolres.933821 · Cited by 10

Clinacanthus nutans: Its potential against diabetic vascular diseases

Azemi, A. K., Mokhtar, S. S., & Rasool, A. H. G. (2020) · Brazilian Journal of Pharmaceutical Sciences · doi:10.1590/s2175-97902020000118838 · Cited by 11

Effect of hemodialysis session on the dynamics of carnitine ester profile changes in l-carnitine pretreated end-stage renal disease patients

Csiky, B. S., Bene, J., Wittmann, I., Sulyok, E., & Melegh, B. (2012) · International Urology and Nephrology · doi:10.1007/s11255-012-0209-x · Cited by 10

Increased skeletal muscle expression of PKC‐θ but not PKC‐α mRNA in type 2 diabetes: inverse relationship with in‐vivo insulin sensitivity

Gray, S., IDRIS, I. R., Davis, K. R., & Donnelly, R. (2003) · European Journal of Clinical Investigation · doi:10.1046/j.1365-2362.2003.01246.x · Cited by 10

Metabolic Characterization of a Woman Homozygous for the Ser113Leu Missense Mutation in Carnitine Palmitoyl Transferase II

Haap, M. M., Thamer, C., Machann, J., Tschritter, O., Löblein, K., Kellerer, M., Schick, F., Jacob, S., Häring, H., & Stümvoll, M. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.87.5.8380 · Cited by 10

The ASP and C5L2 pathway: another bridge between inflammation and metabolic homeostasis

Fisette, A., & Cianflone, K. (2010) · Clinical Lipidology · doi:10.2217/clp.10.21 · Cited by 9

The role of nonesterified fatty acids in pathogenesis of cardiovascular diseases

Tsvetkova, M. V., Хирманов, В. Н., & Zybina, N. N. (2010) · Arterial’naya Gipertenziya (Arterial Hypertension) · doi:10.18705/1607-419x-2010-16-1-93-103 · Cited by 10

Association between neck circumference and cardiometabolic disease in Chinese adults: a community-based cross-sectional study

Fu, W., Zou, L., Yin, X., Wu, J., Zhang, S., Mao, J., Cao, S., Li, W., Gan, Y., Yan, S., et al. (2019) · BMJ Open · doi:10.1136/bmjopen-2018-026253 · Cited by 10

Non-alcoholic Fatty Liver Disease

Smolle, E., Kessler, S. M., Golob, N., & Haybaeck, J. (2015) · Springer eBooks · doi:10.1007/978-3-319-11251-0_36 · Cited by 10

Review: Adipose tissue: passive sump or active pump?

Perry, C., Sattar, N. A., & Petrie, J. R. (2001) · The British Journal of Diabetes · doi:10.1177/14746514010010020801 · Cited by 10

Obesity and T2DM in Youth

Weiss, R., & Caprio, S. (2008) · Endocrine Research · doi:10.1080/07435800802080211 · Cited by 10

Docking protein 1 and free fatty acids are associated with insulin resistance in patients with type 2 diabetes mellitus

Ha, X., Cai, X., Huizhe, C., Li, J., Yang, B. R., Jiang, R., Li, X., Li, B., & Xin, Y. (2021) · Journal of International Medical Research · doi:10.1177/03000605211048293 · Cited by 9

Modification of the all-cause and cardiovascular disease related mortality risk with changes in the metabolic syndrome status: a population-based prospective cohort study in Taiwan

Lai, Y., Yen, Y., Chen, L., Hsu, L., Ahmadi, M. N., Eroglu, E. I., Ku, P., & Stamatakis, E. A. (2022) · Diabetes & Metabolism · doi:10.1016/j.diabet.2022.101415 · Cited by 9

Mechanisms underlying fat-induced hepatic insulin resistaNce

Park, E., & Giacca, A. (2007) · Future Lipidology · doi:10.2217/17460875.2.5.503 · Cited by 9

Excess of the endocannabinoid anandamide during lactation induces overweight, fat accumulation and insulin resistance in adult mice

Aguirre, C. A., Castillo, V. A., & Llanos, M. N. (2012) · Diabetology & Metabolic Syndrome · doi:10.1186/1758-5996-4-35 · Cited by 9

