The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.
The Concept of Selective Leptin Resistance
Open accessAbstract
Leptin, a hormone secreted by adipose tissue, acts to inhibit appetite and promote metabolism, thereby reducing body weight. Leptin also increases sympathetic activity and arterial pressure. Several murine models of obesity, including agouti obese mice, exhibit resistance to the anorexic and weight-reducing effects of leptin. Hypertension in agouti mice has been attributed to hyperleptinemia. These observations pose a seeming paradox. If these mice are leptin-resistant, then how can leptin contribute to hypertension? We tested the novel hypothesis that these mice have selective leptin resistance, with preservation of the sympathoexcitatory action despite resistance to the weight-reducing actions. Leptin-induced decreases in food intake and body weight were less in agouti obese mice than in lean littermates. In contrast, leptin-induced increases in sympathetic nerve activity did not differ in obese and lean mice. These findings support the concept of selective leptin resistance, with resistance to the metabolic actions of leptin but preservation of the sympathoexcitatory actions. This finding may have potential implications for human obesity, which is associated with elevated plasma leptin and is thought to be a leptin-resistant state. If leptin resistance is selective in obese humans, then leptin could contribute to sympathetic overactivity and its adverse consequences in human obesity.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source says what the claim attributes to it.
In the citing paper
“Initial studies purporting this concept suggested that while the effects of leptin on satiety and energy metabolism were resistant, the sympathoexcitatory effects were maintained (60, 61, 222, 223, 290, 291).”
From Cardiac remodeling in obesity (2008) · cites this paper as [61]
In the citing paper
“An intriguing aspect to consider with respect to the influence of leptin on the myocardium is the concept that selective leptin resistance occurs in obesity (60, 61, 222, 223).”
From Cardiac remodeling in obesity (2008) · cites this paper as [61]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Positional cloning of the mouse obese gene and its human homologue
Zhang, Y., Proenca, R., Maffei, M., Barone, M., Leopold, L., & Friedman, J. M. (1994) · Nature · doi:10.1038/372425a0 · Cited by 13,419
Serum Immunoreactive-Leptin Concentrations in Normal-Weight and Obese Humans
Considine, R. V., Sinha, M. K., Heiman, M. L., Kriauciunas, A., Stephens, T. W., Nyce, M. R., Ohannesian, J. P., Marco, C. C., McKee, L. J., Bauer, T. L., et al. (1996) · New England Journal of Medicine · doi:10.1056/nejm199602013340503 · Cited by 6,326
Targeted disruption of the melanocortin-4 receptor results in obesity in mice
Huszar, D., Lynch, C. A., Fairchild-Huntress, V., Dunmore, J. H., Fang, Q., Berkemeier, L. R., Gu, W., Kesterson, R. A., Boston, B. A., Cone, R. D., et al. (1997) · Cell · doi:10.1016/s0092-8674(00)81865-6 · Cited by 3,030
Role of melanocortinergic neurons in feeding and the agouti obesity syndrome
Fan, W., Boston, B. A., Kesterson, R. A., Hruby, V. J., & Cone, R. D. (1997) · Nature · doi:10.1038/385165a0 · Cited by 1,924
Neural control of renal function
DiBona, G. F., & Kopp, U. C. (1997) · Physiological Reviews · doi:10.1152/physrev.1997.77.1.75 · Cited by 1,212
Neural Control of Renal Function*
Kopp, U. C., & DiBona, G. F. (2020) · Reflex Control of the Circulation · doi:10.1201/9780367813338-17 · Cited by 1,126
Agouti protein is an antagonist of the melanocyte-stimulating-hormone receptor
Lu, D., Willard, D. H., Patel, I. R., Kadwell, S. H., Overton, L. K., Kost, T., Luther, M., Chen, W., Woychik, R. P., Wilkison, W. O., et al. (1994) · Nature · doi:10.1038/371799a0 · Cited by 1,075
Physiological response to long-term peripheral and central leptin infusion in lean and obese mice.
Halaas, J. L., Boozer, C., Blair-West, J., Fidahusein, N., Denton, D. A., & Friedman, J. M. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.16.8878 · Cited by 1,033
Receptor-mediated regional sympathetic nerve activation by leptin.
