The DOI matches its Crossref record; 56 of the 56 references it cites were found in a registry or an index.
Human Pancreatic Islets Produce and Secrete MCP-1/CCL2: Relevance in Human Islet Transplantation
Abstract
We investigated the capacity of human islets to produce monocyte chemoattractant protein-1 (MCP-1). Primary cultures of pancreatic islets expressed and secreted MCP-1, as determined by Northern blot, immunohistochemistry, in situ hybridization, and enzyme-linked immunosorbent assay. The produced MCP-1 was biologically active as it attracted monocytes in chemotaxis assay, and chemotactic activity was almost abrogated by a neutralizing anti–MCP-1 monoclonal antibody. Expression of MCP-1 was increased by primary inflammatory cytokines (interleukin-1β, tumor necrosis factor-α) and lipopolysaccharide at both the mRNA and protein levels but not by glucose. However, MCP-1 did not modulate insulin secretion. MCP-1 secreted by pancreatic islets plays a relevant role in the clinical outcome of islet transplant in patients with type 1 diabetes. In fact, low MCP-1 secretion resulted as the most relevant factor for long-lasting insulin independence. This finding opens new approaches in the management of human islet transplantation. Finally, the finding that MCP-1 appears constitutively present in normal human islet β-cells (immunohistochemistry and in situ hybridization), in the absence of an inflammatory infiltrate, suggests that this chemokine could have functions other than monocyte recruitment and opens a new link between the endocrine and immune systems.
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Cited by
The role of inflammation in insulitis and β-cell loss in type 1 diabetes
Eizirik, D. L., Colli, M. L., & Ortis, F. (2009) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2009.21 · Cited by 1,011
Pancreatic Islet Transplantation in Humans: Recent Progress and Future Directions
Rickels, M. R., & Robertson, R. P. (2019) · Endocrine Reviews · doi:10.1210/er.2018-00154 · Cited by 329
Control of instant blood-mediated inflammatory reaction to improve islets of Langerhans engraftment
Nilsson, B., Ekdahl, K. N., & Korsgren, O. (2011) · Current Opinion in Organ Transplantation · doi:10.1097/mot.0b013e32834c2393 · Cited by 194
Bonomi, A., Sordi, V., Dugnani, E., Ceserani, V., Dossena, M., Coccè, V., Cavicchini, L., Ciusani, E., Bondiolotti, G., Piovani, G., et al. (2015) · Cytotherapy · doi:10.1016/j.jcyt.2015.09.005 · Cited by 56
Self-citation
Metadata
- Authors
- Piemonti, L., Leone, B. E., Nano, R., Saccani, A., Monti, P., Maffi, P., Bianchi, G., Sica, A., Peri, G., Melzi, R., Aldrighetti, L., Secchi, A., Di Carlo, V., Allavena, P., & Bertuzzi, F.
- Venue
- Diabetes
- Publisher
- American Diabetes Association
- Published
- 2002-01-01
- Volume
- 51
- Issue
- 1
- Pages
- 55-65
- ISSN
- 0012-1797 (ISSN-L)
- 1939-327X
- OpenAlex
- W2103302057
- Cited by
- 287
- References
- 56
- FWCI
- 13.01
- Type
- journal article
- Language
- en
- Open access
- closed
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- Piemonti, L., Leone, B. E., Nano, R., Saccani, A., Monti, P., Maffi, P., Bianchi, G., Sica, A., Peri, G., Melzi, R., Aldrighetti, L., Secchi, A., Di Carlo, V., Allavena, P., & Bertuzzi, F. (2002). Human Pancreatic Islets Produce and Secrete MCP-1/CCL2: Relevance in Human Islet Transplantation. Diabetes. https://doi.org/10.2337/diabetes.51.1.55
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