Microbubbles and Ultrasound: Therapeutic Applications in Diabetic Nephropathy

Cao, W. J., Matkar, P. N., Chen, H. H., Mofid, A., & Leong-Poi, H. M. (2015) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-22536-4_17 · Cited by 9

The effect of N-stearoylethanolamine on cholesterol content, fatty acid composition and protein carbonylation level in rats with alimentary obesity-induced insulin resistance

Onopchenko, O. V. (2014) · The Ukrainian Biochemical Journal · doi:10.15407/ubj86.06.119 · Cited by 9

TNF-alpha regulates alternative splicing of genes participating in pathways of crucial metabolic syndromes; a transcriptome wide study

Louis, J. M., Vaz, C., Balaji, A., Tanavde, V., & Talukdar, I. (2019) · Cytokine · doi:10.1016/j.cyto.2019.154815 · Cited by 9

De novo synthesis of diacylglycerol in endothelium may mediate the association between PAI-1 and the insulin resistance syndrome

McCarty, M. F. (2004) · Medical Hypotheses · doi:10.1016/j.mehy.2004.03.038 · Cited by 9

Metabolische Nebenwirkungen von Antipsychotika der neuen Generation

Engl, J., Tschoner, A., Laimer, M. W., Rettenbacher, M. A., Fleischhacker, W. W., Patsch, J. R., & Ebenbichler, C. F. (2006) · Wiener klinische Wochenschrift · doi:10.1007/s00508-006-0584-3 · Cited by 10

Association of Serum Lipids with High Blood Pressure and Hypertensionamong Diabetic Patients. Mathematical Regression Models to PredictBlood Pressure from Lipids. An Experience from 12-year Follow Up ofmore than 9000 Patients' Cohort

Aziz, K. M. A. (2017) · General Medicine Open Access · doi:10.4172/2327-5146.1000297 · Cited by 8

The Pathophysiology of Obesity

Mingrone, G., & Castagneto, M. (2015) · Springer eBooks · doi:10.1007/978-3-319-15356-8_3 · Cited by 9

Secretion of atherogenic risk factor apolipoprotein B‐100 is increased by a potential mechanism of JNK/PKC‐mediated insulin resistance in liver cells

Jin, U., Kang, Y., Chang, Y., & Kim, C. (2007) · Journal of Cellular Biochemistry · doi:10.1002/jcb.21462 · Cited by 9

Insulin-sensitising agents: beyond thiazolidinediones

Petrie, J. R., & Perry, C. G. (2002) · Expert Opinion on Emerging Drugs · doi:10.1517/14728214.7.1.165 · Cited by 9

The Pathogenesis of NASH: Human Studies

Sanyal, A. J. (2004) · doi:10.1002/9780470987438.ch7 · Cited by 9

Acute elevation of free fatty acids impairs hepatic glucose uptake in conscious rats

Nakahara, I., Matsuhisa, M., Shiba, Y., Kuroda, A., Nakatani, Y., Hatazaki, M., Kajimoto, Y., Kubota, M., Yamasaki, Y., & Hori, M. (2004) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2004.02.016 · Cited by 9

Association of METS-IR index with psoriasis in US adults: a cross-sectional study

Liu, H., Liu, C., Wang, T., & Fang, D. (2024) · Scientific Reports · doi:10.1038/s41598-024-77784-x · Cited by 14

Di (2-ethyl hexyl) phthalate and its metabolite-induced metabolic syndrome: a review of molecular mechanisms

Ashari, S., Jamialahmadi, T., Davies, N. M., Almahmeed, W. A., & Sahebkar, A. (2024) · Drug and Chemical Toxicology · doi:10.1080/01480545.2024.2405830 · Cited by 10

Polycystic ovary syndrome and nonalcoholic fatty liver disease

Georgescu, C. E. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-823045-9.00007-9 · Cited by 9

The Brain-insulin Connection, Metabolic Diseases and Related Pathologies

Gerozissis, K. (2010) · Research and perspectives in Alzheimer's disease · doi:10.1007/978-3-642-04300-0_2 · Cited by 9