Haynes, W. G., Morgan, D. A., Walsh, S. A., Mark, A. L., & Sivitz, W. I. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119532 · Cited by 979
Self-citationChronic Leptin Infusion Increases Arterial Pressure
Shek, E. W., Brands, M. W., & Hall, J. E. (1998) · Hypertension · doi:10.1161/01.hyp.31.1.409 · Cited by 686
Cited by
Sorted by citations
Obesity, Adipose Tissue and Vascular Dysfunction
Koenen, M., Hill, M. A., Cohen, P., & Sowers, J. R. (2021) · Circulation Research · doi:10.1161/circresaha.121.318093 · Cited by 979
Region-Specific Leptin Resistance within the Hypothalamus of Diet-Induced Obese Mice
Münzberg, H., Flier, J. S., & Bjørbæk, C. (2004) · Endocrinology · doi:10.1210/en.2004-0726 · Cited by 737
Abel, E. D., Litwin, S. E., & Sweeney, G. (2008) · Physiological Reviews · doi:10.1152/physrev.00017.2007 · Cited by 736
Mechanisms of obesity-induced hypertension
Kotsis, V., Stabouli, S., Papakatsika, S., Rizos, Z., & Parati, G. (2010) · Hypertension Research · doi:10.1038/hr.2010.9 · Cited by 632
Martin, S. S., Qasim, A., & Reilly, M. P. (2008) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2008.05.060 · Cited by 516
The cellular and molecular bases of leptin and ghrelin resistance in obesity
Cui, H., López, M., & Rahmouni, K. (2017) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2016.222 · Cited by 498
Self-citationLeptin and Cardiovascular Disease
Koh, K. K., Park, S. M., & Quon, M. J. (2008) · Circulation · doi:10.1161/circulationaha.107.741645 · Cited by 481
Leptin signaling in the hypothalamus: emphasis on energy homeostasis and leptin resistance
Sahu, A. (2003) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2003.10.001 · Cited by 358
Endothelial dysfunction and diabetes: roles of hyperglycemia, impaired insulin signaling and obesity
Bakker, W., Eringa, E. C., Sipkema, P., & van Hinsbergh, V. W. M. (2008) · Cell and Tissue Research · doi:10.1007/s00441-008-0685-6 · Cited by 359
Yang, R., & Barouch, L. A. (2007) · Circulation Research · doi:10.1161/circresaha.107.156596 · Cited by 334
Role of Selective Leptin Resistance in Diet-Induced Obesity Hypertension
Rahmouni, K., Morgan, D. A., Morgan, G. M., Mark, A. L., & Haynes, W. G. (2005) · Diabetes · doi:10.2337/diabetes.54.7.2012 · Cited by 319
Self-citationEnriori, P. J., Sinnayah, P., Simonds, S. E., Rudaz, C. G., & Cowley, M. A. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.2336-11.2011 · Cited by 319
Leptin and hyperleptinemia - from friend to foe for cardiovascular function
Ren, J. (2004) · Journal of Endocrinology · doi:10.1677/joe.0.1810001 · Cited by 305
Selective Insulin and Leptin Resistance in Metabolic Disorders
Könner, A. C., & Brüning, J. C. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.07.004 · Cited by 320
Shore, S. A., & Johnston, R. A. (2005) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2005.10.002 · Cited by 272
Levin, B. E., Dunn-Meynell, A. A., & Banks, W. A. (2004) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00393.2003 · Cited by 269
Leptin receptor action and mechanisms of leptin resistance
Münzberg, H., Björnholm, M., Bates, S. H., & Myers, M. G. (2005) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-004-4432-1 · Cited by 267
The role of leptin in leptin resistance and obesity
Zhang, Y., & Scarpace, P. J. (2006) · Physiology & Behavior · doi:10.1016/j.physbeh.2006.05.038 · Cited by 259
The Role of the Autonomic Nervous System in the Pathophysiology of Obesity
