The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.
The Concept of Selective Leptin Resistance
Open accessAbstract
Leptin, a hormone secreted by adipose tissue, acts to inhibit appetite and promote metabolism, thereby reducing body weight. Leptin also increases sympathetic activity and arterial pressure. Several murine models of obesity, including agouti obese mice, exhibit resistance to the anorexic and weight-reducing effects of leptin. Hypertension in agouti mice has been attributed to hyperleptinemia. These observations pose a seeming paradox. If these mice are leptin-resistant, then how can leptin contribute to hypertension? We tested the novel hypothesis that these mice have selective leptin resistance, with preservation of the sympathoexcitatory action despite resistance to the weight-reducing actions. Leptin-induced decreases in food intake and body weight were less in agouti obese mice than in lean littermates. In contrast, leptin-induced increases in sympathetic nerve activity did not differ in obese and lean mice. These findings support the concept of selective leptin resistance, with resistance to the metabolic actions of leptin but preservation of the sympathoexcitatory actions. This finding may have potential implications for human obesity, which is associated with elevated plasma leptin and is thought to be a leptin-resistant state. If leptin resistance is selective in obese humans, then leptin could contribute to sympathetic overactivity and its adverse consequences in human obesity.
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“Initial studies purporting this concept suggested that while the effects of leptin on satiety and energy metabolism were resistant, the sympathoexcitatory effects were maintained (60, 61, 222, 223, 290, 291).”
From Cardiac remodeling in obesity (2008) · cites this paper as [61]
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“An intriguing aspect to consider with respect to the influence of leptin on the myocardium is the concept that selective leptin resistance occurs in obesity (60, 61, 222, 223).”
From Cardiac remodeling in obesity (2008) · cites this paper as [61]
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Cites
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Self-citationChronic Leptin Infusion Increases Arterial Pressure
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Cardiometabolic regulation by adipocyte-derived leptin and the brain melanocortin system
Hall, J. E., Omoto, A. C. M., do Carmo, J. M., da Silva, A. A., Mouton, A. J., Wang, Z., & Hall, M. E. (2026) · Clinical Science · doi:10.1042/cs20250039
Metadata
- Authors
- Correia, M. L. G., Haynes, W. G., Rahmouni, K., Morgan, D. A., Sivitz, W. I., & Mark, A. L.
- Affiliations
- University of Iowa (US)
- ORCID
- Venue
- Diabetes
- Publisher
- American Diabetes Association
- Published
- 2002-02-01
- Volume
- 51
- Issue
- 2
- Pages
- 439-442
- ISSN
- 0012-1797 (ISSN-L)
- 1939-327X
- OpenAlex
- W2099930994
- Cited by
- 218
- References
- 21
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 4 · 2023: 3 · 2022: 3 · 2021: 8 · 2020: 2 · 2019: 3 · 2018: 4 · 2017: 7 · 2016: 8 · 2015: 6 · 2014: 13 · 2013: 13 · 2012: 8
- FWCI
- 5.57
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Diabetes (publishedVersion)
- PubMed (publishedVersion)
- Funders
- U.S. Department of Veterans Affairs
- American Heart Association
- National Institutes of Health (5p50hl044546-05)
- National Heart, Lung, and Blood Institute (HL-14388, HL-44546, P01HL014388)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Keywords
- leptin resistance, leptin, obesity, sympathetic activity, hypertension, dietary intake, body weight, hyperleptinemia, appetite regulation, sympathetic hyperactivity
- MeSH terms
- Animals, Body Weight, Drug Resistance, Eating, Mice, Inbred Strains, Obesity, Reference Values, Sympathetic Nervous System, Leptin, Mice
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