Common variants associated with changes in levels of circulating free fatty acids after administration of glucose–insulin–potassium (GIK) therapy in the IMMEDIATE trial

Ellis, K. L., Zhou, Y., Rodriguez‐Murillo, L., Beshansky, J. R., Ainehsazan, E., Selker, H. P., Huggins, G. S., Cupples, L. A., & Peter, I. (2015) · The Pharmacogenomics Journal · doi:10.1038/tpj.2015.84 · Cited by 8

In vitro skeletal muscle models for type 2 diabetes

Sheng, C. Y., Son, Y. H., Jang, J., & Park, S. (2022) · Biophysics Reviews · doi:10.1063/5.0096420 · Cited by 8

Role of ectopic fat in the pathogenesis of insulin resistance

Kantartzis, K., Totsikas, C., Häring, H., & Stefan, N. (2009) · Clinical Lipidology · doi:10.2217/clp.09.35 · Cited by 7

Obesity and Type 2 Diabetes

(2012) · BENTHAM SCIENCE PUBLISHERS eBooks · doi:10.2174/978160805361211201010039 · Cited by 7

Expression Profiles of Triacylglycerol Biosynthesis Genes on Fattening Stages in Hanwoo

Kim, N.-K. (2008) · Journal of Animal Science and Technology · doi:10.5187/jast.2008.50.3.293 · Cited by 7

Focal impairment in myocardial fatty acid imaging in the left anterior descending artery area, a strong predictor for cardiac death in hemodialysis patients without obstructive coronary artery disease

Nishimura, M., Hashimoto, T., Tamaki, N., Kobayashi, H., & Ono, T. (2015) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-015-3120-8 · Cited by 7

Identification of a small molecule activator of novel PKCs for promoting glucose-dependent insulin secretion

Han, S., Pan, H., Zhang, J., Tan, L., Ma, D., Yuan, J., & Wu, J. (2010) · Cell Research · doi:10.1038/cr.2010.137 · Cited by 7

Obesity and Type 2 Diabetes

Zhyzhneuskaya, S. V., & Taylor, R. (2017) · Endocrinology · doi:10.1007/978-3-319-47685-8_21-1 · Cited by 8

Short‐term suppression of plasma free fatty acids fails to improve insulin sensitivity when intramyocellular lipid is elevated

Johnson, N. A., Stannard, S. R., ROWLANDS, D. S., Chapman, P., Thompson, C. H., Sachinwalla, T., & Thompson, M. W. (2006) · Diabetic Medicine · doi:10.1111/j.1464-5491.2006.01952.x · Cited by 7

Free fatty acid-induced muscle insulin resistance and glucose uptake dysfunction: Evidence for PKC activation and oxidative stress-activated signaling pathways

Ragheb, R., Shanab, G. M. L., Medhat, A. M., Seoudi, D. M., Adeli, K., & Fantus, I. G. (2009) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2009.08.106 · Cited by 119

Effects of free fatty acids on glucose transport and IRS-1–associated phosphatidylinositol 3-kinase activity

Dresner, A., Laurent, D., Marcucci, M., Griffin, M. E., Dufour, S., Cline, G. W., Slezak, L. A., Andersen, D. K., Hundal, R. S., Rothman, D. L., et al. (1999) · Journal of Clinical Investigation · doi:10.1172/jci5001 · Cited by 1,311

[학술논문] Effects of free fatty acids on glucose transport and IRS-1-associated phosphatidylinositol 3-kinase activity

드리즈너, A. (1999) · 기초학문자료센터(KRM) (Korea Research Foundation)

Mechanism by Which Fatty Acids Inhibit Insulin Activation of Insulin Receptor Substrate-1 (IRS-1)-associated Phosphatidylinositol 3-Kinase Activity in Muscle

Yu, C., Chen, Y., Cline, G. W., Zhang, D., Zong, H., Wang, Y., Bergeron, R., Kim, J. K., Cushman, S. W., Cooney, G. J., et al. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m200958200 · Cited by 1,561

The Mechanisms Underlying Free Fatty Acid-induced Hepatic Insulin Resistance

Park, K. Y. E. (2008) · TSpace (University of Toronto)