Guarino, D., Nannipieri, M., Iervasi, G., Taddei, S., & Bruno, R. M. (2017) · Frontiers in Physiology · doi:10.3389/fphys.2017.00665 · Cited by 259
Leptin resistance contributes to obesity and hypertension in mouse models of Bardet-Biedl syndrome
Rahmouni, K., Fath, M. A., Seo, S., Thedens, D. R., Berry, C. J., Weiss, R. M., Nishimura, D. Y., & Sheffield, V. C. (2008) · Journal of Clinical Investigation · doi:10.1172/jci32357 · Cited by 234
Self-citationSympathetic nervous system in obesity-related hypertension: mechanisms and clinical implications
Kalil, G. Z., & Haynes, W. G. (2011) · Hypertension Research · doi:10.1038/hr.2011.173 · Cited by 234
Self-citationSelective leptin resistance: a new concept in leptin physiology with cardiovascular implications
Mark, A. L., Correia, M. L. G., Rahmouni, K., & Haynes, W. G. (2002) · Journal of Hypertension · doi:10.1097/00004872-200207000-00001 · Cited by 215
Self-citationRole of leptin in blood pressure regulation and arterial hypertension
Bełtowski, J. (2006) · Journal of Hypertension · doi:10.1097/01.hjh.0000222743.06584.66 · Cited by 220
The role of leptin in leptin resistance and obesity
Enriori, P. J., Evans, A. E., Sinnayah, P., & Cowley, M. A. (2006) · Obesity · Cited by 197
DeVries, J. H., Snoek, F. J., Kostense, P. J., Masurel, N., Heine, R. J., & On behalf of the Dutch Insulin Pump Study Group (2002) · Diabetes Care · doi:10.2337/diacare.25.11.2074 · Cited by 185
Weiss, S. T., & Shore, S. A. (2004) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200303-403ws · Cited by 186
Role of melanocortin-4 receptors in mediating renal sympathoactivation to leptin and insulin
Rahmouni, K., Haynes, W. G., Morgan, D. A., & Mark, A. L. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-14-05998.2003 · Cited by 185
Self-citationElevated Hypothalamic TCPTP in Obesity Contributes to Cellular Leptin Resistance
Loh, K., Fukushima, A., Zhang, X., Galić, S., Briggs, D. I., Enriori, P. J., Simonds, S. E., Wiede, F., Reichenbach, A., Hauser, C., et al. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.09.011 · Cited by 185
Huby, A.-C., Otvos, L. J., & de Chantemèle, E. J. B. (2016) · Hypertension · doi:10.1161/hypertensionaha.115.06642 · Cited by 168
Selective leptin resistance revisited
Mark, A. L. (2013) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00180.2013 · Cited by 162
Self-citationObesity-related hypertension: possible pathophysiological mechanisms
Vaněčková, I., Maletı́nská, L., Behuliak, M., Pražienková, V., Zicha, J., & Kuneš, J. (2014) · Journal of Endocrinology · doi:10.1530/joe-14-0368 · Cited by 168
Prior, L. J., Eikelis, N., Armitage, J. A., Davern, P. J., Burke, S. L., Montani, J.-P., Barzel, B., & Head, G. A. (2010) · Hypertension · doi:10.1161/hypertensionaha.109.141119 · Cited by 157
Early life programming of obesity and metabolic disease
Cottrell, E. C., & Ozanne, S. E. (2007) · Physiology & Behavior · doi:10.1016/j.physbeh.2007.11.017 · Cited by 158
Leptin: Linking obesity, the metabolic syndrome, and cardiovascular disease
Patel, S. B., Reams, G. P., Spear, R. M., Freeman, R. H., & Villarreal, D. (2008) · Current Hypertension Reports · doi:10.1007/s11906-008-0025-y · Cited by 156
Leptin, obesity and cardiovascular disease
Correia, M., & Haynes, W. G. (2004) · Current Opinion in Nephrology & Hypertension · doi:10.1097/00041552-200403000-00010 · Cited by 153
Self-citationMurine models for pharmacological studies of the metabolic syndrome
Fellmann, L., do Nascimento, A. R., Tibiriçá, E. V., & Bousquet, P. (2012) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2012.11.004 · Cited by 151
Chronic Sympathetic Activation
Seals, D. R., & Bell, C. (2004) · Diabetes · doi:10.2337/diabetes.53.2.276 · Cited by 142
Marsh, A. J., Fontes, M. A. P., Killinger, S., Pawlak, D. B., Polson, J. W., & Dampney, R. A. L. (2003) · Hypertension · doi:10.1161/01.hyp.0000090097.22678.0a · Cited by 138
Leptin and hypertension in obesity
Bravo, P. E., Morse, S., Borne, D. M., Aguilar, E. A., & Reisin, E. (2006) · Vascular Health and Risk Management · doi:10.2147/vhrm.2006.2.2.163 · Cited by 141
Melanocortin-4 Receptor Mediates Chronic Cardiovascular and Metabolic Actions of Leptin
Tallam, L. S., da Silva, A. A., & Hall, J. E. (2006) · Hypertension · doi:10.1161/01.hyp.0000227966.36744.d9 · Cited by 133
Effects of HIV protease inhibitor therapy on lipid metabolism
Hui, D. Y. (2003) · Progress in Lipid Research · doi:10.1016/s0163-7827(02)00046-2 · Cited by 135
From big fat cells to high blood pressure: a pathway to obesity-associated hypertension
Pausová, Z. (2006) · Current Opinion in Nephrology & Hypertension · doi:10.1097/01.mnh.0000214775.42103.a5 · Cited by 133
Selective Resistance to Central Neural Administration of Leptin in Agouti Obese Mice
Rahmouni, K., Haynes, W. G., Morgan, D. A., & Mark, A. L. (2002) · Hypertension · doi:10.1161/hy0202.102836 · Cited by 126
Self-citationLeptin induces cardiac fibrosis through galectin-3, mTOR and oxidative stress
Martínez‐Martínez, E., Jurado-López, R., Valero‐Muñoz, M., Bartolomé, M. V., Ballesteros, S., Luaces, M., Briones, A. M., López‐Andrés, N., Miana, M., & Cachofeiro, V. (2014) · Journal of Hypertension · doi:10.1097/hjh.0000000000000149 · Cited by 126
Burwell, R. G., Aujla, R. K., Grevitt, M. P., Dangerfield, P., Moulton, A., Randell, T. L., & Anderson, S. (2009) · Scoliosis · doi:10.1186/1748-7161-4-24 · Cited by 130
Role of leptin in the cardiovascular and endocrine complications of metabolic syndrome
Correia, M. L. G., & Rahmouni, K. (2006) · Diabetes, Obesity and Metabolism · doi:10.1111/j.1463-1326.2005.00562.x · Cited by 121
Self-citationIntracellular Mechanisms Involved in Leptin Regulation of Sympathetic Outflow
Rahmouni, K., Haynes, W. G., Morgan, D. A., & Mark, A. L. (2003) · Hypertension · doi:10.1161/01.hyp.0000048342.54392.40 · Cited by 120
Self-citationA brain leptin-renin angiotensin system interaction in the regulation of sympathetic nerve activity
Hilzendeger, A. M., Morgan, D. A., Brooks, L. A., Dellsperger, D., Liu, X., Grobe, J. L., Rahmouni, K., Sigmund, C. D., & Mark, A. L. (2012) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00974.2011 · Cited by 118
Self-citationOxidative stress, nitric oxide production, and renal sodium handling in leptin-induced hypertension
Bełtowski, J., Wójcicka, G., Marciniak, A., & Jamroz, A. (2004) · Life Sciences · doi:10.1016/j.lfs.2003.10.029 · Cited by 118
Eringa, E. C., Bakker, W., Smulders, Y. M., Serné, E. H., Yudkin, J. S., & Stehouwer, C. D. A. (2007) · Microcirculation · doi:10.1080/10739680701303584 · Cited by 116
Role of leptin in obesity‐related hypertension
Haynes, W. G. (2005) · Experimental Physiology · doi:10.1113/expphysiol.2005.031237 · Cited by 117
Self-citationIntra-abdominal Adiposity and Individual Components of the Metabolic Syndrome in Adolescence
Syme, C. A., Abrahamowicz, M., Leonard, G. T., Perron, M., Pitiot, A., Qiu, X., Richer, L., Totman, J. J., Veillette, S., Xiao, Y., et al. (2008) · Archives of Pediatrics and Adolescent Medicine · doi:10.1001/archpedi.162.5.453 · Cited by 114
Leptin and the Cardiovascular System
Rahmouni, K. (2004) · Recent Progress in Hormone Research · doi:10.1210/rp.59.1.225 · Cited by 110
Self-citationSympathetic nervous system as a target for aging and obesity-related cardiovascular diseases
Balasubramanian, P., Hall, D., & Subramanian, M. (2018) · GeroScience · doi:10.1007/s11357-018-0048-5 · Cited by 111
Russo, B., Menduni, M., Borboni, P., Picconi, F., & Frontoni, S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22105187 · Cited by 116
Impact of Leptin-Mediated Sympatho-Activation on Cardiovascular Function in Obese Mice
Belin de Chantemèle, E. J., Mintz, J. D., Rainey, W. E., & Stepp, D. W. (2011) · Hypertension · doi:10.1161/hypertensionaha.110.168427 · Cited by 103
PTG gene deletion causes impaired glycogen synthesis and developmental insulin resistance
Crosson, S. M., Khan, A. H., Printen, J. A., Pessin, J. E., & Saltiel, A. R. (2003) · Journal of Clinical Investigation · doi:10.1172/jci17975 · Cited by 95
Mechanisms mediating renal sympathetic activation to leptin in obesity
Morgan, D. A., Thedens, D. R., Weiss, R., & Rahmouni, K. (2008) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.90324.2008 · Cited by 89
Self-citationDevelopmental programming of energy balance and the metabolic syndrome
Cottrell, E. C., & Ozanne, S. E. (2007) · Proceedings of The Nutrition Society · doi:10.1017/s0029665107005447 · Cited by 89
Neural regulation of blood pressure by leptin and the related peptides
Matsumura, K., Tsuchihashi, T., Fujii, K., & Iida, M. (2003) · Regulatory Peptides · doi:10.1016/s0167-0115(03)00116-2 · Cited by 82
Prpić, V., Watson, P. M., Frampton, I. C., Sabol, M. A., Jezek, G. E., & Gettys, T. W. (2003) · Endocrinology · doi:10.1210/en.2002-220835 · Cited by 82
Neuroprotective effects of leptin in the context of obesity and metabolic disorders
Davis, C., Mudd, J., & Hawkins, M. A. (2014) · Neurobiology of Disease · doi:10.1016/j.nbd.2014.04.012 · Cited by 84
Morrison, C. D., Huypens, P., Stewart, L. K., & Gettys, T. W. (2008) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2008.09.005 · Cited by 83
Nohara, K., Waraich, R. S., Liu, S., Ferron, M., Waget, A., Meyers, M. S., Karsenty, G., Burcelin, R., & Mauvais-Jarvis, F. (2013) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00620.2012 · Cited by 77
Palanivel, R., Eguchi, M., Shuralyova, I., Coe, I. R., & Sweeney, G. (2006) · Metabolism · doi:10.1016/j.metabol.2006.03.020 · Cited by 72
Lugogo, N. L., Hollingsworth, J. W., Howell, D., Que, L. G., Francisco, D., Church, T. D., Potts-Kant, E. N., Ingram, J. L., Wang, Y., Jung, S., et al. (2012) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201109-1671oc · Cited by 73
RetractedModulation of central leptin sensitivity and energy balance in a rat model of diet‐induced obesity
Fam, B. C., Morris, M. J., Hansen, M. J., Kebede, M. A., Andrikopoulos, S., Proietto, J., & Thorburn, A. W. (2006) · Diabetes Obesity and Metabolism · doi:10.1111/j.1463-1326.2006.00653.x · Cited by 72
Soluble Leptin Receptor and Soluble Receptor‐Bound Fraction of Leptin in the Metabolic Syndrome
Sandhofer, A., Laimer, M. W., Ebenbichler, C. F., Kaser, S., Paulweber, B., & Patsch, J. R. (2003) · Obesity Research · doi:10.1038/oby.2003.106 · Cited by 69
Leptin protects H9c2 rat cardiomyocytes from H2O2‐induced apoptosis
Eguchi, M., Liu, Y.-T., Shin, E., & Sweeney, G. (2008) · FEBS Journal · doi:10.1111/j.1742-4658.2008.06465.x · Cited by 67
Circumventricular organs: Targets for integration of circulating fluid and energy balance signals?
Mimee, A., Smith, P., & Ferguson, A. V. (2013) · Physiology & Behavior · doi:10.1016/j.physbeh.2013.02.012 · Cited by 68
Balaskó, M., Soós, S., Székely, M., & Pétervári, E. (2014) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2014.08.006 · Cited by 64
Martin, N. M., Small, C., Sajedi, A., Patterson, M., Ghatei, M. A., & Bloom, S. R. (2004) · International Journal of Obesity · doi:10.1038/sj.ijo.0802646 · Cited by 61
Leptin-Replacement Therapy in Lipodystrophy
Wolfsdorf, J. I., Sadeghi‐Nejad, A., & Senior, B. (2002) · New England Journal of Medicine · doi:10.1056/nejm200206203462515 · Cited by 62
Chausse, B., Solon, C., da Silva, C. C. C., dos Reis, I. G. M., Manchado-Gobatto, F. D. B., Gobatto, C. A., Velloso, L. A., & Kowaltowski, A. J. (2014) · Endocrinology · doi:10.1210/en.2013-2057 · Cited by 59
Young, C. N., Morgan, D. A., Butler, S. D., Mark, A. L., & Davisson, R. L. (2013) · Hypertension · doi:10.1161/hypertensionaha.111.00405 · Cited by 58
Self-citationLiu, C., He, A., Ning, L., Luo, Y., Li, D., Zhang, M., Chen, L., & Du, Z. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00574 · Cited by 58
Hypertension and impaired renal function accompany juvenile obesity: The effect of prenatal diet
Williams, P. J., Kurlak, L. O., Perkins, A. C., Budge, H., Stephenson, T. J., Keisler, D. H., Symonds, M. E., & Gardner, D. S. (2007) · Kidney International · doi:10.1038/sj.ki.5002276 · Cited by 57
Energetic stress: The reciprocal relationship between energy availability and the stress response
Harrell, C. S., Gillespie, C. F., & Neigh, G. N. (2015) · Physiology & Behavior · doi:10.1016/j.physbeh.2015.10.009 · Cited by 51
Emerging concepts in the pathophysiology and treatment of obesity-associated hypertension
Engeli, S., & Sharma, A. M. (2002) · Current Opinion in Cardiology · doi:10.1097/00001573-200207000-00006 · Cited by 50
Matsumura, K., Tsuchihashi, T., Abe, I., & Iida, M. (2002) · Brain Research · doi:10.1016/s0006-8993(02)03045-7 · Cited by 49
Schram, K., Wong, M. M. K., Palanivel, R., No, E. K., Dixon, I., & Sweeney, G. (2008) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2008.03.005 · Cited by 49
Hypothalamic Dysfunction in Obesity and Metabolic Disorders
Carmo‐Silva, S., & Cavadas, C. (2017) · Advances in neurobiology · doi:10.1007/978-3-319-63260-5_4 · Cited by 53
la Paz, S. M., Pérez‐Pérez, A., Vilariño‐García, T., Jiménez‐Cortegana, C., Muriana, F. J. G., Millán-Linares, M. C., & Sánchez‐Margalet, V. (2020) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2020.108561 · Cited by 46
Zhou, D., & Shearman, L. P. (2003) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2003.10.015 · Cited by 51
Obesity-related hypertension: Is there a role for selective leptin resistance?
Correia, M. L. G., & Haynes, W. G. (2004) · Current Hypertension Reports · doi:10.1007/s11906-004-0074-9 · Cited by 46
Self-citationA talk between fat tissue, gut, pancreas and brain to control body weight
Wilson, J. L., & Enriori, P. J. (2015) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2015.08.022 · Cited by 39
High fat diet blunts the effects of leptin on ventilation and on carotid body activity
Ribeiro, M. J., Sacramento, J. F., Gallego‐Martin, T., Olea, E., Melo, B. F., Guarino, M. P., Yubero, S., Obeso, A., & Conde, S. V. (2017) · The Journal of Physiology · doi:10.1113/jp275362 · Cited by 45
Role of the Peroxisome Proliferator Activated Receptors in Hypertension
Fang, S., Livergood, M. C., Nakagawa, P., Wu, J., & Sigmund, C. D. (2021) · Circulation Research · doi:10.1161/circresaha.120.318062 · Cited by 46
Up-regulation of renal Na+, K+-ATPase: the possible novel mechanism of leptin-induced hypertension.
Bełtowski, J., Jamróz-Wiśniewska, A., Borkowska, E., & Wójcicka, G. (2004) · PubMed · Cited by 45
Adipokines: Novel Players in Resistant Hypertension
de Faria, A. P., Modolo, R., Fontana, V., & Moreno, H. (2014) · Journal of Clinical Hypertension · doi:10.1111/jch.12399 · Cited by 44
Obesity Hypertension: The Regulatory Role of Leptin
Kshatriya, S., Liu, K., Salah, A., Szombathy, T., Freeman, R. H., Reams, G. P., Spear, R. M., & Villarreal, D. (2011) · International Journal of Hypertension · doi:10.4061/2011/270624 · Cited by 45
Sušić, D., & Varagić, J. (2016) · Medical Clinics of North America · doi:10.1016/j.mcna.2016.08.008 · Cited by 45
The association between leptin and left ventricular hypertrophy
Pladevall, M., Williams, K. L., Guyer, H., Sadurní, J. R., Falces, C., Ribes, A., Paré, C., Brotons, C., Gabriel, R., Serrano‐Ríos, M., et al. (2003) · Journal of Hypertension · doi:10.1097/00004872-200308000-00009 · Cited by 42
Factors that influence the risk of hypertension in obese individuals
Coatmellec-Taglioni, G., & Ribière, C. (2003) · Current Opinion in Nephrology & Hypertension · doi:10.1097/00041552-200305000-00013 · Cited by 44
Food for Thought: Hormonal, Experiential, and Neural Influences on Feeding and Obesity
Karatsoreos, I. N., Thaler, J. P., Borgland, S. L., Champagne, F. A., Hurd, Y. L., & Hill, M. N. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.3452-13.2013 · Cited by 44
Can breastfeeding affect the rest of our life?
Lisboa, P. C., Miranda, R. A., Souza, L. L., & de Moura, E. G. (2021) · Neuropharmacology · doi:10.1016/j.neuropharm.2021.108821 · Cited by 45
Sympathetic-leptin relationship in obesity: effect of weight loss
Quilliot, D., Böhme, P., Zannad, F. M., & Ziegler, O. (2008) · Metabolism · doi:10.1016/j.metabol.2007.11.020 · Cited by 41
Neuroanatomical determinants of the sympathetic nerve responses evoked by leptin
Harlan, S. M., & Rahmouni, K. (2012) · Clinical Autonomic Research · doi:10.1007/s10286-012-0168-4 · Cited by 39
Self-citationObesity-Hypertension: Emerging Concepts in Pathophysiology and Treatment
Mathew, B., Patel, S. B., Spear, R. M., Villarreal, D., Reams, G. P., & Freeman, R. H. (2007) · The American Journal of the Medical Sciences · doi:10.1097/maj.0b013e3180959e4e · Cited by 38
Oda, E., Hatada, K., Katoh, K., Kodama, M., Nakamura, Y., & Aizawa, Y. (2005) · International Heart Journal · doi:10.1536/ihj.46.583 · Cited by 38
Metadata
- Authors
- Correia, M. L. G., Haynes, W. G., Rahmouni, K., Morgan, D. A., Sivitz, W. I., & Mark, A. L.
- Affiliations
- University of Iowa (US)
- ORCID
- Venue
- Diabetes
- Publisher
- American Diabetes Association
- Published
- 2002-02-01
- Volume
- 51
- Issue
- 2
- Pages
- 439-442
- ISSN
- 0012-1797 (ISSN-L)
- 1939-327X
- OpenAlex
- W2099930994
- Cited by
- 218
- References
- 21
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 4 · 2023: 3 · 2022: 3 · 2021: 8 · 2020: 2 · 2019: 3 · 2018: 4 · 2017: 7 · 2016: 8 · 2015: 6 · 2014: 13 · 2013: 13 · 2012: 8
- FWCI
- 5.57
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Diabetes (publishedVersion)
- PubMed (publishedVersion)
- Funders
- U.S. Department of Veterans Affairs
- American Heart Association
- National Institutes of Health (5p50hl044546-05)
- National Heart, Lung, and Blood Institute (HL-14388, HL-44546, P01HL014388)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Keywords
- leptin resistance, leptin, obesity, sympathetic activity, hypertension, dietary intake, body weight, hyperleptinemia, appetite regulation, sympathetic hyperactivity
- MeSH terms
- Animals, Body Weight, Drug Resistance, Eating, Mice, Inbred Strains, Obesity, Reference Values, Sympathetic Nervous System, Leptin, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
